Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Niwa M et al. | Tumor necrosis factor-alpha-mediated signal transduction in human neutrophils: involvement of sphingomyelin metabolites in the priming effect of TNF-alpha on the fMLP-stimulated superoxide production. | 2000 | Life Sci. | pmid:10666000 |
| Bodennec J et al. | Purification of free sphingoid bases by solid-phase extraction on weak cation exchanger cartridges. | 2000 | Anal. Biochem. | pmid:10706795 |
| Perry DK et al. | Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. | 2000 | J. Biol. Chem. | pmid:10722759 |
| Brandwagt BF et al. | A longevity assurance gene homolog of tomato mediates resistance to Alternaria alternata f. sp. lycopersici toxins and fumonisin B1. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10781105 |
| Smith GW et al. | Sequence of cardiovascular changes leading to pulmonary edema in swine fed culture material containing fumonisin. | 1999 | Am. J. Vet. Res. | pmid:10791944 |
| Zanolari B et al. | Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae. | 2000 | EMBO J. | pmid:10856228 |
| Smith GW et al. | Purified fumonisin B(1) decreases cardiovascular function but does not alter pulmonary capillary permeability in swine. | 2000 | Toxicol. Sci. | pmid:10869473 |
| Mao C et al. | Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide. | 2000 | J. Biol. Chem. | pmid:10900202 |
| Bodennec J et al. | Differential labelling of sphingolipids by [3H]serine and ([3H]methyl)-methionine in fish leukocytes. | 2000 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:10904865 |
| Bose R and Kolesnick R | Measurement of ceramide synthase activity. | 2000 | Meth. Enzymol. | pmid:10914032 |