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Benzene and its metabolite, hydroquinone, induce granulocytic differentiation in myeloblasts by interacting with cellular signaling pathways activated by granulocyte colony-stimulating factor. |
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Differential phospholipid-labeling suggests two subtypes of phospholipase D in rat Leydig cells. |
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Isolation and structural characterization of N-acetyl- and N-glycolylneuraminic-acid-containing GalNAc-GD1a isomers, IV4GalNAcIV3Neu5AcII3Neu5GcGgOse4Cer and IV4GalNAcIV3Neu5GcII3Neu5AcGgOse4Cer, from bovine brain. |
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Inhibition by phospholipids, lysophospholipids and gangliosides of melittin-induced phosphorylation in bovine mammary gland. |
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Toxicology |
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Biochemical characterization of the stimulatory effects of halothane and propofol on purified brain protein kinase C. |
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Sphingosine, oleylamine and stearylamine inhibit both CD11a/CD18-dependent and -independent homotypic aggregation: demonstration by cytofluorimetry. |
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Hierarchical analysis of the nerve growth factor-dependent and nerve growth factor-independent differentiation signaling pathways in PC12 cells with protein kinase inhibitors. |
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PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid. |
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The dimeric and catalytic subunit forms of protein phosphatase 2A from rat brain are stimulated by C2-ceramide. |
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Inhibition of acyl-CoA:cholesterol acyltransferase in Chinese hamster ovary (CHO) cells by short-chain ceramide and dihydroceramide. |
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Biochim. Biophys. Acta |
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Biochemical characterization of blood group-active glycosphingolipids. |
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Cationic amphiphilic drugs inhibit the internalization of cholera toxin to the Golgi apparatus and the subsequent elevation of cyclic AMP. |
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Metabolism of short-chain ceramide and dihydroceramide analogues in Chinese hamster ovary (CHO) cells. |
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Both sphingolipids and cholesterol participate in the detergent insolubility of alkaline phosphatase, a glycosylphosphatidylinositol-anchored protein, in mammalian membranes. |
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Evidence that ceramide selectively inhibits protein kinase C-alpha translocation and modulates bradykinin activation of phospholipase D. |
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Pilot study on the plasma pharmacokinetics of fumonisin B1 in cows following a single dose by oral gavage or intravenous administration. |
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Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells. |
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Protein kinase C modulates calcium channels in isolated presynaptic nerve terminals of rat hippocampus. |
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Structural elucidation of two novel amphoteric glycosphingolipids from the earthworm, Pheretima hilgendorfi. |
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Reinvestigation of the structure of the esterified cerebroside in the epidermis of guinea pigs. |
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Differential roles of de novo sphingolipid biosynthesis and turnover in the "burst" of free sphingosine and sphinganine, and their 1-phosphates and N-acyl-derivatives, that occurs upon changing the medium of cells in culture. |
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Response of the damaged dopamine system to GM1 and semisynthetic gangliosides: effects of dose and extent of lesion. |
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Neuropharmacology |
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Toxicity of the protein kinase C inhibitor safingol administered alone and in combination with chemotherapeutic agents. |
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Retinoic acid induces translocation of protein kinase C (PKC) and activation of nuclear PKC (nPKC) in rat splenocytes. |
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Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets. |
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N,N,N-trimethylsphingosine inhibits interleukin-1 beta-induced NF-kappa B activation and consequent E-selectin expression in human umbilical vein endothelial cells. |
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The signal modulator protein 14-3-3 is a target of sphingosine- or N,N-dimethylsphingosine-dependent kinase in 3T3(A31) cells. |
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Biological activities of synthetic analogues of Alternaria alternata toxin (AAL-toxin) and fumonisin in plant and mammalian cell cultures. |
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Phytochemistry |
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The effect of protein kinase C stimulator and inhibitor on cochlear potentials in the guinea pig. |
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Sphingosylphosphorylcholine rapidly induces tyrosine phosphorylation of p125FAK and paxillin, rearrangement of the actin cytoskeleton and focal contact assembly. Requirement of p21rho in the signaling pathway. |
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Sphingosine-induced inhibition of capacitative calcium influx in CFPAC-1 cells. |
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Cell Calcium |
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A new immunosuppressant, FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes. |
1996 |
Immunology |
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Isolation of a non-steroidal contragestative agent from Sri Lankan marine red alga, Gelidiella acerosa. |
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Contraception |
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Th2 suppressor cells are more susceptible to sphingosine than Th1 cells in murine contact photosensitivity. |
1996 |
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Stereospecific induction of apoptosis in U937 cells by N-octanoyl-sphingosine stereoisomers and N-octyl-sphingosine. The ceramide amide group is not required for apoptosis. |
1996 |
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Myocardial protection by N,N,N-trimethylsphingosine in ischemia reperfusion injury is mediated by inhibition of P-selectin. |
1996 |
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A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation. |
1996 |
Transplantation |
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Metabolic fate of oleic acid derived from lysosomal degradation of cholesteryl oleate in human fibroblasts. |
1996 |
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Characterization of inositolphospholipids in Trypanosoma cruzi trypomastigote forms. |
1996 |
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Suppression of bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation. |
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Induction of apoptotic cell death in hen granulosa cells by ceramide. |
1996 |
Endocrinology |
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Relationship among cellular diacylglycerol, sphingosine formation, protein kinase C activity, and parathyroid hormone secretion from dispersed bovine parathyroid cells. |
1996 |
Endocrinology |
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A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae. |
1996 |
Genes Dev. |
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Fas ligation induces apoptosis and Jun kinase activation independently of CD45 and Lck in human T cells. |
1996 |
Blood |
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A novel enzyme that catalyzes the esterification of N-acetylsphingosine. Metabolism of C2-ceramides. |
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Ganglioside synthesis during the development of neuronal polarity. Major changes occur during axonogenesis and axon elongation, but not during dendrite growth or synaptogenesis. |
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Tumor necrosis factor-alpha and its second messenger, ceramide, stimulate apoptosis in cultured ovarian follicles. |
1996 |
Endocrinology |
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Effect of fumonisin B1 on phosphatidylethanolamine biosynthesis in Chinese hamster ovary cells. |
1996 |
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Okadaic acid, sphingosine, and phorbol ester reversibly modulate heat induction on protein kinase FA/GSK-3 alpha in A431 cells. |
1996 |
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Sphingosine transfer in cell-to-cell interaction. |
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A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils. |
1996 |
Mol. Pharmacol. |
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Involvement of pertussis toxin-sensitive GTP-binding proteins in sphingosine 1-phosphate-induced activation of phospholipase C-Ca2+ system in HL60 leukemia cells. |
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Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. |
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Nature |
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Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor. |
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EMBO J. |
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Elevated sphingoid bases and complex sphingolipid depletion as contributing factors in fumonisin-induced cytotoxicity. |
1996 |
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A new wound healing agent--sphingosylphosphorylcholine. |
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Induction of apoptosis by sphingosine-1-phosphate in human hepatoma cells is associated with enhanced expression of bax gene product. |
1996 |
Biochem. Biophys. Res. Commun. |
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Activation of protein-tyrosine kinase Syk in human platelets stimulated with lysophosphatidic acid or sphingosine 1-phosphate. |
1996 |
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Sphingolipid actions on sodium and calcium currents of rat ventricular myocytes. |
1996 |
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Abnormal expression of sphingomyelin acylase in atopic dermatitis: an etiologic factor for ceramide deficiency? |
1996 |
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Induction of ganglioside biosynthesis and neurite outgrowth of primary cultured neurons by L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol. |
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