Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Tokuda H et al. | Extracellular sphingomyelinase induces interleukin-6 synthesis in osteoblasts. | 1999 | J. Cell. Biochem. | pmid:10022508 |
| Tolleson WH et al. | Fumonisin B1 induces apoptosis in cultured human keratinocytes through sphinganine accumulation and ceramide depletion. | 1999 | Int. J. Oncol. | pmid:10200332 |
| Chen N et al. | Translocation of protein kinase Cepsilon and protein kinase Cdelta to membrane is required for ultraviolet B-induced activation of mitogen-activated protein kinases and apoptosis. | 1999 | J. Biol. Chem. | pmid:10336426 |
| Yang L et al. | Sphingosine 1-phosphate formation and intracellular Ca2+ mobilization in human platelets: evaluation with sphingosine kinase inhibitors. | 1999 | J. Biochem. | pmid:10393324 |
| Yoon HT et al. | Improved fluorescent determination method of cellular sphingoid bases in high-performance liquid chromatography. | 1999 | Arch. Pharm. Res. | pmid:10403133 |
| Turner PC et al. | Fumonisin contamination of food: progress in development of biomarkers to better assess human health risks. | 1999 | Mutat. Res. | pmid:10415433 |
| Tedesco MM and Matile S | Spectroscopic detection of endovesiculation by large unilamellar phosphatidylcholine vesicles: effects of chlorpromazine, dibucaine, and safingol. | 1999 | Bioorg. Med. Chem. | pmid:10465411 |
| Touyz RM and Schiffrin EL | Ang II-stimulated superoxide production is mediated via phospholipase D in human vascular smooth muscle cells. | 1999 | Hypertension | pmid:10523394 |
| Grilley MM and Takemoto JY | Assay of the Saccharomyces cerevisiae dihydrosphingosine C-4 hydroxylase. | 2000 | Meth. Enzymol. | pmid:10563305 |
| Lynch DV | Enzymes of sphingolipid metabolism in plants. | 2000 | Meth. Enzymol. | pmid:10563318 |
| Riley RT and Plattner RD | Fermentation, partial purification, and use of serine palmitoyltransferase inhibitors from Isaria (= Cordyceps) sinclairii. | 2000 | Meth. Enzymol. | pmid:10563339 |
| Bielawska A et al. | Radiolabeling of the sphingolipid backbone. | 2000 | Meth. Enzymol. | pmid:10563345 |
| Sonnino S et al. | Preparation of radioactive gangliosides, 3H or 14C isotopically labeled at oligosaccharide or ceramide moieties. | 2000 | Meth. Enzymol. | pmid:10563353 |
| Castro AF et al. | Mechanism of inhibition of P-glycoprotein-mediated drug transport by protein kinase C blockers. | 1999 | Biochem. Pharmacol. | pmid:10571246 |
| Xu K and Thornalley PJ | Antitumour activity of sphingoid base adducts of phenethyl isothiocyanate. | 2000 | Bioorg. Med. Chem. Lett. | pmid:10636242 |
| Nowak DM et al. | Sphingosine and sphinganine levels in human mesothelial cells in vitro as a potential index of signal transduction pathways impacted by microbes and osmolality. | 1998 | Adv Perit Dial | pmid:10649716 |
| van der Westhuizen L et al. | Sphinganine/sphingosine ratio in plasma and urine as a possible biomarker for fumonisin exposure in humans in rural areas of Africa. | 1999 | Food Chem. Toxicol. | pmid:10654591 |
| Sharma C et al. | Inhibition of Ca2+ release channel (ryanodine receptor) activity by sphingolipid bases: mechanism of action. | 2000 | Chem. Phys. Lipids | pmid:10660207 |
| Jarvis WD and Grant S | Protein kinase C targeting in antineoplastic treatment strategies. | 1999 | Invest New Drugs | pmid:10665476 |
| Niwa M et al. | Tumor necrosis factor-alpha-mediated signal transduction in human neutrophils: involvement of sphingomyelin metabolites in the priming effect of TNF-alpha on the fMLP-stimulated superoxide production. | 2000 | Life Sci. | pmid:10666000 |
| Bodennec J et al. | Purification of free sphingoid bases by solid-phase extraction on weak cation exchanger cartridges. | 2000 | Anal. Biochem. | pmid:10706795 |
| Perry DK et al. | Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. | 2000 | J. Biol. Chem. | pmid:10722759 |
| Brandwagt BF et al. | A longevity assurance gene homolog of tomato mediates resistance to Alternaria alternata f. sp. lycopersici toxins and fumonisin B1. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10781105 |
| Smith GW et al. | Sequence of cardiovascular changes leading to pulmonary edema in swine fed culture material containing fumonisin. | 1999 | Am. J. Vet. Res. | pmid:10791944 |
| Zanolari B et al. | Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae. | 2000 | EMBO J. | pmid:10856228 |
| Smith GW et al. | Purified fumonisin B(1) decreases cardiovascular function but does not alter pulmonary capillary permeability in swine. | 2000 | Toxicol. Sci. | pmid:10869473 |
| Mao C et al. | Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide. | 2000 | J. Biol. Chem. | pmid:10900202 |
| Bodennec J et al. | Differential labelling of sphingolipids by [3H]serine and ([3H]methyl)-methionine in fish leukocytes. | 2000 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:10904865 |
| Bose R and Kolesnick R | Measurement of ceramide synthase activity. | 2000 | Meth. Enzymol. | pmid:10914032 |
| Kwon OS et al. | Biochemical and morphological effects of fumonisin B(1) on primary cultures of rat cerebrum. | 2000 Jul-Aug | Neurotoxicol Teratol | pmid:10974595 |
| van der Westhuizen L et al. | The effect of a single gavage dose of fumonisin B(1) on the sphinganine and sphingosine levels in vervet monkeys. | 2001 Feb-Mar | Toxicon | pmid:10978745 |
| Amin HM et al. | Characterization of apoptosis induced by protein kinase C inhibitors and its modulation by the caspase pathway in acute promyelocytic leukaemia. | 2000 | Br. J. Haematol. | pmid:10997964 |
| Carratù MR et al. | Prenatal exposure model simulating CO inhalation in human cigarette smokers: sphingomyelin alterations in the rat sciatic nerve. | 2000 | Toxicol. Lett. | pmid:11033239 |
| Henry MH et al. | The toxicity of purified fumonisin B1 in broiler chicks. | 2000 | Poult. Sci. | pmid:11055840 |
| Jenkins GM and Hannun YA | Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae. | 2001 | J. Biol. Chem. | pmid:11056159 |
| Merrill AH et al. | Analysis of sphingoid bases and sphingoid base 1-phosphates by high-performance liquid chromatography. | 2000 | Meth. Enzymol. | pmid:11070857 |
| Bodennec J et al. | Purification of sphingolipid classes by solid-phase extraction with aminopropyl and weak cation exchanger cartridges. | 2000 | Meth. Enzymol. | pmid:11070865 |
| Kawamura A et al. | Use of circular dichroism for assigning stereochemistry of sphingosine and other long-chain bases. | 2000 | Meth. Enzymol. | pmid:11070875 |
| Wu WI and Carman GM | Kinetic analysis of sphingoid base inhibition of yeast phosphatidate phosphatase. | 2000 | Meth. Enzymol. | pmid:11070885 |
| Scott RH et al. | Synthesis and use of caged sphingolipids. | 2000 | Meth. Enzymol. | pmid:11070887 |
| Guillas I et al. | Analysis of ceramides present in glycosylphosphatidylinositol anchored proteins of Saccharomyces cerevisiae. | 2000 | Meth. Enzymol. | pmid:11070898 |
| Maurer BJ et al. | Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism. | 2000 | J. Natl. Cancer Inst. | pmid:11106681 |
| Tamama K et al. | Extracellular mechanism through the Edg family of receptors might be responsible for sphingosine-1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth-muscle cells. | 2001 | Biochem. J. | pmid:11115407 |
| Hsu FF and Turk J | Structural determination of glycosphingolipids as lithiated adducts by electrospray ionization mass spectrometry using low-energy collisional-activated dissociation on a triple stage quadrupole instrument. | 2001 | J. Am. Soc. Mass Spectrom. | pmid:11142362 |
| Tamura K et al. | Cloning and characterization of a cDNA encoding serine palmitoyltransferase in Arabidopsis thaliana. | 2000 | Biochem. Soc. Trans. | pmid:11171191 |
| Dasgupta S and Hogan EL | Chromatographic resolution and quantitative assay of CNS tissue sphingoids and sphingolipids. | 2001 | J. Lipid Res. | pmid:11181761 |
| van der Westhuizen L et al. | The effect of repeated gavage doses of fumonisin B1 on the sphinganine and sphingosine levels in vervet monkeys. | 2001 | Toxicon | pmid:11223085 |
| Ziulkoski AL et al. | De novo synthesis and recycling pathways of sphingomyelin in rat Sertoli cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11237757 |
| Senchenkov A et al. | Targeting ceramide metabolism--a strategy for overcoming drug resistance. | 2001 | J. Natl. Cancer Inst. | pmid:11238696 |