Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jiang LH et al. | Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1. | 2011 | Curr Drug Targets | pmid:21291387 |
| Ueno S and Horito S | Synthesis of an O-sulfo Lewis(X) analog as glycolipid antigen. | 2011 | Carbohydr. Res. | pmid:21764041 |
| Siow D and Wattenberg B | The compartmentalization and translocation of the sphingosine kinases: mechanisms and functions in cell signaling and sphingolipid metabolism. | 2011 | Crit. Rev. Biochem. Mol. Biol. | pmid:21864225 |
| Siow DL et al. | Sphingosine kinase localization in the control of sphingolipid metabolism. | 2011 | Adv. Enzyme Regul. | pmid:21075134 |
| Roviezzo F et al. | Sphingosine-1-phosphate modulates vascular permeability and cell recruitment in acute inflammation in vivo. | 2011 | J. Pharmacol. Exp. Ther. | pmid:21421740 |
| Véret J et al. | Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells. | 2011 | Biochem. J. | pmid:21592087 |
| Spijkers LJ et al. | Hypertension is associated with marked alterations in sphingolipid biology: a potential role for ceramide. | 2011 | PLoS ONE | pmid:21818267 |
| O'Reilly C and Murphy PV | Synthesis of α-S-glycosphingolipids based on uronic acids. | 2011 | Org. Lett. | pmid:21875123 |
| Zitomer NC and Riley RT | Extraction and analysis of fumonisins and compounds indicative of fumonisin exposure in plant and mammalian tissues and cultured cells. | 2011 | Methods Mol. Biol. | pmid:21567327 |
| Pan J et al. | An novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma. | 2011 | J Transl Med | pmid:21936950 |
| Zhang H et al. | Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis. | 2011 | Nat. Cell Biol. | pmid:21926990 |
| Van Zeebroeck G et al. | A split-ubiquitin two-hybrid screen for proteins physically interacting with the yeast amino acid transceptor Gap1 and ammonium transceptor Mep2. | 2011 | PLoS ONE | pmid:21912684 |
| Chan EK et al. | Combining genome-wide association mapping and transcriptional networks to identify novel genes controlling glucosinolates in Arabidopsis thaliana. | 2011 | PLoS Biol. | pmid:21857804 |
| Samarakoon R et al. | Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression. | 2011 | PLoS ONE | pmid:21829547 |
| Chu UB et al. | Characterization of interactions of 4-nitrophenylpropyl-N-alkylamine with Ï‚ receptors. | 2011 | Biochemistry | pmid:21790129 |
| Baranowski M et al. | Exercise increases plasma levels of sphingoid base-1 phosphates in humans. | 2011 | Acta Physiol (Oxf) | pmid:21535416 |
| Timmers S et al. | Paradoxical increase in TAG and DAG content parallel the insulin sensitizing effect of unilateral DGAT1 overexpression in rat skeletal muscle. | 2011 | PLoS ONE | pmid:21264296 |
| BÅ‚achnio-Zabielska A et al. | Aerobic training in rats increases skeletal muscle sphingomyelinase and serine palmitoyltransferase activity, while decreasing ceramidase activity. | 2011 | Lipids | pmid:21181285 |
| Lachaud C et al. | Dihydrosphingosine-induced programmed cell death in tobacco BY-2 cells is independent of Hâ‚‚Oâ‚‚ production. | 2011 | Mol Plant | pmid:21199880 |
| Separovic D et al. | Enhanced tumor cures after Foscan photodynamic therapy combined with the ceramide analog LCL29. Evidence from mouse squamous cell carcinomas for sphingolipids as biomarkers of treatment response. | 2011 | Int. J. Oncol. | pmid:21152858 |
| Michaelson LV | New insights into cell death induced by long chain bases in Arabidopsis. | 2011 | New Phytol. | pmid:21834911 |
| Saucedo-GarcÃa M et al. | Reactive oxygen species as transducers of sphinganine-mediated cell death pathway. | 2011 | Plant Signal Behav | pmid:21921699 |
| Zhang L et al. | The involvement of jasmonates and ethylene in Alternaria alternata f. sp. lycopersici toxin-induced tomato cell death. | 2011 | J. Exp. Bot. | pmid:21865178 |
| Blaas N et al. | Structural profiling and quantification of sphingomyelin in human breast milk by HPLC-MS/MS. | 2011 | J. Agric. Food Chem. | pmid:21534545 |
| Clugston RD et al. | Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study. | 2011 | J. Lipid Res. | pmid:21856784 |
| Roe B et al. | Metabolomic profile of hepatitis C virus-infected hepatocytes. | 2011 | PLoS ONE | pmid:21853158 |
| Buzzi Fde C et al. | New antinociceptive agents related to dihydrosphingosine. | 2010 Sep-Oct | Pharmacol Rep | pmid:21098867 |
| Schmitz-Peiffer C | Targeting ceramide synthesis to reverse insulin resistance. | 2010 | Diabetes | pmid:20876726 |
| Sims K et al. | Kdo2-lipid A, a TLR4-specific agonist, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy. | 2010 | J. Biol. Chem. | pmid:20876532 |
| Jung HL and Kang HY | Effects of endurance exercise and high-fat diet on insulin resistance and ceramide contents of skeletal muscle in sprague-dawley rats. | 2010 | Korean Diabetes J | pmid:20835342 |
| van der Westhuizen L et al. | Individual fumonisin exposure and sphingoid base levels in rural populations consuming maize in South Africa. | 2010 | Food Chem. Toxicol. | pmid:20363278 |
| Knapp P et al. | Altered sphingolipid metabolism in human endometrial cancer. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20226264 |
| Peer M et al. | Pseudomonas syringae infection triggers de novo synthesis of phytosphingosine from sphinganine in Arabidopsis thaliana. | 2010 | FEBS Lett. | pmid:20732322 |
| Wattenberg BW | Role of sphingosine kinase localization in sphingolipid signaling. | 2010 | World J Biol Chem | pmid:21537471 |
| Gault CR et al. | An overview of sphingolipid metabolism: from synthesis to breakdown. | 2010 | Adv. Exp. Med. Biol. | pmid:20919643 |
| Bertea M et al. | Deoxysphingoid bases as plasma markers in diabetes mellitus. | 2010 | Lipids Health Dis | pmid:20712864 |
| Chen Y et al. | An introduction to sphingolipid metabolism and analysis by new technologies. | 2010 | Neuromolecular Med. | pmid:20680704 |
| Hammad SM et al. | Blood sphingolipidomics in healthy humans: impact of sample collection methodology. | 2010 | J. Lipid Res. | pmid:20660127 |
| Mao Z et al. | Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells. | 2010 | J. Biol. Chem. | pmid:20628055 |
| Liu Y et al. | Elevation of sulfatides in ovarian cancer: an integrated transcriptomic and lipidomic analysis including tissue-imaging mass spectrometry. | 2010 | Mol. Cancer | pmid:20624317 |
| Levy M and Futerman AH | Mammalian ceramide synthases. | 2010 | IUBMB Life | pmid:20222015 |
| Dilkin P et al. | Toxicokinetics and toxicological effects of single oral dose of fumonisin B1 containing Fusarium verticillioides culture material in weaned piglets. | 2010 | Chem. Biol. Interact. | pmid:20338158 |
| Oda M et al. | Hemolysis induced by Bacillus cereus sphingomyelinase. | 2010 | Biochim. Biophys. Acta | pmid:20214877 |
| Lachaud C et al. | Nuclear calcium controls the apoptotic-like cell death induced by d-erythro-sphinganine in tobacco cells. | 2010 | Cell Calcium | pmid:20022633 |
| Ait-Youcef R et al. | Asymmetric synthesis of sphinganine and ent-clavaminol [corrected] H. | 2010 | J. Org. Chem. | pmid:20578745 |
| Park H et al. | Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies. | 2010 | J. Lipid Res. | pmid:19786568 |
| Cutignano A et al. | UPLC-MS/MS method for analysis of sphingosine 1-phosphate in biological samples. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20601074 |
| Romanowicz L and Bańkowski E | Sphingolipids of human umbilical cord vein and their alteration in preeclampsia. | 2010 | Mol. Cell. Biochem. | pmid:20155487 |
| Fukami H et al. | Preparation of (13)C-labeled ceramide by acetic acid bacteria and its incorporation in mice. | 2010 | J. Lipid Res. | pmid:20656918 |
| Romanowicz L and Bańkowski E | Altered sphingolipid composition in Wharton's jelly of pre-eclamptic newborns. | 2010 | Pathobiology | pmid:20332667 |