Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hattori T et al. | New ceramide from marine sponge Haliclona koremella and related compounds as antifouling substances against macroalgae. | 1998 | J. Nat. Prod. | pmid:9644076 |
| Maurer BJ et al. | Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism. | 2000 | J. Natl. Cancer Inst. | pmid:11106681 |
| Schwartz GK et al. | Protein kinase C: a novel target for inhibiting gastric cancer cell invasion. | 1993 | J. Natl. Cancer Inst. | pmid:8433394 |
| Schwartz GK et al. | Potentiation of apoptosis by treatment with the protein kinase C-specific inhibitor safingol in mitomycin C-treated gastric cancer cells. | 1995 | J. Natl. Cancer Inst. | pmid:7658500 |
| Senchenkov A et al. | Targeting ceramide metabolism--a strategy for overcoming drug resistance. | 2001 | J. Natl. Cancer Inst. | pmid:11238696 |
| Saini HS et al. | Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors. | 2005 | J. Neurochem. | pmid:16313513 |
| Bartschat DK and Rhodes TE | Protein kinase C modulates calcium channels in isolated presynaptic nerve terminals of rat hippocampus. | 1995 | J. Neurochem. | pmid:7536806 |
| Valsecchi M et al. | Changes of free long-chain bases in neuronal cells during differentiation and aging in culture. | 1996 | J. Neurochem. | pmid:8863491 |
| Usuki S et al. | Induction of ganglioside biosynthesis and neurite outgrowth of primary cultured neurons by L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol. | 1996 | J. Neurochem. | pmid:8863486 |
| Choe Y et al. | Selective roles of protein kinase C isoforms on cell motility of GT1 immortalized hypothalamic neurones. | 2003 | J. Neuroendocrinol. | pmid:12694376 |
| Conn PJ et al. | Inhibitors of protein kinase C prevent enhancement of calcium current and action potentials in peptidergic neurons of Aplysia. | 1989 | J. Neurosci. | pmid:2918372 |
| Zhang Y et al. | Prolonged activation of Ca2+-activated K+ current contributes to the long-lasting refractory period of Aplysia bag cell neurons. | 2002 | J. Neurosci. | pmid:12451114 |
| Messmer TO et al. | Sphingolipid biosynthesis by rat liver cells: effects of serine, fatty acids and lipoproteins. | 1989 | J. Nutr. | pmid:2495341 |
| Wang E et al. | Increases in serum sphingosine and sphinganine and decreases in complex sphingolipids in ponies given feed containing fumonisins, mycotoxins produced by Fusarium moniliforme. | 1992 | J. Nutr. | pmid:1640265 |
| Riley RT et al. | Dietary fumonisin B1 induces disruption of sphingolipid metabolism in Sprague-Dawley rats: a new mechanism of nephrotoxicity. | 1994 | J. Nutr. | pmid:8145083 |
| Wang E et al. | Fumonisin B1 consumption by rats causes reversible, dose-dependent increases in urinary sphinganine and sphingosine. | 1999 | J. Nutr. | pmid:9915902 |
| Abnet CC et al. | A cross-sectional study of human serum sphingolipids, diet and physiologic parameters. | 2001 | J. Nutr. | pmid:11584099 |
| Jang Y et al. | Gamma-tocotrienol profoundly alters sphingolipids in cancer cells by inhibition of dihydroceramide desaturase and possibly activation of sphingolipid hydrolysis during prolonged treatment. | 2017 | J. Nutr. Biochem. | pmid:28456081 |
| Yun JM et al. | Efficient synthesis of enantiomerically pure 2-acylaziridines: Facile syntheses of N-Boc-safingol, N-Boc-D-erythro-sphinganine, and N-Boc-spisulosine from a common intermediate. | 2003 | J. Org. Chem. | pmid:14510541 |
| So RC et al. | Straightforward synthesis of sphinganines via a serine-derived Weinreb amide. | 2004 | J. Org. Chem. | pmid:15104474 |
| Séguin C et al. | High-yielding synthesis of sphingoid-type bases. | 2009 | J. Org. Chem. | pmid:19673498 |
| Ait-Youcef R et al. | Asymmetric synthesis of sphinganine and ent-clavaminol [corrected] H. | 2010 | J. Org. Chem. | pmid:20578745 |
| Silveira-Dorta G et al. | Direct stereoselective synthesis of enantiomerically pure anti-β-amino alcohols. | 2014 | J. Org. Chem. | pmid:24708186 |
| Ndonye RM et al. | Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH. | 2005 | J. Org. Chem. | pmid:16323834 |
| Roviezzo F et al. | Sphingosine-1-phosphate modulates vascular permeability and cell recruitment in acute inflammation in vivo. | 2011 | J. Pharmacol. Exp. Ther. | pmid:21421740 |
| Johnson CR et al. | Intrinsic cytotoxicity and chemomodulatory actions of novel phenethylisothiocyanate sphingoid base derivatives in HL-60 human promyelocytic leukemia cells. | 2004 | J. Pharmacol. Exp. Ther. | pmid:14724218 |
| Lee EH et al. | Dimethylsphingosine regulates intracellular pH and Ca(2+) in human monocytes. | 2006 | J. Pharmacol. Sci. | pmid:16575153 |
| Baranowski M et al. | PPARalpha agonist induces the accumulation of ceramide in the heart of rats fed high-fat diet. | 2007 | J. Physiol. Pharmacol. | pmid:17440226 |
| Dobrzyń A et al. | Effect of endurance training on the sphingomyelin-signalling pathway activity in the skeletal muscles of the rat. | 2004 | J. Physiol. Pharmacol. | pmid:15213354 |
| Boczkowska-Radziwon B et al. | Ozonation of human blood increases sphingosine-1-phosphate in plasma. | 2015 | J. Physiol. Pharmacol. | pmid:25903957 |
| Yanagawa D et al. | Synthesis and degradation of long-chain base phosphates affect fumonisin B-induced cell death in Arabidopsis thaliana. | 2017 | J. Plant Res. | pmid:28303405 |
| Nakagawa N et al. | Degradation of long-chain base 1-phosphate (LCBP) in Arabidopsis: functional characterization of LCBP phosphatase involved in the dehydration stress response. | 2012 | J. Plant Res. | pmid:21910031 |
| Song L et al. | Urine Metabonomics Reveals Early Biomarkers in Diabetic Cognitive Dysfunction. | 2017 | J. Proteome Res. | pmid:28722418 |
| Yang F et al. | DNA immunization perturbs lipid metabolites and increases risk of atherogenesis. | 2008 | J. Proteome Res. | pmid:18166009 |
| Vermelho AB et al. | Isolation and characterization of a neutral glycosphingolipid from the epimastigote form of Trypanosoma mega. | 1986 | J. Protozool. | pmid:3735150 |
| Dahm F et al. | Distribution and dynamic changes of sphingolipids in blood in response to platelet activation. | 2006 | J. Thromb. Haemost. | pmid:17010150 |
| Yu MU et al. | Altered de novo sphingolipid biosynthesis is involved in the serum deprivation-induced cell death in LLC-PK1 cells. | 2004 | J. Toxicol. Environ. Health Part A | pmid:15513905 |
| Li W et al. | Role of proliferation in the toxicity of fumonisin B1: enhanced hepatotoxic response in the partially hepatectomized rat. | 2000 | J. Toxicol. Environ. Health Part A | pmid:12607906 |
| Voss KA et al. | Fumonisin concentration and ceramide synthase inhibitory activity of corn, masa, and tortilla chips. | 2006 | J. Toxicol. Environ. Health Part A | pmid:16760143 |
| Son JH et al. | Activation of de novo synthetic pathway of ceramides is responsible for the initiation of hydrogen peroxide-induced apoptosis in HL-60 cells. | 2007 | J. Toxicol. Environ. Health Part A | pmid:17654249 |
| Kim DH et al. | Elevation of sphinganine 1-phosphate as a predictive biomarker for fumonisin exposure and toxicity in mice. | 2006 | J. Toxicol. Environ. Health Part A | pmid:17060094 |
| Sosnowski J et al. | Protein kinase C mediated anti-proliferative glucocorticoid-sphinganine synergism in cultured Pollard III prostate tumor cells. | 1997 | J. Urol. | pmid:9186373 |
| Hsiao SH et al. | Use of formalin-fixed tissues to determine fumonisin B1-induced sphingolipid alterations in swine. | 2007 | J. Vet. Diagn. Invest. | pmid:17609357 |
| Katoh N | Inhibition by sulfatide of 21-kDa protein phosphorylation by protein kinase C in cow mammary gland and its reversal by phosphatidylserine. | 2004 | J. Vet. Med. Sci. | pmid:15297754 |
| Jung HL and Kang HY | Effects of endurance exercise and high-fat diet on insulin resistance and ceramide contents of skeletal muscle in sprague-dawley rats. | 2010 | Korean Diabetes J | pmid:20835342 |
| Park SW et al. | Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation. | 2010 | Lab. Invest. | pmid:20458275 |
| Klostergaard J et al. | Characterization of cytotoxicity induced by sphingolipids in multidrug-resistant leukemia cells. | 1998 | Leuk. Res. | pmid:9783808 |
| He Q et al. | Fumonisin B(1) alters sphingolipid metabolism and tumor necrosis factor alpha expression in heart and lung of mice. | 2002 | Life Sci. | pmid:12175895 |
| Gopee NV and Sharma RP | Selective and transient activation of protein kinase C alpha by fumonisin B1, a ceramide synthase inhibitor mycotoxin, in cultured porcine renal cells. | 2004 | Life Sci. | pmid:14729403 |
| Niwa M et al. | Tumor necrosis factor-alpha-mediated signal transduction in human neutrophils: involvement of sphingomyelin metabolites in the priming effect of TNF-alpha on the fMLP-stimulated superoxide production. | 2000 | Life Sci. | pmid:10666000 |