Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Davidson CD et al. | Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression. | 2009 | PLoS ONE | pmid:19750228 |
| Tokumura A et al. | Elevated serum levels of arachidonoyl-lysophosphatidic acid and sphingosine 1-phosphate in systemic sclerosis. | 2009 | Int J Med Sci | pmid:19521548 |
| Fox LM et al. | Recognition of lyso-phospholipids by human natural killer T lymphocytes. | 2009 | PLoS Biol. | pmid:19859526 |
| Fischbeck A et al. | Analysis of sphingomyelin in meat based on hydrophilic interaction liquid chromatography coupled to electrospray ionization-tandem mass spectrometry (HILIC-HPLC-ESI-MS/MS). | 2009 | J. Agric. Food Chem. | pmid:20175585 |
| Lee YS et al. | Simultaneous HPLC analysis of ceramide and dihydroceramide in human hairs. | 2009 | Arch. Pharm. Res. | pmid:20162410 |
| Jia XM et al. | RTA2 is involved in calcineurin-mediated azole resistance and sphingoid long-chain base release in Candida albicans. | 2009 | Cell. Mol. Life Sci. | pmid:19002381 |
| Coward J et al. | Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway. | 2009 | Autophagy | pmid:19098447 |
| Darios F et al. | Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis. | 2009 | Neuron | pmid:19524527 |
| Silva LJ et al. | Sphinganine-sphingosine ratio in urine from two Portuguese populations as biomarker to fumonisins exposure. | 2009 | Toxicon | pmid:19477192 |
| Séguin C et al. | High-yielding synthesis of sphingoid-type bases. | 2009 | J. Org. Chem. | pmid:19673498 |
| Hornemann T et al. | The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases. | 2009 | J. Biol. Chem. | pmid:19648650 |
| Taouji S et al. | Current Screens Based on the AlphaScreen Technology for Deciphering Cell Signalling Pathways. | 2009 | Curr. Genomics | pmid:19794881 |
| Im JS et al. | Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation. | 2009 | Immunity | pmid:19538930 |
| Momin AA et al. | Characterization of mutant serine palmitoyltransferase 1 in LY-B cells. | 2009 | Lipids | pmid:19536577 |
| Ling LU et al. | The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells. | 2009 | Int. J. Oncol. | pmid:19885570 |
| Cox D et al. | Determination of cellular lipids bound to human CD1d molecules. | 2009 | PLoS ONE | pmid:19415116 |
| Sridevi P et al. | Ceramide synthase 1 is regulated by proteasomal mediated turnover. | 2009 | Biochim. Biophys. Acta | pmid:19393694 |
| Hicks AA et al. | Genetic determinants of circulating sphingolipid concentrations in European populations. | 2009 | PLoS Genet. | pmid:19798445 |
| Guerrera IC et al. | A novel lipidomic strategy reveals plasma phospholipid signatures associated with respiratory disease severity in cystic fibrosis patients. | 2009 | PLoS ONE | pmid:19893743 |
| Kobayashi N et al. | Characterization of the ATP-dependent sphingosine 1-phosphate transporter in rat erythrocytes. | 2009 | J. Biol. Chem. | pmid:19531471 |