Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yung BY et al. | Sphinganine potentiation of dimethyl sulfoxide-induced granulocyte differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60). | 1994 | Biochem. Biophys. Res. Commun. | pmid:8135836 |
| Riley RT et al. | Dietary fumonisin B1 induces disruption of sphingolipid metabolism in Sprague-Dawley rats: a new mechanism of nephrotoxicity. | 1994 | J. Nutr. | pmid:8145083 |
| Van Veldhoven PP and Mannaerts GP | Sphinganine 1-phosphate metabolism in cultured skin fibroblasts: evidence for the existence of a sphingosine phosphatase. | 1994 | Biochem. J. | pmid:8192648 |
| Séror SJ et al. | A mutant cysteinyl-tRNA synthetase affecting timing of chromosomal replication initiation in B. subtilis and conferring resistance to a protein kinase C inhibitor. | 1994 | EMBO J. | pmid:8194536 |
| Rodriguez-Lafrasse C et al. | Free sphingoid bases in tissues from patients with type C Niemann-Pick disease and other lysosomal storage disorders. | 1994 | Biochim. Biophys. Acta | pmid:8204660 |
| Yung BY and Hui EK | Differential regulation of protein kinase C isoenzymes during sphinganine potentiation of retinoic acid-induced granulocytic differentiation in human leukemia HL-60 cells. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8250895 |
| Merrill AH et al. | Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. | 1993 | J. Biol. Chem. | pmid:8262970 |
| Lavie Y et al. | Formation of endogenous free sphingoid bases in cells induced by changing medium conditions. | 1994 | Biochim. Biophys. Acta | pmid:8305506 |
| Wu WI et al. | Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by sphingoid bases. | 1993 | J. Biol. Chem. | pmid:8314751 |
| Olivera A and Spiegel S | Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. | 1993 | Nature | pmid:8413613 |
| Riley RT et al. | Alteration of tissue and serum sphinganine to sphingosine ratio: an early biomarker of exposure to fumonisin-containing feeds in pigs. | 1993 | Toxicol. Appl. Pharmacol. | pmid:8430417 |
| Schwartz GK et al. | Protein kinase C: a novel target for inhibiting gastric cancer cell invasion. | 1993 | J. Natl. Cancer Inst. | pmid:8433394 |
| Clarke BL et al. | Regulation of parathyroid hormone release by protein kinase-C is dependent on extracellular calcium in bovine parathyroid cells. | 1993 | Endocrinology | pmid:8440177 |
| Hirschberg K et al. | The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver. | 1993 | Biochem. J. | pmid:8457204 |
| Sugiyama E et al. | Metabolism and neurite promoting effect of exogenous sphingosylphosphocholine in cultured murine neuroblastoma cells. | 1993 | J. Biochem. | pmid:8514735 |
| Sugita M et al. | Structural elucidation of two novel amphoteric glycosphingolipids from the earthworm, Pheretima hilgendorfi. | 1995 | Biochim. Biophys. Acta | pmid:8541328 |
| Prelusky DB et al. | Pilot study on the plasma pharmacokinetics of fumonisin B1 in cows following a single dose by oral gavage or intravenous administration. | 1995 | Nat. Toxins | pmid:8581325 |
| Gumprecht LA et al. | Effects of intravenous fumonisin B1 in rabbits: nephrotoxicity and sphingolipid alterations. | 1995 | Nat. Toxins | pmid:8581326 |
| Bibel DJ et al. | Topical sphingolipids in antisepsis and antifungal therapy. | 1995 | Clin. Exp. Dermatol. | pmid:8593716 |
| Choi OH et al. | Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor. | 1996 | Nature | pmid:8602265 |
| Wu WI and Carman GM | Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by phospholipids. | 1996 | Biochemistry | pmid:8620000 |
| Wang W et al. | Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8622958 |
| Jarvis WD et al. | Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells. | 1996 | J. Biol. Chem. | pmid:8626522 |
| Carfagna MA et al. | Sex differences in rat hepatic cytolethality of the protein kinase C inhibitor safingol: role of biotransformation. | 1996 | Toxicol. Appl. Pharmacol. | pmid:8661342 |
| Hirschberg K et al. | Ganglioside synthesis during the development of neuronal polarity. Major changes occur during axonogenesis and axon elongation, but not during dendrite growth or synaptogenesis. | 1996 | J. Biol. Chem. | pmid:8663007 |
| Anagnostopoulos CE et al. | Pre-clamp cardioprotection by protein kinase C (PKC) inhibitor improves left ventricular function following canine normothermic arrest. | 1996 | J Cardiovasc Surg (Torino) | pmid:8675519 |
| Rotter BA et al. | Response of growing swine to dietary exposure to pure fumonisin B1 during an eight-week period: growth and clinical parameters. | 1996 | Nat. Toxins | pmid:8680753 |
| Shephard GS et al. | Disruption of sphingolipid metabolism in non-human primates consuming diets of fumonisin-containing Fusarium moniliforme culture material. | 1996 | Toxicon | pmid:8783447 |
| Goel S et al. | Effects of fusarium moniliforme isolates on tissue and serum sphingolipid concentrations in horses. | 1996 | Vet Hum Toxicol | pmid:8829343 |
| Kawamura A et al. | Picomole scale stereochemical analysis of sphingosines and dihydrosphingosines. | 1996 | Bioorg. Med. Chem. | pmid:8831974 |
| Usuki S et al. | Induction of ganglioside biosynthesis and neurite outgrowth of primary cultured neurons by L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol. | 1996 | J. Neurochem. | pmid:8863486 |
| Valsecchi M et al. | Changes of free long-chain bases in neuronal cells during differentiation and aging in culture. | 1996 | J. Neurochem. | pmid:8863491 |
| Tolan D et al. | The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle. | 1996 | Br. J. Pharmacol. | pmid:8886394 |
| Sasaki JI et al. | Sphingosine inhibition of NADPH oxidase activation in a cell-free system. | 1996 | J. Biochem. | pmid:8947830 |
| Groener JE et al. | Metabolic fate of oleic acid derived from lysosomal degradation of cholesteryl oleate in human fibroblasts. | 1996 | J. Lipid Res. | pmid:8978478 |
| Reddy RV et al. | Developmental effects of fumonisin B1 in mice. | 1996 | Mycopathologia | pmid:8981781 |
| Badiani K et al. | Effect of fumonisin B1 on phosphatidylethanolamine biosynthesis in Chinese hamster ovary cells. | 1996 | Biochim. Biophys. Acta | pmid:8982265 |
| Gillard BK et al. | Pathways of glycosphingolipid biosynthesis in SW13 cells in the presence and absence of vimentin intermediate filaments. | 1996 | Glycobiology | pmid:8991507 |
| Crowther GJ and Lynch DV | Characterization of sphinganine kinase activity in corn shoot microsomes. | 1997 | Arch. Biochem. Biophys. | pmid:9016824 |
| Castegnaro M et al. | Development of a new method for the analysis of sphinganine and sphingosine in urine and tissues. | 1996 | Nat. Toxins | pmid:9029554 |
| Rani CS et al. | Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signaling. | 1997 | J. Biol. Chem. | pmid:9099730 |
| Chmura SJ et al. | Loss of ceramide production confers resistance to radiation-induced apoptosis. | 1997 | Cancer Res. | pmid:9102212 |
| Kwon OS et al. | Effects of fumonisin B1 treatment on blood-brain barrier transfer in developing rats. | 1997 Mar-Apr | Neurotoxicol Teratol | pmid:9136132 |
| Sosnowski J et al. | Protein kinase C mediated anti-proliferative glucocorticoid-sphinganine synergism in cultured Pollard III prostate tumor cells. | 1997 | J. Urol. | pmid:9186373 |
| Solfrizzo M et al. | Rapid method to determine sphinganine/sphingosine in human and animal urine as a biomarker for fumonisin exposure. | 1997 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:9187387 |
| van Echten-Deckert G et al. | cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons. | 1997 | J. Biol. Chem. | pmid:9188480 |
| Oh CS et al. | ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation. | 1997 | J. Biol. Chem. | pmid:9211877 |
| Reggiori F et al. | Lipid remodeling leads to the introduction and exchange of defined ceramides on GPI proteins in the ER and Golgi of Saccharomyces cerevisiae. | 1997 | EMBO J. | pmid:9218793 |
| Kishida E et al. | Evaluation of a trans configuration for the apoptosis-inducing activity of ceramide. | 1997 | J Lipid Mediat Cell Signal | pmid:9246602 |
| Porpaczy Z et al. | Internalized plasma membrane cholesterol passes through an endosome compartment that is distinct from the acid vesicle-lysosome compartment. | 1997 | Exp. Cell Res. | pmid:9260888 |