Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abortion, Spontaneous | D000022 | 12 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dobrzyń A and Górski J | Effect of acute exercise on the content of free sphinganine and sphingosine in different skeletal muscle types of the rat. | 2002 | Horm. Metab. Res. | pmid:12384830 |
| Stockmann-Juvala H and Savolainen K | A review of the toxic effects and mechanisms of action of fumonisin B1. | 2008 | Hum Exp Toxicol | pmid:19244287 |
| Abbey-Hosch SE et al. | Sphingosine-1-phosphate inhibits C-type natriuretic peptide activation of guanylyl cyclase B (GC-B/NPR-B). | 2004 | Hypertension | pmid:15037564 |
| Touyz RM and Schiffrin EL | Ang II-stimulated superoxide production is mediated via phospholipase D in human vascular smooth muscle cells. | 1999 | Hypertension | pmid:10523394 |
| Im JS et al. | Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation. | 2009 | Immunity | pmid:19538930 |
| Lee YG et al. | Cell-permeable ceramides act as novel regulators of U937 cell-cell adhesion mediated by CD29, CD98, and CD147. | 2010 | Immunobiology | pmid:19576658 |
| Eigenbrod S et al. | Sphingosine kinase and sphingosine-1-phosphate regulate migration, endocytosis and apoptosis of dendritic cells. | 2006 | Immunol. Invest. | pmid:16698674 |
| Kubota M et al. | Potentiation of murine innate immunity by alpha-galacturonosyl-type glycosphingolipids isolated from Sphingomonas yanoikuyae and S. terrae. | 2009 | Immunopharmacol Immunotoxicol | pmid:19555191 |
| Davies KP and Melman A | Markers of erectile dysfunction. | 2008 | Indian J Urol | pmid:19468461 |
| Bernard BA et al. | Ceramide binding to African-American hair fibre correlates with resistance to hair breakage. | 2002 | Int J Cosmet Sci | pmid:18498489 |
| Tokumura A et al. | Elevated serum levels of arachidonoyl-lysophosphatidic acid and sphingosine 1-phosphate in systemic sclerosis. | 2009 | Int J Med Sci | pmid:19521548 |
| Doi K and Uetsuka K | Mechanisms of mycotoxin-induced neurotoxicity through oxidative stress-associated pathways. | 2011 | Int J Mol Sci | pmid:21954354 |
| Koch A et al. | Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients. | 2017 | Int J Mol Sci | pmid:28714882 |
| Direito GM et al. | Evaluation of sphingolipids in Wistar rats treated to prolonged and single oral doses of fumonisin bâ‚. | 2009 | Int J Mol Sci | pmid:19333435 |
| Ribeiro DH et al. | Effects of aflatoxin B(1) and fumonisin B(1) on the viability and induction of apoptosis in rat primary hepatocytes. | 2010 | Int J Mol Sci | pmid:20480051 |
| Yu M et al. | The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations. | 2017 | Int J Mol Sci | pmid:28287417 |
| Yazar S and Omurtag GZ | Fumonisins, trichothecenes and zearalenone in cereals. | 2008 | Int J Mol Sci | pmid:19330061 |
| Grammatikos G et al. | Persistence of HCV in Acutely-Infected Patients Depletes C24-Ceramide and Upregulates Sphingosine and Sphinganine Serum Levels. | 2016 | Int J Mol Sci | pmid:27304952 |
| Hamada M et al. | Involvement of hydrogen peroxide in safingol-induced endonuclease G-mediated apoptosis of squamous cell carcinoma cells. | 2014 | Int J Mol Sci | pmid:24549171 |
| Zimber A et al. | Inhibition of proliferation and induction of monocytic differentiation on HL60 human promyelocytic leukemia cells treated with bile acids in vitro. | 1994 | Int. J. Cancer | pmid:7927907 |
| Koyanagi S et al. | Elevation of de novo ceramide synthesis in tumor masses and the role of microsomal dihydroceramide synthase. | 2003 | Int. J. Cancer | pmid:12672022 |
| Jiang Q et al. | Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide. | 2012 | Int. J. Cancer | pmid:21400505 |
| Separovic D et al. | Enhanced tumor cures after Foscan photodynamic therapy combined with the ceramide analog LCL29. Evidence from mouse squamous cell carcinomas for sphingolipids as biomarkers of treatment response. | 2011 | Int. J. Oncol. | pmid:21152858 |
| Ling LU et al. | The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells. | 2009 | Int. J. Oncol. | pmid:19885570 |
| Tolleson WH et al. | Fumonisin B1 induces apoptosis in cultured human keratinocytes through sphinganine accumulation and ceramide depletion. | 1999 | Int. J. Oncol. | pmid:10200332 |
| Urai M et al. | Mucilaginibacter kameinonensis sp., nov., isolated from garden soil. | 2008 | Int. J. Syst. Evol. Microbiol. | pmid:18768602 |
| Matsuyama H et al. | Sphingobacterium kitahiroshimense sp. nov., isolated from soil. | 2008 | Int. J. Syst. Evol. Microbiol. | pmid:18599698 |
| Jarvis WD and Grant S | Protein kinase C targeting in antineoplastic treatment strategies. | 1999 | Invest New Drugs | pmid:10665476 |
| Miranda GE et al. | Sphingosine-1-phosphate is a key regulator of proliferation and differentiation in retina photoreceptors. | 2009 | Invest. Ophthalmol. Vis. Sci. | pmid:19357361 |
| Levy M and Futerman AH | Mammalian ceramide synthases. | 2010 | IUBMB Life | pmid:20222015 |
| He Q et al. | S-adenosylmethionine or 5'-methylthioadenosine are unable to prevent fumonisin B1 hepatotoxicity in mice despite increased oxidation in liver. | 2006 Nov-Dec | J Appl Toxicol | pmid:17080400 |
| Niedernberg A et al. | Comparative analysis of functional assays for characterization of agonist ligands at G protein-coupled receptors. | 2003 | J Biomol Screen | pmid:14567777 |
| Anagnostopoulos CE et al. | Pre-clamp cardioprotection by protein kinase C (PKC) inhibitor improves left ventricular function following canine normothermic arrest. | 1996 | J Cardiovasc Surg (Torino) | pmid:8675519 |
| Cho YH et al. | Comparative study of naphthalene-2,3-dicarboxaldehyde and o-phthalaldehyde fluorogenic reagents for chromatographic detection of sphingoid bases. | 2002 | J Chromatogr A | pmid:12456096 |
| Byrdwell WC and Perry RH | Liquid chromatography with dual parallel mass spectrometry and (31)P nuclear magnetic resonance spectroscopy for analysis of sphingomyelin and dihydrosphingomyelin. I. Bovine brain and chicken egg yolk. | 2006 | J Chromatogr A | pmid:16938303 |
| Masukawa Y and Tsujimura H | Highly sensitive determination of N-acyl dihydrosphingosine using liquid chromatography-electrospray ionization mass spectrometry. Application to human hair lipids. | 2006 | J Chromatogr A | pmid:16781721 |
| Tan KB et al. | In vivo efficacy of a novel liposomal formulation of safingol in the treatment of acute myeloid leukemia. | 2012 | J Control Release | pmid:22100388 |
| Kurek K et al. | Inhibition of Ceramide De Novo Synthesis Ameliorates Diet Induced Skeletal Muscles Insulin Resistance. | 2015 | J Diabetes Res | pmid:26380311 |
| Kishida E et al. | Evaluation of a trans configuration for the apoptosis-inducing activity of ceramide. | 1997 | J Lipid Mediat Cell Signal | pmid:9246602 |
| Brodesser S and Kolter T | Dihydroceramide desaturase inhibition by a cyclopropanated dihydroceramide analog in cultured keratinocytes. | 2011 | J Lipids | pmid:21490810 |
| Separovic D et al. | C16-Ceramide Analog Combined with Pc 4 Photodynamic Therapy Evokes Enhanced Total Ceramide Accumulation, Promotion of DEVDase Activation in the Absence of Apoptosis, and Augmented Overall Cell Killing. | 2011 | J Lipids | pmid:21490809 |
| Wojewodka G et al. | Ceramide in cystic fibrosis: a potential new target for therapeutic intervention. | 2011 | J Lipids | pmid:21490807 |
| Huang WC et al. | Apoptotic sphingolipid ceramide in cancer therapy. | 2011 | J Lipids | pmid:21490804 |
| Ejsing CS et al. | Collision-induced dissociation pathways of yeast sphingolipids and their molecular profiling in total lipid extracts: a study by quadrupole TOF and linear ion trap-orbitrap mass spectrometry. | 2006 | J Mass Spectrom | pmid:16498600 |
| Park HM et al. | Royal jelly increases collagen production in rat skin after ovariectomy. | 2012 | J Med Food | pmid:22468645 |
| Uemura M et al. | Inhibitory Effect of Dihydrosphingosine with α-Tocopherol on Volatile Formation during the Autoxidation of Polyunsaturated Triacylglycerols. | 2016 | J Oleo Sci | pmid:27477074 |
| Fu C et al. | Metabonomics study of the protective effects of green tea polyphenols on aging rats induced by d-galactose. | 2011 | J Pharm Biomed Anal | pmid:21444175 |
| Rajewski RA et al. | Stereo-specific analysis of a novel protein kinase C inhibitor. | 1995 | J Pharm Biomed Anal | pmid:7619884 |
| Yoshida T et al. | Pulmonary fibrosis in response to environmental cues and molecular targets involved in its pathogenesis. | 2011 | J Toxicol Pathol | pmid:22272040 |
| Pan J et al. | An novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma. | 2011 | J Transl Med | pmid:21936950 |
| Fernández-Surumay G et al. | Glucose reaction with fumonisin B1 partially reduces its toxicity in swine. | 2004 | J. Agric. Food Chem. | pmid:15675827 |
| Fischbeck A et al. | Analysis of sphingomyelin in meat based on hydrophilic interaction liquid chromatography coupled to electrospray ionization-tandem mass spectrometry (HILIC-HPLC-ESI-MS/MS). | 2009 | J. Agric. Food Chem. | pmid:20175585 |
| Blaas N et al. | Structural profiling and quantification of sphingomyelin in human breast milk by HPLC-MS/MS. | 2011 | J. Agric. Food Chem. | pmid:21534545 |
| Liu H et al. | Reaction of fumonisin with glucose prevents promotion of hepatocarcinogenesis in female F344/N rats while maintaining normal hepatic sphinganine/sphingosine ratios. | 2001 | J. Agric. Food Chem. | pmid:11513718 |
| Hsu FF and Turk J | Structural determination of glycosphingolipids as lithiated adducts by electrospray ionization mass spectrometry using low-energy collisional-activated dissociation on a triple stage quadrupole instrument. | 2001 | J. Am. Soc. Mass Spectrom. | pmid:11142362 |
| Piva A et al. | Activated carbon does not prevent the toxicity of culture material containing fumonisin B1 when fed to weanling piglets. | 2005 | J. Anim. Sci. | pmid:16024715 |
| Gurung NK et al. | Effects of fumonisin B1-contaminated feeds on weanling angora goats. | 1998 | J. Anim. Sci. | pmid:9856397 |
| Ryan AJ et al. | Alveolar sphingolipids generated in response to TNF-alpha modifies surfactant biophysical activity. | 2003 | J. Appl. Physiol. | pmid:12391098 |
| Bauman M et al. | Dependence of the sphingoid bases concentration on growth phase and temperature in the yeast Yarrowia lipolytica. | 2002 | J. Basic Microbiol. | pmid:11925759 |
| Yasugi E et al. | Branched long chain bases in cerebrosides of the guinea pig Harderian gland. | 1987 | J. Biochem. | pmid:3448092 |
| Kyogashima M et al. | Chemical and apoptotic properties of hydroxy-ceramides containing long-chain bases with unusual alkyl chain lengths. | 2008 | J. Biochem. | pmid:18420598 |
| Sugiyama E et al. | Metabolism and neurite promoting effect of exogenous sphingosylphosphocholine in cultured murine neuroblastoma cells. | 1993 | J. Biochem. | pmid:8514735 |
| Sasaki JI et al. | Sphingosine inhibition of NADPH oxidase activation in a cell-free system. | 1996 | J. Biochem. | pmid:8947830 |
| Yang L et al. | Sphingosine 1-phosphate formation and intracellular Ca2+ mobilization in human platelets: evaluation with sphingosine kinase inhibitors. | 1999 | J. Biochem. | pmid:10393324 |
| Vessey DA et al. | Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart. | 2007 | J. Biochem. Mol. Toxicol. | pmid:17912702 |
| Tsunoda M et al. | Early fumonisin B1 toxicity in relation to disrupted sphingolipid metabolism in male BALB/c mice. | 1998 | J. Biochem. Mol. Toxicol. | pmid:9664234 |
| El Bawab S et al. | Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase. | 2001 | J. Biol. Chem. | pmid:11278489 |
| Habrukowich C et al. | Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells. | 2010 | J. Biol. Chem. | pmid:20558741 |
| O'Flaherty JT et al. | Translocation of protein kinase C in human polymorphonuclear neutrophils. Regulation by cytosolic Ca2(+)-independent and Ca2(+)-dependent mechanisms. | 1990 | J. Biol. Chem. | pmid:2160959 |
| Abe M et al. | Yeast 1,3-beta-glucan synthase activity is inhibited by phytosphingosine localized to the endoplasmic reticulum. | 2001 | J. Biol. Chem. | pmid:11337502 |
| Perry DK et al. | Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. | 2000 | J. Biol. Chem. | pmid:10722759 |
| Shichiri M et al. | A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity. | 2012 | J. Biol. Chem. | pmid:22147702 |
| Lamour NF et al. | Ceramide kinase regulates the production of tumor necrosis factor α (TNFα) via inhibition of TNFα-converting enzyme. | 2011 | J. Biol. Chem. | pmid:22009748 |
| Pittet D et al. | Nonselective inhibition of neutrophil functions by sphinganine. | 1987 | J. Biol. Chem. | pmid:3038865 |
| Simpson RU et al. | 1,25-Dihydroxyvitamin D3 regulation of c-myc protooncogene transcription. Possible involvement of protein kinase C. | 1989 | J. Biol. Chem. | pmid:2684961 |
| Deguchi H et al. | Sphingolipids as bioactive regulators of thrombin generation. | 2004 | J. Biol. Chem. | pmid:14722105 |
| Hauser JM et al. | Role of ceramide in mitogenesis induced by exogenous sphingoid bases. | 1994 | J. Biol. Chem. | pmid:8120042 |
| Wu WI et al. | Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by sphingoid bases. | 1993 | J. Biol. Chem. | pmid:8314751 |
| Mao Z et al. | Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells. | 2010 | J. Biol. Chem. | pmid:20628055 |
| Gable K et al. | A disease-causing mutation in the active site of serine palmitoyltransferase causes catalytic promiscuity. | 2010 | J. Biol. Chem. | pmid:20504773 |
| Hornemann T et al. | The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases. | 2009 | J. Biol. Chem. | pmid:19648650 |
| Hirschberg K et al. | Ganglioside synthesis during the development of neuronal polarity. Major changes occur during axonogenesis and axon elongation, but not during dendrite growth or synaptogenesis. | 1996 | J. Biol. Chem. | pmid:8663007 |
| Lahiri S et al. | Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner. | 2009 | J. Biol. Chem. | pmid:19357080 |
| Riebeling C et al. | Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. | 2003 | J. Biol. Chem. | pmid:12912983 |
| Wells GB and Lester RL | The isolation and characterization of a mutant strain of Saccharomyces cerevisiae that requires a long chain base for growth and for synthesis of phosphosphingolipids. | 1983 | J. Biol. Chem. | pmid:6350287 |
| Denny PW et al. | The protozoan inositol phosphorylceramide synthase: a novel drug target that defines a new class of sphingolipid synthase. | 2006 | J. Biol. Chem. | pmid:16861742 |
| Tyagi SR et al. | Phorbol myristate acetate (PMA) augments chemoattractant-induced diglyceride generation in human neutrophils but inhibits phosphoinositide hydrolysis. Implications for the mechanism of PMA priming of the respiratory burst. | 1988 | J. Biol. Chem. | pmid:2843513 |
| Rani CS et al. | Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signaling. | 1997 | J. Biol. Chem. | pmid:9099730 |
| Jenkins GM and Hannun YA | Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae. | 2001 | J. Biol. Chem. | pmid:11056159 |
| Wilson E et al. | Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst. | 1986 | J. Biol. Chem. | pmid:3017982 |
| van Echten-Deckert G et al. | Phosphorylated cis-4-methylsphingosine mimics the mitogenic effect of sphingosine-1-phosphate in Swiss 3T3 fibroblasts. | 1998 | J. Biol. Chem. | pmid:9722598 |
| Merrill AH et al. | Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases. | 1986 | J. Biol. Chem. | pmid:3462189 |
| Lloyd-Evans E et al. | Glucosylceramide and glucosylsphingosine modulate calcium mobilization from brain microsomes via different mechanisms. | 2003 | J. Biol. Chem. | pmid:12709427 |
| Alemany R et al. | Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase. | 1999 | J. Biol. Chem. | pmid:9933590 |
| Arikawa K et al. | Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity. | 2003 | J. Biol. Chem. | pmid:12810709 |
| Mao C et al. | Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. | 2003 | J. Biol. Chem. | pmid:12783875 |
| Mao C et al. | Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide. | 2000 | J. Biol. Chem. | pmid:10900202 |
| van Echten G et al. | Modulation of sphingolipid biosynthesis in primary cultured neurons by long chain bases. | 1990 | J. Biol. Chem. | pmid:2111818 |
| Merrill AH et al. | Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. | 1993 | J. Biol. Chem. | pmid:8262970 |
| Kobayashi N et al. | Characterization of the ATP-dependent sphingosine 1-phosphate transporter in rat erythrocytes. | 2009 | J. Biol. Chem. | pmid:19531471 |