Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Berkey R et al. | Sphingolipids and plant defense/disease: the "death" connection and beyond. | 2012 | Front Plant Sci | pmid:22639658 |
| Lee S et al. | Quantitative analysis of sphingomyelin by high-performance liquid chromatography after enzymatic hydrolysis. | 2012 | Evid Based Complement Alternat Med | pmid:22919412 |
| Healey KR et al. | CRS-MIS in Candida glabrata: sphingolipids modulate echinocandin-Fks interaction. | 2012 | Mol. Microbiol. | pmid:22909030 |
| Shea BS and Tager AM | Sphingolipid regulation of tissue fibrosis. | 2012 | Open Rheumatol J | pmid:22802910 |
| Petrov VD and Van Breusegem F | Hydrogen peroxide-a central hub for information flow in plant cells. | 2012 | AoB Plants | pmid:22708052 |
| Wang L et al. | Proteomic analysis of Rta2p-dependent raft-association of detergent-resistant membranes in Candida albicans. | 2012 | PLoS ONE | pmid:22662216 |
| Kimura T et al. | Hepatic Cerebroside Sulfotransferase Is Induced by PPARα Activation in Mice. | 2012 | PPAR Res | pmid:22645601 |
| Lin L et al. | LC-MS-based serum metabolic profiling for genitourinary cancer classification and cancer type-specific biomarker discovery. | 2012 | Proteomics | pmid:22685041 |
| Wei LN | Chromatin remodeling and epigenetic regulation of the CrabpI gene in adipocyte differentiation. | 2012 | Biochim. Biophys. Acta | pmid:21435396 |
| Duan J et al. | Dietary sphingolipids improve skin barrier functions via the upregulation of ceramide synthases in the epidermis. | 2012 | Exp. Dermatol. | pmid:22621186 |
| Saigusa D et al. | Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry. | 2012 | Anal Bioanal Chem | pmid:22538778 |
| Frank S et al. | Structural characterization of Schistosoma mansoni adult worm glycosphingolipids reveals pronounced differences with those of cercariae. | 2012 | Glycobiology | pmid:22241826 |
| Shin KO et al. | Terpene alcohols inhibit de novo sphingolipid biosynthesis. | 2012 | Planta Med. | pmid:22274813 |
| Dangerfield EM et al. | Species-specific activity of glycolipid ligands for invariant NKT cells. | 2012 | Chembiochem | pmid:22639457 |
| Benlasher E et al. | Comparative effects of fumonisins on sphingolipid metabolism and toxicity in ducks and turkeys. | 2012 | Avian Dis. | pmid:22545537 |
| Sun Y et al. | Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways. | 2012 | Mol. Biol. Cell | pmid:22535525 |
| Gelineau-van Waes J et al. | Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720. | 2012 | Birth Defects Res. Part A Clin. Mol. Teratol. | pmid:22991331 |
| Knapp M et al. | Myocardial infarction differentially alters sphingolipid levels in plasma, erythrocytes and platelets of the rat. | 2012 | Basic Res. Cardiol. | pmid:22961594 |
| Jiang Q et al. | Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide. | 2012 | Int. J. Cancer | pmid:21400505 |
| Knapp M et al. | Decreased free sphingoid base concentration in the plasma of patients with chronic systolic heart failure. | 2012 | Adv Med Sci | pmid:22296975 |