Sphinganine

Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.

Cross Reference

Introduction

To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Sphinganine?

Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Sphinganine

MeSH term MeSH ID Detail
Abortion, Spontaneous D000022 12 associated lipids
Body Weight D001835 333 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Scleroderma, Systemic D012595 16 associated lipids
Swine Diseases D013553 16 associated lipids
Total 5

PubChem Associated disorders and diseases

What pathways are associated with Sphinganine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Sphinganine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Sphinganine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Sphinganine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Sphinganine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Sphinganine?

Knock-out

Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).

Mouse Model

Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Sphinganine

Download all related citations
Per page 10 20 50 100 | Total 790
Authors Title Published Journal PubMed Link
El Bawab S et al. Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase. 2001 J. Biol. Chem. pmid:11278489
Chung N et al. Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae. 2001 J. Biol. Chem. pmid:11468289
Perry DK et al. Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. 2000 J. Biol. Chem. pmid:10722759
Reggiori F and Conzelmann A Biosynthesis of inositol phosphoceramides and remodeling of glycosylphosphatidylinositol anchors in Saccharomyces cerevisiae are mediated by different enzymes. 1998 J. Biol. Chem. pmid:9804825
Berdyshev EV et al. FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells. 2009 J. Biol. Chem. pmid:19119142
Lamour NF et al. Ceramide kinase regulates the production of tumor necrosis factor α (TNFα) via inhibition of TNFα-converting enzyme. 2011 J. Biol. Chem. pmid:22009748
Bouhours D and Bouhours JF Developmental changes of the lipidic part of the neutral glycosphingolipids of the rat stomach. 1985 J. Biol. Chem. pmid:3972786
Zitomer NC et al. Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine: a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals. 2009 J. Biol. Chem. pmid:19095642
Hinkovska-Galcheva V et al. Enhanced phagocytosis through inhibition of de novo ceramide synthesis. 2003 J. Biol. Chem. pmid:12424251
Hauser JM et al. Role of ceramide in mitogenesis induced by exogenous sphingoid bases. 1994 J. Biol. Chem. pmid:8120042
Ochi S et al. Clostridium perfringens alpha-toxin activates the sphingomyelin metabolism system in sheep erythrocytes. 2004 J. Biol. Chem. pmid:14702348
Bu S et al. Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway. 2008 J. Biol. Chem. pmid:18482992
Gable K et al. A disease-causing mutation in the active site of serine palmitoyltransferase causes catalytic promiscuity. 2010 J. Biol. Chem. pmid:20504773
Benaud C et al. Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase. 2002 J. Biol. Chem. pmid:11792696
Han GS and Carman GM Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms. 2010 J. Biol. Chem. pmid:20231281
Pewzner-Jung Y et al. A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy. 2010 J. Biol. Chem. pmid:20110366
Jarvis WD et al. Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells. 1996 J. Biol. Chem. pmid:8626522
Pewzner-Jung Y et al. A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways. 2010 J. Biol. Chem. pmid:20110363
Hirschberg K et al. Ganglioside synthesis during the development of neuronal polarity. Major changes occur during axonogenesis and axon elongation, but not during dendrite growth or synaptogenesis. 1996 J. Biol. Chem. pmid:8663007
Penno A et al. Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids. 2010 J. Biol. Chem. pmid:20097765
Wells GB and Lester RL The isolation and characterization of a mutant strain of Saccharomyces cerevisiae that requires a long chain base for growth and for synthesis of phosphosphingolipids. 1983 J. Biol. Chem. pmid:6350287
Machesky NJ et al. Human cytomegalovirus regulates bioactive sphingolipids. 2008 J. Biol. Chem. pmid:18644793
Denny PW et al. The protozoan inositol phosphorylceramide synthase: a novel drug target that defines a new class of sphingolipid synthase. 2006 J. Biol. Chem. pmid:16861742
Don AS et al. Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues. 2007 J. Biol. Chem. pmid:17400555
Oh CS et al. ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation. 1997 J. Biol. Chem. pmid:9211877
van Echten-Deckert G et al. cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons. 1997 J. Biol. Chem. pmid:9188480
Ogawa C et al. Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2. 2003 J. Biol. Chem. pmid:12411432
Rani CS et al. Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signaling. 1997 J. Biol. Chem. pmid:9099730
Watanabe R et al. Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast. 2002 J. Biol. Chem. pmid:12393888
Han G et al. The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase. 2002 J. Biol. Chem. pmid:12087109
Kihara A and Igarashi Y Identification and characterization of a Saccharomyces cerevisiae gene, RSB1, involved in sphingoid long-chain base release. 2002 J. Biol. Chem. pmid:12034738
Wilson E et al. Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst. 1986 J. Biol. Chem. pmid:3017982
Humpf HU et al. Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor. 1998 J. Biol. Chem. pmid:9668088
van Echten-Deckert G et al. Phosphorylated cis-4-methylsphingosine mimics the mitogenic effect of sphingosine-1-phosphate in Swiss 3T3 fibroblasts. 1998 J. Biol. Chem. pmid:9722598
Alemany R et al. Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase. 1999 J. Biol. Chem. pmid:9933590
Becker KP et al. Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway. 2005 J. Biol. Chem. pmid:15546881
Merrill AH et al. Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. 1993 J. Biol. Chem. pmid:8262970
Chen N et al. Translocation of protein kinase Cepsilon and protein kinase Cdelta to membrane is required for ultraviolet B-induced activation of mitogen-activated protein kinases and apoptosis. 1999 J. Biol. Chem. pmid:10336426
Coste O et al. Sphingosine 1-phosphate modulates spinal nociceptive processing. 2008 J. Biol. Chem. pmid:18805787
BÅ‚achnio-Zabielska A et al. Effect of exercise duration on the key pathways of ceramide metabolism in rat skeletal muscles. 2008 J. Cell. Biochem. pmid:18680146
Tokuda H et al. Extracellular sphingomyelinase induces interleukin-6 synthesis in osteoblasts. 1999 J. Cell. Biochem. pmid:10022508
Chang HC et al. Role of AKT kinase in sphingosine-induced apoptosis in human hepatoma cells. 2001 J. Cell. Physiol. pmid:11424085
BÅ‚achnio-Zabielska AU et al. Ceramide metabolism is affected by obesity and diabetes in human adipose tissue. 2012 J. Cell. Physiol. pmid:21437908
Blachnio-Zabielska A et al. Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle. 2010 J. Cell. Physiol. pmid:20568228
Seefelder W et al. Liquid chromatography/electrospray ionisation-mass spectrometry method for the quantification of sphingosine and sphinganine in cell cultures exposed to fumonisins. 2002 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:12383489
Yoo HH et al. Liquid chromatography-tandem mass spectrometric determination of ceramides and related lipid species in cellular extracts. 2006 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:16891163
Williams LD et al. Fumonisin-ortho-phthalaldehyde derivative is stabilized at low temperature. 2004 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:15171945
Solfrizzo M et al. Rapid method to determine sphinganine/sphingosine in human and animal urine as a biomarker for fumonisin exposure. 1997 J. Chromatogr. B Biomed. Sci. Appl. pmid:9187387
Kwon OS et al. Quantitative analysis of free sphingoid bases in the brain and spinal cord tissues by high-performance liquid chromatography with a fluorescence detection. 1998 J. Chromatogr. B Biomed. Sci. Appl. pmid:9892061
Castegnaro M et al. Analytical method for the determination of sphinganine and sphingosine in serum as a potential biomarker for fumonisin exposure. 1998 J. Chromatogr. B Biomed. Sci. Appl. pmid:9892062
Shephard GS and van der Westhuizen L Liquid chromatographic determination of the sphinganine/sphingosine ratio in serum. 1998 J. Chromatogr. B Biomed. Sci. Appl. pmid:9686890
Ribar S et al. High-performance liquid chromatographic determination of sphinganine and sphingosine in serum and urine of subjects from an endemic nephropathy area in Croatia. 2001 J. Chromatogr. B Biomed. Sci. Appl. pmid:11339295
Flamand N et al. In vivo distribution of free long-chain sphingoid bases in the human stratum corneum by high-performance liquid chromatographic analysis of strippings. 1994 J. Chromatogr. B, Biomed. Appl. pmid:7952048
Mizugishi K et al. Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice. 2007 J. Clin. Invest. pmid:17885683
Takagi S et al. Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function. 2003 J. Clin. Invest. pmid:14597763
Xu H et al. Serum Metabonomics of Mild Acute Pancreatitis. 2016 J. Clin. Lab. Anal. pmid:27169745
Wang Y et al. Transcript and protein profiling analysis of OTA-induced cell death reveals the regulation of the toxicity response process in Arabidopsis thaliana. 2012 J. Exp. Bot. pmid:22207617
Zhang L et al. The involvement of jasmonates and ethylene in Alternaria alternata f. sp. lycopersici toxin-induced tomato cell death. 2011 J. Exp. Bot. pmid:21865178
Meredith FI et al. Extraction, quantification, and biological availability of fumonisin B1 incorporated into the Oregon test diet and fed to rainbow trout. 1998 J. Food Prot. pmid:9713767
Litvak DA et al. Modulators of ceramide metabolism sensitize colorectal cancer cells to chemotherapy: a novel treatment strategy. 2003 J. Gastrointest. Surg. pmid:12559195
Osawa Y et al. TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. 2001 J. Immunol. pmid:11418646
Peters-Golden M et al. Diminished protein kinase C-activated arachidonate metabolism accompanies rat macrophage differentiation in the lung. 1990 J. Immunol. pmid:2160499
Du L et al. Biosynthesis of sphinganine-analog mycotoxins. 2008 J. Ind. Microbiol. Biotechnol. pmid:18214562
Sharma RP et al. Deletion of IFN-gamma reduces fumonisin-induced hepatotoxicity in mice via alterations in inflammatory cytokines and apoptotic factors. 2003 J. Interferon Cytokine Res. pmid:12639295
Wakita H et al. Composition of free long-chain (sphingoid) bases in stratum corneum of normal and pathologic human skin conditions. 1992 J. Invest. Dermatol. pmid:1431224
Stewart ME and Downing DT Free sphingosines of human skin include 6-hydroxysphingosine and unusually long-chain dihydrosphingosines. 1995 J. Invest. Dermatol. pmid:7561168
Shin JH et al. Sphingosine 1-phosphate triggers apoptotic signal for B16 melanoma cells via ERK and caspase activation. 2007 J. Korean Med. Sci. pmid:17449940
Dragusin M et al. Metabolism of the unnatural anticancer lipid safingol, L-threo-dihydrosphingosine, in cultured cells. 2003 J. Lipid Res. pmid:12777464
Lieser B et al. Quantification of sphingosine and sphinganine from crude lipid extracts by HPLC electrospray ionization tandem mass spectrometry. 2003 J. Lipid Res. pmid:12897185
Jiang X and Han X Characterization and direct quantitation of sphingoid base-1-phosphates from lipid extracts: a shotgun lipidomics approach. 2006 J. Lipid Res. pmid:16682747
Groener JE et al. Metabolic fate of oleic acid derived from lysosomal degradation of cholesteryl oleate in human fibroblasts. 1996 J. Lipid Res. pmid:8978478
Abdul-Hammed M et al. Role of endosomal membrane lipids and NPC2 in cholesterol transfer and membrane fusion. 2010 J. Lipid Res. pmid:20179319
Boumendjel A and Miller SP Synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate. 1994 J. Lipid Res. pmid:7897327
van Smeden J et al. LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery. 2011 J. Lipid Res. pmid:21444759
Momin AA et al. A method for visualization of "omic" datasets for sphingolipid metabolism to predict potentially interesting differences. 2011 J. Lipid Res. pmid:21415121
Hu W et al. Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity. 2009 J. Lipid Res. pmid:19369694
Hammad SM et al. Blood sphingolipidomics in healthy humans: impact of sample collection methodology. 2010 J. Lipid Res. pmid:20660127
Sonnino S et al. High performance liquid chromatography preparation of the molecular species of GM1 and GD1a gangliosides with homogeneous long chain base composition. 1984 J. Lipid Res. pmid:6747465
Hamai H et al. Defective CFTR increases synthesis and mass of sphingolipids that modulate membrane composition and lipid signaling. 2009 J. Lipid Res. pmid:19144995
Gupta SD et al. Tsc10p and FVT1: topologically distinct short-chain reductases required for long-chain base synthesis in yeast and mammals. 2009 J. Lipid Res. pmid:19141869
Kisic A et al. Sphingolipid bases. A revisitation of the O-methyl derivatives of sphingosine. Isolation and characterization of diacetate derivatives, with revised 13C nuclear magnetic resonance assignments for D-erythro-sphingosine. 1995 J. Lipid Res. pmid:7616124
Schiffmann S et al. The selective COX-2 inhibitor celecoxib modulates sphingolipid synthesis. 2009 J. Lipid Res. pmid:18711209
Masukawa Y et al. Characterization of overall ceramide species in human stratum corneum. 2008 J. Lipid Res. pmid:18359959
Oda M et al. The relationship between the metabolism of sphingomyelin species and the hemolysis of sheep erythrocytes induced by Clostridium perfringens alpha-toxin. 2008 J. Lipid Res. pmid:18263851
Crossman MW and Hirschberg CB Conversion of erythro-D-sphinganine to its [1-2H1] and [1-3H1] derivatives. 1984 J. Lipid Res. pmid:6481245
Masukawa Y et al. Liquid chromatography-mass spectrometry for comprehensive profiling of ceramide molecules in human hair. 2006 J. Lipid Res. pmid:16639079
Fyrst H et al. Characterization of free endogenous C14 and C16 sphingoid bases from Drosophila melanogaster. 2004 J. Lipid Res. pmid:13130120
Hoekstra D et al. Membrane dynamics and cell polarity: the role of sphingolipids. 2003 J. Lipid Res. pmid:12639977
Dasgupta S and Hogan EL Chromatographic resolution and quantitative assay of CNS tissue sphingoids and sphingolipids. 2001 J. Lipid Res. pmid:11181761
Budnik LT and Brunswig-Spickenheier B Differential effects of lysolipids on steroid synthesis in cells expressing endogenous LPA2 receptor. 2005 J. Lipid Res. pmid:15716590
Ridgway ND 25-Hydroxycholesterol stimulates sphingomyelin synthesis in Chinese hamster ovary cells. 1995 J. Lipid Res. pmid:7666011
Tani M et al. Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets. 2005 J. Lipid Res. pmid:16061940
Yano M et al. Quantitative analysis of ceramide molecular species by high performance liquid chromatography. 1998 J. Lipid Res. pmid:9788256
Park H et al. Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies. 2010 J. Lipid Res. pmid:19786568
Scherer M et al. A rapid and quantitative LC-MS/MS method to profile sphingolipids. 2010 J. Lipid Res. pmid:20228220
Clugston RD et al. Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study. 2011 J. Lipid Res. pmid:21856784
Pruett ST et al. Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. 2008 J. Lipid Res. pmid:18499644
Fukami H et al. Preparation of (13)C-labeled ceramide by acetic acid bacteria and its incorporation in mice. 2010 J. Lipid Res. pmid:20656918
Kim HJ et al. A fluorescent assay for ceramide synthase activity. 2012 J. Lipid Res. pmid:22661289
Azuma H et al. Synthesis and potent antileukemic activities of N-lactylsphingosine and N-lactyldihydrosphingosine. 2003 J. Med. Chem. pmid:12877580