Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Broomhead JN et al. | Chronic effects of fumonisin B1 in broilers and turkeys fed dietary treatments to market age. | 2002 | Poult. Sci. | pmid:11885900 |
| Hoffmann TK et al. | Antitumor activity of protein kinase C inhibitors and cisplatin in human head and neck squamous cell carcinoma lines. | 2002 | Anticancer Drugs | pmid:11914646 |
| Li L et al. | Conformational characterization of ceramides by nuclear magnetic resonance spectroscopy. | 2002 | Biophys. J. | pmid:11916863 |
| Gijsbers S et al. | 1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human sphingosine kinase. | 2002 | Biochim. Biophys. Acta | pmid:11923095 |
| Bauman M et al. | Dependence of the sphingoid bases concentration on growth phase and temperature in the yeast Yarrowia lipolytica. | 2002 | J. Basic Microbiol. | pmid:11925759 |
| Min JK et al. | Simultaneous quantitative analysis of sphingoid base 1-phosphates in biological samples by o-phthalaldehyde precolumn derivatization after dephosphorylation with alkaline phosphatase. | 2002 | Anal. Biochem. | pmid:11950216 |
| Galvano F et al. | DNA damage in astrocytes exposed to fumonisin B1. | 2002 | Neurochem. Res. | pmid:11958538 |
| Ferguson-Yankey SR et al. | Mutant analysis reveals complex regulation of sphingolipid long chain base phosphates and long chain bases during heat stress in yeast. | 2002 | Yeast | pmid:11967828 |
| Ahn EH and Schroeder JJ | Sphingoid bases and ceramide induce apoptosis in HT-29 and HCT-116 human colon cancer cells. | 2002 | Exp. Biol. Med. (Maywood) | pmid:11976405 |
| Enongene EN et al. | Persistence and reversibility of the elevation in free sphingoid bases induced by fumonisin inhibition of ceramide synthase. | 2002 | Toxicol. Sci. | pmid:12011476 |
| Kihara A and Igarashi Y | Identification and characterization of a Saccharomyces cerevisiae gene, RSB1, involved in sphingoid long-chain base release. | 2002 | J. Biol. Chem. | pmid:12034738 |
| Kandyba AG et al. | Dihydroceramide desaturase activity in tumors. | 2002 | Biochemistry Mosc. | pmid:12059782 |
| Dickson RC and Lester RL | Sphingolipid functions in Saccharomyces cerevisiae. | 2002 | Biochim. Biophys. Acta | pmid:12069845 |
| He Q et al. | Pharmacological antagonism of fumonisin B1 cytotoxicity in porcine renal epithelial cells (LLC-PK1): a model for reducing fumonisin-induced nephrotoxicity in vivo. | 2002 | Pharmacol. Toxicol. | pmid:12076308 |
| Han G et al. | The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase. | 2002 | J. Biol. Chem. | pmid:12087109 |
| Swain E et al. | Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1. | 2002 | J. Biol. Chem. | pmid:12145310 |
| He Q et al. | Fumonisin B(1) alters sphingolipid metabolism and tumor necrosis factor alpha expression in heart and lung of mice. | 2002 | Life Sci. | pmid:12175895 |
| Xu CB et al. | D-erythro-N,N-dimethylsphingosine inhibits bFGF-induced proliferation of cerebral, aortic and coronary smooth muscle cells. | 2002 | Atherosclerosis | pmid:12204793 |
| Wispriyono B et al. | A role for the de novo sphingolipids in apoptosis of photosensitized cells. | 2002 | Exp. Cell Res. | pmid:12213223 |
| Uhlenbrock K et al. | Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. | 2002 | Cell. Signal. | pmid:12220620 |
| Seefelder W et al. | Liquid chromatography/electrospray ionisation-mass spectrometry method for the quantification of sphingosine and sphinganine in cell cultures exposed to fumonisins. | 2002 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:12383489 |
| Dobrzyń A and Górski J | Effect of acute exercise on the content of free sphinganine and sphingosine in different skeletal muscle types of the rat. | 2002 | Horm. Metab. Res. | pmid:12384830 |
| Kawase M et al. | Increase of ceramide in adriamycin-induced HL-60 cell apoptosis: detection by a novel anti-ceramide antibody. | 2002 | Biochim. Biophys. Acta | pmid:12385893 |
| Ryan AJ et al. | Alveolar sphingolipids generated in response to TNF-alpha modifies surfactant biophysical activity. | 2003 | J. Appl. Physiol. | pmid:12391098 |
| Sharma RP et al. | Paradoxical role of tumor necrosis factor alpha in fumonisin-induced hepatotoxicity in mice. | 2002 | Toxicology | pmid:12393292 |
| Watanabe R et al. | Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast. | 2002 | J. Biol. Chem. | pmid:12393888 |
| Takakuwa N et al. | Isolation and characterization of the genes encoding delta(8)-sphingolipid desaturase from Saccharomyces kluyveri and Kluyveromyces lactis. | 2002 | Curr. Microbiol. | pmid:12402089 |
| Ogawa C et al. | Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2. | 2003 | J. Biol. Chem. | pmid:12411432 |
| Högback S et al. | Ceramide 1-phosphate increases intracellular free calcium concentrations in thyroid FRTL-5 cells: evidence for an effect mediated by inositol 1,4,5-trisphosphate and intracellular sphingosine 1-phosphate. | 2003 | Biochem. J. | pmid:12416995 |
| Napier JA et al. | A new class of lipid desaturase central to sphingolipid biosynthesis and signalling. | 2002 | Trends Plant Sci. | pmid:12417141 |
| Dresden Osborne C et al. | Host resistance to Trypanosoma cruzi infection is enhanced in mice fed Fusarium verticillioides (=F. moniliforme) culture material containing fumonisins. | 2002 | Food Chem. Toxicol. | pmid:12419693 |
| Hinkovska-Galcheva V et al. | Enhanced phagocytosis through inhibition of de novo ceramide synthesis. | 2003 | J. Biol. Chem. | pmid:12424251 |
| Spassieva SD et al. | The plant disease resistance gene Asc-1 prevents disruption of sphingolipid metabolism during AAL-toxin-induced programmed cell death. | 2002 | Plant J. | pmid:12445127 |
| Zhang Y et al. | Prolonged activation of Ca2+-activated K+ current contributes to the long-lasting refractory period of Aplysia bag cell neurons. | 2002 | J. Neurosci. | pmid:12451114 |
| Cho YH et al. | Comparative study of naphthalene-2,3-dicarboxaldehyde and o-phthalaldehyde fluorogenic reagents for chromatographic detection of sphingoid bases. | 2002 | J Chromatogr A | pmid:12456096 |
| Wang H et al. | Enhanced de novo ceramide generation through activation of serine palmitoyltransferase by the P-glycoprotein antagonist SDZ PSC 833 in breast cancer cells. | 2002 | Mol. Cancer Ther. | pmid:12479368 |
| Cheng J et al. | Induction of apoptosis by sphingoid long-chain bases in Aspergillus nidulans. | 2003 | Mol. Cell. Biol. | pmid:12482970 |
| Katsuma S et al. | Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation. | 2002 | Genes Cells | pmid:12485162 |
| Howard PC et al. | Comparison of the toxicity of several fumonisin derivatives in a 28-day feeding study with female B6C3F(1) mice. | 2002 | Toxicol. Appl. Pharmacol. | pmid:12498732 |
| Desai K et al. | Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis. | 2002 | Biochim. Biophys. Acta | pmid:12531553 |
| Litvak DA et al. | Modulators of ceramide metabolism sensitize colorectal cancer cells to chemotherapy: a novel treatment strategy. | 2003 | J. Gastrointest. Surg. | pmid:12559195 |
| Qiu M et al. | [Survey on the fumonisins intake and the urinary Sa/So ratio of people suffered from a high incidence of esophageal cancer]. | 2001 | Wei Sheng Yan Jiu | pmid:12561623 |
| Jin Y et al. | Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation. | 2003 | Blood | pmid:12586615 |
| Li W et al. | Role of proliferation in the toxicity of fumonisin B1: enhanced hepatotoxic response in the partially hepatectomized rat. | 2000 | J. Toxicol. Environ. Health Part A | pmid:12607906 |
| Niedernberg A et al. | Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. | 2003 | Cell. Signal. | pmid:12618218 |
| Sharma RP et al. | Deletion of IFN-gamma reduces fumonisin-induced hepatotoxicity in mice via alterations in inflammatory cytokines and apoptotic factors. | 2003 | J. Interferon Cytokine Res. | pmid:12639295 |
| Hoekstra D et al. | Membrane dynamics and cell polarity: the role of sphingolipids. | 2003 | J. Lipid Res. | pmid:12639977 |
| Koyanagi S et al. | Elevation of de novo ceramide synthesis in tumor masses and the role of microsomal dihydroceramide synthase. | 2003 | Int. J. Cancer | pmid:12672022 |
| Carratù MR et al. | Antinutritional effects of fumonisin B1 and pathophysiological consequences. | 2003 | Toxicol. Lett. | pmid:12676494 |
| Choe Y et al. | Selective roles of protein kinase C isoforms on cell motility of GT1 immortalized hypothalamic neurones. | 2003 | J. Neuroendocrinol. | pmid:12694376 |
| Ribar S et al. | Sphingoid bases as possible diagnostic parameters. | 2003 | Croat. Med. J. | pmid:12698507 |
| Gopee NV and Sharma RP | Sphingoid bases and their phosphates: transient activation and delayed repression of protein kinase C isoforms and their possible involvement in fumonisin B1 cytotoxicity. | 2003 | Toxicology | pmid:12699912 |
| Solomon JC et al. | A novel role for sphingolipid intermediates in activation-induced cell death in T cells. | 2003 | Cell Death Differ. | pmid:12700647 |
| Borkowf CB et al. | Using lowess to remove systematic trends over time in predictor variables prior to logistic regression with quantile categories. | 2003 | Stat Med | pmid:12704611 |
| Kandyba AG et al. | [The changes in the sphingenine/sphinganine ratio in sphingolipids of transplantable rat tumors depends on a transplantation organ]. | 2003 Mar-Apr | Bioorg. Khim. | pmid:12708324 |
| Lloyd-Evans E et al. | Glucosylceramide and glucosylsphingosine modulate calcium mobilization from brain microsomes via different mechanisms. | 2003 | J. Biol. Chem. | pmid:12709427 |
| Constable PD et al. | Fumonisin-induced blockade of ceramide synthase in sphingolipid biosynthetic pathway alters aortic input impedance spectrum of pigs. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12742826 |
| Dragusin M et al. | Metabolism of the unnatural anticancer lipid safingol, L-threo-dihydrosphingosine, in cultured cells. | 2003 | J. Lipid Res. | pmid:12777464 |
| Mao C et al. | Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. | 2003 | J. Biol. Chem. | pmid:12783875 |
| Ni H et al. | Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis. | 2003 | Br. J. Haematol. | pmid:12786795 |
| Kihara A et al. | Transmembrane topology of sphingoid long-chain base-1-phosphate phosphatase, Lcb3p. | 2003 | Genes Cells | pmid:12786943 |
| Arikawa K et al. | Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity. | 2003 | J. Biol. Chem. | pmid:12810709 |
| Johnson KR et al. | Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. | 2003 | J. Biol. Chem. | pmid:12815058 |
| Wright BS et al. | Synthesis of 4-hydroxysphinganine and characterization of sphinganine hydroxylase activity in corn. | 2003 | Arch. Biochem. Biophys. | pmid:12831841 |
| Azuma H et al. | Synthesis and potent antileukemic activities of N-lactylsphingosine and N-lactyldihydrosphingosine. | 2003 | J. Med. Chem. | pmid:12877580 |
| Lieser B et al. | Quantification of sphingosine and sphinganine from crude lipid extracts by HPLC electrospray ionization tandem mass spectrometry. | 2003 | J. Lipid Res. | pmid:12897185 |
| Tran ST et al. | Sphinganine to sphingosine ratio and predictive biochemical markers of fumonisin B1 exposure in ducks. | 2003 | Chem. Biol. Interact. | pmid:12902153 |
| Riebeling C et al. | Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. | 2003 | J. Biol. Chem. | pmid:12912983 |
| Dolgachev V et al. | Reactive oxygen species generation is independent of de novo sphingolipids in apoptotic photosensitized cells. | 2003 | Exp. Cell Res. | pmid:12915133 |
| Fyrst H et al. | Characterization of free endogenous C14 and C16 sphingoid bases from Drosophila melanogaster. | 2004 | J. Lipid Res. | pmid:13130120 |
| Goldin E et al. | Type C Niemann-Pick disease: a murine model of the lysosomal cholesterol lipidosis accumulates sphingosine and sphinganine in liver. | 1992 | Biochim. Biophys. Acta | pmid:1324734 |
| HAKOMORI S and MASAMUNE H | Chemistry and biology of lipids. XXIII. A new color reaction of sphingosine and dihydrosphingosine. | 1956 | Tohoku J. Exp. Med. | pmid:13371598 |
| Uhrig ML et al. | Metabolic labelling and partial characterisation of a sulfoglycolipid in Trypanosoma cruzi trypomastigotes. | 1992 | Carbohydr. Res. | pmid:1394325 |
| Turinsky J and Nagel GW | Effect of sphingoid bases on basal and insulin-stimulated 2-deoxyglucose transport in skeletal muscle. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1417855 |
| Wakita H et al. | Composition of free long-chain (sphingoid) bases in stratum corneum of normal and pathologic human skin conditions. | 1992 | J. Invest. Dermatol. | pmid:1431224 |
| Rother J et al. | Biosynthesis of sphingolipids: dihydroceramide and not sphinganine is desaturated by cultured cells. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1449467 |
| Yun JM et al. | Efficient synthesis of enantiomerically pure 2-acylaziridines: Facile syntheses of N-Boc-safingol, N-Boc-D-erythro-sphinganine, and N-Boc-spisulosine from a common intermediate. | 2003 | J. Org. Chem. | pmid:14510541 |
| Sullards MC et al. | Metabolomic profiling of sphingolipids in human glioma cell lines by liquid chromatography tandem mass spectrometry. | 2003 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:14528916 |
| Seefelder W et al. | Induction of apoptosis in cultured human proximal tubule cells by fumonisins and fumonisin metabolites. | 2003 | Toxicol. Appl. Pharmacol. | pmid:14550748 |
| Niedernberg A et al. | Comparative analysis of functional assays for characterization of agonist ligands at G protein-coupled receptors. | 2003 | J Biomol Screen | pmid:14567777 |
| Takagi S et al. | Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function. | 2003 | J. Clin. Invest. | pmid:14597763 |
| Bibel DJ et al. | Inhibition of microbial adherence by sphinganine. | 1992 | Can. J. Microbiol. | pmid:1464071 |
| Meyer SG and de Groot H | Cycloserine and threo-dihydrosphingosine inhibit TNF-alpha-induced cytotoxicity: evidence for the importance of de novo ceramide synthesis in TNF-alpha signaling. | 2003 | Biochim. Biophys. Acta | pmid:14654222 |
| Osuchowski MF et al. | Myriocin, a serine palmitoyltransferase inhibitor, alters regional brain neurotransmitter levels without concurrent inhibition of the brain sphingolipid biosynthesis in mice. | 2004 | Toxicol. Lett. | pmid:14700532 |
| Ochi S et al. | Clostridium perfringens alpha-toxin activates the sphingomyelin metabolism system in sheep erythrocytes. | 2004 | J. Biol. Chem. | pmid:14702348 |
| Berg C et al. | Platelets induce reactive oxygen species-dependent growth of human skin fibroblasts. | 2003 | Eur. J. Cell Biol. | pmid:14703013 |
| Deguchi H et al. | Sphingolipids as bioactive regulators of thrombin generation. | 2004 | J. Biol. Chem. | pmid:14722105 |
| Johnson CR et al. | Intrinsic cytotoxicity and chemomodulatory actions of novel phenethylisothiocyanate sphingoid base derivatives in HL-60 human promyelocytic leukemia cells. | 2004 | J. Pharmacol. Exp. Ther. | pmid:14724218 |
| Gopee NV and Sharma RP | Selective and transient activation of protein kinase C alpha by fumonisin B1, a ceramide synthase inhibitor mycotoxin, in cultured porcine renal cells. | 2004 | Life Sci. | pmid:14729403 |
| Omae F et al. | DES2 protein is responsible for phytoceramide biosynthesis in the mouse small intestine. | 2004 | Biochem. J. | pmid:14731113 |
| Tserng KY and Griffin RL | Ceramide metabolite, not intact ceramide molecule, may be responsible for cellular toxicity. | 2004 | Biochem. J. | pmid:14998372 |
| Abbey-Hosch SE et al. | Sphingosine-1-phosphate inhibits C-type natriuretic peptide activation of guanylyl cyclase B (GC-B/NPR-B). | 2004 | Hypertension | pmid:15037564 |
| Mizutani Y et al. | Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation. | 2004 | FEBS Lett. | pmid:15063729 |
| He Q et al. | Silymarin protects against liver damage in BALB/c mice exposed to fumonisin B1 despite increasing accumulation of free sphingoid bases. | 2004 | Toxicol. Sci. | pmid:15103051 |
| So RC et al. | Straightforward synthesis of sphinganines via a serine-derived Weinreb amide. | 2004 | J. Org. Chem. | pmid:15104474 |
| Bae JH et al. | Cloning and functional characterization of the SUR2/SYR2 gene encoding sphinganine hydroxylase in Pichia ciferrii. | 2004 | Yeast | pmid:15116344 |
| van der Westhuizen L et al. | Disruption of sphingolipid biosynthesis in hepatocyte nodules: selective proliferative stimulus induced by fumonisin B1. | 2004 | Toxicology | pmid:15158565 |
| Williams LD et al. | Fumonisin-ortho-phthalaldehyde derivative is stabilized at low temperature. | 2004 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:15171945 |
| He Q et al. | Inhibition of serine palmitoyltransferase by myriocin, a natural mycotoxin, causes induction of c-myc in mouse liver. | 2004 | Mycopathologia | pmid:15180163 |
| Kaneider NC et al. | The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor. | 2004 | FASEB J. | pmid:15208267 |