Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abortion, Spontaneous | D000022 | 12 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hicks AA et al. | Genetic determinants of circulating sphingolipid concentrations in European populations. | 2009 | PLoS Genet. | pmid:19798445 |
| Fox LM et al. | Recognition of lyso-phospholipids by human natural killer T lymphocytes. | 2009 | PLoS Biol. | pmid:19859526 |
| Ling LU et al. | The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells. | 2009 | Int. J. Oncol. | pmid:19885570 |
| Guerrera IC et al. | A novel lipidomic strategy reveals plasma phospholipid signatures associated with respiratory disease severity in cystic fibrosis patients. | 2009 | PLoS ONE | pmid:19893743 |
| Pan Q et al. | microRNA 21: response to hormonal therapies and regulatory function in leiomyoma, transformed leiomyoma and leiomyosarcoma cells. | 2010 | Mol. Hum. Reprod. | pmid:19906824 |
| Diab KJ et al. | Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema. | 2010 | Am. J. Respir. Crit. Care Med. | pmid:19965812 |
| Schmeier S et al. | Deciphering the transcriptional circuitry of microRNA genes expressed during human monocytic differentiation. | 2009 | BMC Genomics | pmid:20003307 |
| Borek C et al. | Long-chain (sphingoid) bases inhibit multistage carcinogenesis in mouse C3H/10T1/2 cells treated with radiation and phorbol 12-myristate 13-acetate. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2000399 |
| Lachaud C et al. | Nuclear calcium controls the apoptotic-like cell death induced by d-erythro-sphinganine in tobacco cells. | 2010 | Cell Calcium | pmid:20022633 |
| Domijan AM et al. | Urine ochratoxin a and sphinganine/sphingosine ratio in residents of the endemic nephropathy area in Croatia. | 2009 | Arh Hig Rada Toksikol | pmid:20061238 |
| Tunsophon S and Nemere I | Protein kinase C isotypes in signal transduction for the 1,25D3-MARRS receptor (ERp57/PDIA3) in steroid hormone-stimulated phosphate uptake. | 2010 | Steroids | pmid:20079367 |
| Penno A et al. | Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids. | 2010 | J. Biol. Chem. | pmid:20097765 |
| Pewzner-Jung Y et al. | A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways. | 2010 | J. Biol. Chem. | pmid:20110363 |
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| Cowart LA et al. | Revealing a signaling role of phytosphingosine-1-phosphate in yeast. | 2010 | Mol. Syst. Biol. | pmid:20160710 |
| Lee YS et al. | Simultaneous HPLC analysis of ceramide and dihydroceramide in human hairs. | 2009 | Arch. Pharm. Res. | pmid:20162410 |
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| Abdul-Hammed M et al. | Role of endosomal membrane lipids and NPC2 in cholesterol transfer and membrane fusion. | 2010 | J. Lipid Res. | pmid:20179319 |
| Oda M et al. | Hemolysis induced by Bacillus cereus sphingomyelinase. | 2010 | Biochim. Biophys. Acta | pmid:20214877 |
| Levy M and Futerman AH | Mammalian ceramide synthases. | 2010 | IUBMB Life | pmid:20222015 |
| Knapp P et al. | Altered sphingolipid metabolism in human endometrial cancer. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20226264 |
| Scherer M et al. | A rapid and quantitative LC-MS/MS method to profile sphingolipids. | 2010 | J. Lipid Res. | pmid:20228220 |
| Han GS and Carman GM | Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms. | 2010 | J. Biol. Chem. | pmid:20231281 |
| Bu S et al. | Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels. | 2010 | Arthritis Rheum. | pmid:20309867 |
| Romanowicz L and Bańkowski E | Altered sphingolipid composition in Wharton's jelly of pre-eclamptic newborns. | 2010 | Pathobiology | pmid:20332667 |
| Dilkin P et al. | Toxicokinetics and toxicological effects of single oral dose of fumonisin B1 containing Fusarium verticillioides culture material in weaned piglets. | 2010 | Chem. Biol. Interact. | pmid:20338158 |
| van der Westhuizen L et al. | Individual fumonisin exposure and sphingoid base levels in rural populations consuming maize in South Africa. | 2010 | Food Chem. Toxicol. | pmid:20363278 |
| Park SW et al. | Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation. | 2010 | Lab. Invest. | pmid:20458275 |
| Ribeiro DH et al. | Effects of aflatoxin B(1) and fumonisin B(1) on the viability and induction of apoptosis in rat primary hepatocytes. | 2010 | Int J Mol Sci | pmid:20480051 |
| Gable K et al. | A disease-causing mutation in the active site of serine palmitoyltransferase causes catalytic promiscuity. | 2010 | J. Biol. Chem. | pmid:20504773 |
| Vanier MT | Niemann-Pick disease type C. | 2010 | Orphanet J Rare Dis | pmid:20525256 |
| Habrukowich C et al. | Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells. | 2010 | J. Biol. Chem. | pmid:20558741 |
| Blachnio-Zabielska A et al. | Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle. | 2010 | J. Cell. Physiol. | pmid:20568228 |
| Ait-Youcef R et al. | Asymmetric synthesis of sphinganine and ent-clavaminol [corrected] H. | 2010 | J. Org. Chem. | pmid:20578745 |
| Xu L et al. | Evaluation of fumonisin biomarkers in a cross-sectional study with two high-risk populations in China. | 2010 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:20589550 |
| Zabielski P et al. | The effect of high-fat diet on the sphingolipid pathway of signal transduction in regenerating rat liver. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20599517 |
| Monette JS et al. | Characteristics of the rat cardiac sphingolipid pool in two mitochondrial subpopulations. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20599536 |
| Cutignano A et al. | UPLC-MS/MS method for analysis of sphingosine 1-phosphate in biological samples. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20601074 |
| Liu Y et al. | Elevation of sulfatides in ovarian cancer: an integrated transcriptomic and lipidomic analysis including tissue-imaging mass spectrometry. | 2010 | Mol. Cancer | pmid:20624317 |
| Mao Z et al. | Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells. | 2010 | J. Biol. Chem. | pmid:20628055 |
| Mortazavi PN et al. | Possible roles of phospholipase A(2) in the biological activities of Acanthamoeba castellanii (T4 Genotype). | 2011 | Protist | pmid:20650684 |
| Fukami H et al. | Preparation of (13)C-labeled ceramide by acetic acid bacteria and its incorporation in mice. | 2010 | J. Lipid Res. | pmid:20656918 |
| Hammad SM et al. | Blood sphingolipidomics in healthy humans: impact of sample collection methodology. | 2010 | J. Lipid Res. | pmid:20660127 |
| Chen Y et al. | An introduction to sphingolipid metabolism and analysis by new technologies. | 2010 | Neuromolecular Med. | pmid:20680704 |
| Ahn EH and Schroeder JJ | Induction of apoptosis by sphingosine, sphinganine, and C(2)-ceramide in human colon cancer cells, but not by C(2)-dihydroceramide. | 2010 | Anticancer Res. | pmid:20683027 |
| Bertea M et al. | Deoxysphingoid bases as plasma markers in diabetes mellitus. | 2010 | Lipids Health Dis | pmid:20712864 |
| Peer M et al. | Pseudomonas syringae infection triggers de novo synthesis of phytosphingosine from sphinganine in Arabidopsis thaliana. | 2010 | FEBS Lett. | pmid:20732322 |
| Jung HL and Kang HY | Effects of endurance exercise and high-fat diet on insulin resistance and ceramide contents of skeletal muscle in sprague-dawley rats. | 2010 | Korean Diabetes J | pmid:20835342 |
| Feng J et al. | Effects of cardiopulmonary bypass on endothelin-1-induced contraction and signaling in human skeletal muscle microcirculation. | 2010 | Circulation | pmid:20837906 |
| Kumar P et al. | A general and concise asymmetric synthesis of sphingosine, safingol and phytosphingosines via tethered aminohydroxylation. | 2010 | Org. Biomol. Chem. | pmid:20844791 |
| Zabielski P et al. | Activation of PPARα by bezafibrate negatively affects de novo synthesis of sphingolipids in regenerating rat liver. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20851774 |
| Sims K et al. | Kdo2-lipid A, a TLR4-specific agonist, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy. | 2010 | J. Biol. Chem. | pmid:20876532 |
| Schmitz-Peiffer C | Targeting ceramide synthesis to reverse insulin resistance. | 2010 | Diabetes | pmid:20876726 |
| Gault CR et al. | An overview of sphingolipid metabolism: from synthesis to breakdown. | 2010 | Adv. Exp. Med. Biol. | pmid:20919643 |
| Fuller M | Sphingolipids: the nexus between Gaucher disease and insulin resistance. | 2010 | Lipids Health Dis | pmid:20937139 |
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| Siow DL et al. | Sphingosine kinase localization in the control of sphingolipid metabolism. | 2011 | Adv. Enzyme Regul. | pmid:21075134 |
| Buzzi Fde C et al. | New antinociceptive agents related to dihydrosphingosine. | 2010 Sep-Oct | Pharmacol Rep | pmid:21098867 |
| Kim J et al. | Royal jelly enhances migration of human dermal fibroblasts and alters the levels of cholesterol and sphinganine in an in vitro wound healing model. | 2010 | Nutr Res Pract | pmid:21103081 |
| van Echten G et al. | Modulation of sphingolipid biosynthesis in primary cultured neurons by long chain bases. | 1990 | J. Biol. Chem. | pmid:2111818 |
| Gallego O et al. | A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae. | 2010 | Mol. Syst. Biol. | pmid:21119626 |
| Ling Y et al. | Involvement of the PLCε/PKCα pathway in human BIU-87 bladder cancer cell proliferation. | 2011 | Cell Biol. Int. | pmid:21121899 |
| Samuel GH et al. | Autocrine transforming growth factor β signaling regulates extracellular signal-regulated kinase 1/2 phosphorylation via modulation of protein phosphatase 2A expression in scleroderma fibroblasts. | 2010 | Fibrogenesis Tissue Repair | pmid:21134273 |
| Separovic D et al. | Enhanced tumor cures after Foscan photodynamic therapy combined with the ceramide analog LCL29. Evidence from mouse squamous cell carcinomas for sphingolipids as biomarkers of treatment response. | 2011 | Int. J. Oncol. | pmid:21152858 |
| Bricard G et al. | Α-galactosylceramide analogs with weak agonist activity for human iNKT cells define new candidate anti-inflammatory agents. | 2010 | PLoS ONE | pmid:21179412 |
| BÅ‚achnio-Zabielska A et al. | Aerobic training in rats increases skeletal muscle sphingomyelinase and serine palmitoyltransferase activity, while decreasing ceramidase activity. | 2011 | Lipids | pmid:21181285 |
| Lachaud C et al. | Dihydrosphingosine-induced programmed cell death in tobacco BY-2 cells is independent of Hâ‚‚Oâ‚‚ production. | 2011 | Mol Plant | pmid:21199880 |
| Dickson MA et al. | A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors. | 2011 | Clin. Cancer Res. | pmid:21257722 |
| Timmers S et al. | Paradoxical increase in TAG and DAG content parallel the insulin sensitizing effect of unilateral DGAT1 overexpression in rat skeletal muscle. | 2011 | PLoS ONE | pmid:21264296 |
| Tam AK et al. | Role for protein kinase C in controlling Aplysia bag cell neuron excitability. | 2011 | Neuroscience | pmid:21277944 |
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| Gupta S et al. | Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolism. | 2011 | BMC Syst Biol | pmid:21303545 |
| Ling LU et al. | The role of reactive oxygen species and autophagy in safingol-induced cell death. | 2011 | Cell Death Dis | pmid:21390063 |
| Sánchez BA et al. | Targeted analysis of sphingoid precursors in human biofluids by solid-phase extraction with in situ derivatization prior to μ-LC-LIF determination. | 2011 | Anal Bioanal Chem | pmid:21394454 |
| Jiang Q et al. | Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide. | 2012 | Int. J. Cancer | pmid:21400505 |
| Momin AA et al. | A method for visualization of "omic" datasets for sphingolipid metabolism to predict potentially interesting differences. | 2011 | J. Lipid Res. | pmid:21415121 |
| Roviezzo F et al. | Sphingosine-1-phosphate modulates vascular permeability and cell recruitment in acute inflammation in vivo. | 2011 | J. Pharmacol. Exp. Ther. | pmid:21421740 |
| Chao DY et al. | Sphingolipids in the root play an important role in regulating the leaf ionome in Arabidopsis thaliana. | 2011 | Plant Cell | pmid:21421810 |
| Wei LN | Chromatin remodeling and epigenetic regulation of the CrabpI gene in adipocyte differentiation. | 2012 | Biochim. Biophys. Acta | pmid:21435396 |
| BÅ‚achnio-Zabielska AU et al. | Ceramide metabolism is affected by obesity and diabetes in human adipose tissue. | 2012 | J. Cell. Physiol. | pmid:21437908 |
| Fu C et al. | Metabonomics study of the protective effects of green tea polyphenols on aging rats induced by d-galactose. | 2011 | J Pharm Biomed Anal | pmid:21444175 |
| van Smeden J et al. | LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery. | 2011 | J. Lipid Res. | pmid:21444759 |
| Da Silva D et al. | Nitric oxide production is not required for dihydrosphingosine-induced cell death in tobacco BY-2 cells. | 2011 | Plant Signal Behav | pmid:21455022 |
| Huang WC et al. | Apoptotic sphingolipid ceramide in cancer therapy. | 2011 | J Lipids | pmid:21490804 |
| Wojewodka G et al. | Ceramide in cystic fibrosis: a potential new target for therapeutic intervention. | 2011 | J Lipids | pmid:21490807 |
| Separovic D et al. | C16-Ceramide Analog Combined with Pc 4 Photodynamic Therapy Evokes Enhanced Total Ceramide Accumulation, Promotion of DEVDase Activation in the Absence of Apoptosis, and Augmented Overall Cell Killing. | 2011 | J Lipids | pmid:21490809 |
| Brodesser S and Kolter T | Dihydroceramide desaturase inhibition by a cyclopropanated dihydroceramide analog in cultured keratinocytes. | 2011 | J Lipids | pmid:21490810 |
| Hartinger D et al. | Enzyme characteristics of aminotransferase FumI of Sphingopyxis sp. MTA144 for deamination of hydrolyzed fumonisin Bâ‚. | 2011 | Appl. Microbiol. Biotechnol. | pmid:21503761 |
| Blaas N et al. | Structural profiling and quantification of sphingomyelin in human breast milk by HPLC-MS/MS. | 2011 | J. Agric. Food Chem. | pmid:21534545 |
| Saucedo-GarcÃa M et al. | MPK6, sphinganine and the LCB2a gene from serine palmitoyltransferase are required in the signaling pathway that mediates cell death induced by long chain bases in Arabidopsis. | 2011 | New Phytol. | pmid:21534970 |
| Baranowski M et al. | Exercise increases plasma levels of sphingoid base-1 phosphates in humans. | 2011 | Acta Physiol (Oxf) | pmid:21535416 |
| Wattenberg BW | Role of sphingosine kinase localization in sphingolipid signaling. | 2010 | World J Biol Chem | pmid:21537471 |
| Argraves KM et al. | S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease. | 2011 | Lipids Health Dis | pmid:21554699 |
| Rittenour WR et al. | Control of glucosylceramide production and morphogenesis by the Bar1 ceramide synthase in Fusarium graminearum. | 2011 | PLoS ONE | pmid:21559419 |
| Gangoiti P et al. | Implication of ceramide, ceramide 1-phosphate and sphingosine 1-phosphate in tumorigenesis. | 2008 | Transl Oncogenomics | pmid:21566746 |
| Zitomer NC and Riley RT | Extraction and analysis of fumonisins and compounds indicative of fumonisin exposure in plant and mammalian tissues and cultured cells. | 2011 | Methods Mol. Biol. | pmid:21567327 |
| Véret J et al. | Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells. | 2011 | Biochem. J. | pmid:21592087 |
| Koeller CM and Heise N | The Sphingolipid Biosynthetic Pathway Is a Potential Target for Chemotherapy against Chagas Disease. | 2011 | Enzyme Res | pmid:21603271 |