sphingosine

sphingosine is a lipid of Sphingolipids (SP) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 26061 references associated with sphingosine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Authors Title Published Journal PubMed Link
Kasbi-Chadli F et al. Direct and maternal n-3 long-chain polyunsaturated fatty acid supplementation improved triglyceridemia and glycemia through the regulation of hepatic and muscle sphingolipid synthesis in offspring hamsters fed a high-fat diet. 2016 Eur J Nutr pmid:25787885
Fu P et al. Role of Sphingosine Kinase 1 and S1P Transporter Spns2 in HGF-mediated Lamellipodia Formation in Lung Endothelium. 2016 J. Biol. Chem. pmid:27864331
Gharbaran R Insights into the molecular roles of heparan sulfate proteoglycans (HSPGs-syndecans) in autocrine and paracrine growth factor signaling in the pathogenesis of Hodgkin's lymphoma. 2016 Tumour Biol. pmid:27317256
Higashi K et al. Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts. 2016 Bone pmid:27612439
Sasset L et al. Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis. 2016 Trends Endocrinol. Metab. pmid:27562337
Roviezzo F et al. Disodium cromoglycate inhibits asthma-like features induced by sphingosine-1-phosphate. 2016 Pharmacol. Res. pmid:27713021
Hemdan NY et al. Modulating sphingosine 1-phosphate signaling with DOP or FTY720 alleviates vascular and immune defects in mouse sepsis. 2016 Eur. J. Immunol. pmid:27683081
Chew WS et al. To fingolimod and beyond: The rich pipeline of drug candidates that target S1P signaling. 2016 Pharmacol. Res. pmid:27663260
Hamidi Shishavan M et al. Differential Effects of Long Term FTY720 Treatment on Endothelial versus Smooth Muscle Cell Signaling to S1P in Rat Mesenteric Arteries. 2016 PLoS ONE pmid:27583547
Gazit SL et al. Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. 2016 Circ. Res. pmid:27582371
Machida T et al. Cellular function and signaling pathways of vascular smooth muscle cells modulated by sphingosine 1-phosphate. 2016 J. Pharmacol. Sci. pmid:27581589
Nagahashi M et al. High levels of sphingolipids in human breast cancer. 2016 J. Surg. Res. pmid:27565080
Tiper IV et al. Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection. 2016 Pathog Dis pmid:27354294
Jung M et al. Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis. 2016 Sci Signal pmid:27353364
Rodvold JJ and Zanetti M Tumor microenvironment on the move and the Aselli connection. 2016 Sci Signal pmid:27353363
Harijith A et al. Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&2 signaling axis in lung endothelium. 2016 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:27343196
Hernández-Coronado CG et al. Sphingosine-1-phosphate, regulated by FSH and VEGF, stimulates granulosa cell proliferation. 2016 Gen. Comp. Endocrinol. pmid:27342378
Barnawi J et al. Pro-phagocytic Effects of Thymoquinone on Cigarette Smoke-exposed Macrophages Occur by Modulation of the Sphingosine-1-phosphate Signalling System. 2016 COPD pmid:27144721
Jin L et al. The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined. 2016 World J Surg Oncol pmid:27129720
Sanchez T Sphingosine-1-Phosphate Signaling in Endothelial Disorders. 2016 Curr Atheroscler Rep pmid:27115142
Crespo I et al. Melatonin inhibits the sphingosine kinase 1/sphingosine-1-phosphate signaling pathway in rabbits with fulminant hepatitis of viral origin. 2016 J. Pineal Res. pmid:27101794
Wang H et al. Potential serum biomarkers from a metabolomics study of autism. 2016 J Psychiatry Neurosci pmid:26395811
Jin J et al. Aldo-keto Reductase Family 1 Member B 10 Mediates Liver Cancer Cell Proliferation through Sphingosine-1-Phosphate. 2016 Sci Rep pmid:26948042
Guerrero M et al. Sphingosine 1-phosphate receptor 1 agonists: a patent review (2013-2015). 2016 Expert Opin Ther Pat pmid:26947494
Li J et al. Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway. 2016 Tumour Biol. pmid:26857281
Camaré C et al. The neutral sphingomyelinase-2 is involved in angiogenic signaling triggered by oxidized LDL. 2016 Free Radic. Biol. Med. pmid:26855418
Kim SE et al. The Role of Sphingosine-1-Phosphate in Adipogenesis of Graves' Orbitopathy. 2016 Invest. Ophthalmol. Vis. Sci. pmid:26830367
Messias CV et al. Sphingosine-1-Phosphate Induces Dose-Dependent Chemotaxis or Fugetaxis of T-ALL Blasts through S1P1 Activation. 2016 PLoS ONE pmid:26824863
Testard A et al. Calcium- and Nitric Oxide-Dependent Nuclear Accumulation of Cytosolic Glyceraldehyde-3-Phosphate Dehydrogenase in Response to Long Chain Bases in Tobacco BY-2 Cells. 2016 Plant Cell Physiol. pmid:27585463
Pászti-Gere E et al. Reinforced Epithelial Barrier Integrity via Matriptase Induction with Sphingosine-1-Phosphate Did Not Result in Disturbances in Physiological Redox Status. 2016 Oxid Med Cell Longev pmid:26823955
Vijai Kumar Reddy T et al. Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. 2016 Eur J Med Chem pmid:27128176
Wiltshire R et al. Regulation of human cerebro-microvascular endothelial baso-lateral adhesion and barrier function by S1P through dual involvement of S1P1 and S1P2 receptors. 2016 Sci Rep pmid:26813587
Xu R et al. Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response. 2016 Oncotarget pmid:26943039
Ottenlinger F et al. Fingolimod targeting protein phosphatase 2A differently affects IL-33 induced IL-2 and IFN-γ production in CD8(+) lymphocytes. 2016 Eur. J. Immunol. pmid:26683421
Fan A et al. Liver X receptor-α and miR-130a-3p regulate expression of sphingosine 1-phosphate receptor 2 in human umbilical vein endothelial cells. 2016 Am. J. Physiol., Cell Physiol. pmid:26669941
Campos LS et al. Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-κB Activation in Melanoma Cells by Inhibition of Akt Signaling. 2016 Mol. Cell. Biol. pmid:26552704
Nagahashi M et al. DNA damage response and sphingolipid signaling in liver diseases. 2016 Surg. Today pmid:26514817
Zhang D et al. FTY-720P Suppresses Osteoclast Formation by Regulating Expression of Interleukin-6 (IL-6), Interleukin-4 (IL-4), and Matrix Metalloproteinase 2 (MMP-2). 2016 Med. Sci. Monit. pmid:27344392
Yönel N et al. Anti-erosive effects of fluoride and phytosphingosine: an in vitro study. 2016 Eur. J. Oral Sci. pmid:27342101
Patmanathan SN et al. Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2. 2016 Sci Rep pmid:27160553
Ohtoyo M et al. Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1-Phosphate Levels. 2016 Lipids pmid:27585475
Ratajczak MZ and Suszynska M Emerging Strategies to Enhance Homing and Engraftment of Hematopoietic Stem Cells. 2016 Stem Cell Rev pmid:26400757
Kalhori V et al. FTY720 (Fingolimod) attenuates basal and sphingosine-1-phosphate-evoked thyroid cancer cell invasion. 2016 Endocr. Relat. Cancer pmid:26935838
Bae YC et al. Effects of sphingosylphosphorylcholine on cryopreserved fat tissue graft survival. 2016 Mol Med Rep pmid:27572900
Vanier MT et al. Diagnostic tests for Niemann-Pick disease type C (NP-C): A critical review. 2016 Mol. Genet. Metab. pmid:27339554
Fujiwara T et al. Practical Synthesis of Pachastrissamine (Jaspine B), 2-epi-Pachastrissamine, and the 2-epi-Pyrrolidine Analogue. 2016 Chem. Pharm. Bull. pmid:26833446
Gowda SG et al. Highly efficient preparation of sphingoid bases from glucosylceramides by chemoenzymatic method. 2016 J. Lipid Res. pmid:26667669
Lee WJ et al. Inhibitory effects of N,N,N-trimethyl phytosphingosine-iodide on melanogenesis via ERK activation-mediated MITF degradation. 2016 Biosci. Biotechnol. Biochem. pmid:26263195
Grammatikos G et al. Serum sphingolipidomic analyses reveal an upregulation of C16-ceramide and sphingosine-1-phosphate in hepatocellular carcinoma. 2016 Oncotarget pmid:26933996
Stahlberg S et al. Probing the Role of Ceramide Headgroup Polarity in Short-Chain Model Skin Barrier Lipid Mixtures by ²H Solid-State NMR Spectroscopy. 2016 Langmuir pmid:26828109