Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Peters-Golden M et al. | Diminished protein kinase C-activated arachidonate metabolism accompanies rat macrophage differentiation in the lung. | 1990 | J. Immunol. | pmid:2160499 |
| O'Flaherty JT et al. | Translocation of protein kinase C in human polymorphonuclear neutrophils. Regulation by cytosolic Ca2(+)-independent and Ca2(+)-dependent mechanisms. | 1990 | J. Biol. Chem. | pmid:2160959 |
| Zhao L et al. | A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. | 2011 | PLoS Genet. | pmid:21625621 |
| Cano-Sancho G et al. | Sphinganine and sphingosine levels and ratio in urine and blood samples from a Catalonian population, Spain. | 2011 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:21644119 |
| Hernández-Corbacho MJ et al. | Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction. | 2011 | PLoS ONE | pmid:21687659 |
| Uchida Y | The role of fatty acid elongation in epidermal structure and function. | 2011 | Dermatoendocrinol | pmid:21695014 |
| Radner FP et al. | Fat in the skin: Triacylglycerol metabolism in keratinocytes and its role in the development of neutral lipid storage disease. | 2011 | Dermatoendocrinol | pmid:21695016 |
| Lee H et al. | Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation. | 2011 | PLoS ONE | pmid:21695182 |
| Barbosa AD et al. | Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells. | 2011 | Mol. Microbiol. | pmid:21707788 |
| Ueno S and Horito S | Synthesis of an O-sulfo Lewis(X) analog as glycolipid antigen. | 2011 | Carbohydr. Res. | pmid:21764041 |
| Chu UB et al. | Characterization of interactions of 4-nitrophenylpropyl-N-alkylamine with Ï‚ receptors. | 2011 | Biochemistry | pmid:21790129 |
| Spijkers LJ et al. | Hypertension is associated with marked alterations in sphingolipid biology: a potential role for ceramide. | 2011 | PLoS ONE | pmid:21818267 |
| Samarakoon R et al. | Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression. | 2011 | PLoS ONE | pmid:21829547 |
| Michaelson LV | New insights into cell death induced by long chain bases in Arabidopsis. | 2011 | New Phytol. | pmid:21834911 |
| Roe B et al. | Metabolomic profile of hepatitis C virus-infected hepatocytes. | 2011 | PLoS ONE | pmid:21853158 |
| Clugston RD et al. | Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study. | 2011 | J. Lipid Res. | pmid:21856784 |
| Chan EK et al. | Combining genome-wide association mapping and transcriptional networks to identify novel genes controlling glucosinolates in Arabidopsis thaliana. | 2011 | PLoS Biol. | pmid:21857804 |
| Murakami I et al. | Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors. | 2011 | Lipids Health Dis | pmid:21861924 |
| Siow D and Wattenberg B | The compartmentalization and translocation of the sphingosine kinases: mechanisms and functions in cell signaling and sphingolipid metabolism. | 2011 | Crit. Rev. Biochem. Mol. Biol. | pmid:21864225 |
| Zhang L et al. | The involvement of jasmonates and ethylene in Alternaria alternata f. sp. lycopersici toxin-induced tomato cell death. | 2011 | J. Exp. Bot. | pmid:21865178 |
| O'Reilly C and Murphy PV | Synthesis of α-S-glycosphingolipids based on uronic acids. | 2011 | Org. Lett. | pmid:21875123 |
| Nakagawa N et al. | Degradation of long-chain base 1-phosphate (LCBP) in Arabidopsis: functional characterization of LCBP phosphatase involved in the dehydration stress response. | 2012 | J. Plant Res. | pmid:21910031 |
| Van Zeebroeck G et al. | A split-ubiquitin two-hybrid screen for proteins physically interacting with the yeast amino acid transceptor Gap1 and ammonium transceptor Mep2. | 2011 | PLoS ONE | pmid:21912684 |
| Saucedo-GarcÃa M et al. | Reactive oxygen species as transducers of sphinganine-mediated cell death pathway. | 2011 | Plant Signal Behav | pmid:21921699 |
| Zhang H et al. | Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis. | 2011 | Nat. Cell Biol. | pmid:21926990 |
| Pan J et al. | An novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma. | 2011 | J Transl Med | pmid:21936950 |
| Merrill AH | Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. | 2011 | Chem. Rev. | pmid:21942574 |
| Doi K and Uetsuka K | Mechanisms of mycotoxin-induced neurotoxicity through oxidative stress-associated pathways. | 2011 | Int J Mol Sci | pmid:21954354 |
| Watson ML et al. | Chronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cells. | 2011 | PLoS ONE | pmid:21998735 |
| Lamour NF et al. | Ceramide kinase regulates the production of tumor necrosis factor α (TNFα) via inhibition of TNFα-converting enzyme. | 2011 | J. Biol. Chem. | pmid:22009748 |
| Callihan P et al. | Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells. | 2012 | Neuropharmacology | pmid:22016110 |
| Nimrichter L and Rodrigues ML | Fungal glucosylceramides: from structural components to biologically active targets of new antimicrobials. | 2011 | Front Microbiol | pmid:22025918 |
| Bensaci MF et al. | Fungicidal Activities and Mechanisms of Action of Pseudomonas syringae pv. syringae Lipodepsipeptide Syringopeptins 22A and 25A. | 2011 | Front Microbiol | pmid:22046175 |
| Apraiz A et al. | Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells. | 2011 | BMC Cancer | pmid:22061047 |
| Milićević DR et al. | Real and perceived risks for mycotoxin contamination in foods and feeds: challenges for food safety control. | 2010 | Toxins (Basel) | pmid:22069600 |
| Tan KB et al. | In vivo efficacy of a novel liposomal formulation of safingol in the treatment of acute myeloid leukemia. | 2012 | J Control Release | pmid:22100388 |
| Kim J et al. | Analysis of ceramide metabolites in differentiating epidermal keratinocytes treated with calcium or vitamin C. | 2011 | Nutr Res Pract | pmid:22125676 |
| Ota H et al. | S1P(4) receptor mediates S1P-induced vasoconstriction in normotensive and hypertensive rat lungs. | 2011 Jul-Sep | Pulm Circ | pmid:22140630 |
| Shichiri M et al. | A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity. | 2012 | J. Biol. Chem. | pmid:22147702 |
| Fischer CL et al. | Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria. | 2012 | Antimicrob. Agents Chemother. | pmid:22155833 |
| Wang L et al. | Genome characterization of the oleaginous fungus Mortierella alpina. | 2011 | PLoS ONE | pmid:22174787 |
| Schorsch C et al. | High-level production of tetraacetyl phytosphingosine (TAPS) by combined genetic engineering of sphingoid base biosynthesis and L-serine availability in the non-conventional yeast Pichia ciferrii. | 2012 | Metab. Eng. | pmid:22178746 |
| Dickman MB and Figueiredo Pd | Comparative pathobiology of fungal pathogens of plants and animals. | 2011 | PLoS Pathog. | pmid:22194681 |
| Alvarez-Vasquez F et al. | Mathematical modeling and validation of the ergosterol pathway in Saccharomyces cerevisiae. | 2011 | PLoS ONE | pmid:22194828 |
| Spijkers LJ et al. | Antihypertensive treatment differentially affects vascular sphingolipid biology in spontaneously hypertensive rats. | 2011 | PLoS ONE | pmid:22195025 |
| Wang Y et al. | Transcript and protein profiling analysis of OTA-induced cell death reveals the regulation of the toxicity response process in Arabidopsis thaliana. | 2012 | J. Exp. Bot. | pmid:22207617 |
| Figueiredo JM et al. | Molecular and functional characterization of the ceramide synthase from Trypanosoma cruzi. | 2012 Mar-Apr | Mol. Biochem. Parasitol. | pmid:22226824 |
| Zhao YY et al. | Urinary metabonomics study on biochemical changes in an experimental model of chronic renal failure by adenine based on UPLC Q-TOF/MS. | 2012 | Clin. Chim. Acta | pmid:22227165 |
| Frank S et al. | Structural characterization of Schistosoma mansoni adult worm glycosphingolipids reveals pronounced differences with those of cercariae. | 2012 | Glycobiology | pmid:22241826 |
| De Larichaudy J et al. | TNF-α- and tumor-induced skeletal muscle atrophy involves sphingolipid metabolism. | 2012 | Skelet Muscle | pmid:22257771 |