Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nowak DM et al. | Sphingosine and sphinganine levels in human mesothelial cells in vitro as a potential index of signal transduction pathways impacted by microbes and osmolality. | 1998 | Adv Perit Dial | pmid:10649716 |
| Meyer zu Heringdorf D et al. | Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors. | 1998 | EMBO J. | pmid:9582276 |
| Schmelz EM et al. | Induction of apoptosis by fumonisin B1 in HT29 cells is mediated by the accumulation of endogenous free sphingoid bases. | 1998 | Toxicol. Appl. Pharmacol. | pmid:9473533 |
| Auzenne E et al. | Cytotoxic effects of sphingolipids as single or multi-modality agents on human melanoma and soft tissue sarcoma in vitro. | 1998 | Melanoma Res. | pmid:9664144 |
| Tsunoda M et al. | Early fumonisin B1 toxicity in relation to disrupted sphingolipid metabolism in male BALB/c mice. | 1998 | J. Biochem. Mol. Toxicol. | pmid:9664234 |
| Humpf HU et al. | Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor. | 1998 | J. Biol. Chem. | pmid:9668088 |
| van der Westhuizen L et al. | Inhibition of sphingolipid biosynthesis in rat primary hepatocyte cultures by fumonisin B1 and other structurally related compounds. | 1998 | Food Chem. Toxicol. | pmid:9674957 |
| Shephard GS and van der Westhuizen L | Liquid chromatographic determination of the sphinganine/sphingosine ratio in serum. | 1998 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:9686890 |
| Meredith FI et al. | Extraction, quantification, and biological availability of fumonisin B1 incorporated into the Oregon test diet and fed to rainbow trout. | 1998 | J. Food Prot. | pmid:9713767 |
| van Echten-Deckert G et al. | Phosphorylated cis-4-methylsphingosine mimics the mitogenic effect of sphingosine-1-phosphate in Swiss 3T3 fibroblasts. | 1998 | J. Biol. Chem. | pmid:9722598 |
| Abbas HK et al. | Ultrastructural effects of AAL-toxin TA from the fungus Alternaria alternata on black nightshade (Solanum nigrum L.) leaf discs and correlation with biochemical measures of toxicity. | 1998 | Toxicon | pmid:9839666 |
| Ayar A et al. | Mobilization of intracellular calcium by intracellular flash photolysis of caged dihydrosphingosine in cultured neonatal rat sensory neurones. | 1998 | Acta Biochim. Pol. | pmid:9821863 |
| Hattori T et al. | New ceramide from marine sponge Haliclona koremella and related compounds as antifouling substances against macroalgae. | 1998 | J. Nat. Prod. | pmid:9644076 |
| Gumprecht LA et al. | Development of fumonisin-induced hepatotoxicity and pulmonary edema in orally dosed swine: morphological and biochemical alterations. | 1998 Nov-Dec | Toxicol Pathol | pmid:9864095 |
| Ciacci-Zanella JR et al. | Characterization of cell-cycle arrest by fumonisin B1 in CV-1 cells. | 1998 Sep-Oct | Food Chem. Toxicol. | pmid:9737426 |
| Jarvis WD and Grant S | Protein kinase C targeting in antineoplastic treatment strategies. | 1999 | Invest New Drugs | pmid:10665476 |
| van der Westhuizen L et al. | Sphinganine/sphingosine ratio in plasma and urine as a possible biomarker for fumonisin exposure in humans in rural areas of Africa. | 1999 | Food Chem. Toxicol. | pmid:10654591 |
| Castro AF et al. | Mechanism of inhibition of P-glycoprotein-mediated drug transport by protein kinase C blockers. | 1999 | Biochem. Pharmacol. | pmid:10571246 |
| Smith GW et al. | Sequence of cardiovascular changes leading to pulmonary edema in swine fed culture material containing fumonisin. | 1999 | Am. J. Vet. Res. | pmid:10791944 |
| Wang E et al. | Fumonisin B1 consumption by rats causes reversible, dose-dependent increases in urinary sphinganine and sphingosine. | 1999 | J. Nutr. | pmid:9915902 |
| Turner PC et al. | Fumonisin contamination of food: progress in development of biomarkers to better assess human health risks. | 1999 | Mutat. Res. | pmid:10415433 |
| Yang L et al. | Sphingosine 1-phosphate formation and intracellular Ca2+ mobilization in human platelets: evaluation with sphingosine kinase inhibitors. | 1999 | J. Biochem. | pmid:10393324 |
| Yoon HT et al. | Improved fluorescent determination method of cellular sphingoid bases in high-performance liquid chromatography. | 1999 | Arch. Pharm. Res. | pmid:10403133 |
| Tolleson WH et al. | Fumonisin B1 induces apoptosis in cultured human keratinocytes through sphinganine accumulation and ceramide depletion. | 1999 | Int. J. Oncol. | pmid:10200332 |
| Tokuda H et al. | Extracellular sphingomyelinase induces interleukin-6 synthesis in osteoblasts. | 1999 | J. Cell. Biochem. | pmid:10022508 |
| Touyz RM and Schiffrin EL | Ang II-stimulated superoxide production is mediated via phospholipase D in human vascular smooth muscle cells. | 1999 | Hypertension | pmid:10523394 |
| Tedesco MM and Matile S | Spectroscopic detection of endovesiculation by large unilamellar phosphatidylcholine vesicles: effects of chlorpromazine, dibucaine, and safingol. | 1999 | Bioorg. Med. Chem. | pmid:10465411 |
| Alemany R et al. | Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase. | 1999 | J. Biol. Chem. | pmid:9933590 |
| Chen N et al. | Translocation of protein kinase Cepsilon and protein kinase Cdelta to membrane is required for ultraviolet B-induced activation of mitogen-activated protein kinases and apoptosis. | 1999 | J. Biol. Chem. | pmid:10336426 |
| Xu K and Thornalley PJ | Antitumour activity of sphingoid base adducts of phenethyl isothiocyanate. | 2000 | Bioorg. Med. Chem. Lett. | pmid:10636242 |
| Sharma C et al. | Inhibition of Ca2+ release channel (ryanodine receptor) activity by sphingolipid bases: mechanism of action. | 2000 | Chem. Phys. Lipids | pmid:10660207 |
| Niwa M et al. | Tumor necrosis factor-alpha-mediated signal transduction in human neutrophils: involvement of sphingomyelin metabolites in the priming effect of TNF-alpha on the fMLP-stimulated superoxide production. | 2000 | Life Sci. | pmid:10666000 |
| Grilley MM and Takemoto JY | Assay of the Saccharomyces cerevisiae dihydrosphingosine C-4 hydroxylase. | 2000 | Meth. Enzymol. | pmid:10563305 |
| Lynch DV | Enzymes of sphingolipid metabolism in plants. | 2000 | Meth. Enzymol. | pmid:10563318 |
| Riley RT and Plattner RD | Fermentation, partial purification, and use of serine palmitoyltransferase inhibitors from Isaria (= Cordyceps) sinclairii. | 2000 | Meth. Enzymol. | pmid:10563339 |
| Bielawska A et al. | Radiolabeling of the sphingolipid backbone. | 2000 | Meth. Enzymol. | pmid:10563345 |
| Sonnino S et al. | Preparation of radioactive gangliosides, 3H or 14C isotopically labeled at oligosaccharide or ceramide moieties. | 2000 | Meth. Enzymol. | pmid:10563353 |
| Brandwagt BF et al. | A longevity assurance gene homolog of tomato mediates resistance to Alternaria alternata f. sp. lycopersici toxins and fumonisin B1. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10781105 |
| Henry MH et al. | The toxicity of purified fumonisin B1 in broiler chicks. | 2000 | Poult. Sci. | pmid:11055840 |
| Merrill AH et al. | Analysis of sphingoid bases and sphingoid base 1-phosphates by high-performance liquid chromatography. | 2000 | Meth. Enzymol. | pmid:11070857 |
| Bodennec J et al. | Purification of sphingolipid classes by solid-phase extraction with aminopropyl and weak cation exchanger cartridges. | 2000 | Meth. Enzymol. | pmid:11070865 |
| Kawamura A et al. | Use of circular dichroism for assigning stereochemistry of sphingosine and other long-chain bases. | 2000 | Meth. Enzymol. | pmid:11070875 |
| Wu WI and Carman GM | Kinetic analysis of sphingoid base inhibition of yeast phosphatidate phosphatase. | 2000 | Meth. Enzymol. | pmid:11070885 |
| Scott RH et al. | Synthesis and use of caged sphingolipids. | 2000 | Meth. Enzymol. | pmid:11070887 |
| Guillas I et al. | Analysis of ceramides present in glycosylphosphatidylinositol anchored proteins of Saccharomyces cerevisiae. | 2000 | Meth. Enzymol. | pmid:11070898 |
| Carratù MR et al. | Prenatal exposure model simulating CO inhalation in human cigarette smokers: sphingomyelin alterations in the rat sciatic nerve. | 2000 | Toxicol. Lett. | pmid:11033239 |
| Bodennec J et al. | Purification of free sphingoid bases by solid-phase extraction on weak cation exchanger cartridges. | 2000 | Anal. Biochem. | pmid:10706795 |
| Perry DK et al. | Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. | 2000 | J. Biol. Chem. | pmid:10722759 |
| Bose R and Kolesnick R | Measurement of ceramide synthase activity. | 2000 | Meth. Enzymol. | pmid:10914032 |
| Mao C et al. | Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide. | 2000 | J. Biol. Chem. | pmid:10900202 |