Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zimber A et al. | Inhibition of proliferation and induction of monocytic differentiation on HL60 human promyelocytic leukemia cells treated with bile acids in vitro. | 1994 | Int. J. Cancer | pmid:7927907 |
| Pedrera C et al. | Receptor-independent mechanisms are involved in the priming of neutrophil's oxidase by vasoactive intestinal peptide. | 1994 | Regul. Pept. | pmid:7716283 |
| Boumendjel A and Miller SP | Synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate. | 1994 | J. Lipid Res. | pmid:7897327 |
| Lerner RA et al. | Cerebrodiene: a brain lipid isolated from sleep-deprived cats. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7937797 |
| Flamand N et al. | In vivo distribution of free long-chain sphingoid bases in the human stratum corneum by high-performance liquid chromatographic analysis of strippings. | 1994 | J. Chromatogr. B, Biomed. Appl. | pmid:7952048 |
| Riley RT et al. | Dietary fumonisin B1 induces disruption of sphingolipid metabolism in Sprague-Dawley rats: a new mechanism of nephrotoxicity. | 1994 | J. Nutr. | pmid:8145083 |
| Van Veldhoven PP and Mannaerts GP | Sphinganine 1-phosphate metabolism in cultured skin fibroblasts: evidence for the existence of a sphingosine phosphatase. | 1994 | Biochem. J. | pmid:8192648 |
| Séror SJ et al. | A mutant cysteinyl-tRNA synthetase affecting timing of chromosomal replication initiation in B. subtilis and conferring resistance to a protein kinase C inhibitor. | 1994 | EMBO J. | pmid:8194536 |
| Lavie Y et al. | Formation of endogenous free sphingoid bases in cells induced by changing medium conditions. | 1994 | Biochim. Biophys. Acta | pmid:8305506 |
| Yung BY | Sphinganine potentiation of cellular differentiation induced by various anti-leukemia drugs in human leukemia cell line HL-60. | 1994 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:7870198 |
| Rodriguez-Lafrasse C et al. | Free sphingoid bases in tissues from patients with type C Niemann-Pick disease and other lysosomal storage disorders. | 1994 | Biochim. Biophys. Acta | pmid:8204660 |
| Schroeder JJ et al. | Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin B1. A molecular mechanism for carcinogenesis associated with Fusarium moniliforme. | 1994 | J. Biol. Chem. | pmid:8106389 |
| Yung BY and Hui EK | Differential regulation of protein kinase C isoenzymes during sphinganine potentiation of retinoic acid-induced granulocytic differentiation in human leukemia HL-60 cells. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8250895 |
| Wu WI et al. | Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by sphingoid bases. | 1993 | J. Biol. Chem. | pmid:8314751 |
| Schwartz GK et al. | Protein kinase C: a novel target for inhibiting gastric cancer cell invasion. | 1993 | J. Natl. Cancer Inst. | pmid:8433394 |
| Hirschberg K et al. | The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver. | 1993 | Biochem. J. | pmid:8457204 |
| Olivera A and Spiegel S | Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. | 1993 | Nature | pmid:8413613 |
| Bibel DJ et al. | Sphingosines: antimicrobial barriers of the skin. | 1993 | Acta Derm. Venereol. | pmid:7906449 |
| Clarke BL et al. | Regulation of parathyroid hormone release by protein kinase-C is dependent on extracellular calcium in bovine parathyroid cells. | 1993 | Endocrinology | pmid:8440177 |
| Merrill AH et al. | Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. | 1993 | J. Biol. Chem. | pmid:8262970 |