Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abortion, Spontaneous | D000022 | 12 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kaneider NC et al. | The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor. | 2004 | FASEB J. | pmid:15208267 |
| Gude DR et al. | Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal. | 2008 | FASEB J. | pmid:18362204 |
| Ashkenazi A et al. | Sphingopeptides: dihydrosphingosine-based fusion inhibitors against wild-type and enfuvirtide-resistant HIV-1. | 2012 | FASEB J. | pmid:22872679 |
| Peer M et al. | Pseudomonas syringae infection triggers de novo synthesis of phytosphingosine from sphinganine in Arabidopsis thaliana. | 2010 | FEBS Lett. | pmid:20732322 |
| Lahiri S et al. | Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. | 2007 | FEBS Lett. | pmid:17977534 |
| Takeda H et al. | Sphingomyelinase and ceramide inhibit formation of F-actin ring in and bone resorption by rabbit mature osteoclasts. | 1998 | FEBS Lett. | pmid:9490019 |
| Mizutani Y et al. | Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation. | 2004 | FEBS Lett. | pmid:15063729 |
| Hui EK and Yung BY | Cell cycle phase-dependent effect of retinoic acid on the induction of granulocytic differentiation in HL-60 promyelocytic leukemia cells. Evidence for sphinganine potentiation of retinoic acid-induced differentiation. | 1993 | FEBS Lett. | pmid:7680007 |
| Alemany R et al. | Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate. | 2001 | FEBS Lett. | pmid:11741596 |
| Samuel GH et al. | Autocrine transforming growth factor β signaling regulates extracellular signal-regulated kinase 1/2 phosphorylation via modulation of protein phosphatase 2A expression in scleroderma fibroblasts. | 2010 | Fibrogenesis Tissue Repair | pmid:21134273 |
| Shephard GS et al. | Biomarkers of exposure to fumonisin mycotoxins: a review. | 2007 | Food Addit Contam | pmid:17886192 |
| Garren L et al. | The induction and persistence of altered sphingolipid biosynthesis in rats treated with fumonisin B1. | 2001 | Food Addit Contam | pmid:11552753 |
| Kodell RL et al. | A mechanistic approach to modelling the risk of liver tumours in mice exposed to fumonisin B1 in the diet. | 2001 | Food Addit Contam | pmid:11304033 |
| Delongchamp RR and Young JF | Tissue sphinganine as a biomarker of fumonisin-induced apoptosis. | 2001 | Food Addit Contam | pmid:11304034 |
| Qiu M and Liu X | Determination of sphinganine, sphingosine and Sa/So ratio in urine of humans exposed to dietary fumonisin B1. | 2001 | Food Addit Contam | pmid:11304035 |
| Cano-Sancho G et al. | Sphinganine and sphingosine levels and ratio in urine and blood samples from a Catalonian population, Spain. | 2011 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:21644119 |
| van der Westhuizen L et al. | Sphingoid base levels in humans consuming fumonisin-contaminated maize in rural areas of the former Transkei, South Africa: a cross-sectional study. | 2008 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:19680846 |
| Xu L et al. | Evaluation of fumonisin biomarkers in a cross-sectional study with two high-risk populations in China. | 2010 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:20589550 |
| van der Westhuizen L et al. | The effect of a single gavage dose of fumonisin B(2) on the sphinganine and sphingosine concentrations in vervet monkeys. | 2001 | Food Chem. Toxicol. | pmid:11313111 |
| Solfrizzo M et al. | Ineffectiveness of activated carbon in reducing the alteration of sphingolipid metabolism in rats exposed to fumonisin-contaminated diets. | 2001 | Food Chem. Toxicol. | pmid:11313118 |
| Rentz SS et al. | Inhibition of sphingolipid biosynthesis decreases phosphorylated ERK2 in LLC-PK1 cells. | 2005 | Food Chem. Toxicol. | pmid:15582204 |
| Dresden Osborne C et al. | Host resistance to Trypanosoma cruzi infection is enhanced in mice fed Fusarium verticillioides (=F. moniliforme) culture material containing fumonisins. | 2002 | Food Chem. Toxicol. | pmid:12419693 |
| Osuchowski MF et al. | Endotoxin exposure alters brain and liver effects of fumonisin B1 in BALB/c mice: implication of blood brain barrier. | 2005 | Food Chem. Toxicol. | pmid:15913876 |
| van der Westhuizen L et al. | Sphinganine/sphingosine ratio in plasma and urine as a possible biomarker for fumonisin exposure in humans in rural areas of Africa. | 1999 | Food Chem. Toxicol. | pmid:10654591 |
| Collins TF et al. | Effects of fumonisin B1 in pregnant rats. | 1998 | Food Chem. Toxicol. | pmid:9662415 |
| van der Westhuizen L et al. | Individual fumonisin exposure and sphingoid base levels in rural populations consuming maize in South Africa. | 2010 | Food Chem. Toxicol. | pmid:20363278 |
| Burns TD et al. | Fumonisin concentrations and in vivo toxicity of nixtamalized Fusarium verticillioides culture material: evidence for fumonisin-matrix interactions. | 2008 | Food Chem. Toxicol. | pmid:18602734 |
| Denli M et al. | Efficacy of AdiDetoxâ„¢ in reducing the toxicity of fumonisin B1 in rats. | 2015 | Food Chem. Toxicol. | pmid:25660482 |
| Hahn I et al. | Effects of orally administered fumonisin Bâ‚ (FBâ‚), partially hydrolysed FBâ‚, hydrolysed FBâ‚ and N-(1-deoxy-D-fructos-1-yl) FBâ‚ on the sphingolipid metabolism in rats. | 2015 | Food Chem. Toxicol. | pmid:25475052 |
| Theumer MG et al. | Subchronic mycotoxicoses in rats. Histopathological changes and modulation of the sphinganine to sphingosine (Sa/So) ratio imbalance induced by Fusarium verticillioides culture material, due to the coexistence of aflatoxin B1 in the diet. | 2008 | Food Chem. Toxicol. | pmid:18079032 |
| He Q et al. | Myriocin prevents fumonisin B1-induced sphingoid base accumulation in mice liver without ameliorating hepatotoxicity. | 2005 | Food Chem. Toxicol. | pmid:15811577 |
| Ciacci-Zanella JR et al. | Characterization of cell-cycle arrest by fumonisin B1 in CV-1 cells. | 1998 Sep-Oct | Food Chem. Toxicol. | pmid:9737426 |
| van der Westhuizen L et al. | Inhibition of sphingolipid biosynthesis in rat primary hepatocyte cultures by fumonisin B1 and other structurally related compounds. | 1998 | Food Chem. Toxicol. | pmid:9674957 |
| Galvano F et al. | DNA damage in human fibroblasts exposed to fumonisin B(1). | 2002 | Food Chem. Toxicol. | pmid:11731033 |
| Nimrichter L and Rodrigues ML | Fungal glucosylceramides: from structural components to biologically active targets of new antimicrobials. | 2011 | Front Microbiol | pmid:22025918 |
| Bensaci MF et al. | Fungicidal Activities and Mechanisms of Action of Pseudomonas syringae pv. syringae Lipodepsipeptide Syringopeptins 22A and 25A. | 2011 | Front Microbiol | pmid:22046175 |
| Berkey R et al. | Sphingolipids and plant defense/disease: the "death" connection and beyond. | 2012 | Front Plant Sci | pmid:22639658 |
| Guo L and Wang X | Crosstalk between Phospholipase D and Sphingosine Kinase in Plant Stress Signaling. | 2012 | Front Plant Sci | pmid:22639650 |
| Kedderis LB et al. | Toxicity of the protein kinase C inhibitor safingol administered alone and in combination with chemotherapeutic agents. | 1995 | Fundam Appl Toxicol | pmid:7665004 |
| Katsuma S et al. | Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation. | 2002 | Genes Cells | pmid:12485162 |
| Kihara A et al. | Transmembrane topology of sphingoid long-chain base-1-phosphate phosphatase, Lcb3p. | 2003 | Genes Cells | pmid:12786943 |
| Kariya Y et al. | Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis. | 2005 | Genes Cells | pmid:15938718 |
| Henry SA et al. | Metabolism and regulation of glycerolipids in the yeast Saccharomyces cerevisiae. | 2012 | Genetics | pmid:22345606 |
| Li S et al. | basA regulates cell wall organization and asexual/sexual sporulation ratio in Aspergillus nidulans. | 2007 | Genetics | pmid:17409079 |
| Vitkup D et al. | Influence of metabolic network structure and function on enzyme evolution. | 2006 | Genome Biol. | pmid:16684370 |
| Frank S et al. | Structural characterization of Schistosoma mansoni adult worm glycosphingolipids reveals pronounced differences with those of cercariae. | 2012 | Glycobiology | pmid:22241826 |
| Gillard BK et al. | Pathways of glycosphingolipid biosynthesis in SW13 cells in the presence and absence of vimentin intermediate filaments. | 1996 | Glycobiology | pmid:8991507 |
| Tanaka K et al. | Individual profiles of free ceramide species and the constituent ceramide species of sphingomyelin and neutral glycosphingolipid and their alteration according to the sequential changes of environmental oxygen content in human colorectal cancer Caco-2 cells. | 2014 | Glycoconj. J. | pmid:24310545 |
| Dobrzyń A and Górski J | Effect of acute exercise on the content of free sphinganine and sphingosine in different skeletal muscle types of the rat. | 2002 | Horm. Metab. Res. | pmid:12384830 |
| Knapp P et al. | Ceramides, sphinganine, sphingosine and acid sphingomyelinases in the human umbilical cord blood. | 2005 | Horm. Metab. Res. | pmid:16034716 |