Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dobrzyń A et al. | Effect of endurance training on the sphingomyelin-signalling pathway activity in the skeletal muscles of the rat. | 2004 | J. Physiol. Pharmacol. | pmid:15213354 |
| Van IJzendoorn SC et al. | Polarized membrane traffic and cell polarity development is dependent on dihydroceramide synthase-regulated sphinganine turnover. | 2004 | Mol. Biol. Cell | pmid:15229289 |
| Batra S et al. | Fenretinide cytotoxicity for Ewing's sarcoma and primitive neuroectodermal tumor cell lines is decreased by hypoxia and synergistically enhanced by ceramide modulators. | 2004 | Cancer Res. | pmid:15289350 |
| Johnson VJ et al. | Disruption of sphingolipid homeostasis by myriocin, a mycotoxin, reduces thymic and splenic T-lymphocyte populations. | 2004 | Toxicology | pmid:15297021 |
| Katoh N | Inhibition by sulfatide of 21-kDa protein phosphorylation by protein kinase C in cow mammary gland and its reversal by phosphatidylserine. | 2004 | J. Vet. Med. Sci. | pmid:15297754 |
| Kihara A and Igarashi Y | FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane. | 2004 | J. Biol. Chem. | pmid:15328338 |
| Tardieu D et al. | Toxicity of maize containing known levels of fumonisin B1 during force-feeding of ducks. | 2004 | Poult. Sci. | pmid:15339002 |
| Sharma N et al. | Augmented fumonisin B1 toxicity in co-cultures: evidence for crosstalk between macrophages and non-parenchymatous liver epithelial cells involving proinflammatory cytokines. | 2004 | Toxicology | pmid:15363598 |
| Gopee NV and Sharma RP | The mycotoxin fumonisin B1 transiently activates nuclear factor-kappaB, tumor necrosis factor alpha and caspase 3 via protein kinase Calpha-dependent pathway in porcine renal epithelial cells. | 2004 | Cell Biol. Toxicol. | pmid:15499968 |
| Rehman F et al. | Fenretinide stimulates redox-sensitive ceramide production in breast cancer cells: potential role in drug-induced cytotoxicity. | 2004 | Br. J. Cancer | pmid:15505623 |
| Yu MU et al. | Altered de novo sphingolipid biosynthesis is involved in the serum deprivation-induced cell death in LLC-PK1 cells. | 2004 | J. Toxicol. Environ. Health Part A | pmid:15513905 |
| Park TS et al. | Inhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout mice. | 2004 | Circulation | pmid:15545514 |
| Becker KP et al. | Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway. | 2005 | J. Biol. Chem. | pmid:15546881 |
| Grimm C et al. | Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine [corrected]. | 2005 | Mol. Pharmacol. | pmid:15550678 |
| Lee WJ et al. | Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells. | 2004 | Exp. Mol. Med. | pmid:15557814 |
| Wang JP et al. | Stimulation of cellular free Ca2+ elevation and inhibition of store-operated Ca2+ entry by kazinol B in neutrophils. | 2004 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:15558242 |
| Houjou T et al. | Rapid and selective identification of molecular species in phosphatidylcholine and sphingomyelin by conditional neutral loss scanning and MS3. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15565732 |
| Rentz SS et al. | Inhibition of sphingolipid biosynthesis decreases phosphorylated ERK2 in LLC-PK1 cells. | 2005 | Food Chem. Toxicol. | pmid:15582204 |
| He Q et al. | Fumonisin B1 hepatotoxicity in mice is attenuated by depletion of Kupffer cells by gadolinium chloride. | 2005 | Toxicology | pmid:15590129 |
| Sharma N et al. | Sphingosine kinase activity confers resistance to apoptosis by fumonisin B1 in human embryonic kidney (HEK-293) cells. | 2004 | Chem. Biol. Interact. | pmid:15607760 |
| Górska M et al. | Concentrations of sphingosine and sphinganine in plasma of patients with type 2 diabetes. | 2005 | Med. Sci. Monit. | pmid:15614193 |
| Sugawara T et al. | Efflux of sphingoid bases by P-glycoprotein in human intestinal Caco-2 cells. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15618625 |
| Coursol S et al. | Arabidopsis sphingosine kinase and the effects of phytosphingosine-1-phosphate on stomatal aperture. | 2005 | Plant Physiol. | pmid:15665242 |
| Fernández-Surumay G et al. | Glucose reaction with fumonisin B1 partially reduces its toxicity in swine. | 2004 | J. Agric. Food Chem. | pmid:15675827 |
| Tran ST et al. | Chronic effects of fumonisin B1 on ducks. | 2005 | Poult. Sci. | pmid:15685938 |
| Vallée B and Riezman H | Lip1p: a novel subunit of acyl-CoA ceramide synthase. | 2005 | EMBO J. | pmid:15692566 |
| Osuchowski MF et al. | Fumonisin B1-induced neurodegeneration in mice after intracerebroventricular infusion is concurrent with disruption of sphingolipid metabolism and activation of proinflammatory signaling. | 2005 | Neurotoxicology | pmid:15713342 |
| Budnik LT and Brunswig-Spickenheier B | Differential effects of lysolipids on steroid synthesis in cells expressing endogenous LPA2 receptor. | 2005 | J. Lipid Res. | pmid:15716590 |
| Nagahara Y et al. | Phytosphingosine induced mitochondria-involved apoptosis. | 2005 | Cancer Sci. | pmid:15723652 |
| Inagaki Y et al. | Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors. | 2005 | Biochem. J. | pmid:15733055 |
| Ikeda M et al. | Sphingolipid-to-glycerophospholipid conversion in SPL-null cells implies the existence of an alternative isozyme. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15737611 |
| Berdyshev EV et al. | Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry. | 2005 | Anal. Biochem. | pmid:15766719 |
| Cheek S et al. | A comprehensive update of the sequence and structure classification of kinases. | 2005 | BMC Struct. Biol. | pmid:15771780 |
| He Q et al. | Myriocin prevents fumonisin B1-induced sphingoid base accumulation in mice liver without ameliorating hepatotoxicity. | 2005 | Food Chem. Toxicol. | pmid:15811577 |
| Hsiao SH et al. | Effects of exogenous sphinganine, sphingosine, and sphingosine-1-phosphate on relaxation and contraction of porcine thoracic aortic and pulmonary arterial rings. | 2005 | Toxicol. Sci. | pmid:15829618 |
| Yoo HS et al. | Fumonisin inhibition of de novo sphingolipid biosynthesis and cytotoxicity are correlated in LLC-PK1 cells. | 1992 | Toxicol. Appl. Pharmacol. | pmid:1585377 |
| Osuchowski MF et al. | Endotoxin exposure alters brain and liver effects of fumonisin B1 in BALB/c mice: implication of blood brain barrier. | 2005 | Food Chem. Toxicol. | pmid:15913876 |
| Alkan S et al. | Survival role of protein kinase C (PKC) in chronic lymphocytic leukemia and determination of isoform expression pattern and genes altered by PKC inhibition. | 2005 | Am. J. Hematol. | pmid:15929099 |
| Kariya Y et al. | Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis. | 2005 | Genes Cells | pmid:15938718 |
| Touboul D et al. | Fast fingerprinting by MALDI-TOF mass spectrometry of urinary sediment glycosphingolipids in Fabry disease. | 2005 | Anal Bioanal Chem | pmid:15959771 |
| Gelineau-van Waes J et al. | Maternal fumonisin exposure and risk for neural tube defects: mechanisms in an in vivo mouse model. | 2005 | Birth Defects Res. Part A Clin. Mol. Teratol. | pmid:15959874 |
| Osuchowski MF and Sharma RP | Fumonisin B1 induces necrotic cell death in BV-2 cells and murine cultured astrocytes and is antiproliferative in BV-2 cells while N2A cells and primary cortical neurons are resistant. | 2005 | Neurotoxicology | pmid:16005069 |
| Piva A et al. | Activated carbon does not prevent the toxicity of culture material containing fumonisin B1 when fed to weanling piglets. | 2005 | J. Anim. Sci. | pmid:16024715 |
| Knapp P et al. | Ceramides, sphinganine, sphingosine and acid sphingomyelinases in the human umbilical cord blood. | 2005 | Horm. Metab. Res. | pmid:16034716 |
| He Q and Sharma RP | Inhibition of tumor necrosis factor alpha signaling by anti-tumor necrosis factor alpha antibodies and pentoxifylline is unable to prevent fumonisin hepatotoxicity in mice. | 2005 | Toxicon | pmid:16054185 |
| Tani M et al. | Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets. | 2005 | J. Lipid Res. | pmid:16061940 |
| Uhlig S et al. | 2-Amino-14,16-dimethyloctadecan-3-ol, a new sphingosine analogue toxin in the fungal genus Fusarium. | 2005 | Toxicon | pmid:16084551 |
| Alanko SM et al. | Displacement of sterols from sterol/sphingomyelin domains in fluid bilayer membranes by competing molecules. | 2005 | Biochim. Biophys. Acta | pmid:16126159 |
| Sharma RP et al. | Lupus-prone NZBWF1/J mice, defective in cytokine signaling, are resistant to fumonisin hepatotoxicity despite accumulation of liver sphinganine. | 2005 | Toxicology | pmid:16159691 |
| Yung BY et al. | Interaction of antileukemia agents adriamycin and daunomycin with sphinganine on the differentiation of human leukemia cell line HL-60. | 1992 | Cancer Res. | pmid:1617630 |
| Voss KA et al. | Toxic effects of fumonisin in mouse liver are independent of the peroxisome proliferator-activated receptor alpha. | 2006 | Toxicol. Sci. | pmid:16221962 |
| Liu K et al. | Signalling functions for sphingolipid long-chain bases in Saccharomyces cerevisiae. | 2005 | Biochem. Soc. Trans. | pmid:16246074 |
| Soriano JM et al. | Mechanism of action of sphingolipids and their metabolites in the toxicity of fumonisin B1. | 2005 | Prog. Lipid Res. | pmid:16266752 |
| Bu S et al. | Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. | 2006 | FASEB J. | pmid:16278291 |
| Saini HS et al. | Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors. | 2005 | J. Neurochem. | pmid:16313513 |
| Waters CM et al. | Cell migration activated by platelet-derived growth factor receptor is blocked by an inverse agonist of the sphingosine 1-phosphate receptor-1. | 2006 | FASEB J. | pmid:16319133 |
| Ndonye RM et al. | Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH. | 2005 | J. Org. Chem. | pmid:16323834 |
| Hamada M et al. | Induction of endonuclease G-mediated apopotosis in human oral squamous cell carcinoma cells by protein kinase C inhibitor safingol. | 2006 | Apoptosis | pmid:16374540 |
| Wang E et al. | Increases in serum sphingosine and sphinganine and decreases in complex sphingolipids in ponies given feed containing fumonisins, mycotoxins produced by Fusarium moniliforme. | 1992 | J. Nutr. | pmid:1640265 |
| Tardieu D et al. | Effects of fumonisins on liver and kidney sphinganine and the sphinganine to sphingosine ratio during chronic exposure in ducks. | 2006 | Chem. Biol. Interact. | pmid:16412405 |
| Tran ST et al. | Serum sphinganine and the sphinganine to sphingosine ratio as a biomarker of dietary fumonisins during chronic exposure in ducks. | 2006 | Chem. Biol. Interact. | pmid:16413517 |
| Campbell SE et al. | Comparative effects of RRR-alpha- and RRR-gamma-tocopherol on proliferation and apoptosis in human colon cancer cell lines. | 2006 | BMC Cancer | pmid:16417629 |
| Missmer SA et al. | Exposure to fumonisins and the occurrence of neural tube defects along the Texas-Mexico border. | 2006 | Environ. Health Perspect. | pmid:16451860 |
| Ahn EH and Schroeder JJ | Sphinganine causes early activation of JNK and p38 MAPK and inhibition of AKT activation in HT-29 human colon cancer cells. | 2006 Jan-Feb | Anticancer Res. | pmid:16475687 |
| Ejsing CS et al. | Collision-induced dissociation pathways of yeast sphingolipids and their molecular profiling in total lipid extracts: a study by quadrupole TOF and linear ion trap-orbitrap mass spectrometry. | 2006 | J Mass Spectrom | pmid:16498600 |
| Cai Y et al. | A general, efficient and stereospecific route to sphingosine, sphinganines, phytosphingosines and their analogs. | 2006 | Org. Biomol. Chem. | pmid:16525559 |
| Berdyshev EV et al. | De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells. | 2006 | Cell. Signal. | pmid:16529909 |
| Enomoto A et al. | Dihydroceramide:sphinganine C-4-hydroxylation requires Des2 hydroxylase and the membrane form of cytochrome b5. | 2006 | Biochem. J. | pmid:16571104 |
| Voss KA et al. | The role of tumor necrosis factor alpha and the peroxisome proliferator-activated receptor alpha in modulating the effects of fumonisin in mouse liver. | 2006 | Toxicology | pmid:16574297 |
| Lee EH et al. | Dimethylsphingosine regulates intracellular pH and Ca(2+) in human monocytes. | 2006 | J. Pharmacol. Sci. | pmid:16575153 |
| Riley RT and Voss KA | Differential sensitivity of rat kidney and liver to fumonisin toxicity: organ-specific differences in toxin accumulation and sphingoid base metabolism. | 2006 | Toxicol. Sci. | pmid:16613836 |
| Masukawa Y et al. | Liquid chromatography-mass spectrometry for comprehensive profiling of ceramide molecules in human hair. | 2006 | J. Lipid Res. | pmid:16639079 |
| Jiang X and Han X | Characterization and direct quantitation of sphingoid base-1-phosphates from lipid extracts: a shotgun lipidomics approach. | 2006 | J. Lipid Res. | pmid:16682747 |
| Vitkup D et al. | Influence of metabolic network structure and function on enzyme evolution. | 2006 | Genome Biol. | pmid:16684370 |
| Eigenbrod S et al. | Sphingosine kinase and sphingosine-1-phosphate regulate migration, endocytosis and apoptosis of dendritic cells. | 2006 | Immunol. Invest. | pmid:16698674 |
| Voss KA et al. | Fumonisin concentration and ceramide synthase inhibitory activity of corn, masa, and tortilla chips. | 2006 | J. Toxicol. Environ. Health Part A | pmid:16760143 |
| Masukawa Y and Tsujimura H | Highly sensitive determination of N-acyl dihydrosphingosine using liquid chromatography-electrospray ionization mass spectrometry. Application to human hair lipids. | 2006 | J Chromatogr A | pmid:16781721 |
| Denny PW et al. | The protozoan inositol phosphorylceramide synthase: a novel drug target that defines a new class of sphingolipid synthase. | 2006 | J. Biol. Chem. | pmid:16861742 |
| Yoo HH et al. | Liquid chromatography-tandem mass spectrometric determination of ceramides and related lipid species in cellular extracts. | 2006 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16891163 |
| Byrdwell WC and Perry RH | Liquid chromatography with dual parallel mass spectrometry and (31)P nuclear magnetic resonance spectroscopy for analysis of sphingomyelin and dihydrosphingomyelin. I. Bovine brain and chicken egg yolk. | 2006 | J Chromatogr A | pmid:16938303 |
| Cerantola V et al. | Yeast sphingolipids do not need to contain very long chain fatty acids. | 2007 | Biochem. J. | pmid:16987101 |
| Dahm F et al. | Distribution and dynamic changes of sphingolipids in blood in response to platelet activation. | 2006 | J. Thromb. Haemost. | pmid:17010150 |
| Andréani P and Gräler MH | Comparative quantification of sphingolipids and analogs in biological samples by high-performance liquid chromatography after chloroform extraction. | 2006 | Anal. Biochem. | pmid:17027903 |
| Kim DH et al. | Elevation of sphinganine 1-phosphate as a predictive biomarker for fumonisin exposure and toxicity in mice. | 2006 | J. Toxicol. Environ. Health Part A | pmid:17060094 |
| Ahn EH et al. | Evaluation of sphinganine and sphingosine as human breast cancer chemotherapeutic and chemopreventive agents. | 2006 | Exp. Biol. Med. (Maywood) | pmid:17060688 |
| He Q et al. | S-adenosylmethionine or 5'-methylthioadenosine are unable to prevent fumonisin B1 hepatotoxicity in mice despite increased oxidation in liver. | 2006 Nov-Dec | J Appl Toxicol | pmid:17080400 |
| Schmidt H et al. | LC-MS/MS-analysis of sphingosine-1-phosphate and related compounds in plasma samples. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:17085324 |
| Suzuki H et al. | Inducible nitric oxide has protective effect on fumonisin B1 hepatotoxicity in mice via modulation of sphingosine kinase. | 2007 | Toxicology | pmid:17095132 |
| Giussani P et al. | Sphingosine-1-phosphate and calcium signaling in cerebellar astrocytes and differentiated granule cells. | 2007 | Neurochem. Res. | pmid:17151916 |
| Delgado A et al. | Chemical tools to investigate sphingolipid metabolism and functions. | 2007 | ChemMedChem | pmid:17252619 |
| Baranowski M et al. | Pioglitazone induces de novo ceramide synthesis in the rat heart. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17259076 |
| Domijan AM et al. | Fumonisin B(1): oxidative status and DNA damage in rats. | 2007 | Toxicology | pmid:17291664 |
| Cowart LA and Hannun YA | Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis. | 2007 | J. Biol. Chem. | pmid:17322298 |
| Groener JE et al. | HPLC for simultaneous quantification of total ceramide, glucosylceramide, and ceramide trihexoside concentrations in plasma. | 2007 | Clin. Chem. | pmid:17332150 |
| Wei LL et al. | Alkaline phosphatase activity during differentiation of the human promyelocytic leukemia cell line, HL-60. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1734863 |
| Frgala T et al. | A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations. | 2007 | Mol. Cancer Ther. | pmid:17363483 |
| Tian YS et al. | Stereoselective synthesis of L-threo-sphingosine, L-threo-sphinganine, D-threo-sphingosine, and D-threo-sphinganine via oxazoline formation and olefin cross-metathesis; potent protein kinase C inhibitor analogues. | 2007 | Arch. Pharm. Res. | pmid:17366737 |
| Don AS et al. | Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues. | 2007 | J. Biol. Chem. | pmid:17400555 |
| Li S et al. | basA regulates cell wall organization and asexual/sexual sporulation ratio in Aspergillus nidulans. | 2007 | Genetics | pmid:17409079 |
| Burenjargal M et al. | Endogenous sphingolipid metabolites related to the growth in Sphingomonas chungbukensis. | 2007 | Arch. Pharm. Res. | pmid:17424937 |