Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Touboul D et al. | Fast fingerprinting by MALDI-TOF mass spectrometry of urinary sediment glycosphingolipids in Fabry disease. | 2005 | Anal Bioanal Chem | pmid:15959771 |
| Kariya Y et al. | Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis. | 2005 | Genes Cells | pmid:15938718 |
| Alkan S et al. | Survival role of protein kinase C (PKC) in chronic lymphocytic leukemia and determination of isoform expression pattern and genes altered by PKC inhibition. | 2005 | Am. J. Hematol. | pmid:15929099 |
| Osuchowski MF et al. | Endotoxin exposure alters brain and liver effects of fumonisin B1 in BALB/c mice: implication of blood brain barrier. | 2005 | Food Chem. Toxicol. | pmid:15913876 |
| Yoo HS et al. | Fumonisin inhibition of de novo sphingolipid biosynthesis and cytotoxicity are correlated in LLC-PK1 cells. | 1992 | Toxicol. Appl. Pharmacol. | pmid:1585377 |
| Hsiao SH et al. | Effects of exogenous sphinganine, sphingosine, and sphingosine-1-phosphate on relaxation and contraction of porcine thoracic aortic and pulmonary arterial rings. | 2005 | Toxicol. Sci. | pmid:15829618 |
| He Q et al. | Myriocin prevents fumonisin B1-induced sphingoid base accumulation in mice liver without ameliorating hepatotoxicity. | 2005 | Food Chem. Toxicol. | pmid:15811577 |
| Cheek S et al. | A comprehensive update of the sequence and structure classification of kinases. | 2005 | BMC Struct. Biol. | pmid:15771780 |
| Berdyshev EV et al. | Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry. | 2005 | Anal. Biochem. | pmid:15766719 |
| Ikeda M et al. | Sphingolipid-to-glycerophospholipid conversion in SPL-null cells implies the existence of an alternative isozyme. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15737611 |
| Inagaki Y et al. | Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors. | 2005 | Biochem. J. | pmid:15733055 |
| Nagahara Y et al. | Phytosphingosine induced mitochondria-involved apoptosis. | 2005 | Cancer Sci. | pmid:15723652 |
| Budnik LT and Brunswig-Spickenheier B | Differential effects of lysolipids on steroid synthesis in cells expressing endogenous LPA2 receptor. | 2005 | J. Lipid Res. | pmid:15716590 |
| Osuchowski MF et al. | Fumonisin B1-induced neurodegeneration in mice after intracerebroventricular infusion is concurrent with disruption of sphingolipid metabolism and activation of proinflammatory signaling. | 2005 | Neurotoxicology | pmid:15713342 |
| Vallée B and Riezman H | Lip1p: a novel subunit of acyl-CoA ceramide synthase. | 2005 | EMBO J. | pmid:15692566 |
| Tran ST et al. | Chronic effects of fumonisin B1 on ducks. | 2005 | Poult. Sci. | pmid:15685938 |
| Fernández-Surumay G et al. | Glucose reaction with fumonisin B1 partially reduces its toxicity in swine. | 2004 | J. Agric. Food Chem. | pmid:15675827 |
| Coursol S et al. | Arabidopsis sphingosine kinase and the effects of phytosphingosine-1-phosphate on stomatal aperture. | 2005 | Plant Physiol. | pmid:15665242 |
| Sugawara T et al. | Efflux of sphingoid bases by P-glycoprotein in human intestinal Caco-2 cells. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15618625 |
| Górska M et al. | Concentrations of sphingosine and sphinganine in plasma of patients with type 2 diabetes. | 2005 | Med. Sci. Monit. | pmid:15614193 |
| Sharma N et al. | Sphingosine kinase activity confers resistance to apoptosis by fumonisin B1 in human embryonic kidney (HEK-293) cells. | 2004 | Chem. Biol. Interact. | pmid:15607760 |
| He Q et al. | Fumonisin B1 hepatotoxicity in mice is attenuated by depletion of Kupffer cells by gadolinium chloride. | 2005 | Toxicology | pmid:15590129 |
| Rentz SS et al. | Inhibition of sphingolipid biosynthesis decreases phosphorylated ERK2 in LLC-PK1 cells. | 2005 | Food Chem. Toxicol. | pmid:15582204 |
| Houjou T et al. | Rapid and selective identification of molecular species in phosphatidylcholine and sphingomyelin by conditional neutral loss scanning and MS3. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15565732 |
| Wang JP et al. | Stimulation of cellular free Ca2+ elevation and inhibition of store-operated Ca2+ entry by kazinol B in neutrophils. | 2004 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:15558242 |
| Lee WJ et al. | Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells. | 2004 | Exp. Mol. Med. | pmid:15557814 |
| Grimm C et al. | Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine [corrected]. | 2005 | Mol. Pharmacol. | pmid:15550678 |
| Becker KP et al. | Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway. | 2005 | J. Biol. Chem. | pmid:15546881 |
| Park TS et al. | Inhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout mice. | 2004 | Circulation | pmid:15545514 |
| Yu MU et al. | Altered de novo sphingolipid biosynthesis is involved in the serum deprivation-induced cell death in LLC-PK1 cells. | 2004 | J. Toxicol. Environ. Health Part A | pmid:15513905 |
| Rehman F et al. | Fenretinide stimulates redox-sensitive ceramide production in breast cancer cells: potential role in drug-induced cytotoxicity. | 2004 | Br. J. Cancer | pmid:15505623 |
| Gopee NV and Sharma RP | The mycotoxin fumonisin B1 transiently activates nuclear factor-kappaB, tumor necrosis factor alpha and caspase 3 via protein kinase Calpha-dependent pathway in porcine renal epithelial cells. | 2004 | Cell Biol. Toxicol. | pmid:15499968 |
| Sharma N et al. | Augmented fumonisin B1 toxicity in co-cultures: evidence for crosstalk between macrophages and non-parenchymatous liver epithelial cells involving proinflammatory cytokines. | 2004 | Toxicology | pmid:15363598 |
| Tardieu D et al. | Toxicity of maize containing known levels of fumonisin B1 during force-feeding of ducks. | 2004 | Poult. Sci. | pmid:15339002 |
| Kihara A and Igarashi Y | FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane. | 2004 | J. Biol. Chem. | pmid:15328338 |
| Katoh N | Inhibition by sulfatide of 21-kDa protein phosphorylation by protein kinase C in cow mammary gland and its reversal by phosphatidylserine. | 2004 | J. Vet. Med. Sci. | pmid:15297754 |
| Johnson VJ et al. | Disruption of sphingolipid homeostasis by myriocin, a mycotoxin, reduces thymic and splenic T-lymphocyte populations. | 2004 | Toxicology | pmid:15297021 |
| Batra S et al. | Fenretinide cytotoxicity for Ewing's sarcoma and primitive neuroectodermal tumor cell lines is decreased by hypoxia and synergistically enhanced by ceramide modulators. | 2004 | Cancer Res. | pmid:15289350 |
| Van IJzendoorn SC et al. | Polarized membrane traffic and cell polarity development is dependent on dihydroceramide synthase-regulated sphinganine turnover. | 2004 | Mol. Biol. Cell | pmid:15229289 |
| Dobrzyń A et al. | Effect of endurance training on the sphingomyelin-signalling pathway activity in the skeletal muscles of the rat. | 2004 | J. Physiol. Pharmacol. | pmid:15213354 |
| Kaneider NC et al. | The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor. | 2004 | FASEB J. | pmid:15208267 |
| He Q et al. | Inhibition of serine palmitoyltransferase by myriocin, a natural mycotoxin, causes induction of c-myc in mouse liver. | 2004 | Mycopathologia | pmid:15180163 |
| Williams LD et al. | Fumonisin-ortho-phthalaldehyde derivative is stabilized at low temperature. | 2004 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:15171945 |
| van der Westhuizen L et al. | Disruption of sphingolipid biosynthesis in hepatocyte nodules: selective proliferative stimulus induced by fumonisin B1. | 2004 | Toxicology | pmid:15158565 |
| Bae JH et al. | Cloning and functional characterization of the SUR2/SYR2 gene encoding sphinganine hydroxylase in Pichia ciferrii. | 2004 | Yeast | pmid:15116344 |
| So RC et al. | Straightforward synthesis of sphinganines via a serine-derived Weinreb amide. | 2004 | J. Org. Chem. | pmid:15104474 |
| He Q et al. | Silymarin protects against liver damage in BALB/c mice exposed to fumonisin B1 despite increasing accumulation of free sphingoid bases. | 2004 | Toxicol. Sci. | pmid:15103051 |
| Mizutani Y et al. | Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation. | 2004 | FEBS Lett. | pmid:15063729 |
| Abbey-Hosch SE et al. | Sphingosine-1-phosphate inhibits C-type natriuretic peptide activation of guanylyl cyclase B (GC-B/NPR-B). | 2004 | Hypertension | pmid:15037564 |
| Tserng KY and Griffin RL | Ceramide metabolite, not intact ceramide molecule, may be responsible for cellular toxicity. | 2004 | Biochem. J. | pmid:14998372 |