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Sphingosine-1-phosphate improves endothelialization with reduction of thrombosis in recellularized human umbilical vein graft by inhibiting syndecan-1 shedding in vitro. |
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Acta Biomater |
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Metastatic triple-negative breast cancer is dependent on SphKs/S1P signaling for growth and survival. |
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Cell. Signal. |
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High-Density Lipoprotein-Associated Apolipoprotein M Limits Endothelial Inflammation by Delivering Sphingosine-1-Phosphate to the Sphingosine-1-Phosphate Receptor 1. |
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Arterioscler. Thromb. Vasc. Biol. |
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Barnawi J et al. |
Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis. |
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Respirology |
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High-density lipoprotein-associated sphingosine-1-phosphate activity in heterozygous familial hypercholesterolaemia. |
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Eur. J. Clin. Invest. |
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Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response. |
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Nat. Immunol. |
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Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration. |
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Am. J. Pathol. |
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Synergistic Action of Genistein and Calcitriol in Immature Osteosarcoma MG-63 Cells by SGPL1 Up-Regulation. |
2017 |
PLoS ONE |
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A phase 2 study of the sphingosine-1-phosphate antibody sonepcizumab in patients with metastatic renal cell carcinoma. |
2017 |
Cancer |
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Valproic acid enforces the priming effect of sphingosine-1 phosphate on human mesenchymal stem cells. |
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Acid ceramidase confers radioresistance to glioblastoma cells. |
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Urine Metabonomics Reveals Early Biomarkers in Diabetic Cognitive Dysfunction. |
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Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease. |
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Cell Death Dis |
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Involvement of sphingosine kinase/sphingosine 1-phosphate metabolic pathway in spondyloarthritis. |
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Bone |
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Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression. |
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Mol Oncol |
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Targeting sphingosine-1-phosphate signaling for cancer therapy. |
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Sci China Life Sci |
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Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. |
2017 |
Proc. Natl. Acad. Sci. U.S.A. |
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Angiogenesis Model of Cornea to Understand the Role of Sphingosine 1-Phosphate. |
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Methods Mol. Biol. |
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The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles. |
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J. Biol. Chem. |
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Phytosphingosine, sphingosine and dihydrosphingosine ceramides in model skin lipid membranes: permeability and biophysics. |
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Biochim. Biophys. Acta |
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Stereoselective preparation of quaternary 2-vinyl sphingosines and ceramides and their effect on basal sphingolipid metabolism. |
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Chem. Phys. Lipids |
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Ionizing radiation induces long-term senescence in endothelial cells through mitochondrial respiratory complex II dysfunction and superoxide generation. |
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Free Radic. Biol. Med. |
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Identification of selective inhibitors of sphingosine kinases 1 and 2 through a structure-activity relationship study of 4-epi-jaspine B. |
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Bioorg. Med. Chem. |
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Anti-melanogenic activity of phytosphingosine via the modulation of the microphthalmia-associated transcription factor signaling pathway. |
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J. Dermatol. Sci. |
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The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations. |
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Int J Mol Sci |
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Autophagy inhibits C2-ceramide-mediated cell death by decreasing the reactive oxygen species levels in SH-SY5Y cells. |
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Neurosci. Lett. |
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Sphingosine-1-phosphate activates the AKT pathway to inhibit chemotherapy induced human granulosa cell apoptosis. |
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Gynecol. Endocrinol. |
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The Utility of Biomarkers in Osteoporosis Management. |
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Mol Diagn Ther |
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Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury: Role of S1P lyase. |
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Adv Biol Regul |
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Effect of sphingosine kinase modulators on interleukin-1β release, sphingosine 1-phosphate receptor 1 expression and experimental autoimmune encephalomyelitis. |
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Br. J. Pharmacol. |
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Detection of Urine Metabolites in a Rat Model of Chronic Fatigue Syndrome before and after Exercise. |
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Biomed Res Int |
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Sphingosine-1-phosphate modulators in inflammatory skin diseases - lining up for clinical translation. |
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Exp. Dermatol. |
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Gamma-tocotrienol profoundly alters sphingolipids in cancer cells by inhibition of dihydroceramide desaturase and possibly activation of sphingolipid hydrolysis during prolonged treatment. |
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J. Nutr. Biochem. |
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Fas/S1P crosstalk via NF-κB activation in osteoclasts controls subchondral bone remodeling in murine TMJ arthritis. |
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Biochem. Biophys. Res. Commun. |
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β-Blockade Prevents Post-Ischemic Myocardial Decompensation Via βAR-Dependent Protective Sphingosine-1 Phosphate Signaling. |
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J. Am. Coll. Cardiol. |
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Punsawad C and Viriyavejakul P |
Reduction in serum sphingosine 1-phosphate concentration in malaria. |
2017 |
PLoS ONE |
pmid:28666023
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The effects of berberine on a murine model of multiple sclerosis and the SPHK1/S1P signaling pathway. |
2017 |
Biochem. Biophys. Res. Commun. |
pmid:28655617
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Chang CH and Randolph GJ |
Sphingosine-1-Phosphate as the Lymphocyte's Ticket to Ride and Survive. |
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Dev. Cell |
pmid:28633013
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Sphingosine-1-Phosphate (S1P)-Related Response of Human Conjunctival Fibroblasts After Filtration Surgery for Glaucoma. |
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Invest. Ophthalmol. Vis. Sci. |
pmid:28418499
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A Shift in ApoM/S1P Between HDL-Particles in Women With Type 1 Diabetes Mellitus Is Associated With Impaired Anti-Inflammatory Effects of the ApoM/S1P Complex. |
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Arterioscler. Thromb. Vasc. Biol. |
pmid:28385702
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The role of sphingosine-1-phosphate in the tumor microenvironment and its clinical implications. |
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Tumour Biol. |
pmid:28381169
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Sphingosine-1-Phosphate Signaling in Inflammatory Bowel Disease. |
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Trends Mol Med |
pmid:28283249
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Modulation of sphingosine-1-phosphate in inflammatory bowel disease. |
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Autoimmun Rev |
pmid:28279838
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Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate. |
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J. Immunol. |
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Phosphatidylserine lipids and membrane order precisely regulate the activity of Polybia-MP1 peptide. |
2017 |
Biochim. Biophys. Acta |
pmid:28274844
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Inositol Depletion Induced by Acute Treatment of the Bipolar Disorder Drug Valproate Increases Levels of Phytosphingosine. |
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J. Biol. Chem. |
pmid:28100786
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Altered Expression of Sphingosine-1-Phosphate Metabolizing Enzymes in Oral Cancer Correlate With Clinicopathological Attributes. |
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Cancer Invest. |
pmid:28135860
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Involvement of CETP (Cholesteryl Ester Transfer Protein) in the Shift of Sphingosine-1-Phosphate Among Lipoproteins and in the Modulation of its Functions. |
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Arterioscler. Thromb. Vasc. Biol. |
pmid:28126827
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The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice. |
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Hepatology |
pmid:28120434
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S1P/S1PR3 signaling mediated proliferation of pericytes via Ras/pERK pathway and CAY10444 had beneficial effects on spinal cord injury. |
2018 |
Biochem. Biophys. Res. Commun. |
pmid:29534963
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Protective effect of sphingosine-1-phosphate for chronic intermittent hypoxia-induced endothelial cell injury. |
2018 |
Biochem. Biophys. Res. Commun. |
pmid:29550481
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[The role of apolipoprotein M and sphingosine 1-phosphate axis in the prevention of atherosclerosis]. |
2018 |
Orv Hetil |
pmid:29376427
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Sphingosine-1-phosphate (S1P) activates STAT3 to protect against de novo acute heart failure (AHF). |
2018 |
Life Sci. |
pmid:29373815
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Arteriovenous Sphingosine-1-Phosphate Differences Across Selected Organs of the Rat. |
2018 |
Cell. Physiol. Biochem. |
pmid:29316552
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S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense. |
2018 |
Science |
pmid:29302015
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Sphingosine Induces Apoptosis and Down-regulation of in PAX3-FOXO1-positive Alveolar Rhabdomyosarcoma Cells Irrespective of Mutation. |
2018 |
Anticancer Res. |
pmid:29277758
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Zhang YL et al. |
Non-invasive assessment of culture media from goat cloned embryos associated with subjective morphology by gas chromatography - mass spectroscopy-based metabolomic analysis. |
2018 |
Anim. Sci. J. |
pmid:28833899
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A Sphingosine-type cerebroside in Clavicorona pyxidata induce fruit body formation. |
2018 |
Nat. Prod. Res. |
pmid:28347179
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Ogretmen B |
Sphingolipid metabolism in cancer signalling and therapy. |
2018 |
Nat. Rev. Cancer |
pmid:29147025
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