Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Ayar A et al. | Mobilization of intracellular calcium by intracellular flash photolysis of caged dihydrosphingosine in cultured neonatal rat sensory neurones. | 1998 | Acta Biochim. Pol. | pmid:9821863 |
| Bibel DJ et al. | Sphingosines: antimicrobial barriers of the skin. | 1993 | Acta Derm. Venereol. | pmid:7906449 |
| Baranowski M et al. | Exercise increases plasma levels of sphingoid base-1 phosphates in humans. | 2011 | Acta Physiol (Oxf) | pmid:21535416 |
| Siow D et al. | Regulation of de novo sphingolipid biosynthesis by the ORMDL proteins and sphingosine kinase-1. | 2015 | Adv Biol Regul | pmid:25319495 |
| Knapp M et al. | Dose-dependent effect of aspirin on the level of sphingolipids in human blood. | 2013 | Adv Med Sci | pmid:24101372 |
| Knapp M et al. | Decreased free sphingoid base concentration in the plasma of patients with chronic systolic heart failure. | 2012 | Adv Med Sci | pmid:22296975 |
| Nowak DM et al. | Sphingosine and sphinganine levels in human mesothelial cells in vitro as a potential index of signal transduction pathways impacted by microbes and osmolality. | 1998 | Adv Perit Dial | pmid:10649716 |
| Siow DL et al. | Sphingosine kinase localization in the control of sphingolipid metabolism. | 2011 | Adv. Enzyme Regul. | pmid:21075134 |
| Gault CR et al. | An overview of sphingolipid metabolism: from synthesis to breakdown. | 2010 | Adv. Exp. Med. Biol. | pmid:20919643 |
| Alkan S et al. | Survival role of protein kinase C (PKC) in chronic lymphocytic leukemia and determination of isoform expression pattern and genes altered by PKC inhibition. | 2005 | Am. J. Hematol. | pmid:15929099 |
| Constable PD et al. | Fumonisin-induced blockade of ceramide synthase in sphingolipid biosynthetic pathway alters aortic input impedance spectrum of pigs. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12742826 |
| Diab KJ et al. | Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema. | 2010 | Am. J. Respir. Crit. Care Med. | pmid:19965812 |
| Smith GW et al. | Sequence of cardiovascular changes leading to pulmonary edema in swine fed culture material containing fumonisin. | 1999 | Am. J. Vet. Res. | pmid:10791944 |
| Saigusa D et al. | Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry. | 2012 | Anal Bioanal Chem | pmid:22538778 |
| Sánchez BA et al. | Targeted analysis of sphingoid precursors in human biofluids by solid-phase extraction with in situ derivatization prior to μ-LC-LIF determination. | 2011 | Anal Bioanal Chem | pmid:21394454 |
| Touboul D et al. | Fast fingerprinting by MALDI-TOF mass spectrometry of urinary sediment glycosphingolipids in Fabry disease. | 2005 | Anal Bioanal Chem | pmid:15959771 |
| Bodennec J et al. | Purification of free sphingoid bases by solid-phase extraction on weak cation exchanger cartridges. | 2000 | Anal. Biochem. | pmid:10706795 |
| Merrill AH et al. | Quantitation of free sphingosine in liver by high-performance liquid chromatography. | 1988 | Anal. Biochem. | pmid:3407935 |
| Andréani P and Gräler MH | Comparative quantification of sphingolipids and analogs in biological samples by high-performance liquid chromatography after chloroform extraction. | 2006 | Anal. Biochem. | pmid:17027903 |
| Min JK et al. | Simultaneous quantitative analysis of sphingoid base 1-phosphates in biological samples by o-phthalaldehyde precolumn derivatization after dephosphorylation with alkaline phosphatase. | 2002 | Anal. Biochem. | pmid:11950216 |
| Berdyshev EV et al. | Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry. | 2005 | Anal. Biochem. | pmid:15766719 |
| Masood MA et al. | Enhanced detection of sphingoid bases via divalent ruthenium bipyridine complex derivatization and electrospray ionization tandem mass spectrometry. | 2009 | Anal. Chem. | pmid:19055420 |
| Zhang J et al. | Metabonomics research of diabetic nephropathy and type 2 diabetes mellitus based on UPLC-oaTOF-MS system. | 2009 | Anal. Chim. Acta | pmid:19720167 |
| Hoffmann TK et al. | Antitumor activity of protein kinase C inhibitors and cisplatin in human head and neck squamous cell carcinoma lines. | 2002 | Anticancer Drugs | pmid:11914646 |
| Ahn EH and Schroeder JJ | Induction of apoptosis by sphingosine, sphinganine, and C(2)-ceramide in human colon cancer cells, but not by C(2)-dihydroceramide. | 2010 | Anticancer Res. | pmid:20683027 |
| Ahn EH and Schroeder JJ | Sphinganine causes early activation of JNK and p38 MAPK and inhibition of AKT activation in HT-29 human colon cancer cells. | 2006 Jan-Feb | Anticancer Res. | pmid:16475687 |
| Fischer CL et al. | Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria. | 2012 | Antimicrob. Agents Chemother. | pmid:22155833 |
| Vandenbosch D et al. | Phytosphingosine-1-phosphate is a signaling molecule involved in miconazole resistance in sessile Candida albicans cells. | 2012 | Antimicrob. Agents Chemother. | pmid:22354293 |
| Petrov VD and Van Breusegem F | Hydrogen peroxide-a central hub for information flow in plant cells. | 2012 | AoB Plants | pmid:22708052 |
| Noda T et al. | Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol. Possible role of Bim, focal adhesion kinase and endonuclease G. | 2009 | Apoptosis | pmid:19199036 |
| Hamada M et al. | Induction of endonuclease G-mediated apopotosis in human oral squamous cell carcinoma cells by protein kinase C inhibitor safingol. | 2006 | Apoptosis | pmid:16374540 |
| Hartinger D et al. | Enzyme characteristics of aminotransferase FumI of Sphingopyxis sp. MTA144 for deamination of hydrolyzed fumonisin Bâ‚. | 2011 | Appl. Microbiol. Biotechnol. | pmid:21503761 |
| Sperling P et al. | Functional identification of a delta8-sphingolipid desaturase from Borago officinalis. | 2001 | Arch. Biochem. Biophys. | pmid:11368168 |
| Wright BS et al. | Synthesis of 4-hydroxysphinganine and characterization of sphinganine hydroxylase activity in corn. | 2003 | Arch. Biochem. Biophys. | pmid:12831841 |
| Crowther GJ and Lynch DV | Characterization of sphinganine kinase activity in corn shoot microsomes. | 1997 | Arch. Biochem. Biophys. | pmid:9016824 |
| Meyer SG et al. | Myriocin, an inhibitor of serine palmitoyl transferase, impairs the uptake of transferrin and low-density lipoprotein in mammalian cells. | 2012 | Arch. Biochem. Biophys. | pmid:22841978 |
| Wilson E et al. | Protein kinase C inhibition by sphingoid long-chain bases: effects on secretion in human neutrophils. | 1987 | Arch. Biochem. Biophys. | pmid:2825597 |
| Restum JC et al. | Chronic toxicity of fumonisins from Fusarium moniliforme culture material (M-1325) to mink. | 1995 | Arch. Environ. Contam. Toxicol. | pmid:7574884 |
| Olmo ED et al. | Efficacious In Vitro and In Vivo Effects of Dihydrosphingosine-Ethambutol Analogues Against Susceptible and Multi-drug-resistant Mycobacterium tuberculosis. | 2016 | Arch. Med. Res. | pmid:27664485 |
| Lee YS et al. | Simultaneous HPLC analysis of ceramide and dihydroceramide in human hairs. | 2009 | Arch. Pharm. Res. | pmid:20162410 |
| Burenjargal M et al. | Endogenous sphingolipid metabolites related to the growth in Sphingomonas chungbukensis. | 2007 | Arch. Pharm. Res. | pmid:17424937 |
| Baek MY et al. | Sphingolipid metabolic changes during chiral C2-ceramides induced apoptosis in human leukemia cells. | 2001 | Arch. Pharm. Res. | pmid:11339634 |
| Tian YS et al. | Stereoselective synthesis of L-threo-sphingosine, L-threo-sphinganine, D-threo-sphingosine, and D-threo-sphinganine via oxazoline formation and olefin cross-metathesis; potent protein kinase C inhibitor analogues. | 2007 | Arch. Pharm. Res. | pmid:17366737 |
| Kim DH et al. | Elevation of sphingoid base 1-phosphate as a potential contributor to hepatotoxicity in fumonisin B1-exposed mice. | 2007 | Arch. Pharm. Res. | pmid:17879749 |
| Yoon HT et al. | Improved fluorescent determination method of cellular sphingoid bases in high-performance liquid chromatography. | 1999 | Arch. Pharm. Res. | pmid:10403133 |
| Yu CH et al. | Differential effects of fumonisin B1 on cell death in cultured cells: the significance of the elevated sphinganine. | 2001 | Arch. Pharm. Res. | pmid:11339633 |
| Domijan AM et al. | Urine ochratoxin a and sphinganine/sphingosine ratio in residents of the endemic nephropathy area in Croatia. | 2009 | Arh Hig Rada Toksikol | pmid:20061238 |
| Bu S et al. | Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels. | 2010 | Arthritis Rheum. | pmid:20309867 |
| Xu CB et al. | D-erythro-N,N-dimethylsphingosine inhibits bFGF-induced proliferation of cerebral, aortic and coronary smooth muscle cells. | 2002 | Atherosclerosis | pmid:12204793 |