Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abortion, Spontaneous | D000022 | 12 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yung BY et al. | Sphinganine potentiation of dimethyl sulfoxide-induced granulocyte differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60). | 1994 | Biochem. Biophys. Res. Commun. | pmid:8135836 |
| Riley RT et al. | Dietary fumonisin B1 induces disruption of sphingolipid metabolism in Sprague-Dawley rats: a new mechanism of nephrotoxicity. | 1994 | J. Nutr. | pmid:8145083 |
| Van Veldhoven PP and Mannaerts GP | Sphinganine 1-phosphate metabolism in cultured skin fibroblasts: evidence for the existence of a sphingosine phosphatase. | 1994 | Biochem. J. | pmid:8192648 |
| Séror SJ et al. | A mutant cysteinyl-tRNA synthetase affecting timing of chromosomal replication initiation in B. subtilis and conferring resistance to a protein kinase C inhibitor. | 1994 | EMBO J. | pmid:8194536 |
| Rodriguez-Lafrasse C et al. | Free sphingoid bases in tissues from patients with type C Niemann-Pick disease and other lysosomal storage disorders. | 1994 | Biochim. Biophys. Acta | pmid:8204660 |
| Yung BY and Hui EK | Differential regulation of protein kinase C isoenzymes during sphinganine potentiation of retinoic acid-induced granulocytic differentiation in human leukemia HL-60 cells. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8250895 |
| Merrill AH et al. | Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. | 1993 | J. Biol. Chem. | pmid:8262970 |
| Lavie Y et al. | Formation of endogenous free sphingoid bases in cells induced by changing medium conditions. | 1994 | Biochim. Biophys. Acta | pmid:8305506 |
| Wu WI et al. | Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by sphingoid bases. | 1993 | J. Biol. Chem. | pmid:8314751 |
| Olivera A and Spiegel S | Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. | 1993 | Nature | pmid:8413613 |
| Riley RT et al. | Alteration of tissue and serum sphinganine to sphingosine ratio: an early biomarker of exposure to fumonisin-containing feeds in pigs. | 1993 | Toxicol. Appl. Pharmacol. | pmid:8430417 |
| Schwartz GK et al. | Protein kinase C: a novel target for inhibiting gastric cancer cell invasion. | 1993 | J. Natl. Cancer Inst. | pmid:8433394 |
| Clarke BL et al. | Regulation of parathyroid hormone release by protein kinase-C is dependent on extracellular calcium in bovine parathyroid cells. | 1993 | Endocrinology | pmid:8440177 |
| Hirschberg K et al. | The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver. | 1993 | Biochem. J. | pmid:8457204 |
| Sugiyama E et al. | Metabolism and neurite promoting effect of exogenous sphingosylphosphocholine in cultured murine neuroblastoma cells. | 1993 | J. Biochem. | pmid:8514735 |
| Sugita M et al. | Structural elucidation of two novel amphoteric glycosphingolipids from the earthworm, Pheretima hilgendorfi. | 1995 | Biochim. Biophys. Acta | pmid:8541328 |
| Prelusky DB et al. | Pilot study on the plasma pharmacokinetics of fumonisin B1 in cows following a single dose by oral gavage or intravenous administration. | 1995 | Nat. Toxins | pmid:8581325 |
| Gumprecht LA et al. | Effects of intravenous fumonisin B1 in rabbits: nephrotoxicity and sphingolipid alterations. | 1995 | Nat. Toxins | pmid:8581326 |
| Bibel DJ et al. | Topical sphingolipids in antisepsis and antifungal therapy. | 1995 | Clin. Exp. Dermatol. | pmid:8593716 |
| Choi OH et al. | Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor. | 1996 | Nature | pmid:8602265 |
| Wu WI and Carman GM | Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by phospholipids. | 1996 | Biochemistry | pmid:8620000 |
| Wang W et al. | Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8622958 |
| Jarvis WD et al. | Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells. | 1996 | J. Biol. Chem. | pmid:8626522 |
| Carfagna MA et al. | Sex differences in rat hepatic cytolethality of the protein kinase C inhibitor safingol: role of biotransformation. | 1996 | Toxicol. Appl. Pharmacol. | pmid:8661342 |
| Hirschberg K et al. | Ganglioside synthesis during the development of neuronal polarity. Major changes occur during axonogenesis and axon elongation, but not during dendrite growth or synaptogenesis. | 1996 | J. Biol. Chem. | pmid:8663007 |
| Anagnostopoulos CE et al. | Pre-clamp cardioprotection by protein kinase C (PKC) inhibitor improves left ventricular function following canine normothermic arrest. | 1996 | J Cardiovasc Surg (Torino) | pmid:8675519 |
| Rotter BA et al. | Response of growing swine to dietary exposure to pure fumonisin B1 during an eight-week period: growth and clinical parameters. | 1996 | Nat. Toxins | pmid:8680753 |
| Shephard GS et al. | Disruption of sphingolipid metabolism in non-human primates consuming diets of fumonisin-containing Fusarium moniliforme culture material. | 1996 | Toxicon | pmid:8783447 |
| Goel S et al. | Effects of fusarium moniliforme isolates on tissue and serum sphingolipid concentrations in horses. | 1996 | Vet Hum Toxicol | pmid:8829343 |
| Kawamura A et al. | Picomole scale stereochemical analysis of sphingosines and dihydrosphingosines. | 1996 | Bioorg. Med. Chem. | pmid:8831974 |
| Usuki S et al. | Induction of ganglioside biosynthesis and neurite outgrowth of primary cultured neurons by L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol. | 1996 | J. Neurochem. | pmid:8863486 |
| Valsecchi M et al. | Changes of free long-chain bases in neuronal cells during differentiation and aging in culture. | 1996 | J. Neurochem. | pmid:8863491 |
| Tolan D et al. | The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle. | 1996 | Br. J. Pharmacol. | pmid:8886394 |
| Sasaki JI et al. | Sphingosine inhibition of NADPH oxidase activation in a cell-free system. | 1996 | J. Biochem. | pmid:8947830 |
| Groener JE et al. | Metabolic fate of oleic acid derived from lysosomal degradation of cholesteryl oleate in human fibroblasts. | 1996 | J. Lipid Res. | pmid:8978478 |
| Reddy RV et al. | Developmental effects of fumonisin B1 in mice. | 1996 | Mycopathologia | pmid:8981781 |
| Badiani K et al. | Effect of fumonisin B1 on phosphatidylethanolamine biosynthesis in Chinese hamster ovary cells. | 1996 | Biochim. Biophys. Acta | pmid:8982265 |
| Gillard BK et al. | Pathways of glycosphingolipid biosynthesis in SW13 cells in the presence and absence of vimentin intermediate filaments. | 1996 | Glycobiology | pmid:8991507 |
| Crowther GJ and Lynch DV | Characterization of sphinganine kinase activity in corn shoot microsomes. | 1997 | Arch. Biochem. Biophys. | pmid:9016824 |
| Castegnaro M et al. | Development of a new method for the analysis of sphinganine and sphingosine in urine and tissues. | 1996 | Nat. Toxins | pmid:9029554 |
| Rani CS et al. | Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signaling. | 1997 | J. Biol. Chem. | pmid:9099730 |
| Chmura SJ et al. | Loss of ceramide production confers resistance to radiation-induced apoptosis. | 1997 | Cancer Res. | pmid:9102212 |
| Kwon OS et al. | Effects of fumonisin B1 treatment on blood-brain barrier transfer in developing rats. | 1997 Mar-Apr | Neurotoxicol Teratol | pmid:9136132 |
| Sosnowski J et al. | Protein kinase C mediated anti-proliferative glucocorticoid-sphinganine synergism in cultured Pollard III prostate tumor cells. | 1997 | J. Urol. | pmid:9186373 |
| Solfrizzo M et al. | Rapid method to determine sphinganine/sphingosine in human and animal urine as a biomarker for fumonisin exposure. | 1997 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:9187387 |
| van Echten-Deckert G et al. | cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons. | 1997 | J. Biol. Chem. | pmid:9188480 |
| Oh CS et al. | ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation. | 1997 | J. Biol. Chem. | pmid:9211877 |
| Reggiori F et al. | Lipid remodeling leads to the introduction and exchange of defined ceramides on GPI proteins in the ER and Golgi of Saccharomyces cerevisiae. | 1997 | EMBO J. | pmid:9218793 |
| Kishida E et al. | Evaluation of a trans configuration for the apoptosis-inducing activity of ceramide. | 1997 | J Lipid Mediat Cell Signal | pmid:9246602 |
| Porpaczy Z et al. | Internalized plasma membrane cholesterol passes through an endosome compartment that is distinct from the acid vesicle-lysosome compartment. | 1997 | Exp. Cell Res. | pmid:9260888 |
| Kashiwagi M et al. | Occurrence of nonenzymatic N-acetylation of sphinganine with acetyl coenzyme A producing C2-H2-ceramide and its inconvertibility to apoptotic C2-ceramide. | 1997 | Biochem. Mol. Biol. Int. | pmid:9285076 |
| Kwon OS et al. | Fumonisin B1 in developing rats alters brain sphinganine levels and myelination. | 1997 | Neurotoxicology | pmid:9291505 |
| Norred WP et al. | Mycotoxin-induced elevation of free sphingoid bases in precision-cut rat liver slices: specificity of the response and structure-activity relationships. | 1997 | Toxicol. Appl. Pharmacol. | pmid:9356308 |
| Morgan MK et al. | Dietary fumonisins disrupt sphingolipid metabolism in mink and increase the free sphinganine to sphingosine ratio in urine but not in hair. | 1997 | Vet Hum Toxicol | pmid:9397500 |
| van Echten-Deckert G et al. | 1-Methylthiodihydroceramide, a novel analog of dihydroceramide, stimulates sphinganine degradation resulting in decreased de novo sphingolipid biosynthesis. | 1998 | J. Biol. Chem. | pmid:9422785 |
| Zehavi U | Synthesis of potentially caged sphingolipids, possible precursors of cellular modulators and second messengers. | 1997 | Chem. Phys. Lipids | pmid:9450322 |
| Chigorno V et al. | Metabolic processing of gangliosides by human fibroblasts in culture--formation and recycling of separate pools of sphingosine. | 1997 | Eur. J. Biochem. | pmid:9461288 |
| MartÃnez G et al. | Plasma free fatty acids in mitochondrial fatty acid oxidation defects. | 1997 | Clin. Chim. Acta | pmid:9469249 |
| Schmelz EM et al. | Induction of apoptosis by fumonisin B1 in HT29 cells is mediated by the accumulation of endogenous free sphingoid bases. | 1998 | Toxicol. Appl. Pharmacol. | pmid:9473533 |
| Takeda H et al. | Sphingomyelinase and ceramide inhibit formation of F-actin ring in and bone resorption by rabbit mature osteoclasts. | 1998 | FEBS Lett. | pmid:9490019 |
| Meyer zu Heringdorf D et al. | Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors. | 1998 | EMBO J. | pmid:9582276 |
| Lanterman MM and Saba JD | Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants. | 1998 | Biochem. J. | pmid:9601083 |
| Sakakura C et al. | Selectivity of sphingosine-induced apoptosis. Lack of activity of DL-erythyro-dihydrosphingosine. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9618297 |
| Hattori T et al. | New ceramide from marine sponge Haliclona koremella and related compounds as antifouling substances against macroalgae. | 1998 | J. Nat. Prod. | pmid:9644076 |
| Shimeno H et al. | Partial purification and characterization of sphingosine N-acyltransferase (ceramide synthase) from bovine liver mitochondrion-rich fraction. | 1998 | Lipids | pmid:9655376 |
| Collins TF et al. | Effects of fumonisin B1 in pregnant rats. | 1998 | Food Chem. Toxicol. | pmid:9662415 |
| Auzenne E et al. | Cytotoxic effects of sphingolipids as single or multi-modality agents on human melanoma and soft tissue sarcoma in vitro. | 1998 | Melanoma Res. | pmid:9664144 |
| Tsunoda M et al. | Early fumonisin B1 toxicity in relation to disrupted sphingolipid metabolism in male BALB/c mice. | 1998 | J. Biochem. Mol. Toxicol. | pmid:9664234 |
| Humpf HU et al. | Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor. | 1998 | J. Biol. Chem. | pmid:9668088 |
| van der Westhuizen L et al. | Inhibition of sphingolipid biosynthesis in rat primary hepatocyte cultures by fumonisin B1 and other structurally related compounds. | 1998 | Food Chem. Toxicol. | pmid:9674957 |
| Shephard GS and van der Westhuizen L | Liquid chromatographic determination of the sphinganine/sphingosine ratio in serum. | 1998 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:9686890 |
| Meredith FI et al. | Extraction, quantification, and biological availability of fumonisin B1 incorporated into the Oregon test diet and fed to rainbow trout. | 1998 | J. Food Prot. | pmid:9713767 |
| van Echten-Deckert G et al. | Phosphorylated cis-4-methylsphingosine mimics the mitogenic effect of sphingosine-1-phosphate in Swiss 3T3 fibroblasts. | 1998 | J. Biol. Chem. | pmid:9722598 |
| Voss KA et al. | In vivo effects of fumonisin B1-producing and fumonisin B1-nonproducing Fusarium moniliforme isolates are similar: fumonisins B2 and B3 cause hepato- and nephrotoxicity in rats. | 1998 | Mycopathologia | pmid:9725030 |
| Ciacci-Zanella JR et al. | Characterization of cell-cycle arrest by fumonisin B1 in CV-1 cells. | 1998 Sep-Oct | Food Chem. Toxicol. | pmid:9737426 |
| Banno Y et al. | Evidence for the presence of multiple forms of Sph kinase in human platelets. | 1998 | Biochem. J. | pmid:9761727 |
| Klostergaard J et al. | Characterization of cytotoxicity induced by sphingolipids in multidrug-resistant leukemia cells. | 1998 | Leuk. Res. | pmid:9783808 |
| Yano M et al. | Quantitative analysis of ceramide molecular species by high performance liquid chromatography. | 1998 | J. Lipid Res. | pmid:9788256 |
| Rylova SN et al. | Comparative investigation of sphingoid bases and fatty acids in ceramides and sphingomyelins from human ovarian malignant tumors and normal ovary. | 1998 | Biochemistry Mosc. | pmid:9795275 |
| Jarvis WD et al. | Evidence for involvement of mitogen-activated protein kinase, rather than stress-activated protein kinase, in potentiation of 1-beta-D-arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling. | 1998 | Mol. Pharmacol. | pmid:9804619 |
| Reggiori F and Conzelmann A | Biosynthesis of inositol phosphoceramides and remodeling of glycosylphosphatidylinositol anchors in Saccharomyces cerevisiae are mediated by different enzymes. | 1998 | J. Biol. Chem. | pmid:9804825 |
| Schwartz GK et al. | A pilot clinical/pharmacological study of the protein kinase C-specific inhibitor safingol alone and in combination with doxorubicin. | 1997 | Clin. Cancer Res. | pmid:9815717 |
| Ayar A et al. | Mobilization of intracellular calcium by intracellular flash photolysis of caged dihydrosphingosine in cultured neonatal rat sensory neurones. | 1998 | Acta Biochim. Pol. | pmid:9821863 |
| Abbas HK et al. | Ultrastructural effects of AAL-toxin TA from the fungus Alternaria alternata on black nightshade (Solanum nigrum L.) leaf discs and correlation with biochemical measures of toxicity. | 1998 | Toxicon | pmid:9839666 |
| Gurung NK et al. | Effects of fumonisin B1-contaminated feeds on weanling angora goats. | 1998 | J. Anim. Sci. | pmid:9856397 |
| Gumprecht LA et al. | Development of fumonisin-induced hepatotoxicity and pulmonary edema in orally dosed swine: morphological and biochemical alterations. | 1998 Nov-Dec | Toxicol Pathol | pmid:9864095 |
| Kwon OS et al. | Quantitative analysis of free sphingoid bases in the brain and spinal cord tissues by high-performance liquid chromatography with a fluorescence detection. | 1998 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:9892061 |
| Castegnaro M et al. | Analytical method for the determination of sphinganine and sphingosine in serum as a potential biomarker for fumonisin exposure. | 1998 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:9892062 |
| Wang E et al. | Fumonisin B1 consumption by rats causes reversible, dose-dependent increases in urinary sphinganine and sphingosine. | 1999 | J. Nutr. | pmid:9915902 |
| Alemany R et al. | Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase. | 1999 | J. Biol. Chem. | pmid:9933590 |