| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zupancic E et al. | Biophysical implications of sphingosine accumulation in membrane properties at neutral and acidic pH. | 2014 | J Phys Chem B | pmid:24731183 |
| Völzke A et al. | Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells. | 2014 | Biochim. Biophys. Acta | pmid:24064301 |
| Pyne NJ et al. | The role of sphingosine 1-phosphate in inflammation and cancer. | 2014 | Adv Biol Regul | pmid:24070975 |
| Kihara A | Sphingosine 1-phosphate is a key metabolite linking sphingolipids to glycerophospholipids. | 2014 | Biochim. Biophys. Acta | pmid:23994042 |
| Freed JK et al. | Ceramide changes the mediator of flow-induced vasodilation from nitric oxide to hydrogen peroxide in the human microcirculation. | 2014 | Circ. Res. | pmid:24920698 |
| Qin Z et al. | Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma. | 2014 | Mol. Cancer Ther. | pmid:24140934 |
| Ryu JM et al. | Sphingosine-1-phosphate-induced Flk-1 transactivation stimulates mouse embryonic stem cell proliferation through S1P1/S1P3-dependent β-arrestin/c-Src pathways. | 2014 | Stem Cell Res | pmid:24145189 |
| Yang D et al. | Blocking lymphocyte trafficking with FTY720 prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns. | 2014 | J. Neurosci. | pmid:25471584 |
| Camm J et al. | Cardiac and vascular effects of fingolimod: mechanistic basis and clinical implications. | 2014 | Am. Heart J. | pmid:25440790 |
| Yu Y et al. | Phospholipid transfer protein deficiency decreases the content of S1P in HDL via the loss of its transfer capability. | 2014 | Lipids | pmid:24158769 |
| Oda M et al. | Novel inhibitor of bacterial sphingomyelinase, SMY-540, developed based on three-dimensional structure analysis. | 2014 | J Enzyme Inhib Med Chem | pmid:23488740 |
| Kurano M et al. | Induction of insulin secretion by apolipoprotein M, a carrier for sphingosine 1-phosphate. | 2014 | Biochim. Biophys. Acta | pmid:24814049 |
| Ceccom J et al. | [Sphingosine 1-phosphate as a biomarker for Alzheimer's disease?]. | 2014 | Med Sci (Paris) | pmid:24939530 |
| Moses H | Recognizing and overcoming potential barriers to oral medications for MS. | 2014 | J Clin Psychiatry | pmid:25373133 |
| Warnke C et al. | Initial lymphocyte count and low BMI may affect fingolimod-induced lymphopenia. | 2014 | Neurology | pmid:25361781 |
| Claes N et al. | Compositional changes of B and T cell subtypes during fingolimod treatment in multiple sclerosis patients: a 12-month follow-up study. | 2014 | PLoS ONE | pmid:25360562 |
| Hikawa H et al. | Enantioselective desymmetrization of FTY720. | 2014 | Chem. Pharm. Bull. | pmid:25273063 |
| Zhou Y et al. | Acidic ionic liquid catalyzed crosslinking of oxycellulose with chitosan for advanced biocomposites. | 2014 | Carbohydr Polym | pmid:25256465 |
| Purschke WG et al. | Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis. | 2014 | Biochem. J. | pmid:24832383 |
| Kang JW and Lee SM | Impaired expression of caveolin-1 contributes to hepatic ischemia and reperfusion injury. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24997335 |
| Shimizu Y et al. | Potentials of the circulating pruritogenic mediator lysophosphatidic acid in development of allergic skin inflammation in mice: role of blood cell-associated lysophospholipase D activity of autotaxin. | 2014 | Am. J. Pathol. | pmid:24641902 |
| Kowluru A | Deoxysphingolipids: β-cell, beware of these new kids on the block. | 2014 | Diabetes | pmid:24651803 |
| Al-Jarallah A et al. | High density lipoprotein stimulated migration of macrophages depends on the scavenger receptor class B, type I, PDZK1 and Akt1 and is blocked by sphingosine 1 phosphate receptor antagonists. | 2014 | PLoS ONE | pmid:25188469 |
| Snider AJ et al. | Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease. | 2014 | PLoS ONE | pmid:25460165 |
| El-Dahshan A et al. | Flexible, polymer-supported synthesis of sphingosine derivatives provides ceramides with enhanced biological activity. | 2014 | Bioorg. Med. Chem. | pmid:25172146 |
| Conway DS and Cohen JA | Natalizumab and fingolimod: insight into their relative efficacies in clinical practice. | 2014 | Mult. Scler. | pmid:25160120 |
| Nakanaga K et al. | Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo. | 2014 | J. Biochem. | pmid:24451492 |
| Pewzner-Jung Y et al. | Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa. | 2014 | EMBO Mol Med | pmid:25085879 |
| Racke MK et al. | Is T-bet a potential therapeutic target in multiple sclerosis? | 2014 | J. Interferon Cytokine Res. | pmid:25084179 |
| Mencl S et al. | FTY720 does not protect from traumatic brain injury in mice despite reducing posttraumatic inflammation. | 2014 | J. Neuroimmunol. | pmid:25081505 |
| Huang K et al. | AP-1 regulates sphingosine kinase 1 expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose. | 2014 | Cell. Signal. | pmid:24342046 |
| Das A et al. | Delivery of bioactive lipids from composite microgel-microsphere injectable scaffolds enhances stem cell recruitment and skeletal repair. | 2014 | PLoS ONE | pmid:25077607 |
| Zhang L et al. | FTY720 reduces migration and invasion of human glioblastoma cell lines via inhibiting the PI3K/AKT/mTOR/p70S6K signaling pathway. | 2014 | Tumour Biol. | pmid:25070489 |
| Ito K et al. | Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24516133 |
| Nakajima C et al. | The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development. | 2014 | Development | pmid:25377550 |
| Barnes J and Dweik RA | Is pulmonary hypertension a metabolic disease? | 2014 | Am. J. Respir. Crit. Care Med. | pmid:25360726 |
| Chen J et al. | Spinster homolog 2 (spns2) deficiency causes early onset progressive hearing loss. | 2014 | PLoS Genet. | pmid:25356849 |
| Kempf A et al. | The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. | 2014 | PLoS Biol. | pmid:24453941 |
| Hsieh CT et al. | Ceramide inhibits insulin-stimulated Akt phosphorylation through activation of Rheb/mTORC1/S6K signaling in skeletal muscle. | 2014 | Cell. Signal. | pmid:24650522 |
| Sheth KN and Rosand J | Targeting the immune system in intracerebral hemorrhage. | 2014 | JAMA Neurol | pmid:25004375 |
| Fernández-Pisonero I et al. | Synergy between sphingosine 1-phosphate and lipopolysaccharide signaling promotes an inflammatory, angiogenic and osteogenic response in human aortic valve interstitial cells. | 2014 | PLoS ONE | pmid:25275309 |
| Bonitz JA et al. | A sphingosine-1 phosphate agonist (FTY720) limits trauma/hemorrhagic shock-induced multiple organ dysfunction syndrome. | 2014 | Shock | pmid:25004059 |
| Sassoli C et al. | Mesenchymal stromal cell secreted sphingosine 1-phosphate (S1P) exerts a stimulatory effect on skeletal myoblast proliferation. | 2014 | PLoS ONE | pmid:25264785 |
| Fu Y et al. | Fingolimod for the treatment of intracerebral hemorrhage: a 2-arm proof-of-concept study. | 2014 | JAMA Neurol | pmid:25003359 |
| Silva VR et al. | Hypothalamic S1P/S1PR1 axis controls energy homeostasis. | 2014 | Nat Commun | pmid:25255053 |
| Hellmann MA et al. | Tumefactive demyelination and a malignant course in an MS patient during and following fingolimod therapy. | 2014 | J. Neurol. Sci. | pmid:25001515 |
| Bigaud M et al. | Second generation S1P pathway modulators: research strategies and clinical developments. | 2014 | Biochim. Biophys. Acta | pmid:24239768 |
| Emery SM et al. | Combined antiproliferative effects of the aminoalkylindole WIN55,212-2 and radiation in breast cancer cells. | 2014 | J. Pharmacol. Exp. Ther. | pmid:24259678 |
| Adamson RH et al. | Albumin modulates S1P delivery from red blood cells in perfused microvessels: mechanism of the protein effect. | 2014 | Am. J. Physiol. Heart Circ. Physiol. | pmid:24531813 |
| Hanson MA and Peach R | Structural biology of the S1P1 receptor. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728592 |
| Cahalan SM | Chemical and genetic tools to explore S1P biology. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728593 |
| Arnon TI and Cyster JG | Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728595 |
| Ward MD et al. | Overview and safety of fingolimod hydrochloride use in patients with multiple sclerosis. | 2014 | Expert Opin Drug Saf | pmid:24935480 |
| Oldstone MB and Rosen H | Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728596 |
| Yang W et al. | Sphingosine-1-phosphate promotes extravillous trophoblast cell invasion by activating MEK/ERK/MMP-2 signaling pathways via S1P/S1PR1 axis activation. | 2014 | PLoS ONE | pmid:25188412 |
| Martin R and Sospedra M | Sphingosine-1 phosphate and central nervous system. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728597 |
| Chen J et al. | The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension. | 2014 | Am. J. Respir. Crit. Care Med. | pmid:25180446 |
| Kamath-Loeb AS et al. | Sphingosine, a modulator of human translesion DNA polymerase activity. | 2014 | J. Biol. Chem. | pmid:24928506 |
| Mao Y et al. | Quantification of OSU-2S, a novel derivative of FTY720, in mouse plasma by liquid chromatography-tandem mass spectrometry. | 2014 | J Pharm Biomed Anal | pmid:24927402 |
| Ruiz A et al. | Testing Aβ toxicity on primary CNS cultures using drug-screening microfluidic chips. | 2014 | Lab Chip | pmid:24914747 |
| Awojoodu AO et al. | Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD. | 2014 | Blood | pmid:25075126 |
| Belvitch P et al. | Proline-rich region of non-muscle myosin light chain kinase modulates kinase activity and endothelial cytoskeletal dynamics. | 2014 | Microvasc. Res. | pmid:25072537 |
| Xu JM et al. | Synthesis and preliminary biological evaluation of 1,2,3-triazole-Jaspine B hybrids as potential cytotoxic agents. | 2014 | Eur J Med Chem | pmid:24835817 |
| Baldi E et al. | Previous treatment influences fingolimod efficacy in relapsing-remitting multiple sclerosis: results from an observational study. | 2014 | Curr Med Res Opin | pmid:24831186 |
| Stenovec M et al. | Alterations of calcium homoeostasis in cultured rat astrocytes evoked by bioactive sphingolipids. | 2014 | Acta Physiol (Oxf) | pmid:24825022 |
| Samarska IV et al. | S1P1 receptor modulation preserves vascular function in mesenteric and coronary arteries after CPB in the rat independent of depletion of lymphocytes. | 2014 | PLoS ONE | pmid:24819611 |
| Barkhof F et al. | The influence of patient demographics, disease characteristics and treatment on brain volume loss in Trial Assessing Injectable Interferon vs FTY720 Oral in Relapsing-Remitting Multiple Sclerosis (TRANSFORMS), a phase 3 study of fingolimod in multiple sclerosis. | 2014 | Mult. Scler. | pmid:24812043 |
| Kim EY et al. | Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching. | 2014 | FASEB J. | pmid:25002116 |
| Hao J et al. | The interaction between C5a and sphingosine-1-phosphate in neutrophils for antineutrophil cytoplasmic antibody mediated activation. | 2014 | Arthritis Res. Ther. | pmid:25000985 |
| Xiong Y and Hla T | S1P control of endothelial integrity. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728594 |
| Mendelson K et al. | Sphingosine 1-phosphate signalling. | 2014 | Development | pmid:24346695 |
| Rahman MM et al. | Sphingosine 1-phosphate induces neutrophil chemoattractant IL-8: repression by steroids. | 2014 | PLoS ONE | pmid:24647471 |
| Park SM et al. | Sphingosine-1-phosphate lyase is expressed by CD68+ cells on the parenchymal side of marginal reticular cells in human lymph nodes. | 2014 | Eur. J. Immunol. | pmid:24825162 |
| Mistry PK et al. | Glucocerebrosidase 2 gene deletion rescues type 1 Gaucher disease. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24639522 |
| Jesko H et al. | Sphingosine kinases modulate the secretion of amyloid β precursor protein from SH-SY5Y neuroblastoma cells: the role of α-synuclein. | 2014 | Folia Neuropathol | pmid:24729344 |
| Nakamura M et al. | Differential effects of fingolimod on B-cell populations in multiple sclerosis. | 2014 | Mult. Scler. | pmid:24526661 |
| Rolf L et al. | Paroxysmal atrial fibrillation after initiation of fingolimod for multiple sclerosis treatment. | 2014 | Neurology | pmid:24523479 |
| Bergvall N et al. | Relapse rates in patients with multiple sclerosis switching from interferon to fingolimod or glatiramer acetate: a US claims database study. | 2014 | PLoS ONE | pmid:24516663 |
| Sykes DA et al. | Investigating the molecular mechanisms through which FTY720-P causes persistent S1P1 receptor internalization. | 2014 | Br. J. Pharmacol. | pmid:24641481 |
| Tohda C and Kuboyama T | [New perspective in pharmacology brought by studying traditional medicine]. | 2014 | Nippon Yakurigaku Zasshi | pmid:24531900 |
| Couttas TA et al. | Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis. | 2014 | Acta Neuropathol Commun | pmid:24456642 |
| Gassowska M et al. | Sphingosine kinases/sphingosine-1-phosphate and death Signalling in APP-transfected cells. | 2014 | Neurochem. Res. | pmid:24452756 |
| Fujii K et al. | Sphingosine 1-phosphate increases an intracellular Ca(2+) concentration via S1P3 receptor in cultured vascular smooth muscle cells. | 2014 | J. Pharm. Pharmacol. | pmid:24450400 |
| Chierico L et al. | Live cell imaging of membrane/cytoskeleton interactions and membrane topology. | 2014 | Sci Rep | pmid:25205456 |
| Blaho VA and Hla T | An update on the biology of sphingosine 1-phosphate receptors. | 2014 | J. Lipid Res. | pmid:24459205 |
| Jirošová A et al. | Sphinganine-like biogenesis of (E)-1-nitropentadec-1-ene in termite soldiers of the genus Prorhinotermes. | 2014 | Chembiochem | pmid:24458870 |
| Cristóbal I et al. | PP2A inhibition is a common event in colorectal cancer and its restoration using FTY720 shows promising therapeutic potential. | 2014 | Mol. Cancer Ther. | pmid:24448818 |
| Maeda Y et al. | S1P lyase in thymic perivascular spaces promotes egress of mature thymocytes via up-regulation of S1P receptor 1. | 2014 | Int. Immunol. | pmid:24343820 |
| Guo L et al. | Roles of sphingosine-1-phosphate in reproduction. | 2014 | Reprod Sci | pmid:24336672 |
| Whisler JA et al. | Control of perfusable microvascular network morphology using a multiculture microfluidic system. | 2014 | Tissue Eng Part C Methods | pmid:24151838 |
| Lu E et al. | A review of safety-related pregnancy data surrounding the oral disease-modifying drugs for multiple sclerosis. | 2014 | CNS Drugs | pmid:24343726 |
| Asensio-Sánchez VM et al. | [Cystoid macular oedema after fingolimod treatment in multiple sclerosis]. | 2014 | Arch Soc Esp Oftalmol | pmid:24269406 |
| Freedman MS | Treatment options for patients with multiple sclerosis who have a suboptimal response to interferon-β therapy. | 2014 | Eur. J. Neurol. | pmid:24237582 |
| Grether-Beck S et al. | Topical ceramides neither enhance UVB-induced apoptosis in normal human keratinocytes nor affect viability in UVB-irradiated reconstructed human epidermis. | 2014 | Exp. Dermatol. | pmid:25078364 |
| Noack J et al. | A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy. | 2014 | Cell Death Dis | pmid:25255218 |
| Hamada M et al. | Involvement of hydrogen peroxide in safingol-induced endonuclease G-mediated apoptosis of squamous cell carcinoma cells. | 2014 | Int J Mol Sci | pmid:24549171 |
| Wang L et al. | FTY720 (s)-phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury. | 2014 | Crit. Care Med. | pmid:24335440 |
| Huys AC et al. | Fingolimod in a patient with Wolff-Parkinson-White syndrome. | 2014 | Mult. Scler. | pmid:23897641 |
| Albinet V et al. | Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells. | 2014 | Oncogene | pmid:23893239 |
| Speak AO et al. | Altered distribution and function of natural killer cells in murine and human Niemann-Pick disease type C1. | 2014 | Blood | pmid:24235134 |
sphingosine
sphingosine is a lipid of Sphingolipids (SP) class.
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