| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Williams PA et al. | Hypoxia augments outgrowth endothelial cell (OEC) sprouting and directed migration in response to sphingosine-1-phosphate (S1P). | 2015 | PLoS ONE | pmid:25875493 |
| Wang Z et al. | The Effect of Sphingosine 1-Phosphate/Sphingosine 1-Phosphate Receptor on Neutrophil Function and the Relevant Signaling Pathway. | 2015 | Acta Haematol. | pmid:25872153 |
| Gendron D et al. | Treatment with a sphingosine analog after the inception of house dust mite-induced airway inflammation alleviates key features of experimental asthma. | 2015 | Respir. Res. | pmid:25645346 |
| Goldman MD and Naismith RT | Multiple sclerosis, immunomodulation, and immunizations: balancing the benefits. | 2015 | Neurology | pmid:25636716 |
| Kappos L et al. | Randomized trial of vaccination in fingolimod-treated patients with multiple sclerosis. | 2015 | Neurology | pmid:25636714 |
| Ogiso H et al. | Analysis of lipid-composition changes in plasma membrane microdomains. | 2015 | J. Lipid Res. | pmid:26116739 |
| Thomas RH and Wakefield RA | Oral disease-modifying therapies for relapsing-remitting multiple sclerosis. | 2015 | Am J Health Syst Pharm | pmid:25511835 |
| Brulhart-Meynet MC et al. | Improving reconstituted HDL composition for efficient post-ischemic reduction of ischemia reperfusion injury. | 2015 | PLoS ONE | pmid:25781943 |
| Nojima H et al. | Sphingolipids in liver injury, repair and regeneration. | 2015 | Biol. Chem. | pmid:25781682 |
| Newton J et al. | Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy. | 2015 | Exp. Cell Res. | pmid:25770011 |
| Muñoz-Sáez E et al. | Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y). | 2015 | Neurosci. Lett. | pmid:25769802 |
| Tyler KL | Fingolimod and risk of varicella-zoster virus infection: back to the future with an old infection and a new drug. | 2015 | JAMA Neurol | pmid:25420159 |
| Arvin AM et al. | Varicella-zoster virus infections in patients treated with fingolimod: risk assessment and consensus recommendations for management. | 2015 | JAMA Neurol | pmid:25419615 |
| Kalhori V and Törnquist K | MMP2 and MMP9 participate in S1P-induced invasion of follicular ML-1 thyroid cancer cells. | 2015 | Mol. Cell. Endocrinol. | pmid:25643979 |
| Sivasubramanian M et al. | Sphingosine kinase 2 and sphingosine-1-phosphate promotes mitochondrial function in dopaminergic neurons of mouse model of Parkinson's disease and in MPP+ -treated MN9D cells in vitro. | 2015 | Neuroscience | pmid:25637806 |
| Yokota K and Ogino T | Phase separation in lipid bilayer membranes induced by intermixing at a boundary of two phases with different components. | 2015 | Chem. Phys. Lipids | pmid:26363303 |
| Zhong Y et al. | Nephrokeli, a Chinese herbal formula, may improve IgA nephropathy through regulation of the sphingosine-1-phosphate pathway. | 2015 | PLoS ONE | pmid:25633986 |
| Zhang X et al. | Cost effectiveness of fingolimod, teriflunomide, dimethyl fumarate and intramuscular interferon-β1a in relapsing-remitting multiple sclerosis. | 2015 | CNS Drugs | pmid:25326785 |
| Montecucco F et al. | Impact of systemic inflammation and autoimmune diseases on apoA-I and HDL plasma levels and functions. | 2015 | Handb Exp Pharmacol | pmid:25522998 |
| Nofer JR | Signal transduction by HDL: agonists, receptors, and signaling cascades. | 2015 | Handb Exp Pharmacol | pmid:25522990 |
| Baranowski M et al. | Exercise increases sphingoid base-1-phosphate levels in human blood and skeletal muscle in a time- and intensity-dependent manner. | 2015 | Eur. J. Appl. Physiol. | pmid:25519954 |
| Oskeritzian CA et al. | The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses. | 2015 | J. Allergy Clin. Immunol. | pmid:25512083 |
| Opal SM and van der Poll T | Endothelial barrier dysfunction in septic shock. | 2015 | J. Intern. Med. | pmid:25418337 |
| Hernández-Coronado CG et al. | Sphingosine-1-phosphate and ceramide are associated with health and atresia of bovine ovarian antral follicles. | 2015 | Animal | pmid:25245232 |
| Klocke S et al. | Slow-freezing versus vitrification for human ovarian tissue cryopreservation. | 2015 | Arch. Gynecol. Obstet. | pmid:25115279 |
| Sar JI et al. | Sphingosine-1-phosphate stimulated connective tissue growth factor expression in human buccal fibroblasts: Inhibition by epigallocatechin-3-gallate. | 2015 | J. Formos. Med. Assoc. | pmid:24035571 |
| Siow D et al. | Regulation of de novo sphingolipid biosynthesis by the ORMDL proteins and sphingosine kinase-1. | 2015 | Adv Biol Regul | pmid:25319495 |
| Oskeritzian CA | Mast cell plasticity and sphingosine-1-phosphate in immunity, inflammation and cancer. | 2015 | Mol. Immunol. | pmid:24766823 |
| Ejsing CS et al. | Quantitative Profiling of Long-Chain Bases by Mass Tagging and Parallel Reaction Monitoring. | 2015 | PLoS ONE | pmid:26660097 |
| Jones EE et al. | Tissue biomarkers of drug efficacy: case studies using a MALDI-MSI workflow. | 2015 | Bioanalysis | pmid:26505686 |
| Ramos-Perez WD et al. | A map of the distribution of sphingosine 1-phosphate in the spleen. | 2015 | Nat. Immunol. | pmid:26502404 |
| Winkler MS et al. | Decreased serum concentrations of sphingosine-1-phosphate in sepsis. | 2015 | Crit Care | pmid:26498205 |
| Matula K et al. | Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer. | 2015 | BMC Cancer | pmid:26493335 |
| Klyachkin YM et al. | Pharmacological Elevation of Circulating Bioactive Phosphosphingolipids Enhances Myocardial Recovery After Acute Infarction. | 2015 | Stem Cells Transl Med | pmid:26371341 |
| Zeng Y et al. | Sphingosine 1-phosphate induced synthesis of glycocalyx on endothelial cells. | 2015 | Exp. Cell Res. | pmid:26364737 |
| Yue HW et al. | Sphingosylphosphorylcholine protects cardiomyocytes against ischemic apoptosis via lipid raft/PTEN/Akt1/mTOR mediated autophagy. | 2015 | Biochim. Biophys. Acta | pmid:25871970 |
| Choi S et al. | A genetic variant of cortactin linked to acute lung injury impairs lamellipodia dynamics and endothelial wound healing. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26361873 |
| Li C et al. | Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3. | 2015 | J Neuroinflammation | pmid:25880547 |
| Attiori Essis S et al. | GluN2B-containing NMDA receptors are upregulated in plasma membranes by the sphingosine-1-phosphate analog FTY720P. | 2015 | Brain Res. | pmid:26260438 |
| Davis W | The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene. | 2015 | Curr Alzheimer Res | pmid:26510981 |
| Bekpinar S et al. | The effect of nephropathy on plasma sphingosine 1-phosphate concentrations in patients with type 2 diabetes. | 2015 | Clin. Biochem. | pmid:26255120 |
| Yester JW et al. | Sphingosine-1-phosphate inhibits IL-1-induced expression of C-C motif ligand 5 via c-Fos-dependent suppression of IFN-β amplification loop. | 2015 | FASEB J. | pmid:26246404 |
| Hui S et al. | Sphingosine-1-Phosphate Signaling Regulates Myogenic Responsiveness in Human Resistance Arteries. | 2015 | PLoS ONE | pmid:26367262 |
| Dabkowska AP et al. | Assembly of RNA nanostructures on supported lipid bilayers. | 2015 | Nanoscale | pmid:25417592 |
| Nakagawa Y and Chiba K | Diversity and plasticity of microglial cells in psychiatric and neurological disorders. | 2015 | Pharmacol. Ther. | pmid:26129625 |
| Jeong SK et al. | Sphingosine kinase 1 activation enhances epidermal innate immunity through sphingosine-1-phosphate stimulation of cathelicidin production. | 2015 | J. Dermatol. Sci. | pmid:26113114 |
| Marycz K et al. | The effect of the bioactive sphingolipids S1P and C1P on multipotent stromal cells--new opportunities in regenerative medicine. | 2015 | Cell. Mol. Biol. Lett. | pmid:26110483 |
| Woodcock JM et al. | Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics. | 2015 | Oncotarget | pmid:25971334 |
| Chen Y et al. | Biomarker identification and pathway analysis by serum metabolomics of lung cancer. | 2015 | Biomed Res Int | pmid:25961003 |
| Pfender N et al. | Reactivation of herpesvirus under fingolimod: A case of severe herpes simplex encephalitis. | 2015 | Neurology | pmid:25957334 |
| Tully T et al. | Kaposi sarcoma in a patient with relapsing-remitting multiple sclerosis receiving fingolimod. | 2015 | Neurology | pmid:25878178 |
| Lee KP et al. | DJ-1-mediated upregulation of serine palmitoyltransferase 2 controls vascular neointima via S1P autocrine. | 2015 | Int. J. Cardiol. | pmid:25978603 |
| Morad SA and Cabot MC | Tamoxifen regulation of sphingolipid metabolism--Therapeutic implications. | 2015 | Biochim. Biophys. Acta | pmid:25964209 |
| Jing XD et al. | The relationship between the high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) and coronary in-stent restenosis. | 2015 | Clin. Chim. Acta | pmid:25958848 |
| Betker JL and Anchordoquy TJ | Relating toxicity to transfection: using sphingosine to maintain prolonged expression in vitro. | 2015 | Mol. Pharm. | pmid:25418523 |
| Nishihara H et al. | Fingolimod prevents blood-brain barrier disruption induced by the sera from patients with multiple sclerosis. | 2015 | PLoS ONE | pmid:25774903 |
| Zheng XD et al. | Role of Sphk1 in the malignant transformation of breast epithelial cells and breast cancer progression. | 2014 Oct-Dec | Indian J Cancer | pmid:26842184 |
| Rao PV | Bioactive lysophospholipids: role in regulation of aqueous humor outflow and intraocular pressure in the context of pathobiology and therapy of glaucoma. | 2014 Mar-Apr | J Ocul Pharmacol Ther | pmid:24283588 |
| Radi ZA and Vogel MW | Gastric parietal cell atrophy and depletion after administration of a sphingosine-1-phosphate 1 inhibitor. | 2014 | Toxicol Pathol | pmid:24178572 |
| Tanaka K et al. | Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model. | 2014 | Clin. Exp. Immunol. | pmid:24028747 |
| Steinman L and Shoenfeld Y | From defining antigens to new therapies in multiple sclerosis: honoring the contributions of Ruth Arnon and Michael Sela. | 2014 | J. Autoimmun. | pmid:25308417 |
| Castro-Rojas C et al. | Testing effects of glatiramer acetate and fingolimod in an infectious model of CNS immune surveillance. | 2014 | J. Neuroimmunol. | pmid:25227585 |
| Gajofatto A et al. | Are natalizumab and fingolimod analogous second-line options for the treatment of relapsing-remitting multiple sclerosis? A clinical practice observational study. | 2014 | Eur. Neurol. | pmid:25226868 |
| Evangelisti C et al. | Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics. | 2014 | Oncotarget | pmid:25226616 |
| Zuellig RA et al. | Deoxysphingolipids, novel biomarkers for type 2 diabetes, are cytotoxic for insulin-producing cells. | 2014 | Diabetes | pmid:24379346 |
| de Assuncao TM et al. | New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. | 2014 | J. Biol. Chem. | pmid:24759103 |
| Kim YI et al. | An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production. | 2014 | Mol. Cell. Biol. | pmid:25312644 |
| Gomes L et al. | Sphingosine 1-phosphate in acute dengue infection. | 2014 | PLoS ONE | pmid:25409037 |
| Miller DS | Sphingolipid signaling reduces basal P-glycoprotein activity in renal proximal tubule. | 2014 | J. Pharmacol. Exp. Ther. | pmid:24385389 |
| Wang M et al. | FTY720 attenuates hypoxia-reoxygenation-induced apoptosis in cardiomyocytes. | 2014 | Exp. Mol. Pathol. | pmid:25034934 |
| Cruz VT and Fonseca J | Central effects of fingolimod. | 2014 | Rev Neurol | pmid:25030072 |
| Nakamura H and Murayama T | Role of sphingolipids in arachidonic acid metabolism. | 2014 | J. Pharmacol. Sci. | pmid:24599139 |
| Cohen M and Lebrun C | Moving to fingolimod from natalizumab in multiple sclerosis-reply. | 2014 | JAMA Neurol | pmid:25023556 |
| Xu H et al. | Sphingosine-1-phosphate receptor agonist, FTY720, restores coronary flow reserve in diabetic rats. | 2014 | Circ. J. | pmid:25319164 |
| Fukui H et al. | S1P-Yap1 signaling regulates endoderm formation required for cardiac precursor cell migration in zebrafish. | 2014 | Dev. Cell | pmid:25313964 |
| Costanzi E et al. | Hypermethylation contributes to down-regulation of lysosomal β-hexosaminidase α subunit in prostate cancer cells. | 2014 | Biochimie | pmid:24389457 |
| Ntranos A et al. | FTY720 impairs CD8 T-cell function independently of the sphingosine-1-phosphate pathway. | 2014 | J. Neuroimmunol. | pmid:24680062 |
| Matheos DP and Wood MA | Unlocking the constraints on memory formation. | 2014 | Nat. Neurosci. | pmid:24964157 |
| Shayegi N et al. | CXCR4 blockade and sphingosine-1-phosphate activation facilitate engraftment of haematopoietic stem and progenitor cells in a non-myeloablative transplant model. | 2014 | Br. J. Haematol. | pmid:24180707 |
| Bi Y et al. | Sphingosine-1-phosphate mediates a reciprocal signaling pathway between stellate cells and cancer cells that promotes pancreatic cancer growth. | 2014 | Am. J. Pathol. | pmid:25111230 |
| Ishitsuka A et al. | FTY720 and cisplatin synergistically induce the death of cisplatin-resistant melanoma cells through the downregulation of the PI3K pathway and the decrease in epidermal growth factor receptor expression. | 2014 | Int. J. Mol. Med. | pmid:25109763 |
| Xiong H et al. | SphK1 confers resistance to apoptosis in gastric cancer cells by downregulating Bim via stimulating Akt/FoxO3a signaling. | 2014 | Oncol. Rep. | pmid:25109605 |
| Ruvolo PP et al. | The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells. | 2014 | Biochim. Biophys. Acta | pmid:24858343 |
| Carruthers RL et al. | An observational comparison of natalizumab vs. fingolimod using JCV serology to determine therapy. | 2014 | Mult. Scler. | pmid:24852928 |
| Sorensen PS | New management algorithms in multiple sclerosis. | 2014 | Curr. Opin. Neurol. | pmid:24759080 |
| Snelder N et al. | Translational pharmacokinetic modeling of fingolimod (FTY720) as a paradigm compound subject to sphingosine kinase-mediated phosphorylation. | 2014 | Drug Metab. Dispos. | pmid:24965813 |
| Agius M et al. | Fingolimod therapy in early multiple sclerosis: an efficacy analysis of the TRANSFORMS and FREEDOMS studies by time since first symptom. | 2014 | CNS Neurosci Ther | pmid:24684973 |
| Kong Y et al. | FTY720, a sphingosine-1 phosphate receptor modulator, improves liver fibrosis in a mouse model by impairing the motility of bone marrow-derived mesenchymal stem cells. | 2014 | Inflammation | pmid:24682874 |
| Yan W et al. | Adiponectin regulates SR Ca(2+) cycling following ischemia/reperfusion via sphingosine 1-phosphate-CaMKII signaling in mice. | 2014 | J. Mol. Cell. Cardiol. | pmid:24852843 |
| Sheridan GK and Dev KK | Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations. | 2014 | Sci Rep | pmid:24851861 |
| Tanasescu R and Constantinescu CS | Pharmacokinetic evaluation of fingolimod for the treatment of multiple sclerosis. | 2014 | Expert Opin Drug Metab Toxicol | pmid:24579791 |
| Smyth SS et al. | Arguing the case for the autotaxin-lysophosphatidic acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis. | 2014 | Arterioscler. Thromb. Vasc. Biol. | pmid:24482375 |
| Oizumi A et al. | Pseudomonas-derived ceramidase induces production of inflammatory mediators from human keratinocytes via sphingosine-1-phosphate. | 2014 | PLoS ONE | pmid:24586752 |
| Takabe K and Spiegel S | Export of sphingosine-1-phosphate and cancer progression. | 2014 | J. Lipid Res. | pmid:24474820 |
| Kira J et al. | Fingolimod (FTY720) therapy in Japanese patients with relapsing multiple sclerosis over 12 months: results of a phase 2 observational extension. | 2014 | BMC Neurol | pmid:24475777 |
| Baranowski M et al. | Ultramarathon run markedly reduces plasma sphingosine-1-phosphate concentration. | 2014 | Int J Sport Nutr Exerc Metab | pmid:24092763 |
| Abu El-Asrar AM et al. | Expression of bioactive lysophospholipids and processing enzymes in the vitreous from patients with proliferative diabetic retinopathy. | 2014 | Lipids Health Dis | pmid:25496321 |
| Stephenson M et al. | Deliberate fingolimod overdose presenting with delayed hypotension and bradycardia responsive to atropine. | 2014 | J Med Toxicol | pmid:24178903 |
| Klug YA et al. | Early and late HIV-1 membrane fusion events are impaired by sphinganine lipidated peptides that target the fusion site. | 2014 | Biochem. J. | pmid:24766462 |
| Zeng Y et al. | Sphingosine-1-phosphate protects endothelial glycocalyx by inhibiting syndecan-1 shedding. | 2014 | Am. J. Physiol. Heart Circ. Physiol. | pmid:24285115 |
sphingosine
sphingosine is a lipid of Sphingolipids (SP) class.
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