Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wu WI and Carman GM | Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by phospholipids. | 1996 | Biochemistry | pmid:8620000 |
| Wang W et al. | Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8622958 |
| Jarvis WD et al. | Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells. | 1996 | J. Biol. Chem. | pmid:8626522 |
| Carfagna MA et al. | Sex differences in rat hepatic cytolethality of the protein kinase C inhibitor safingol: role of biotransformation. | 1996 | Toxicol. Appl. Pharmacol. | pmid:8661342 |
| Hirschberg K et al. | Ganglioside synthesis during the development of neuronal polarity. Major changes occur during axonogenesis and axon elongation, but not during dendrite growth or synaptogenesis. | 1996 | J. Biol. Chem. | pmid:8663007 |
| Anagnostopoulos CE et al. | Pre-clamp cardioprotection by protein kinase C (PKC) inhibitor improves left ventricular function following canine normothermic arrest. | 1996 | J Cardiovasc Surg (Torino) | pmid:8675519 |
| Rotter BA et al. | Response of growing swine to dietary exposure to pure fumonisin B1 during an eight-week period: growth and clinical parameters. | 1996 | Nat. Toxins | pmid:8680753 |
| Shephard GS et al. | Disruption of sphingolipid metabolism in non-human primates consuming diets of fumonisin-containing Fusarium moniliforme culture material. | 1996 | Toxicon | pmid:8783447 |
| Goel S et al. | Effects of fusarium moniliforme isolates on tissue and serum sphingolipid concentrations in horses. | 1996 | Vet Hum Toxicol | pmid:8829343 |
| Kawamura A et al. | Picomole scale stereochemical analysis of sphingosines and dihydrosphingosines. | 1996 | Bioorg. Med. Chem. | pmid:8831974 |
| Usuki S et al. | Induction of ganglioside biosynthesis and neurite outgrowth of primary cultured neurons by L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol. | 1996 | J. Neurochem. | pmid:8863486 |
| Valsecchi M et al. | Changes of free long-chain bases in neuronal cells during differentiation and aging in culture. | 1996 | J. Neurochem. | pmid:8863491 |
| Tolan D et al. | The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle. | 1996 | Br. J. Pharmacol. | pmid:8886394 |
| Sasaki JI et al. | Sphingosine inhibition of NADPH oxidase activation in a cell-free system. | 1996 | J. Biochem. | pmid:8947830 |
| Groener JE et al. | Metabolic fate of oleic acid derived from lysosomal degradation of cholesteryl oleate in human fibroblasts. | 1996 | J. Lipid Res. | pmid:8978478 |
| Reddy RV et al. | Developmental effects of fumonisin B1 in mice. | 1996 | Mycopathologia | pmid:8981781 |
| Badiani K et al. | Effect of fumonisin B1 on phosphatidylethanolamine biosynthesis in Chinese hamster ovary cells. | 1996 | Biochim. Biophys. Acta | pmid:8982265 |
| Gillard BK et al. | Pathways of glycosphingolipid biosynthesis in SW13 cells in the presence and absence of vimentin intermediate filaments. | 1996 | Glycobiology | pmid:8991507 |
| Crowther GJ and Lynch DV | Characterization of sphinganine kinase activity in corn shoot microsomes. | 1997 | Arch. Biochem. Biophys. | pmid:9016824 |
| Castegnaro M et al. | Development of a new method for the analysis of sphinganine and sphingosine in urine and tissues. | 1996 | Nat. Toxins | pmid:9029554 |