| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hisano N et al. | Quantification of sphingosine derivatives in human platelets: inducible formation of free sphingosine. | 1998 | J. Biochem. | pmid:9538201 |
| Iwasaki-Bessho Y et al. | Decreased phospholipase D (PLD) activity in ceramide-induced apoptosis of human keratinocyte cell line HaCaT. | 1998 | J. Invest. Dermatol. | pmid:9540978 |
| Sweeney EA et al. | Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide. | 1998 | FEBS Lett. | pmid:9541007 |
| Kimura M and Ogihara M | Proliferation of adult rat hepatocytes in primary cultures induced by platelet-derived growth factor is potentiated by phenylephrine. | 1998 | Jpn. J. Pharmacol. | pmid:9541279 |
| Melendez A et al. | FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking. | 1998 | J. Biol. Chem. | pmid:9545263 |
| Harada-Shiba M et al. | Oxidized low density lipoprotein induces apoptosis in cultured human umbilical vein endothelial cells by common and unique mechanisms. | 1998 | J. Biol. Chem. | pmid:9545302 |
| Kishida E et al. | Distinctive inhibitory activity of docosahexaenoic acid against sphingosine-induced apoptosis. | 1998 | Biochim. Biophys. Acta | pmid:9555103 |
| Suzuki S et al. | An immunosuppressive regimen using FTY720 combined with cyclosporin in canine kidney transplantation. | 1998 | Transpl. Int. | pmid:9561675 |
| Kirtikara K et al. | An accessory role for ceramide in interleukin-1beta induced prostaglandin synthesis. | 1998 | Mol. Cell. Biochem. | pmid:9562240 |
| Wang ME et al. | Immunosuppressive effects of FTY720 alone or in combination with cyclosporine and/or sirolimus. | 1998 | Transplantation | pmid:9565092 |
| Kuo ML et al. | Transforming growth factor beta1 attenuates ceramide-induced CPP32/Yama activation and apoptosis in human leukaemic HL-60 cells. | 1997 | Biochem. J. | pmid:9581540 |
| Kleuser B et al. | 1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase. | 1998 | Cancer Res. | pmid:9581819 |
| Meyer zu Heringdorf D et al. | Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors. | 1998 | EMBO J. | pmid:9582276 |
| Himmel HM et al. | Guanine nucleotide-sensitive inhibition of L-type Ca2+ current by lysosphingolipids in RINm5F insulinoma cells. | 1998 | Mol. Pharmacol. | pmid:9584212 |
| Tas PW and Koschel K | Sphingosine-1-phosphate induces a Ca2+ signal in primary rat astrocytes and a Ca2+ signal and shape changes in C6 rat glioma cells. | 1998 | J. Neurosci. Res. | pmid:9589387 |
| Chiba K et al. | FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. | 1998 | J. Immunol. | pmid:9590253 |
| Marks N et al. | Activation of caspase-3 and apoptosis in cerebellar granule cells. | 1998 | J. Neurosci. Res. | pmid:9590441 |
| Canova C et al. | Epigenetic control of programmed cell death: inhibition by 5-azacytidine of 1,25-dihydroxyvitamin D3-induced programmed cell death in C6.9 glioma cells. | 1998 | Mech. Ageing Dev. | pmid:9593321 |
| Durrieu F et al. | Caspase activation is an early event in anthracycline-induced apoptosis and allows detection of apoptotic cells before they are ingested by phagocytes. | 1998 | Exp. Cell Res. | pmid:9596989 |
| Lanterman MM and Saba JD | Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants. | 1998 | Biochem. J. | pmid:9601083 |
| Ichinose Y et al. | Apoptosis induction in synovial fibroblasts by ceramide: in vitro and in vivo effects. | 1998 | J. Lab. Clin. Med. | pmid:9605105 |
| Yanagawa Y et al. | FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. II. FTY720 prolongs skin allograft survival by decreasing T cell infiltration into grafts but not cytokine production in vivo. | 1998 | J. Immunol. | pmid:9605152 |
| Sakakura C et al. | Selectivity of sphingosine-induced apoptosis. Lack of activity of DL-erythyro-dihydrosphingosine. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9618297 |
| Koolpe M et al. | Adenosine 5'-triphosphate, uridine 5'-triphosphate, bradykinin, and lysophosphatidic acid induce different patterns of calcium responses by human articular chondrocytes. | 1998 | J. Orthop. Res. | pmid:9621896 |
| Oyama Y et al. | Cytotoxic actions of FTY720, a novel immunosuppressant, on thymocytes and brain neurons dissociated from the rat. | 1998 | Jpn. J. Pharmacol. | pmid:9623716 |
| Nakamura H et al. | Survival by Mac-1-mediated adherence and anoikis in phorbol ester-treated HL-60 cells. | 1998 | J. Biol. Chem. | pmid:9624115 |
| Boland MP and O'Neill LA | Ceramide activates NFkappaB by inducing the processing of p105. | 1998 | J. Biol. Chem. | pmid:9624136 |
| Zhou H et al. | Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. | 1998 | J. Biol. Chem. | pmid:9632728 |
| Antoniou EA et al. | Donor-specific blood transfusion does not enhance the effect of FTY720 in rat cardiac allotransplantation. | 1998 | Transplant. Proc. | pmid:9636420 |
| Suzuki K et al. | Prevention of experimentally induced autoimmune type I diabetes in rats by the new immunosuppressive reagent FTY720. | 1998 | Transplant. Proc. | pmid:9636421 |
| Yuzawa K et al. | An effect of FTY720 on acute rejection in canine renal transplantation. | 1998 | Transplant. Proc. | pmid:9636422 |
| Suzuki K et al. | Beneficial immunosuppressive effect of FTY720 combined with intrathymic injection of splenic cells on rat pancreaticoduodenal allograft. | 1998 | Transplant. Proc. | pmid:9636432 |
| Hershberger PA et al. | In vitro thymocyte maturation is associated with reduced cellular susceptibility to Fas-mediated apoptosis. | 1998 | Cell. Immunol. | pmid:9636691 |
| Storchak LG et al. | Differential effect of protein kinase inhibitors on calcium-dependent and calcium-independent [14C]GABA release from rat brain synaptosomes. | 1998 | Neuroscience | pmid:9639290 |
| Gardas A | A structural study on a macro-glycolipid containing 22 sugars isolated from human erythrocytes. | 1976 | Eur. J. Biochem. | pmid:964264 |
| Edmunds NJ and Woodward B | Effects of tumour necrosis factor-alpha on the coronary circulation of the rat isolated perfused heart: a potential role for thromboxane A2 and sphingosine. | 1998 | Br. J. Pharmacol. | pmid:9647473 |
| Hartfield PJ et al. | Neurotrophic factors prevent ceramide-induced apoptosis downstream of c-Jun N-terminal kinase activation in PC12 cells. | 1998 | J. Neurochem. | pmid:9648862 |
| Furuya S et al. | Ceramide and its interconvertible metabolite sphingosine function as indispensable lipid factors involved in survival and dendritic differentiation of cerebellar Purkinje cells. | 1998 | J. Neurochem. | pmid:9648886 |
| Noh SJ et al. | Different signaling pathway between sphingosine-1-phosphate and lysophosphatidic acid in Xenopus oocytes: functional coupling of the sphingosine-1-phosphate receptor to PLC-xbeta in Xenopus oocytes. | 1998 | J. Cell. Physiol. | pmid:9648929 |
| Oshima M | Identification of glucosyl sphingosine from Gaucher's spleen by gas chromatography-electron impact and GC-chemical ionization mass spectrometry. | 1976 | J. Biochem. | pmid:965366 |
| Shimeno H et al. | Partial purification and characterization of sphingosine N-acyltransferase (ceramide synthase) from bovine liver mitochondrion-rich fraction. | 1998 | Lipids | pmid:9655376 |
| Freysz L et al. | Metabolism of brain sphingomyelins: half-lives of sphingosine, fatty acids and phosphate from two types of rat brain sphingomyelin. | 1976 | J. Neurochem. | pmid:965975 |
| Van Brocklyn JR et al. | Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival. | 1998 | J. Cell Biol. | pmid:9660876 |
| Collins TF et al. | Effects of fumonisin B1 in pregnant rats. | 1998 | Food Chem. Toxicol. | pmid:9662415 |
| Auzenne E et al. | Cytotoxic effects of sphingolipids as single or multi-modality agents on human melanoma and soft tissue sarcoma in vitro. | 1998 | Melanoma Res. | pmid:9664144 |
| Tsunoda M et al. | Early fumonisin B1 toxicity in relation to disrupted sphingolipid metabolism in male BALB/c mice. | 1998 | J. Biochem. Mol. Toxicol. | pmid:9664234 |
| Fukuda Y et al. | Effect of FTY720 on immunoregulation in concordant xenotransplantation. | 1998 | Transpl. Int. | pmid:9665039 |
| Pfau JC et al. | A comparison of the effects of lipopolysaccharide and ceramide on arachidonic acid metabolism in THP-1 monocytic cells. | 1998 | Cell. Immunol. | pmid:9665757 |
| Humpf HU et al. | Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor. | 1998 | J. Biol. Chem. | pmid:9668088 |
| RodrÃguez-Fernández JL and Rozengurt E | Bombesin, vasopressin, lysophosphatidic acid, and sphingosylphosphorylcholine induce focal adhesion kinase activation in intact Swiss 3T3 cells. | 1998 | J. Biol. Chem. | pmid:9668122 |
| Spiegel S et al. | Sphingosine-1-phosphate in cell growth and cell death. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668339 |
| Igarashi Y | Sphingosine-1-phosphate as an intercellular signaling molecule. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668340 |
| Riboni L et al. | Metabolic fate of exogenous sphingosine in neuroblastoma neuro2A cells. Dose-dependence and biological effects. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668342 |
| Saito M et al. | The semisynthetic glycosphingolipid LIGA20 potently protects neurons against apoptosis. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668359 |
| Stam JC et al. | Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling. | 1998 | EMBO J. | pmid:9670021 |
| Johns DG et al. | The role of the endothelium in ceramide-induced vasodilation. | 1998 | Eur. J. Pharmacol. | pmid:9671089 |
| van der Westhuizen L et al. | Inhibition of sphingolipid biosynthesis in rat primary hepatocyte cultures by fumonisin B1 and other structurally related compounds. | 1998 | Food Chem. Toxicol. | pmid:9674957 |
| Nagiec MM et al. | The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases. | 1998 | J. Biol. Chem. | pmid:9677363 |
| Rossner S et al. | p75 and TrkA receptor signaling independently regulate amyloid precursor protein mRNA expression, isoform composition, and protein secretion in PC12 cells. | 1998 | J. Neurochem. | pmid:9681467 |
| Nakabo Y and Pabst MJ | Inhibition by sphingosine of leukemic cell killing by human monocytes activated with interleukin-2: a possible role of protein kinase C. | 1998 | Jpn. J. Cancer Res. | pmid:9685859 |
| Ragg SJ et al. | The mitogen-activated protein kinase pathway inhibits ceramide-induced terminal differentiation of a human monoblastic leukemia cell line, U937. | 1998 | J. Immunol. | pmid:9686602 |
| Lochhead KM and Zager RA | Fluorinated anesthetic exposure "activates" the renal cortical sphingomyelinase cascade. | 1998 | Kidney Int. | pmid:9690203 |
| López-González MA et al. | The production of free oxygen radicals and nitric oxide in the rat cochlea. | 1998 | Neurochem. Int. | pmid:9694043 |
| Galadari S et al. | Purification and characterization of ceramide-activated protein phosphatases. | 1998 | Biochemistry | pmid:9698369 |
| Cha SH et al. | Effect of silica on phospholipase D activity in rat alveolar macrophages. | 1998 | Ind Health | pmid:9701905 |
| Xu M et al. | Effect of peritransplant FTY720 alone or in combination with post-transplant tacrolimus in a rat model of cardiac allotransplantation. | 1998 | Transpl. Int. | pmid:9704394 |
| Megidish T et al. | A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein. | 1998 | J. Biol. Chem. | pmid:9705322 |
| Roberts R et al. | Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. | 1998 | J. Biol. Chem. | pmid:9705349 |
| Yamasaki T et al. | Effect of a new immunosuppressive agent, FTY720, on survival of islet allografts. | Cell Transplant | pmid:9710310 | |
| Summers SA et al. | Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. | 1998 | Mol. Cell. Biol. | pmid:9710629 |
| Zhang J et al. | Regulation of membrane release in apoptosis. | 1998 | Biochem. J. | pmid:9716508 |
| Troncoso P and Kahan BD | Preclinical evaluation of a new immunosuppressive agent, FTY720. | 1998 | Clin. Biochem. | pmid:9721436 |
| Patel M | Inhibition of neuronal apoptosis by a metalloporphyrin superoxide dismutase mimic. | 1998 | J. Neurochem. | pmid:9721731 |
| van Echten-Deckert G et al. | Phosphorylated cis-4-methylsphingosine mimics the mitogenic effect of sphingosine-1-phosphate in Swiss 3T3 fibroblasts. | 1998 | J. Biol. Chem. | pmid:9722598 |
| Kahan BD | FTY720: a new immunosuppressive agent with novel mechanism(s) of action. | 1998 | Transplant. Proc. | pmid:9723444 |
| Stepkowski SM et al. | Synergistic interaction of FTY720 with cyclosporine or sirolimus to prolong heart allograft survival. | 1998 | Transplant. Proc. | pmid:9723445 |
| Nakajima H et al. | FTY720 inhibits the mRNA expression of intragraft cytotoxic molecules, leading to cardiac allograft survival. | 1998 | Transplant. Proc. | pmid:9723446 |
| Xu M et al. | FTY720 compares with FK 506 as rescue therapy in rat heterotopic cardiac transplantation. | 1998 | Transplant. Proc. | pmid:9723447 |
| Matsuda T et al. | Caspase requirement for the apoptotic death of WR19L-induced by FTY720. | 1998 | Transplant. Proc. | pmid:9723502 |
| Lakics V and Vogel SN | Lipopolysaccharide and ceramide use divergent signaling pathways to induce cell death in murine macrophages. | 1998 | J. Immunol. | pmid:9725248 |
| Hama-Inaba H et al. | Radio-sensitive murine thymoma cell line 3SB: characterization of its apoptosis-resistant variants induced by repeated X-irradiation. | 1998 | Mutat. Res. | pmid:9726009 |
| Meyer zu Heringdorf D et al. | Discrimination between plasma membrane and intracellular target sites of sphingosylphosphorylcholine. | 1998 | Eur. J. Pharmacol. | pmid:9726638 |
| Zager RA et al. | Ceramide accumulation during oxidant renal tubular injury: mechanisms and potential consequences. | 1998 | J. Am. Soc. Nephrol. | pmid:9727376 |
| Orlati S et al. | Intracellular calcium mobilization and phospholipid degradation in sphingosylphosphorylcholine-stimulated human airway epithelial cells. | 1998 | Biochem. J. | pmid:9729473 |
| Bodennec J et al. | Phytosphingosine biosynthesis differs from sphingosine in fish leukocytes and involves a transfer of methyl groups from [3H-methyl]methionine precursor. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9735337 |
| Ciacci-Zanella JR et al. | Characterization of cell-cycle arrest by fumonisin B1 in CV-1 cells. | 1998 Sep-Oct | Food Chem. Toxicol. | pmid:9737426 |
| Edsall LC et al. | N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide. | 1998 | Biochemistry | pmid:9737868 |
| Mathes C et al. | Calcium release-activated calcium current (ICRAC) is a direct target for sphingosine. | 1998 | J. Biol. Chem. | pmid:9737958 |
| Ghahremani M et al. | Activation of Fas ligand/receptor system kills ovarian cancer cell lines by an apoptotic mechanism. | 1998 | Gynecol. Oncol. | pmid:9740705 |
| Asfaw B et al. | Degradation of blood group A glycolipid A-6-2 by normal and mutant human skin fibroblasts. | 1998 | J. Lipid Res. | pmid:9741689 |
| Vento R et al. | Induction of programmed cell death in human retinoblastoma Y79 cells by C2-ceramide. | 1998 | Mol. Cell. Biochem. | pmid:9746206 |
| Mutoh T et al. | Glucosylceramide synthase inhibitor inhibits the action of nerve growth factor in PC12 cells. | 1998 | J. Biol. Chem. | pmid:9748278 |
| Sakaguchi M et al. | Cytokine production by T cells infiltrating in the eye of uveitis patients. | 1998 Jul-Aug | Jpn. J. Ophthalmol. | pmid:9749865 |
| Kimura M and Ogihara M | Effects of insulin-like growth factor I and II on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes. | 1998 | Eur. J. Pharmacol. | pmid:9754929 |
| Banno Y et al. | Evidence for the presence of multiple forms of Sph kinase in human platelets. | 1998 | Biochem. J. | pmid:9761727 |
| Okamoto H et al. | EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition. | 1998 | J. Biol. Chem. | pmid:9765227 |
| Escargueil-Blanc I et al. | Apoptosis and activation of the sphingomyelin-ceramide pathway induced by oxidized low density lipoproteins are not causally related in ECV-304 endothelial cells. | 1998 | J. Biol. Chem. | pmid:9765267 |
| Vasta V et al. | Effects of sphingosine 1-phosphate and bradykinin on phospholipid signalling in human epithelial A549 cells. | 1998 | Biochem. Soc. Trans. | pmid:9765948 |
| Shimizu C et al. | A novel immunosuppressant, FTY720, increases the efficiency of a superantigen-induced peripheral T-cell deletion whilst inhibiting negative selection in the thymus. | 1998 | Immunology | pmid:9767438 |
| Birt DF et al. | Inhibition of skin carcinomas but not papillomas by sphingosine, N-methylsphingosine, and N-acetylsphingosine. | 1998 | Nutr Cancer | pmid:9770723 |
sphingosine
sphingosine is a lipid of Sphingolipids (SP) class.
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