Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
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| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yoo HS et al. | Fumonisin inhibition of de novo sphingolipid biosynthesis and cytotoxicity are correlated in LLC-PK1 cells. | 1992 | Toxicol. Appl. Pharmacol. | pmid:1585377 |
| Wakita H et al. | Composition of free long-chain (sphingoid) bases in stratum corneum of normal and pathologic human skin conditions. | 1992 | J. Invest. Dermatol. | pmid:1431224 |
| Rother J et al. | Biosynthesis of sphingolipids: dihydroceramide and not sphinganine is desaturated by cultured cells. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1449467 |
| Nishimura K et al. | Sphingolipids of a cestode Metroliasthes coturnix. | 1991 | Biochim. Biophys. Acta | pmid:1932097 |
| Roff CF et al. | Type C Niemann-Pick disease: use of hydrophobic amines to study defective cholesterol transport. | 1991 | Dev. Neurosci. | pmid:1817037 |
| Agopyan N and Agopyan I | Effects of protein kinase C activators and inhibitors on membrane properties, synaptic responses, and cholinergic actions in CA1 subfield of rat hippocampus in situ and in vitro. | 1991 | Synapse | pmid:1882329 |
| Borek C et al. | Long-chain (sphingoid) bases inhibit multistage carcinogenesis in mouse C3H/10T1/2 cells treated with radiation and phorbol 12-myristate 13-acetate. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2000399 |
| O'Flaherty JT et al. | Translocation of protein kinase C in human polymorphonuclear neutrophils. Regulation by cytosolic Ca2(+)-independent and Ca2(+)-dependent mechanisms. | 1990 | J. Biol. Chem. | pmid:2160959 |
| Peters-Golden M et al. | Diminished protein kinase C-activated arachidonate metabolism accompanies rat macrophage differentiation in the lung. | 1990 | J. Immunol. | pmid:2160499 |
| Stevens VL et al. | Characteristics of the growth inhibition and cytotoxicity of long-chain (sphingoid) bases for Chinese hamster ovary cells: evidence for an involvement of protein kinase C. | 1990 | Biochim. Biophys. Acta | pmid:2297538 |
| van Echten G et al. | Modulation of sphingolipid biosynthesis in primary cultured neurons by long chain bases. | 1990 | J. Biol. Chem. | pmid:2111818 |
| Kobayashi T et al. | Metabolism of free sphingoid bases in murine tissues and in cultured human fibroblasts. | 1989 | Eur. J. Biochem. | pmid:2606103 |
| Messmer TO et al. | Sphingolipid biosynthesis by rat liver cells: effects of serine, fatty acids and lipoproteins. | 1989 | J. Nutr. | pmid:2495341 |
| Simpson RU et al. | 1,25-Dihydroxyvitamin D3 regulation of c-myc protooncogene transcription. Possible involvement of protein kinase C. | 1989 | J. Biol. Chem. | pmid:2684961 |
| Wertz PW and Downing DT | Free sphingosines in porcine epidermis. | 1989 | Biochim. Biophys. Acta | pmid:2930769 |
| Conn PJ et al. | Inhibitors of protein kinase C prevent enhancement of calcium current and action potentials in peptidergic neurons of Aplysia. | 1989 | J. Neurosci. | pmid:2918372 |
| O'Flaherty JT and Jacobson D | Protein kinase C blockers and neutrophil receptors for leukotriene B4. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2551291 |
| Stevens VL et al. | Differential effects of long-chain (sphingoid) bases on the monocytic differentiation of human leukemia (HL-60) cells induced by phorbol esters, 1 alpha, 25-dihydroxyvitamin D3, or ganglioside GM3. | 1989 | Cancer Res. | pmid:2720676 |
| Nelson DH and Murray DK | Dexamethasone and sphingolipids inhibit concanavalin A stimulated glucose uptake in 3T3-L1 fibroblasts. | 1988-1989 | Endocr. Res. | pmid:3074919 |
| Hamanaka S et al. | Occurrence of galactosylceramide in pig epidermal cells. | 1988 | Biochim. Biophys. Acta | pmid:3401502 |
| Lambeth JD et al. | Sphinganine effects on chemoattractant-induced diacylglycerol generation, calcium fluxes, superoxide production, and on cell viability in the human neutrophil. Delivery of sphinganine with bovine serum albumin minimizes cytotoxicity without affecting inhibition of the respiratory burst. | 1988 | J. Biol. Chem. | pmid:2831206 |
| Merrill AH et al. | Quantitation of free sphingosine in liver by high-performance liquid chromatography. | 1988 | Anal. Biochem. | pmid:3407935 |
| Medlock KA and Merrill AH | Inhibition of serine palmitoyltransferase in vitro and long-chain base biosynthesis in intact Chinese hamster ovary cells by beta-chloroalanine. | 1988 | Biochemistry | pmid:3143407 |
| Tyagi SR et al. | Phorbol myristate acetate (PMA) augments chemoattractant-induced diglyceride generation in human neutrophils but inhibits phosphoinositide hydrolysis. Implications for the mechanism of PMA priming of the respiratory burst. | 1988 | J. Biol. Chem. | pmid:2843513 |
| Yasugi E et al. | Branched long chain bases in cerebrosides of the guinea pig Harderian gland. | 1987 | J. Biochem. | pmid:3448092 |
| Bouchon B et al. | Selective enrichment of phytosphingosine in glycosphingolipids of isolated human thyrocytes as compared to the whole thyroid. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3566758 |
| Pittet D et al. | Nonselective inhibition of neutrophil functions by sphinganine. | 1987 | J. Biol. Chem. | pmid:3038865 |
| Wilson E et al. | Protein kinase C inhibition by sphingoid long-chain bases: effects on secretion in human neutrophils. | 1987 | Arch. Biochem. Biophys. | pmid:2825597 |
| Nelson DH and Murray DK | Sphingolipids inhibit insulin and phorbol ester stimulated uptake of 2-deoxyglucose. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3527163 |
| Merrill AH and Wang E | Biosynthesis of long-chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s). | 1986 | J. Biol. Chem. | pmid:3081509 |
| Wilson E et al. | Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst. | 1986 | J. Biol. Chem. | pmid:3017982 |
| Merrill AH et al. | Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases. | 1986 | J. Biol. Chem. | pmid:3462189 |
| Vermelho AB et al. | Isolation and characterization of a neutral glycosphingolipid from the epimastigote form of Trypanosoma mega. | 1986 | J. Protozool. | pmid:3735150 |
| Bouhours D and Bouhours JF | Developmental changes of the lipidic part of the neutral glycosphingolipids of the rat stomach. | 1985 | J. Biol. Chem. | pmid:3972786 |
| Sonnino S et al. | High performance liquid chromatography preparation of the molecular species of GM1 and GD1a gangliosides with homogeneous long chain base composition. | 1984 | J. Lipid Res. | pmid:6747465 |
| Crossman MW and Hirschberg CB | Conversion of erythro-D-sphinganine to its [1-2H1] and [1-3H1] derivatives. | 1984 | J. Lipid Res. | pmid:6481245 |
| Crossman MW and Hirschberg CB | Biosynthesis of 4D-hydroxysphinganine by the rat. En bloc incorporation of the sphinganine carbon backbone. | 1984 | Biochim. Biophys. Acta | pmid:6477953 |
| Wells GB and Lester RL | The isolation and characterization of a mutant strain of Saccharomyces cerevisiae that requires a long chain base for growth and for synthesis of phosphosphingolipids. | 1983 | J. Biol. Chem. | pmid:6350287 |
| HAKOMORI S and MASAMUNE H | Chemistry and biology of lipids. XXIII. A new color reaction of sphingosine and dihydrosphingosine. | 1956 | Tohoku J. Exp. Med. | pmid:13371598 |
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