Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fischer CL et al. | Sphingoid bases are taken up by Escherichia coli and Staphylococcus aureus and induce ultrastructural damage. | 2013 | Skin Pharmacol Physiol | pmid:23128426 |
| Qin DD et al. | syn- and enantioselective Henry reactions of aliphatic aldehydes and application to the synthesis of safingol. | 2013 | Chemistry | pmid:24281803 |
| Marrouchi R et al. | Toxic c17-sphinganine analogue mycotoxin, contaminating tunisian mussels, causes flaccid paralysis in rodents. | 2013 | Mar Drugs | pmid:24287956 |
| Knapp M et al. | Dose-dependent effect of aspirin on the level of sphingolipids in human blood. | 2013 | Adv Med Sci | pmid:24101372 |
| Holliday MW et al. | C22:0- and C24:0-dihydroceramides confer mixed cytotoxicity in T-cell acute lymphoblastic leukemia cell lines. | 2013 | PLoS ONE | pmid:24040340 |
| Figueiredo JM et al. | Molecular and functional characterization of the ceramide synthase from Trypanosoma cruzi. | 2012 Mar-Apr | Mol. Biochem. Parasitol. | pmid:22226824 |
| Henry SA et al. | Metabolism and regulation of glycerolipids in the yeast Saccharomyces cerevisiae. | 2012 | Genetics | pmid:22345606 |
| Berkey R et al. | Sphingolipids and plant defense/disease: the "death" connection and beyond. | 2012 | Front Plant Sci | pmid:22639658 |
| Siddique MM et al. | Ablation of dihydroceramide desaturase confers resistance to etoposide-induced apoptosis in vitro. | 2012 | PLoS ONE | pmid:22984457 |
| Lee S et al. | Quantitative analysis of sphingomyelin by high-performance liquid chromatography after enzymatic hydrolysis. | 2012 | Evid Based Complement Alternat Med | pmid:22919412 |
| Healey KR et al. | CRS-MIS in Candida glabrata: sphingolipids modulate echinocandin-Fks interaction. | 2012 | Mol. Microbiol. | pmid:22909030 |
| Shea BS and Tager AM | Sphingolipid regulation of tissue fibrosis. | 2012 | Open Rheumatol J | pmid:22802910 |
| Petrov VD and Van Breusegem F | Hydrogen peroxide-a central hub for information flow in plant cells. | 2012 | AoB Plants | pmid:22708052 |
| Wang L et al. | Proteomic analysis of Rta2p-dependent raft-association of detergent-resistant membranes in Candida albicans. | 2012 | PLoS ONE | pmid:22662216 |
| Kimura T et al. | Hepatic Cerebroside Sulfotransferase Is Induced by PPARα Activation in Mice. | 2012 | PPAR Res | pmid:22645601 |
| Guo L and Wang X | Crosstalk between Phospholipase D and Sphingosine Kinase in Plant Stress Signaling. | 2012 | Front Plant Sci | pmid:22639650 |
| Park HM et al. | Royal jelly increases collagen production in rat skin after ovariectomy. | 2012 | J Med Food | pmid:22468645 |
| Lin L et al. | LC-MS-based serum metabolic profiling for genitourinary cancer classification and cancer type-specific biomarker discovery. | 2012 | Proteomics | pmid:22685041 |
| Wei LN | Chromatin remodeling and epigenetic regulation of the CrabpI gene in adipocyte differentiation. | 2012 | Biochim. Biophys. Acta | pmid:21435396 |
| Roede JR et al. | Detailed mitochondrial phenotyping by high resolution metabolomics. | 2012 | PLoS ONE | pmid:22412977 |
| Duan J et al. | Dietary sphingolipids improve skin barrier functions via the upregulation of ceramide synthases in the epidermis. | 2012 | Exp. Dermatol. | pmid:22621186 |
| Lu Y et al. | Metabolomic profiles of myocardial ischemia under treatment with salvianolic acid B. | 2012 | Chin Med | pmid:22409910 |
| Saigusa D et al. | Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry. | 2012 | Anal Bioanal Chem | pmid:22538778 |
| Demirkan A et al. | Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. | 2012 | PLoS Genet. | pmid:22359512 |
| Frank S et al. | Structural characterization of Schistosoma mansoni adult worm glycosphingolipids reveals pronounced differences with those of cercariae. | 2012 | Glycobiology | pmid:22241826 |
| Montefusco DJ et al. | Sphingoid bases and the serine catabolic enzyme CHA1 define a novel feedforward/feedback mechanism in the response to serine availability. | 2012 | J. Biol. Chem. | pmid:22277656 |
| Zhao YY et al. | Urinary metabonomics study on biochemical changes in an experimental model of chronic renal failure by adenine based on UPLC Q-TOF/MS. | 2012 | Clin. Chim. Acta | pmid:22227165 |
| Schorsch C et al. | High-level production of tetraacetyl phytosphingosine (TAPS) by combined genetic engineering of sphingoid base biosynthesis and L-serine availability in the non-conventional yeast Pichia ciferrii. | 2012 | Metab. Eng. | pmid:22178746 |
| De Larichaudy J et al. | TNF-α- and tumor-induced skeletal muscle atrophy involves sphingolipid metabolism. | 2012 | Skelet Muscle | pmid:22257771 |
| Wang Y et al. | Transcript and protein profiling analysis of OTA-induced cell death reveals the regulation of the toxicity response process in Arabidopsis thaliana. | 2012 | J. Exp. Bot. | pmid:22207617 |
| Shin KO et al. | Terpene alcohols inhibit de novo sphingolipid biosynthesis. | 2012 | Planta Med. | pmid:22274813 |
| BÅ‚achnio-Zabielska AU et al. | Ceramide metabolism is affected by obesity and diabetes in human adipose tissue. | 2012 | J. Cell. Physiol. | pmid:21437908 |
| Behjati M et al. | Comparative modeling of CCRL1, a key protein in masked immune diseases and virtual screening for finding inhibitor of this protein. | 2012 | Bioinformation | pmid:22553392 |
| Shichiri M et al. | A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity. | 2012 | J. Biol. Chem. | pmid:22147702 |
| Young SA et al. | Sphingolipid and ceramide homeostasis: potential therapeutic targets. | 2012 | Biochem Res Int | pmid:22400113 |
| Knapp M et al. | Myocardial infarction changes sphingolipid metabolism in the uninfarcted ventricular wall of the rat. | 2012 | Lipids | pmid:22833182 |
| Dangerfield EM et al. | Species-specific activity of glycolipid ligands for invariant NKT cells. | 2012 | Chembiochem | pmid:22639457 |
| Benlasher E et al. | Comparative effects of fumonisins on sphingolipid metabolism and toxicity in ducks and turkeys. | 2012 | Avian Dis. | pmid:22545537 |
| Callihan P et al. | Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells. | 2012 | Neuropharmacology | pmid:22016110 |
| Sun Y et al. | Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways. | 2012 | Mol. Biol. Cell | pmid:22535525 |
| Gelineau-van Waes J et al. | Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720. | 2012 | Birth Defects Res. Part A Clin. Mol. Teratol. | pmid:22991331 |
| Knapp M et al. | Myocardial infarction differentially alters sphingolipid levels in plasma, erythrocytes and platelets of the rat. | 2012 | Basic Res. Cardiol. | pmid:22961594 |
| Börgel D et al. | Metabolic engineering of the non-conventional yeast Pichia ciferrii for production of rare sphingoid bases. | 2012 | Metab. Eng. | pmid:22449569 |
| Tan KB et al. | In vivo efficacy of a novel liposomal formulation of safingol in the treatment of acute myeloid leukemia. | 2012 | J Control Release | pmid:22100388 |
| Kim HJ et al. | A fluorescent assay for ceramide synthase activity. | 2012 | J. Lipid Res. | pmid:22661289 |
| Meyer SG et al. | Myriocin, an inhibitor of serine palmitoyl transferase, impairs the uptake of transferrin and low-density lipoprotein in mammalian cells. | 2012 | Arch. Biochem. Biophys. | pmid:22841978 |
| Ashkenazi A et al. | Sphingopeptides: dihydrosphingosine-based fusion inhibitors against wild-type and enfuvirtide-resistant HIV-1. | 2012 | FASEB J. | pmid:22872679 |
| Jiang Q et al. | Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide. | 2012 | Int. J. Cancer | pmid:21400505 |
| Rauber RH et al. | Individual and combined effects of Salmonella typhimurium lipopolysaccharide and fumonisin B1 in broiler chickens. | 2012 | Poult. Sci. | pmid:23091133 |
| Knapp M et al. | Decreased free sphingoid base concentration in the plasma of patients with chronic systolic heart failure. | 2012 | Adv Med Sci | pmid:22296975 |