Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Delgado A et al. | Chemical tools to investigate sphingolipid metabolism and functions. | 2007 | ChemMedChem | pmid:17252619 |
| Giussani P et al. | Sphingosine-1-phosphate and calcium signaling in cerebellar astrocytes and differentiated granule cells. | 2007 | Neurochem. Res. | pmid:17151916 |
| Suzuki H et al. | Inducible nitric oxide has protective effect on fumonisin B1 hepatotoxicity in mice via modulation of sphingosine kinase. | 2007 | Toxicology | pmid:17095132 |
| Schmidt H et al. | LC-MS/MS-analysis of sphingosine-1-phosphate and related compounds in plasma samples. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:17085324 |
| He Q et al. | S-adenosylmethionine or 5'-methylthioadenosine are unable to prevent fumonisin B1 hepatotoxicity in mice despite increased oxidation in liver. | 2006 Nov-Dec | J Appl Toxicol | pmid:17080400 |
| Ahn EH et al. | Evaluation of sphinganine and sphingosine as human breast cancer chemotherapeutic and chemopreventive agents. | 2006 | Exp. Biol. Med. (Maywood) | pmid:17060688 |
| Kim DH et al. | Elevation of sphinganine 1-phosphate as a predictive biomarker for fumonisin exposure and toxicity in mice. | 2006 | J. Toxicol. Environ. Health Part A | pmid:17060094 |
| Andréani P and Gräler MH | Comparative quantification of sphingolipids and analogs in biological samples by high-performance liquid chromatography after chloroform extraction. | 2006 | Anal. Biochem. | pmid:17027903 |
| Dahm F et al. | Distribution and dynamic changes of sphingolipids in blood in response to platelet activation. | 2006 | J. Thromb. Haemost. | pmid:17010150 |
| Cerantola V et al. | Yeast sphingolipids do not need to contain very long chain fatty acids. | 2007 | Biochem. J. | pmid:16987101 |
| Byrdwell WC and Perry RH | Liquid chromatography with dual parallel mass spectrometry and (31)P nuclear magnetic resonance spectroscopy for analysis of sphingomyelin and dihydrosphingomyelin. I. Bovine brain and chicken egg yolk. | 2006 | J Chromatogr A | pmid:16938303 |
| Yoo HH et al. | Liquid chromatography-tandem mass spectrometric determination of ceramides and related lipid species in cellular extracts. | 2006 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16891163 |
| Denny PW et al. | The protozoan inositol phosphorylceramide synthase: a novel drug target that defines a new class of sphingolipid synthase. | 2006 | J. Biol. Chem. | pmid:16861742 |
| Masukawa Y and Tsujimura H | Highly sensitive determination of N-acyl dihydrosphingosine using liquid chromatography-electrospray ionization mass spectrometry. Application to human hair lipids. | 2006 | J Chromatogr A | pmid:16781721 |
| Voss KA et al. | Fumonisin concentration and ceramide synthase inhibitory activity of corn, masa, and tortilla chips. | 2006 | J. Toxicol. Environ. Health Part A | pmid:16760143 |
| Eigenbrod S et al. | Sphingosine kinase and sphingosine-1-phosphate regulate migration, endocytosis and apoptosis of dendritic cells. | 2006 | Immunol. Invest. | pmid:16698674 |
| Vitkup D et al. | Influence of metabolic network structure and function on enzyme evolution. | 2006 | Genome Biol. | pmid:16684370 |
| Jiang X and Han X | Characterization and direct quantitation of sphingoid base-1-phosphates from lipid extracts: a shotgun lipidomics approach. | 2006 | J. Lipid Res. | pmid:16682747 |
| Masukawa Y et al. | Liquid chromatography-mass spectrometry for comprehensive profiling of ceramide molecules in human hair. | 2006 | J. Lipid Res. | pmid:16639079 |
| Riley RT and Voss KA | Differential sensitivity of rat kidney and liver to fumonisin toxicity: organ-specific differences in toxin accumulation and sphingoid base metabolism. | 2006 | Toxicol. Sci. | pmid:16613836 |
| Lee EH et al. | Dimethylsphingosine regulates intracellular pH and Ca(2+) in human monocytes. | 2006 | J. Pharmacol. Sci. | pmid:16575153 |
| Voss KA et al. | The role of tumor necrosis factor alpha and the peroxisome proliferator-activated receptor alpha in modulating the effects of fumonisin in mouse liver. | 2006 | Toxicology | pmid:16574297 |
| Enomoto A et al. | Dihydroceramide:sphinganine C-4-hydroxylation requires Des2 hydroxylase and the membrane form of cytochrome b5. | 2006 | Biochem. J. | pmid:16571104 |
| Berdyshev EV et al. | De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells. | 2006 | Cell. Signal. | pmid:16529909 |
| Cai Y et al. | A general, efficient and stereospecific route to sphingosine, sphinganines, phytosphingosines and their analogs. | 2006 | Org. Biomol. Chem. | pmid:16525559 |
| Ejsing CS et al. | Collision-induced dissociation pathways of yeast sphingolipids and their molecular profiling in total lipid extracts: a study by quadrupole TOF and linear ion trap-orbitrap mass spectrometry. | 2006 | J Mass Spectrom | pmid:16498600 |
| Ahn EH and Schroeder JJ | Sphinganine causes early activation of JNK and p38 MAPK and inhibition of AKT activation in HT-29 human colon cancer cells. | 2006 Jan-Feb | Anticancer Res. | pmid:16475687 |
| Missmer SA et al. | Exposure to fumonisins and the occurrence of neural tube defects along the Texas-Mexico border. | 2006 | Environ. Health Perspect. | pmid:16451860 |
| Campbell SE et al. | Comparative effects of RRR-alpha- and RRR-gamma-tocopherol on proliferation and apoptosis in human colon cancer cell lines. | 2006 | BMC Cancer | pmid:16417629 |
| Tran ST et al. | Serum sphinganine and the sphinganine to sphingosine ratio as a biomarker of dietary fumonisins during chronic exposure in ducks. | 2006 | Chem. Biol. Interact. | pmid:16413517 |
| Tardieu D et al. | Effects of fumonisins on liver and kidney sphinganine and the sphinganine to sphingosine ratio during chronic exposure in ducks. | 2006 | Chem. Biol. Interact. | pmid:16412405 |
| Wang E et al. | Increases in serum sphingosine and sphinganine and decreases in complex sphingolipids in ponies given feed containing fumonisins, mycotoxins produced by Fusarium moniliforme. | 1992 | J. Nutr. | pmid:1640265 |
| Hamada M et al. | Induction of endonuclease G-mediated apopotosis in human oral squamous cell carcinoma cells by protein kinase C inhibitor safingol. | 2006 | Apoptosis | pmid:16374540 |
| Ndonye RM et al. | Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH. | 2005 | J. Org. Chem. | pmid:16323834 |
| Waters CM et al. | Cell migration activated by platelet-derived growth factor receptor is blocked by an inverse agonist of the sphingosine 1-phosphate receptor-1. | 2006 | FASEB J. | pmid:16319133 |
| Saini HS et al. | Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors. | 2005 | J. Neurochem. | pmid:16313513 |
| Bu S et al. | Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. | 2006 | FASEB J. | pmid:16278291 |
| Soriano JM et al. | Mechanism of action of sphingolipids and their metabolites in the toxicity of fumonisin B1. | 2005 | Prog. Lipid Res. | pmid:16266752 |
| Liu K et al. | Signalling functions for sphingolipid long-chain bases in Saccharomyces cerevisiae. | 2005 | Biochem. Soc. Trans. | pmid:16246074 |
| Voss KA et al. | Toxic effects of fumonisin in mouse liver are independent of the peroxisome proliferator-activated receptor alpha. | 2006 | Toxicol. Sci. | pmid:16221962 |
| Yung BY et al. | Interaction of antileukemia agents adriamycin and daunomycin with sphinganine on the differentiation of human leukemia cell line HL-60. | 1992 | Cancer Res. | pmid:1617630 |
| Sharma RP et al. | Lupus-prone NZBWF1/J mice, defective in cytokine signaling, are resistant to fumonisin hepatotoxicity despite accumulation of liver sphinganine. | 2005 | Toxicology | pmid:16159691 |
| Alanko SM et al. | Displacement of sterols from sterol/sphingomyelin domains in fluid bilayer membranes by competing molecules. | 2005 | Biochim. Biophys. Acta | pmid:16126159 |
| Uhlig S et al. | 2-Amino-14,16-dimethyloctadecan-3-ol, a new sphingosine analogue toxin in the fungal genus Fusarium. | 2005 | Toxicon | pmid:16084551 |
| Tani M et al. | Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets. | 2005 | J. Lipid Res. | pmid:16061940 |
| He Q and Sharma RP | Inhibition of tumor necrosis factor alpha signaling by anti-tumor necrosis factor alpha antibodies and pentoxifylline is unable to prevent fumonisin hepatotoxicity in mice. | 2005 | Toxicon | pmid:16054185 |
| Knapp P et al. | Ceramides, sphinganine, sphingosine and acid sphingomyelinases in the human umbilical cord blood. | 2005 | Horm. Metab. Res. | pmid:16034716 |
| Piva A et al. | Activated carbon does not prevent the toxicity of culture material containing fumonisin B1 when fed to weanling piglets. | 2005 | J. Anim. Sci. | pmid:16024715 |
| Osuchowski MF and Sharma RP | Fumonisin B1 induces necrotic cell death in BV-2 cells and murine cultured astrocytes and is antiproliferative in BV-2 cells while N2A cells and primary cortical neurons are resistant. | 2005 | Neurotoxicology | pmid:16005069 |
| Gelineau-van Waes J et al. | Maternal fumonisin exposure and risk for neural tube defects: mechanisms in an in vivo mouse model. | 2005 | Birth Defects Res. Part A Clin. Mol. Teratol. | pmid:15959874 |