Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jin Y et al. | Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation. | 2003 | Blood | pmid:12586615 |
| Sharma RP et al. | Deletion of IFN-gamma reduces fumonisin-induced hepatotoxicity in mice via alterations in inflammatory cytokines and apoptotic factors. | 2003 | J. Interferon Cytokine Res. | pmid:12639295 |
| Johnson KR et al. | Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. | 2003 | J. Biol. Chem. | pmid:12815058 |
| Wright BS et al. | Synthesis of 4-hydroxysphinganine and characterization of sphinganine hydroxylase activity in corn. | 2003 | Arch. Biochem. Biophys. | pmid:12831841 |
| Dragusin M et al. | Metabolism of the unnatural anticancer lipid safingol, L-threo-dihydrosphingosine, in cultured cells. | 2003 | J. Lipid Res. | pmid:12777464 |
| Niedernberg A et al. | Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. | 2003 | Cell. Signal. | pmid:12618218 |
| Ribar S et al. | Sphingoid bases as possible diagnostic parameters. | 2003 | Croat. Med. J. | pmid:12698507 |
| Solomon JC et al. | A novel role for sphingolipid intermediates in activation-induced cell death in T cells. | 2003 | Cell Death Differ. | pmid:12700647 |
| Borkowf CB et al. | Using lowess to remove systematic trends over time in predictor variables prior to logistic regression with quantile categories. | 2003 | Stat Med | pmid:12704611 |
| Litvak DA et al. | Modulators of ceramide metabolism sensitize colorectal cancer cells to chemotherapy: a novel treatment strategy. | 2003 | J. Gastrointest. Surg. | pmid:12559195 |
| Cheng J et al. | Induction of apoptosis by sphingoid long-chain bases in Aspergillus nidulans. | 2003 | Mol. Cell. Biol. | pmid:12482970 |
| Lieser B et al. | Quantification of sphingosine and sphinganine from crude lipid extracts by HPLC electrospray ionization tandem mass spectrometry. | 2003 | J. Lipid Res. | pmid:12897185 |
| Tran ST et al. | Sphinganine to sphingosine ratio and predictive biochemical markers of fumonisin B1 exposure in ducks. | 2003 | Chem. Biol. Interact. | pmid:12902153 |
| Meyer SG and de Groot H | Cycloserine and threo-dihydrosphingosine inhibit TNF-alpha-induced cytotoxicity: evidence for the importance of de novo ceramide synthesis in TNF-alpha signaling. | 2003 | Biochim. Biophys. Acta | pmid:14654222 |
| Ni H et al. | Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis. | 2003 | Br. J. Haematol. | pmid:12786795 |
| Choe Y et al. | Selective roles of protein kinase C isoforms on cell motility of GT1 immortalized hypothalamic neurones. | 2003 | J. Neuroendocrinol. | pmid:12694376 |
| Carratù MR et al. | Antinutritional effects of fumonisin B1 and pathophysiological consequences. | 2003 | Toxicol. Lett. | pmid:12676494 |
| Yun JM et al. | Efficient synthesis of enantiomerically pure 2-acylaziridines: Facile syntheses of N-Boc-safingol, N-Boc-D-erythro-sphinganine, and N-Boc-spisulosine from a common intermediate. | 2003 | J. Org. Chem. | pmid:14510541 |
| Seefelder W et al. | Induction of apoptosis in cultured human proximal tubule cells by fumonisins and fumonisin metabolites. | 2003 | Toxicol. Appl. Pharmacol. | pmid:14550748 |
| Berg C et al. | Platelets induce reactive oxygen species-dependent growth of human skin fibroblasts. | 2003 | Eur. J. Cell Biol. | pmid:14703013 |
| Hinkovska-Galcheva V et al. | Enhanced phagocytosis through inhibition of de novo ceramide synthesis. | 2003 | J. Biol. Chem. | pmid:12424251 |
| Gopee NV and Sharma RP | Sphingoid bases and their phosphates: transient activation and delayed repression of protein kinase C isoforms and their possible involvement in fumonisin B1 cytotoxicity. | 2003 | Toxicology | pmid:12699912 |
| Koyanagi S et al. | Elevation of de novo ceramide synthesis in tumor masses and the role of microsomal dihydroceramide synthase. | 2003 | Int. J. Cancer | pmid:12672022 |
| Dolgachev V et al. | Reactive oxygen species generation is independent of de novo sphingolipids in apoptotic photosensitized cells. | 2003 | Exp. Cell Res. | pmid:12915133 |
| Azuma H et al. | Synthesis and potent antileukemic activities of N-lactylsphingosine and N-lactyldihydrosphingosine. | 2003 | J. Med. Chem. | pmid:12877580 |
| Riebeling C et al. | Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. | 2003 | J. Biol. Chem. | pmid:12912983 |
| Kihara A et al. | Transmembrane topology of sphingoid long-chain base-1-phosphate phosphatase, Lcb3p. | 2003 | Genes Cells | pmid:12786943 |
| Takagi S et al. | Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function. | 2003 | J. Clin. Invest. | pmid:14597763 |
| Constable PD et al. | Fumonisin-induced blockade of ceramide synthase in sphingolipid biosynthetic pathway alters aortic input impedance spectrum of pigs. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12742826 |
| Hoekstra D et al. | Membrane dynamics and cell polarity: the role of sphingolipids. | 2003 | J. Lipid Res. | pmid:12639977 |
| Ogawa C et al. | Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2. | 2003 | J. Biol. Chem. | pmid:12411432 |
| Ryan AJ et al. | Alveolar sphingolipids generated in response to TNF-alpha modifies surfactant biophysical activity. | 2003 | J. Appl. Physiol. | pmid:12391098 |
| Sullards MC et al. | Metabolomic profiling of sphingolipids in human glioma cell lines by liquid chromatography tandem mass spectrometry. | 2003 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:14528916 |
| Niedernberg A et al. | Comparative analysis of functional assays for characterization of agonist ligands at G protein-coupled receptors. | 2003 | J Biomol Screen | pmid:14567777 |
| Lloyd-Evans E et al. | Glucosylceramide and glucosylsphingosine modulate calcium mobilization from brain microsomes via different mechanisms. | 2003 | J. Biol. Chem. | pmid:12709427 |
| Högback S et al. | Ceramide 1-phosphate increases intracellular free calcium concentrations in thyroid FRTL-5 cells: evidence for an effect mediated by inositol 1,4,5-trisphosphate and intracellular sphingosine 1-phosphate. | 2003 | Biochem. J. | pmid:12416995 |
| Arikawa K et al. | Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity. | 2003 | J. Biol. Chem. | pmid:12810709 |
| Mao C et al. | Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. | 2003 | J. Biol. Chem. | pmid:12783875 |
| Diatlovitskaia EV | [Biologically effective sphingolipids devoid of 4-trans-double bond in the sphingoid hydrocarbon chain]. | 2002 Jan-Feb | Bioorg. Khim. | pmid:11875973 |
| Katsuma S et al. | Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation. | 2002 | Genes Cells | pmid:12485162 |
| Cho YH et al. | Comparative study of naphthalene-2,3-dicarboxaldehyde and o-phthalaldehyde fluorogenic reagents for chromatographic detection of sphingoid bases. | 2002 | J Chromatogr A | pmid:12456096 |
| Howard PC et al. | Comparison of the toxicity of several fumonisin derivatives in a 28-day feeding study with female B6C3F(1) mice. | 2002 | Toxicol. Appl. Pharmacol. | pmid:12498732 |
| Wang H et al. | Enhanced de novo ceramide generation through activation of serine palmitoyltransferase by the P-glycoprotein antagonist SDZ PSC 833 in breast cancer cells. | 2002 | Mol. Cancer Ther. | pmid:12479368 |
| Galvano F et al. | DNA damage in astrocytes exposed to fumonisin B1. | 2002 | Neurochem. Res. | pmid:11958538 |
| Enongene EN et al. | Persistence and reversibility of the elevation in free sphingoid bases induced by fumonisin inhibition of ceramide synthase. | 2002 | Toxicol. Sci. | pmid:12011476 |
| Dickson RC and Lester RL | Sphingolipid functions in Saccharomyces cerevisiae. | 2002 | Biochim. Biophys. Acta | pmid:12069845 |
| Min JK et al. | Simultaneous quantitative analysis of sphingoid base 1-phosphates in biological samples by o-phthalaldehyde precolumn derivatization after dephosphorylation with alkaline phosphatase. | 2002 | Anal. Biochem. | pmid:11950216 |
| Xu CB et al. | D-erythro-N,N-dimethylsphingosine inhibits bFGF-induced proliferation of cerebral, aortic and coronary smooth muscle cells. | 2002 | Atherosclerosis | pmid:12204793 |
| Zhang Y et al. | Prolonged activation of Ca2+-activated K+ current contributes to the long-lasting refractory period of Aplysia bag cell neurons. | 2002 | J. Neurosci. | pmid:12451114 |
| Galvano F et al. | DNA damage in human fibroblasts exposed to fumonisin B(1). | 2002 | Food Chem. Toxicol. | pmid:11731033 |