Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tan KB et al. | Liposomal codelivery of a synergistic combination of bioactive lipids in the treatment of acute myeloid leukemia. | 2014 | Nanomedicine (Lond) | pmid:24294981 |
| Tanaka K et al. | Individual profiles of free ceramide species and the constituent ceramide species of sphingomyelin and neutral glycosphingolipid and their alteration according to the sequential changes of environmental oxygen content in human colorectal cancer Caco-2 cells. | 2014 | Glycoconj. J. | pmid:24310545 |
| Noack J et al. | A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy. | 2014 | Cell Death Dis | pmid:25255218 |
| Farhat M et al. | Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to spindle poisons by exogenous activation of JNK and p38 MAP kinases. | 2014 | Cell Death Dis | pmid:24787013 |
| Hamada M et al. | Involvement of hydrogen peroxide in safingol-induced endonuclease G-mediated apoptosis of squamous cell carcinoma cells. | 2014 | Int J Mol Sci | pmid:24549171 |
| Dekker MJ et al. | Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction. | 2013 | Atherosclerosis | pmid:23466071 |
| Chabowski A et al. | Fiber specific changes in sphingolipid metabolism in skeletal muscles of hyperthyroid rats. | 2013 | Lipids | pmid:23467817 |
| Burel C et al. | Effect of low dose of fumonisins on pig health: immune status, intestinal microbiota and sensitivity to Salmonella. | 2013 | Toxins (Basel) | pmid:23612754 |
| Hu L et al. | TF/FVIIa/PAR2 promotes cell proliferation and migration via PKCα and ERK-dependent c-Jun/AP-1 pathway in colon cancer cell line SW620. | 2013 | Tumour Biol. | pmid:23616010 |
| Tibboel J et al. | Amelioration of hyperoxia-induced lung injury using a sphingolipid-based intervention. | 2013 | Eur. Respir. J. | pmid:23143542 |
| Fischer CL et al. | Sphingoid bases are taken up by Escherichia coli and Staphylococcus aureus and induce ultrastructural damage. | 2013 | Skin Pharmacol Physiol | pmid:23128426 |
| Qin DD et al. | syn- and enantioselective Henry reactions of aliphatic aldehydes and application to the synthesis of safingol. | 2013 | Chemistry | pmid:24281803 |
| Marrouchi R et al. | Toxic c17-sphinganine analogue mycotoxin, contaminating tunisian mussels, causes flaccid paralysis in rodents. | 2013 | Mar Drugs | pmid:24287956 |
| Knapp M et al. | Dose-dependent effect of aspirin on the level of sphingolipids in human blood. | 2013 | Adv Med Sci | pmid:24101372 |
| Holliday MW et al. | C22:0- and C24:0-dihydroceramides confer mixed cytotoxicity in T-cell acute lymphoblastic leukemia cell lines. | 2013 | PLoS ONE | pmid:24040340 |
| Figueiredo JM et al. | Molecular and functional characterization of the ceramide synthase from Trypanosoma cruzi. | 2012 Mar-Apr | Mol. Biochem. Parasitol. | pmid:22226824 |
| Longato L et al. | Insulin resistance, ceramide accumulation, and endoplasmic reticulum stress in human chronic alcohol-related liver disease. | 2012 | Oxid Med Cell Longev | pmid:22577490 |
| Anand K et al. | Structural analyses of the Slm1-PH domain demonstrate ligand binding in the non-canonical site. | 2012 | PLoS ONE | pmid:22574179 |
| Vizcarra-Olvera JE et al. | Evaluation of pathological effects in broilers during fumonisins and clays exposure. | 2012 | Mycopathologia | pmid:22396010 |
| Vandenbosch D et al. | Phytosphingosine-1-phosphate is a signaling molecule involved in miconazole resistance in sessile Candida albicans cells. | 2012 | Antimicrob. Agents Chemother. | pmid:22354293 |