Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abortion, Spontaneous | D000022 | 12 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Banno Y et al. | Evidence for the presence of multiple forms of Sph kinase in human platelets. | 1998 | Biochem. J. | pmid:9761727 |
| Van Veldhoven PP and Mannaerts GP | Sphinganine 1-phosphate metabolism in cultured skin fibroblasts: evidence for the existence of a sphingosine phosphatase. | 1994 | Biochem. J. | pmid:8192648 |
| De Ceuster P et al. | Identification and subcellular localization of sphinganine-phosphatases in rat liver. | 1995 | Biochem. J. | pmid:7575445 |
| Cerantola V et al. | Yeast sphingolipids do not need to contain very long chain fatty acids. | 2007 | Biochem. J. | pmid:16987101 |
| Tserng KY and Griffin RL | Ceramide metabolite, not intact ceramide molecule, may be responsible for cellular toxicity. | 2004 | Biochem. J. | pmid:14998372 |
| Klug YA et al. | Early and late HIV-1 membrane fusion events are impaired by sphinganine lipidated peptides that target the fusion site. | 2014 | Biochem. J. | pmid:24766462 |
| Kashiwagi M et al. | Occurrence of nonenzymatic N-acetylation of sphinganine with acetyl coenzyme A producing C2-H2-ceramide and its inconvertibility to apoptotic C2-ceramide. | 1997 | Biochem. Mol. Biol. Int. | pmid:9285076 |
| Castro AF et al. | Mechanism of inhibition of P-glycoprotein-mediated drug transport by protein kinase C blockers. | 1999 | Biochem. Pharmacol. | pmid:10571246 |
| Loiseau N et al. | Fumonisin B1 exposure and its selective effect on porcine jejunal segment: sphingolipids, glycolipids and trans-epithelial passage disturbance. | 2007 | Biochem. Pharmacol. | pmid:17499218 |
| Linn SC et al. | Regulation of de novo sphingolipid biosynthesis and the toxic consequences of its disruption. | 2001 | Biochem. Soc. Trans. | pmid:11709083 |
| Liu K et al. | Signalling functions for sphingolipid long-chain bases in Saccharomyces cerevisiae. | 2005 | Biochem. Soc. Trans. | pmid:16246074 |
| Tamura K et al. | Cloning and characterization of a cDNA encoding serine palmitoyltransferase in Arabidopsis thaliana. | 2000 | Biochem. Soc. Trans. | pmid:11171191 |
| Chu UB et al. | Characterization of interactions of 4-nitrophenylpropyl-N-alkylamine with Ï‚ receptors. | 2011 | Biochemistry | pmid:21790129 |
| Medlock KA and Merrill AH | Inhibition of serine palmitoyltransferase in vitro and long-chain base biosynthesis in intact Chinese hamster ovary cells by beta-chloroalanine. | 1988 | Biochemistry | pmid:3143407 |
| Ito Y et al. | Structural requirements of sphingosine molecules for inhibition of DNA primase: biochemical and computational analyses. | 2001 | Biochemistry | pmid:11560507 |
| Wu WI and Carman GM | Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by phospholipids. | 1996 | Biochemistry | pmid:8620000 |
| Dyatlovitskaya EV et al. | Sphinganine in sphingomyelins of tumors and mouse regenerating liver. | 2001 | Biochemistry Mosc. | pmid:11405884 |
| Kandyba AG et al. | Dihydroceramide desaturase activity in tumors. | 2002 | Biochemistry Mosc. | pmid:12059782 |
| Rylova SN et al. | Comparative investigation of sphingoid bases and fatty acids in ceramides and sphingomyelins from human ovarian malignant tumors and normal ovary. | 1998 | Biochemistry Mosc. | pmid:9795275 |
| Stevens VL et al. | Characteristics of the growth inhibition and cytotoxicity of long-chain (sphingoid) bases for Chinese hamster ovary cells: evidence for an involvement of protein kinase C. | 1990 | Biochim. Biophys. Acta | pmid:2297538 |