Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abortion, Spontaneous | D000022 | 12 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Cox D et al. | Determination of cellular lipids bound to human CD1d molecules. | 2009 | PLoS ONE | pmid:19415116 |
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| Da Silva D et al. | Nitric oxide production is not required for dihydrosphingosine-induced cell death in tobacco BY-2 cells. | 2011 | Plant Signal Behav | pmid:21455022 |
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| Mansfield MA et al. | Relationship of sphinganine analog mycotoxin contamination in maize silage to seasonal weather conditions and to agronomic and ensiling practices. | 2007 | Phytopathology | pmid:18943291 |
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| Vanier MT | Niemann-Pick disease type C. | 2010 | Orphanet J Rare Dis | pmid:20525256 |
| O'Reilly C and Murphy PV | Synthesis of α-S-glycosphingolipids based on uronic acids. | 2011 | Org. Lett. | pmid:21875123 |
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| Mun J et al. | Structural confirmation of the dihydrosphinganine and fatty acid constituents of the dental pathogen Porphyromonas gingivalis. | 2007 | Org. Biomol. Chem. | pmid:18004463 |
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| Kim J et al. | Analysis of ceramide metabolites in differentiating epidermal keratinocytes treated with calcium or vitamin C. | 2011 | Nutr Res Pract | pmid:22125676 |
| Kim J et al. | Royal jelly enhances migration of human dermal fibroblasts and alters the levels of cholesterol and sphinganine in an in vitro wound healing model. | 2010 | Nutr Res Pract | pmid:21103081 |
| Saucedo-GarcÃa M et al. | MPK6, sphinganine and the LCB2a gene from serine palmitoyltransferase are required in the signaling pathway that mediates cell death induced by long chain bases in Arabidopsis. | 2011 | New Phytol. | pmid:21534970 |
| Michaelson LV | New insights into cell death induced by long chain bases in Arabidopsis. | 2011 | New Phytol. | pmid:21834911 |
| Osuchowski MF et al. | Fumonisin B1-induced neurodegeneration in mice after intracerebroventricular infusion is concurrent with disruption of sphingolipid metabolism and activation of proinflammatory signaling. | 2005 | Neurotoxicology | pmid:15713342 |
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