Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| De Larichaudy J et al. | TNF-α- and tumor-induced skeletal muscle atrophy involves sphingolipid metabolism. | 2012 | Skelet Muscle | pmid:22257771 |
| Fischer CL et al. | Sphingoid bases are taken up by Escherichia coli and Staphylococcus aureus and induce ultrastructural damage. | 2013 | Skin Pharmacol Physiol | pmid:23128426 |
| Borkowf CB et al. | Using lowess to remove systematic trends over time in predictor variables prior to logistic regression with quantile categories. | 2003 | Stat Med | pmid:12704611 |
| Hazel BA et al. | Benzene and its metabolite, hydroquinone, induce granulocytic differentiation in myeloblasts by interacting with cellular signaling pathways activated by granulocyte colony-stimulating factor. | 1995 | Stem Cells | pmid:7542115 |
| Tunsophon S and Nemere I | Protein kinase C isotypes in signal transduction for the 1,25D3-MARRS receptor (ERp57/PDIA3) in steroid hormone-stimulated phosphate uptake. | 2010 | Steroids | pmid:20079367 |
| Agopyan N and Agopyan I | Effects of protein kinase C activators and inhibitors on membrane properties, synaptic responses, and cholinergic actions in CA1 subfield of rat hippocampus in situ and in vitro. | 1991 | Synapse | pmid:1882329 |
| Alvarez-Vasquez F et al. | Coordination of the dynamics of yeast sphingolipid metabolism during the diauxic shift. | 2007 | Theor Biol Med Model | pmid:17974024 |
| González-DÃez M et al. | Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: effect of simvastatin. | 2008 | Thromb. Haemost. | pmid:18612546 |
| HAKOMORI S and MASAMUNE H | Chemistry and biology of lipids. XXIII. A new color reaction of sphingosine and dihydrosphingosine. | 1956 | Tohoku J. Exp. Med. | pmid:13371598 |
| Gumprecht LA et al. | Development of fumonisin-induced hepatotoxicity and pulmonary edema in orally dosed swine: morphological and biochemical alterations. | 1998 Nov-Dec | Toxicol Pathol | pmid:9864095 |
| He Q et al. | Fumonisin-induced tumor necrosis factor-alpha expression in a porcine kidney cell line is independent of sphingoid base accumulation induced by ceramide synthase inhibition. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11437650 |
| Howard PC et al. | Comparison of the toxicity of several fumonisin derivatives in a 28-day feeding study with female B6C3F(1) mice. | 2002 | Toxicol. Appl. Pharmacol. | pmid:12498732 |
| Yoo HS et al. | Fumonisin inhibition of de novo sphingolipid biosynthesis and cytotoxicity are correlated in LLC-PK1 cells. | 1992 | Toxicol. Appl. Pharmacol. | pmid:1585377 |
| Ramasamy S et al. | Fumonisin B1 alters sphingolipid metabolism and disrupts the barrier function of endothelial cells in culture. | 1995 | Toxicol. Appl. Pharmacol. | pmid:7645031 |
| Riley RT et al. | Alteration of tissue and serum sphinganine to sphingosine ratio: an early biomarker of exposure to fumonisin-containing feeds in pigs. | 1993 | Toxicol. Appl. Pharmacol. | pmid:8430417 |
| Cai Q et al. | Validation of fumonisin biomarkers in F344 rats. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17904604 |
| Schmelz EM et al. | Induction of apoptosis by fumonisin B1 in HT29 cells is mediated by the accumulation of endogenous free sphingoid bases. | 1998 | Toxicol. Appl. Pharmacol. | pmid:9473533 |
| Norred WP et al. | Mycotoxin-induced elevation of free sphingoid bases in precision-cut rat liver slices: specificity of the response and structure-activity relationships. | 1997 | Toxicol. Appl. Pharmacol. | pmid:9356308 |
| Carlson DB et al. | Fumonisin B1 promotes aflatoxin B1 and N-methyl-N'-nitro-nitrosoguanidine-initiated liver tumors in rainbow trout. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11264020 |
| Kim MS et al. | Fumonisin B(1) induces apoptosis in LLC-PK(1) renal epithelial cells via a sphinganine- and calmodulin-dependent pathway. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11601888 |