Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| He Q et al. | Fumonisin-induced tumor necrosis factor-alpha expression in a porcine kidney cell line is independent of sphingoid base accumulation induced by ceramide synthase inhibition. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11437650 |
| Boujaoude LC et al. | Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. | 2001 | J. Biol. Chem. | pmid:11443135 |
| Masur K et al. | High PKC alpha and low E-cadherin expression contribute to high migratory activity of colon carcinoma cells. | 2001 | Mol. Biol. Cell | pmid:11451996 |
| Chung N et al. | Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae. | 2001 | J. Biol. Chem. | pmid:11468289 |
| Liu H et al. | Reaction of fumonisin with glucose prevents promotion of hepatocarcinogenesis in female F344/N rats while maintaining normal hepatic sphinganine/sphingosine ratios. | 2001 | J. Agric. Food Chem. | pmid:11513718 |
| Bhandari N et al. | Gender-related differences in subacute fumonisin B1 hepatotoxicity in BALB/c mice. | 2001 | Toxicology | pmid:11522378 |
| Garren L et al. | The induction and persistence of altered sphingolipid biosynthesis in rats treated with fumonisin B1. | 2001 | Food Addit Contam | pmid:11552753 |
| Ito Y et al. | Structural requirements of sphingosine molecules for inhibition of DNA primase: biochemical and computational analyses. | 2001 | Biochemistry | pmid:11560507 |
| Abnet CC et al. | A cross-sectional study of human serum sphingolipids, diet and physiologic parameters. | 2001 | J. Nutr. | pmid:11584099 |
| Kim MS et al. | Fumonisin B(1) induces apoptosis in LLC-PK(1) renal epithelial cells via a sphinganine- and calmodulin-dependent pathway. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11601888 |
| Solfrizzo M et al. | In vitro and in vivo studies to assess the effectiveness of cholestyramine as a binding agent for fumonisins. | 2001 | Mycopathologia | pmid:11678589 |
| Linn SC et al. | Regulation of de novo sphingolipid biosynthesis and the toxic consequences of its disruption. | 2001 | Biochem. Soc. Trans. | pmid:11709083 |
| Abnet CC et al. | Sphingolipids as biomarkers of fumonisin exposure and risk of esophageal squamous cell carcinoma in china. | 2001 | Cancer Causes Control | pmid:11714110 |
| Tamura K et al. | Characterization of an Arabidopsis cDNA encoding a subunit of serine palmitoyltransferase, the initial enzyme in sphingolipid biosynthesis. | 2001 | Plant Cell Physiol. | pmid:11726713 |
| Galvano F et al. | DNA damage in human fibroblasts exposed to fumonisin B(1). | 2002 | Food Chem. Toxicol. | pmid:11731033 |
| Alemany R et al. | Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate. | 2001 | FEBS Lett. | pmid:11741596 |
| Benaud C et al. | Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase. | 2002 | J. Biol. Chem. | pmid:11792696 |
| Toxicology and carcinogenesis studies of fumonisin B1 (cas no. 116355-83-0) in F344/N rats and B6C3F1 mice (feed studies). | 2001 | Natl Toxicol Program Tech Rep Ser | pmid:11852482 | |
| da Rocha AB et al. | Targeting protein kinase C: new therapeutic opportunities against high-grade malignant gliomas? | 2002 | Oncologist | pmid:11854544 |
| Diatlovitskaia EV | [Biologically effective sphingolipids devoid of 4-trans-double bond in the sphingoid hydrocarbon chain]. | 2002 Jan-Feb | Bioorg. Khim. | pmid:11875973 |