Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
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| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| HAKOMORI S and MASAMUNE H | Chemistry and biology of lipids. XXIII. A new color reaction of sphingosine and dihydrosphingosine. | 1956 | Tohoku J. Exp. Med. | pmid:13371598 |
| Wells GB and Lester RL | The isolation and characterization of a mutant strain of Saccharomyces cerevisiae that requires a long chain base for growth and for synthesis of phosphosphingolipids. | 1983 | J. Biol. Chem. | pmid:6350287 |
| Sonnino S et al. | High performance liquid chromatography preparation of the molecular species of GM1 and GD1a gangliosides with homogeneous long chain base composition. | 1984 | J. Lipid Res. | pmid:6747465 |
| Crossman MW and Hirschberg CB | Conversion of erythro-D-sphinganine to its [1-2H1] and [1-3H1] derivatives. | 1984 | J. Lipid Res. | pmid:6481245 |
| Crossman MW and Hirschberg CB | Biosynthesis of 4D-hydroxysphinganine by the rat. En bloc incorporation of the sphinganine carbon backbone. | 1984 | Biochim. Biophys. Acta | pmid:6477953 |
| Bouhours D and Bouhours JF | Developmental changes of the lipidic part of the neutral glycosphingolipids of the rat stomach. | 1985 | J. Biol. Chem. | pmid:3972786 |
| Nelson DH and Murray DK | Sphingolipids inhibit insulin and phorbol ester stimulated uptake of 2-deoxyglucose. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3527163 |
| Merrill AH and Wang E | Biosynthesis of long-chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s). | 1986 | J. Biol. Chem. | pmid:3081509 |
| Wilson E et al. | Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst. | 1986 | J. Biol. Chem. | pmid:3017982 |
| Merrill AH et al. | Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases. | 1986 | J. Biol. Chem. | pmid:3462189 |
| Vermelho AB et al. | Isolation and characterization of a neutral glycosphingolipid from the epimastigote form of Trypanosoma mega. | 1986 | J. Protozool. | pmid:3735150 |
| Yasugi E et al. | Branched long chain bases in cerebrosides of the guinea pig Harderian gland. | 1987 | J. Biochem. | pmid:3448092 |
| Bouchon B et al. | Selective enrichment of phytosphingosine in glycosphingolipids of isolated human thyrocytes as compared to the whole thyroid. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3566758 |
| Pittet D et al. | Nonselective inhibition of neutrophil functions by sphinganine. | 1987 | J. Biol. Chem. | pmid:3038865 |
| Wilson E et al. | Protein kinase C inhibition by sphingoid long-chain bases: effects on secretion in human neutrophils. | 1987 | Arch. Biochem. Biophys. | pmid:2825597 |
| Hamanaka S et al. | Occurrence of galactosylceramide in pig epidermal cells. | 1988 | Biochim. Biophys. Acta | pmid:3401502 |
| Lambeth JD et al. | Sphinganine effects on chemoattractant-induced diacylglycerol generation, calcium fluxes, superoxide production, and on cell viability in the human neutrophil. Delivery of sphinganine with bovine serum albumin minimizes cytotoxicity without affecting inhibition of the respiratory burst. | 1988 | J. Biol. Chem. | pmid:2831206 |
| Merrill AH et al. | Quantitation of free sphingosine in liver by high-performance liquid chromatography. | 1988 | Anal. Biochem. | pmid:3407935 |
| Medlock KA and Merrill AH | Inhibition of serine palmitoyltransferase in vitro and long-chain base biosynthesis in intact Chinese hamster ovary cells by beta-chloroalanine. | 1988 | Biochemistry | pmid:3143407 |
| Tyagi SR et al. | Phorbol myristate acetate (PMA) augments chemoattractant-induced diglyceride generation in human neutrophils but inhibits phosphoinositide hydrolysis. Implications for the mechanism of PMA priming of the respiratory burst. | 1988 | J. Biol. Chem. | pmid:2843513 |
| Nelson DH and Murray DK | Dexamethasone and sphingolipids inhibit concanavalin A stimulated glucose uptake in 3T3-L1 fibroblasts. | 1988-1989 | Endocr. Res. | pmid:3074919 |
| Kobayashi T et al. | Metabolism of free sphingoid bases in murine tissues and in cultured human fibroblasts. | 1989 | Eur. J. Biochem. | pmid:2606103 |
| Messmer TO et al. | Sphingolipid biosynthesis by rat liver cells: effects of serine, fatty acids and lipoproteins. | 1989 | J. Nutr. | pmid:2495341 |
| Simpson RU et al. | 1,25-Dihydroxyvitamin D3 regulation of c-myc protooncogene transcription. Possible involvement of protein kinase C. | 1989 | J. Biol. Chem. | pmid:2684961 |
| Wertz PW and Downing DT | Free sphingosines in porcine epidermis. | 1989 | Biochim. Biophys. Acta | pmid:2930769 |
| Conn PJ et al. | Inhibitors of protein kinase C prevent enhancement of calcium current and action potentials in peptidergic neurons of Aplysia. | 1989 | J. Neurosci. | pmid:2918372 |
| O'Flaherty JT and Jacobson D | Protein kinase C blockers and neutrophil receptors for leukotriene B4. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2551291 |
| Stevens VL et al. | Differential effects of long-chain (sphingoid) bases on the monocytic differentiation of human leukemia (HL-60) cells induced by phorbol esters, 1 alpha, 25-dihydroxyvitamin D3, or ganglioside GM3. | 1989 | Cancer Res. | pmid:2720676 |
| O'Flaherty JT et al. | Translocation of protein kinase C in human polymorphonuclear neutrophils. Regulation by cytosolic Ca2(+)-independent and Ca2(+)-dependent mechanisms. | 1990 | J. Biol. Chem. | pmid:2160959 |
| Peters-Golden M et al. | Diminished protein kinase C-activated arachidonate metabolism accompanies rat macrophage differentiation in the lung. | 1990 | J. Immunol. | pmid:2160499 |
| Stevens VL et al. | Characteristics of the growth inhibition and cytotoxicity of long-chain (sphingoid) bases for Chinese hamster ovary cells: evidence for an involvement of protein kinase C. | 1990 | Biochim. Biophys. Acta | pmid:2297538 |
| van Echten G et al. | Modulation of sphingolipid biosynthesis in primary cultured neurons by long chain bases. | 1990 | J. Biol. Chem. | pmid:2111818 |
| Nishimura K et al. | Sphingolipids of a cestode Metroliasthes coturnix. | 1991 | Biochim. Biophys. Acta | pmid:1932097 |
| Roff CF et al. | Type C Niemann-Pick disease: use of hydrophobic amines to study defective cholesterol transport. | 1991 | Dev. Neurosci. | pmid:1817037 |
| Agopyan N and Agopyan I | Effects of protein kinase C activators and inhibitors on membrane properties, synaptic responses, and cholinergic actions in CA1 subfield of rat hippocampus in situ and in vitro. | 1991 | Synapse | pmid:1882329 |
| Borek C et al. | Long-chain (sphingoid) bases inhibit multistage carcinogenesis in mouse C3H/10T1/2 cells treated with radiation and phorbol 12-myristate 13-acetate. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2000399 |
| Wei LL et al. | Alkaline phosphatase activity during differentiation of the human promyelocytic leukemia cell line, HL-60. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1734863 |
| Yoo HS et al. | Fumonisin inhibition of de novo sphingolipid biosynthesis and cytotoxicity are correlated in LLC-PK1 cells. | 1992 | Toxicol. Appl. Pharmacol. | pmid:1585377 |
| Wang E et al. | Increases in serum sphingosine and sphinganine and decreases in complex sphingolipids in ponies given feed containing fumonisins, mycotoxins produced by Fusarium moniliforme. | 1992 | J. Nutr. | pmid:1640265 |
| Goldin E et al. | Type C Niemann-Pick disease: a murine model of the lysosomal cholesterol lipidosis accumulates sphingosine and sphinganine in liver. | 1992 | Biochim. Biophys. Acta | pmid:1324734 |
| Bibel DJ et al. | Inhibition of microbial adherence by sphinganine. | 1992 | Can. J. Microbiol. | pmid:1464071 |
| Uhrig ML et al. | Metabolic labelling and partial characterisation of a sulfoglycolipid in Trypanosoma cruzi trypomastigotes. | 1992 | Carbohydr. Res. | pmid:1394325 |
| Wakita H et al. | Composition of free long-chain (sphingoid) bases in stratum corneum of normal and pathologic human skin conditions. | 1992 | J. Invest. Dermatol. | pmid:1431224 |
| Rother J et al. | Biosynthesis of sphingolipids: dihydroceramide and not sphinganine is desaturated by cultured cells. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1449467 |
| Turinsky J and Nagel GW | Effect of sphingoid bases on basal and insulin-stimulated 2-deoxyglucose transport in skeletal muscle. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1417855 |
| Yung BY et al. | Interaction of antileukemia agents adriamycin and daunomycin with sphinganine on the differentiation of human leukemia cell line HL-60. | 1992 | Cancer Res. | pmid:1617630 |
| Yung BY and Hui EK | Differential regulation of protein kinase C isoenzymes during sphinganine potentiation of retinoic acid-induced granulocytic differentiation in human leukemia HL-60 cells. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8250895 |
| Wu WI et al. | Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by sphingoid bases. | 1993 | J. Biol. Chem. | pmid:8314751 |
| Schwartz GK et al. | Protein kinase C: a novel target for inhibiting gastric cancer cell invasion. | 1993 | J. Natl. Cancer Inst. | pmid:8433394 |
| Hirschberg K et al. | The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver. | 1993 | Biochem. J. | pmid:8457204 |
| Olivera A and Spiegel S | Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. | 1993 | Nature | pmid:8413613 |
| Sugiyama E et al. | Metabolism and neurite promoting effect of exogenous sphingosylphosphocholine in cultured murine neuroblastoma cells. | 1993 | J. Biochem. | pmid:8514735 |
| Riley RT et al. | Alteration of tissue and serum sphinganine to sphingosine ratio: an early biomarker of exposure to fumonisin-containing feeds in pigs. | 1993 | Toxicol. Appl. Pharmacol. | pmid:8430417 |
| Bibel DJ et al. | Sphingosines: antimicrobial barriers of the skin. | 1993 | Acta Derm. Venereol. | pmid:7906449 |
| Hui EK and Yung BY | Cell cycle phase-dependent effect of retinoic acid on the induction of granulocytic differentiation in HL-60 promyelocytic leukemia cells. Evidence for sphinganine potentiation of retinoic acid-induced differentiation. | 1993 | FEBS Lett. | pmid:7680007 |
| Clarke BL et al. | Regulation of parathyroid hormone release by protein kinase-C is dependent on extracellular calcium in bovine parathyroid cells. | 1993 | Endocrinology | pmid:8440177 |
| Merrill AH et al. | Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. | 1993 | J. Biol. Chem. | pmid:8262970 |
| Thurman RG et al. | SPC-100270, a protein kinase C inhibitor, reduced hypoxic injury due to reperfusion following orthotopic liver transplantation in the rat. | 1994 | Transpl. Int. | pmid:11271195 |
| Zimber A et al. | Inhibition of proliferation and induction of monocytic differentiation on HL60 human promyelocytic leukemia cells treated with bile acids in vitro. | 1994 | Int. J. Cancer | pmid:7927907 |
| Pedrera C et al. | Receptor-independent mechanisms are involved in the priming of neutrophil's oxidase by vasoactive intestinal peptide. | 1994 | Regul. Pept. | pmid:7716283 |
| Boumendjel A and Miller SP | Synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate. | 1994 | J. Lipid Res. | pmid:7897327 |
| Lerner RA et al. | Cerebrodiene: a brain lipid isolated from sleep-deprived cats. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7937797 |
| Flamand N et al. | In vivo distribution of free long-chain sphingoid bases in the human stratum corneum by high-performance liquid chromatographic analysis of strippings. | 1994 | J. Chromatogr. B, Biomed. Appl. | pmid:7952048 |
| Hauser JM et al. | Role of ceramide in mitogenesis induced by exogenous sphingoid bases. | 1994 | J. Biol. Chem. | pmid:8120042 |
| Yung BY et al. | Sphinganine potentiation of dimethyl sulfoxide-induced granulocyte differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60). | 1994 | Biochem. Biophys. Res. Commun. | pmid:8135836 |
| Riley RT et al. | Dietary fumonisin B1 induces disruption of sphingolipid metabolism in Sprague-Dawley rats: a new mechanism of nephrotoxicity. | 1994 | J. Nutr. | pmid:8145083 |
| Van Veldhoven PP and Mannaerts GP | Sphinganine 1-phosphate metabolism in cultured skin fibroblasts: evidence for the existence of a sphingosine phosphatase. | 1994 | Biochem. J. | pmid:8192648 |
| Séror SJ et al. | A mutant cysteinyl-tRNA synthetase affecting timing of chromosomal replication initiation in B. subtilis and conferring resistance to a protein kinase C inhibitor. | 1994 | EMBO J. | pmid:8194536 |
| Lavie Y et al. | Formation of endogenous free sphingoid bases in cells induced by changing medium conditions. | 1994 | Biochim. Biophys. Acta | pmid:8305506 |
| Yung BY | Sphinganine potentiation of cellular differentiation induced by various anti-leukemia drugs in human leukemia cell line HL-60. | 1994 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:7870198 |
| Rodriguez-Lafrasse C et al. | Free sphingoid bases in tissues from patients with type C Niemann-Pick disease and other lysosomal storage disorders. | 1994 | Biochim. Biophys. Acta | pmid:8204660 |
| Schroeder JJ et al. | Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin B1. A molecular mechanism for carcinogenesis associated with Fusarium moniliforme. | 1994 | J. Biol. Chem. | pmid:8106389 |
| Sachs CW et al. | Partial inhibition of multidrug resistance by safingol is independent of modulation of P-glycoprotein substrate activities and correlated with inhibition of protein kinase C. | 1995 | J. Biol. Chem. | pmid:7592889 |
| Hazel BA et al. | Benzene and its metabolite, hydroquinone, induce granulocytic differentiation in myeloblasts by interacting with cellular signaling pathways activated by granulocyte colony-stimulating factor. | 1995 | Stem Cells | pmid:7542115 |
| Wei LN et al. | Retinoic acid induction of mouse cellular retinoic acid-binding protein-I gene expression is enhanced by sphinganine. | 1995 | Mol. Cell. Endocrinol. | pmid:7556883 |
| Gelderblom WC et al. | Mitoinhibitory effect of fumonisin B1 on rat hepatocytes in primary culture. | 1995 | Carcinogenesis | pmid:7697823 |
| Persat F et al. | Free ceramides of Echinococcus multilocularis metacestodes. | 1995 | Biochim. Biophys. Acta | pmid:7734444 |
| Ridgway ND and Merriam DL | Metabolism of short-chain ceramide and dihydroceramide analogues in Chinese hamster ovary (CHO) cells. | 1995 | Biochim. Biophys. Acta | pmid:7742357 |
| Schwartz GK et al. | Potentiation of apoptosis by treatment with the protein kinase C-specific inhibitor safingol in mitomycin C-treated gastric cancer cells. | 1995 | J. Natl. Cancer Inst. | pmid:7658500 |
| Ramasamy S et al. | Fumonisin B1 alters sphingolipid metabolism and disrupts the barrier function of endothelial cells in culture. | 1995 | Toxicol. Appl. Pharmacol. | pmid:7645031 |
| Bibel DJ et al. | Topical sphingolipids in antisepsis and antifungal therapy. | 1995 | Clin. Exp. Dermatol. | pmid:8593716 |
| Prelusky DB et al. | Pilot study on the plasma pharmacokinetics of fumonisin B1 in cows following a single dose by oral gavage or intravenous administration. | 1995 | Nat. Toxins | pmid:8581325 |
| Gumprecht LA et al. | Effects of intravenous fumonisin B1 in rabbits: nephrotoxicity and sphingolipid alterations. | 1995 | Nat. Toxins | pmid:8581326 |
| Bartschat DK and Rhodes TE | Protein kinase C modulates calcium channels in isolated presynaptic nerve terminals of rat hippocampus. | 1995 | J. Neurochem. | pmid:7536806 |
| Sugita M et al. | Structural elucidation of two novel amphoteric glycosphingolipids from the earthworm, Pheretima hilgendorfi. | 1995 | Biochim. Biophys. Acta | pmid:8541328 |
| Kisic A et al. | Sphingolipid bases. A revisitation of the O-methyl derivatives of sphingosine. Isolation and characterization of diacetate derivatives, with revised 13C nuclear magnetic resonance assignments for D-erythro-sphingosine. | 1995 | J. Lipid Res. | pmid:7616124 |
| Rajewski RA et al. | Stereo-specific analysis of a novel protein kinase C inhibitor. | 1995 | J Pharm Biomed Anal | pmid:7619884 |
| Restum JC et al. | Chronic toxicity of fumonisins from Fusarium moniliforme culture material (M-1325) to mink. | 1995 | Arch. Environ. Contam. Toxicol. | pmid:7574884 |
| De Ceuster P et al. | Identification and subcellular localization of sphinganine-phosphatases in rat liver. | 1995 | Biochem. J. | pmid:7575445 |
| Stewart ME and Downing DT | Free sphingosines of human skin include 6-hydroxysphingosine and unusually long-chain dihydrosphingosines. | 1995 | J. Invest. Dermatol. | pmid:7561168 |
| Smith ER and Merrill AH | Differential roles of de novo sphingolipid biosynthesis and turnover in the "burst" of free sphingosine and sphinganine, and their 1-phosphates and N-acyl-derivatives, that occurs upon changing the medium of cells in culture. | 1995 | J. Biol. Chem. | pmid:7642524 |
| Kedderis LB et al. | Toxicity of the protein kinase C inhibitor safingol administered alone and in combination with chemotherapeutic agents. | 1995 | Fundam Appl Toxicol | pmid:7665004 |
| Ridgway ND | 25-Hydroxycholesterol stimulates sphingomyelin synthesis in Chinese hamster ovary cells. | 1995 | J. Lipid Res. | pmid:7666011 |
| Weibking T et al. | Effects on turkey poults of feeding Fusarium moniliforme M-1325 culture material grown under different environmental conditions. | 1995 Jan-Mar | Avian Dis. | pmid:7794188 |
| Groener JE et al. | Metabolic fate of oleic acid derived from lysosomal degradation of cholesteryl oleate in human fibroblasts. | 1996 | J. Lipid Res. | pmid:8978478 |
| Choi OH et al. | Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor. | 1996 | Nature | pmid:8602265 |
| Wu WI and Carman GM | Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by phospholipids. | 1996 | Biochemistry | pmid:8620000 |
| Tolan D et al. | The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle. | 1996 | Br. J. Pharmacol. | pmid:8886394 |
| Valsecchi M et al. | Changes of free long-chain bases in neuronal cells during differentiation and aging in culture. | 1996 | J. Neurochem. | pmid:8863491 |