Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Schmitz-Peiffer C | Targeting ceramide synthesis to reverse insulin resistance. | 2010 | Diabetes | pmid:20876726 |
| Diab KJ et al. | Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema. | 2010 | Am. J. Respir. Crit. Care Med. | pmid:19965812 |
| Sims K et al. | Kdo2-lipid A, a TLR4-specific agonist, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy. | 2010 | J. Biol. Chem. | pmid:20876532 |
| Jung HL and Kang HY | Effects of endurance exercise and high-fat diet on insulin resistance and ceramide contents of skeletal muscle in sprague-dawley rats. | 2010 | Korean Diabetes J | pmid:20835342 |
| Abdul-Hammed M et al. | Role of endosomal membrane lipids and NPC2 in cholesterol transfer and membrane fusion. | 2010 | J. Lipid Res. | pmid:20179319 |
| Feng J et al. | Effects of cardiopulmonary bypass on endothelin-1-induced contraction and signaling in human skeletal muscle microcirculation. | 2010 | Circulation | pmid:20837906 |
| Bricard G et al. | Α-galactosylceramide analogs with weak agonist activity for human iNKT cells define new candidate anti-inflammatory agents. | 2010 | PLoS ONE | pmid:21179412 |
| Samuel GH et al. | Autocrine transforming growth factor β signaling regulates extracellular signal-regulated kinase 1/2 phosphorylation via modulation of protein phosphatase 2A expression in scleroderma fibroblasts. | 2010 | Fibrogenesis Tissue Repair | pmid:21134273 |
| Gallego O et al. | A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae. | 2010 | Mol. Syst. Biol. | pmid:21119626 |
| Fuller M | Sphingolipids: the nexus between Gaucher disease and insulin resistance. | 2010 | Lipids Health Dis | pmid:20937139 |
| Gault CR et al. | An overview of sphingolipid metabolism: from synthesis to breakdown. | 2010 | Adv. Exp. Med. Biol. | pmid:20919643 |
| Ribeiro DH et al. | Effects of aflatoxin B(1) and fumonisin B(1) on the viability and induction of apoptosis in rat primary hepatocytes. | 2010 | Int J Mol Sci | pmid:20480051 |
| Gable K et al. | A disease-causing mutation in the active site of serine palmitoyltransferase causes catalytic promiscuity. | 2010 | J. Biol. Chem. | pmid:20504773 |
| Han GS and Carman GM | Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms. | 2010 | J. Biol. Chem. | pmid:20231281 |
| Cowart LA et al. | Revealing a signaling role of phytosphingosine-1-phosphate in yeast. | 2010 | Mol. Syst. Biol. | pmid:20160710 |
| Pewzner-Jung Y et al. | A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy. | 2010 | J. Biol. Chem. | pmid:20110366 |
| Pewzner-Jung Y et al. | A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways. | 2010 | J. Biol. Chem. | pmid:20110363 |
| Pan Q et al. | microRNA 21: response to hormonal therapies and regulatory function in leiomyoma, transformed leiomyoma and leiomyosarcoma cells. | 2010 | Mol. Hum. Reprod. | pmid:19906824 |
| Penno A et al. | Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids. | 2010 | J. Biol. Chem. | pmid:20097765 |
| Blachnio-Zabielska A et al. | Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle. | 2010 | J. Cell. Physiol. | pmid:20568228 |
| Tunsophon S and Nemere I | Protein kinase C isotypes in signal transduction for the 1,25D3-MARRS receptor (ERp57/PDIA3) in steroid hormone-stimulated phosphate uptake. | 2010 | Steroids | pmid:20079367 |
| Kumar P et al. | A general and concise asymmetric synthesis of sphingosine, safingol and phytosphingosines via tethered aminohydroxylation. | 2010 | Org. Biomol. Chem. | pmid:20844791 |
| Zabielski P et al. | Activation of PPARα by bezafibrate negatively affects de novo synthesis of sphingolipids in regenerating rat liver. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20851774 |
| Sweeley CC | Reflections on my career in analytical chemistry and biochemistry. | 2010 | Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. | pmid:20948176 |
| Bu S et al. | Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels. | 2010 | Arthritis Rheum. | pmid:20309867 |
| Milićević DR et al. | Real and perceived risks for mycotoxin contamination in foods and feeds: challenges for food safety control. | 2010 | Toxins (Basel) | pmid:22069600 |
| Arana L et al. | Ceramide and ceramide 1-phosphate in health and disease. | 2010 | Lipids Health Dis | pmid:20137073 |
| Park SW et al. | Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation. | 2010 | Lab. Invest. | pmid:20458275 |
| Park H et al. | Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies. | 2010 | J. Lipid Res. | pmid:19786568 |
| Scherer M et al. | A rapid and quantitative LC-MS/MS method to profile sphingolipids. | 2010 | J. Lipid Res. | pmid:20228220 |
| Kim J et al. | Royal jelly enhances migration of human dermal fibroblasts and alters the levels of cholesterol and sphinganine in an in vitro wound healing model. | 2010 | Nutr Res Pract | pmid:21103081 |
| Cutignano A et al. | UPLC-MS/MS method for analysis of sphingosine 1-phosphate in biological samples. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20601074 |
| Lee YG et al. | Cell-permeable ceramides act as novel regulators of U937 cell-cell adhesion mediated by CD29, CD98, and CD147. | 2010 | Immunobiology | pmid:19576658 |
| Zabielski P et al. | The effect of high-fat diet on the sphingolipid pathway of signal transduction in regenerating rat liver. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20599517 |
| Tokumura A et al. | Elevated serum levels of arachidonoyl-lysophosphatidic acid and sphingosine 1-phosphate in systemic sclerosis. | 2009 | Int J Med Sci | pmid:19521548 |
| Fischbeck A et al. | Analysis of sphingomyelin in meat based on hydrophilic interaction liquid chromatography coupled to electrospray ionization-tandem mass spectrometry (HILIC-HPLC-ESI-MS/MS). | 2009 | J. Agric. Food Chem. | pmid:20175585 |
| Lee YS et al. | Simultaneous HPLC analysis of ceramide and dihydroceramide in human hairs. | 2009 | Arch. Pharm. Res. | pmid:20162410 |
| Romanowicz L and Bańkowski E | Preeclampsia-associated alterations in sphingolipid composition of the umbilical cord artery. | 2009 | Clin. Biochem. | pmid:19616530 |
| Yin P et al. | A metabonomic study of hepatitis B-induced liver cirrhosis and hepatocellular carcinoma by using RP-LC and HILIC coupled with mass spectrometry. | 2009 | Mol Biosyst | pmid:19603122 |
| Kubota M et al. | Potentiation of murine innate immunity by alpha-galacturonosyl-type glycosphingolipids isolated from Sphingomonas yanoikuyae and S. terrae. | 2009 | Immunopharmacol Immunotoxicol | pmid:19555191 |
| Hornemann T et al. | The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases. | 2009 | J. Biol. Chem. | pmid:19648650 |
| Momin AA et al. | Characterization of mutant serine palmitoyltransferase 1 in LY-B cells. | 2009 | Lipids | pmid:19536577 |
| Ling LU et al. | The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells. | 2009 | Int. J. Oncol. | pmid:19885570 |
| Cox D et al. | Determination of cellular lipids bound to human CD1d molecules. | 2009 | PLoS ONE | pmid:19415116 |
| Sridevi P et al. | Ceramide synthase 1 is regulated by proteasomal mediated turnover. | 2009 | Biochim. Biophys. Acta | pmid:19393694 |
| Camoletto PG et al. | Synaptic vesicle docking: sphingosine regulates syntaxin1 interaction with Munc18. | 2009 | PLoS ONE | pmid:19390577 |
| Lahiri S et al. | Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner. | 2009 | J. Biol. Chem. | pmid:19357080 |
| Domijan AM et al. | Urine ochratoxin a and sphinganine/sphingosine ratio in residents of the endemic nephropathy area in Croatia. | 2009 | Arh Hig Rada Toksikol | pmid:20061238 |
| Scherer M et al. | High-throughput analysis of sphingosine 1-phosphate, sphinganine 1-phosphate, and lysophosphatidic acid in plasma samples by liquid chromatography-tandem mass spectrometry. | 2009 | Clin. Chem. | pmid:19325012 |
| Kobayashi N et al. | Characterization of the ATP-dependent sphingosine 1-phosphate transporter in rat erythrocytes. | 2009 | J. Biol. Chem. | pmid:19531471 |