Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Park HM et al. | Royal jelly increases collagen production in rat skin after ovariectomy. | 2012 | J Med Food | pmid:22468645 |
| Roede JR et al. | Detailed mitochondrial phenotyping by high resolution metabolomics. | 2012 | PLoS ONE | pmid:22412977 |
| Lu Y et al. | Metabolomic profiles of myocardial ischemia under treatment with salvianolic acid B. | 2012 | Chin Med | pmid:22409910 |
| Behjati M et al. | Comparative modeling of CCRL1, a key protein in masked immune diseases and virtual screening for finding inhibitor of this protein. | 2012 | Bioinformation | pmid:22553392 |
| Anand K et al. | Structural analyses of the Slm1-PH domain demonstrate ligand binding in the non-canonical site. | 2012 | PLoS ONE | pmid:22574179 |
| Meyer SG et al. | Myriocin, an inhibitor of serine palmitoyl transferase, impairs the uptake of transferrin and low-density lipoprotein in mammalian cells. | 2012 | Arch. Biochem. Biophys. | pmid:22841978 |
| Ashkenazi A et al. | Sphingopeptides: dihydrosphingosine-based fusion inhibitors against wild-type and enfuvirtide-resistant HIV-1. | 2012 | FASEB J. | pmid:22872679 |
| Ota H et al. | S1P(4) receptor mediates S1P-induced vasoconstriction in normotensive and hypertensive rat lungs. | 2011 Jul-Sep | Pulm Circ | pmid:22140630 |
| Alvarez-Vasquez F et al. | Mathematical modeling and validation of the ergosterol pathway in Saccharomyces cerevisiae. | 2011 | PLoS ONE | pmid:22194828 |
| Chao DY et al. | Sphingolipids in the root play an important role in regulating the leaf ionome in Arabidopsis thaliana. | 2011 | Plant Cell | pmid:21421810 |
| Wang L et al. | Genome characterization of the oleaginous fungus Mortierella alpina. | 2011 | PLoS ONE | pmid:22174787 |
| Hartinger D et al. | Enzyme characteristics of aminotransferase FumI of Sphingopyxis sp. MTA144 for deamination of hydrolyzed fumonisin Bâ‚. | 2011 | Appl. Microbiol. Biotechnol. | pmid:21503761 |
| Nimrichter L and Rodrigues ML | Fungal glucosylceramides: from structural components to biologically active targets of new antimicrobials. | 2011 | Front Microbiol | pmid:22025918 |
| Yoshida T et al. | Pulmonary fibrosis in response to environmental cues and molecular targets involved in its pathogenesis. | 2011 | J Toxicol Pathol | pmid:22272040 |
| Fu C et al. | Metabonomics study of the protective effects of green tea polyphenols on aging rats induced by d-galactose. | 2011 | J Pharm Biomed Anal | pmid:21444175 |
| Spijkers LJ et al. | Antihypertensive treatment differentially affects vascular sphingolipid biology in spontaneously hypertensive rats. | 2011 | PLoS ONE | pmid:22195025 |
| Dickman MB and Figueiredo Pd | Comparative pathobiology of fungal pathogens of plants and animals. | 2011 | PLoS Pathog. | pmid:22194681 |
| Tam AK et al. | Role for protein kinase C in controlling Aplysia bag cell neuron excitability. | 2011 | Neuroscience | pmid:21277944 |
| Kim J et al. | Analysis of ceramide metabolites in differentiating epidermal keratinocytes treated with calcium or vitamin C. | 2011 | Nutr Res Pract | pmid:22125676 |
| Bensaci MF et al. | Fungicidal Activities and Mechanisms of Action of Pseudomonas syringae pv. syringae Lipodepsipeptide Syringopeptins 22A and 25A. | 2011 | Front Microbiol | pmid:22046175 |
| Brodesser S and Kolter T | Dihydroceramide desaturase inhibition by a cyclopropanated dihydroceramide analog in cultured keratinocytes. | 2011 | J Lipids | pmid:21490810 |
| Lamour NF et al. | Ceramide kinase regulates the production of tumor necrosis factor α (TNFα) via inhibition of TNFα-converting enzyme. | 2011 | J. Biol. Chem. | pmid:22009748 |
| Doi K and Uetsuka K | Mechanisms of mycotoxin-induced neurotoxicity through oxidative stress-associated pathways. | 2011 | Int J Mol Sci | pmid:21954354 |
| Barbosa AD et al. | Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells. | 2011 | Mol. Microbiol. | pmid:21707788 |
| Radner FP et al. | Fat in the skin: Triacylglycerol metabolism in keratinocytes and its role in the development of neutral lipid storage disease. | 2011 | Dermatoendocrinol | pmid:21695016 |
| Uchida Y | The role of fatty acid elongation in epidermal structure and function. | 2011 | Dermatoendocrinol | pmid:21695014 |
| Hernández-Corbacho MJ et al. | Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction. | 2011 | PLoS ONE | pmid:21687659 |
| Ling Y et al. | Involvement of the PLCε/PKCα pathway in human BIU-87 bladder cancer cell proliferation. | 2011 | Cell Biol. Int. | pmid:21121899 |
| Zhao L et al. | A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. | 2011 | PLoS Genet. | pmid:21625621 |
| Rittenour WR et al. | Control of glucosylceramide production and morphogenesis by the Bar1 ceramide synthase in Fusarium graminearum. | 2011 | PLoS ONE | pmid:21559419 |
| Cano-Sancho G et al. | Sphinganine and sphingosine levels and ratio in urine and blood samples from a Catalonian population, Spain. | 2011 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:21644119 |
| Ling LU et al. | The role of reactive oxygen species and autophagy in safingol-induced cell death. | 2011 | Cell Death Dis | pmid:21390063 |
| Separovic D et al. | C16-Ceramide Analog Combined with Pc 4 Photodynamic Therapy Evokes Enhanced Total Ceramide Accumulation, Promotion of DEVDase Activation in the Absence of Apoptosis, and Augmented Overall Cell Killing. | 2011 | J Lipids | pmid:21490809 |
| Sánchez BA et al. | Targeted analysis of sphingoid precursors in human biofluids by solid-phase extraction with in situ derivatization prior to μ-LC-LIF determination. | 2011 | Anal Bioanal Chem | pmid:21394454 |
| Wojewodka G et al. | Ceramide in cystic fibrosis: a potential new target for therapeutic intervention. | 2011 | J Lipids | pmid:21490807 |
| Huang WC et al. | Apoptotic sphingolipid ceramide in cancer therapy. | 2011 | J Lipids | pmid:21490804 |
| van Smeden J et al. | LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery. | 2011 | J. Lipid Res. | pmid:21444759 |
| Da Silva D et al. | Nitric oxide production is not required for dihydrosphingosine-induced cell death in tobacco BY-2 cells. | 2011 | Plant Signal Behav | pmid:21455022 |
| Momin AA et al. | A method for visualization of "omic" datasets for sphingolipid metabolism to predict potentially interesting differences. | 2011 | J. Lipid Res. | pmid:21415121 |
| Saucedo-GarcÃa M et al. | MPK6, sphinganine and the LCB2a gene from serine palmitoyltransferase are required in the signaling pathway that mediates cell death induced by long chain bases in Arabidopsis. | 2011 | New Phytol. | pmid:21534970 |
| Gupta S et al. | Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolism. | 2011 | BMC Syst Biol | pmid:21303545 |
| Dickson MA et al. | A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors. | 2011 | Clin. Cancer Res. | pmid:21257722 |
| Koeller CM and Heise N | The Sphingolipid Biosynthetic Pathway Is a Potential Target for Chemotherapy against Chagas Disease. | 2011 | Enzyme Res | pmid:21603271 |
| Mortazavi PN et al. | Possible roles of phospholipase A(2) in the biological activities of Acanthamoeba castellanii (T4 Genotype). | 2011 | Protist | pmid:20650684 |
| Lee H et al. | Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation. | 2011 | PLoS ONE | pmid:21695182 |
| Apraiz A et al. | Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells. | 2011 | BMC Cancer | pmid:22061047 |
| Murakami I et al. | Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors. | 2011 | Lipids Health Dis | pmid:21861924 |
| Michaelson LV | New insights into cell death induced by long chain bases in Arabidopsis. | 2011 | New Phytol. | pmid:21834911 |
| Argraves KM et al. | S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease. | 2011 | Lipids Health Dis | pmid:21554699 |
| Watson ML et al. | Chronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cells. | 2011 | PLoS ONE | pmid:21998735 |