Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Baranowski M et al. | PPARalpha agonist induces the accumulation of ceramide in the heart of rats fed high-fat diet. | 2007 | J. Physiol. Pharmacol. | pmid:17440226 |
| Shin JH et al. | Sphingosine 1-phosphate triggers apoptotic signal for B16 melanoma cells via ERK and caspase activation. | 2007 | J. Korean Med. Sci. | pmid:17449940 |
| Separovic D et al. | Sphingomyelin synthase 1 suppresses ceramide production and apoptosis post-photodamage. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17467659 |
| Loiseau N et al. | Fumonisin B1 exposure and its selective effect on porcine jejunal segment: sphingolipids, glycolipids and trans-epithelial passage disturbance. | 2007 | Biochem. Pharmacol. | pmid:17499218 |
| Imamura T et al. | A rice dihydrosphingosine C4 hydroxylase (DSH1) gene, which is abundantly expressed in the stigmas, vascular cells and apical meristem, may be involved in fertility. | 2007 | Plant Cell Physiol. | pmid:17609219 |
| Hsiao SH et al. | Use of formalin-fixed tissues to determine fumonisin B1-induced sphingolipid alterations in swine. | 2007 | J. Vet. Diagn. Invest. | pmid:17609357 |
| Morales PR et al. | Safingol toxicology after oral administration to TRAMP mice: demonstration of safingol uptake and metabolism by N-acylation and N-methylation. | 2007 | Drug Chem Toxicol | pmid:17613006 |
| Son JH et al. | Activation of de novo synthetic pathway of ceramides is responsible for the initiation of hydrogen peroxide-induced apoptosis in HL-60 cells. | 2007 | J. Toxicol. Environ. Health Part A | pmid:17654249 |
| Tardieu D et al. | Chronic toxicity of fumonisins in turkeys. | 2007 | Poult. Sci. | pmid:17704375 |
| Straczkowski M et al. | Increased skeletal muscle ceramide level in men at risk of developing type 2 diabetes. | 2007 | Diabetologia | pmid:17724577 |
| Kim DH et al. | Elevation of sphingoid base 1-phosphate as a potential contributor to hepatotoxicity in fumonisin B1-exposed mice. | 2007 | Arch. Pharm. Res. | pmid:17879749 |
| Mizugishi K et al. | Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice. | 2007 | J. Clin. Invest. | pmid:17885683 |
| Shephard GS et al. | Biomarkers of exposure to fumonisin mycotoxins: a review. | 2007 | Food Addit Contam | pmid:17886192 |
| Cai Q et al. | Validation of fumonisin biomarkers in F344 rats. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17904604 |
| Vessey DA et al. | Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart. | 2007 | J. Biochem. Mol. Toxicol. | pmid:17912702 |
| Alvarez-Vasquez F et al. | Coordination of the dynamics of yeast sphingolipid metabolism during the diauxic shift. | 2007 | Theor Biol Med Model | pmid:17974024 |
| Lahiri S et al. | Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. | 2007 | FEBS Lett. | pmid:17977534 |
| Tuuf J and Mattjus P | Human glycolipid transfer protein--intracellular localization and effects on the sphingolipid synthesis. | 2007 | Biochim. Biophys. Acta | pmid:17980653 |
| Mun J et al. | Structural confirmation of the dihydrosphinganine and fatty acid constituents of the dental pathogen Porphyromonas gingivalis. | 2007 | Org. Biomol. Chem. | pmid:18004463 |
| Zabielski P et al. | Bezafibrate decreases growth stimulatory action of the sphingomyelin signaling pathway in regenerating rat liver. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18024222 |
| Dahm F et al. | Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice. | 2008 | Br. J. Cancer | pmid:18026195 |
| Walther TC et al. | Pkh-kinases control eisosome assembly and organization. | 2007 | EMBO J. | pmid:18034155 |
| Costantino V et al. | Corrugoside, a new immunostimulatory alpha-galactoglycosphingolipid from the marine sponge Axinella corrugata. | 2008 | Bioorg. Med. Chem. | pmid:18037298 |
| Shi L et al. | Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis. | 2007 | Cell Res. | pmid:18059378 |
| Theumer MG et al. | Subchronic mycotoxicoses in rats. Histopathological changes and modulation of the sphinganine to sphingosine (Sa/So) ratio imbalance induced by Fusarium verticillioides culture material, due to the coexistence of aflatoxin B1 in the diet. | 2008 | Food Chem. Toxicol. | pmid:18079032 |
| Yang F et al. | DNA immunization perturbs lipid metabolites and increases risk of atherogenesis. | 2008 | J. Proteome Res. | pmid:18166009 |
| Roff CF et al. | Type C Niemann-Pick disease: use of hydrophobic amines to study defective cholesterol transport. | 1991 | Dev. Neurosci. | pmid:1817037 |
| Du L et al. | Biosynthesis of sphinganine-analog mycotoxins. | 2008 | J. Ind. Microbiol. Biotechnol. | pmid:18214562 |
| Oda M et al. | The relationship between the metabolism of sphingomyelin species and the hemolysis of sheep erythrocytes induced by Clostridium perfringens alpha-toxin. | 2008 | J. Lipid Res. | pmid:18263851 |
| Masukawa Y et al. | Characterization of overall ceramide species in human stratum corneum. | 2008 | J. Lipid Res. | pmid:18359959 |
| Gude DR et al. | Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal. | 2008 | FASEB J. | pmid:18362204 |
| Gehrmann M et al. | Tumor-specific Hsp70 plasma membrane localization is enabled by the glycosphingolipid Gb3. | 2008 | PLoS ONE | pmid:18382692 |
| Garcia J et al. | Mathematical modeling of pathogenicity of Cryptococcus neoformans. | 2008 | Mol. Syst. Biol. | pmid:18414484 |
| Kyogashima M et al. | Chemical and apoptotic properties of hydroxy-ceramides containing long-chain bases with unusual alkyl chain lengths. | 2008 | J. Biochem. | pmid:18420598 |
| Abraham E et al. | Asymmetric synthesis of vicinal amino alcohols: xestoaminol C, sphinganine and sphingosine. | 2008 | Org. Biomol. Chem. | pmid:18421400 |
| Bu S et al. | Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway. | 2008 | J. Biol. Chem. | pmid:18482992 |
| Bernard BA et al. | Ceramide binding to African-American hair fibre correlates with resistance to hair breakage. | 2002 | Int J Cosmet Sci | pmid:18498489 |
| Pruett ST et al. | Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. | 2008 | J. Lipid Res. | pmid:18499644 |
| Thevissen K et al. | Fungicidal activity of truncated analogues of dihydrosphingosine. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18524581 |
| Matsuyama H et al. | Sphingobacterium kitahiroshimense sp. nov., isolated from soil. | 2008 | Int. J. Syst. Evol. Microbiol. | pmid:18599698 |
| Burns TD et al. | Fumonisin concentrations and in vivo toxicity of nixtamalized Fusarium verticillioides culture material: evidence for fumonisin-matrix interactions. | 2008 | Food Chem. Toxicol. | pmid:18602734 |
| Park TS et al. | Serine palmitoyltransferase inhibitor myriocin induces the regression of atherosclerotic plaques in hyperlipidemic ApoE-deficient mice. | 2008 | Pharmacol. Res. | pmid:18611440 |
| González-DÃez M et al. | Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: effect of simvastatin. | 2008 | Thromb. Haemost. | pmid:18612546 |
| Paragh G et al. | Novel sphingolipid derivatives promote keratinocyte differentiation. | 2008 | Exp. Dermatol. | pmid:18631249 |
| Machesky NJ et al. | Human cytomegalovirus regulates bioactive sphingolipids. | 2008 | J. Biol. Chem. | pmid:18644793 |
| BÅ‚achnio-Zabielska A et al. | Effect of exercise duration on the key pathways of ceramide metabolism in rat skeletal muscles. | 2008 | J. Cell. Biochem. | pmid:18680146 |
| Schiffmann S et al. | The selective COX-2 inhibitor celecoxib modulates sphingolipid synthesis. | 2009 | J. Lipid Res. | pmid:18711209 |
| Urai M et al. | Mucilaginibacter kameinonensis sp., nov., isolated from garden soil. | 2008 | Int. J. Syst. Evol. Microbiol. | pmid:18768602 |
| Wang H et al. | N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing. | 2008 | Mol. Cancer Ther. | pmid:18790777 |
| Coste O et al. | Sphingosine 1-phosphate modulates spinal nociceptive processing. | 2008 | J. Biol. Chem. | pmid:18805787 |