Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jiang LH et al. | Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1. | 2011 | Curr Drug Targets | pmid:21291387 |
| Chao DY et al. | Sphingolipids in the root play an important role in regulating the leaf ionome in Arabidopsis thaliana. | 2011 | Plant Cell | pmid:21421810 |
| Lamour NF et al. | Ceramide kinase regulates the production of tumor necrosis factor α (TNFα) via inhibition of TNFα-converting enzyme. | 2011 | J. Biol. Chem. | pmid:22009748 |
| Doi K and Uetsuka K | Mechanisms of mycotoxin-induced neurotoxicity through oxidative stress-associated pathways. | 2011 | Int J Mol Sci | pmid:21954354 |
| Pan J et al. | An novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma. | 2011 | J Transl Med | pmid:21936950 |
| Ling LU et al. | The role of reactive oxygen species and autophagy in safingol-induced cell death. | 2011 | Cell Death Dis | pmid:21390063 |
| Sánchez BA et al. | Targeted analysis of sphingoid precursors in human biofluids by solid-phase extraction with in situ derivatization prior to μ-LC-LIF determination. | 2011 | Anal Bioanal Chem | pmid:21394454 |
| van Smeden J et al. | LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery. | 2011 | J. Lipid Res. | pmid:21444759 |
| Da Silva D et al. | Nitric oxide production is not required for dihydrosphingosine-induced cell death in tobacco BY-2 cells. | 2011 | Plant Signal Behav | pmid:21455022 |
| Momin AA et al. | A method for visualization of "omic" datasets for sphingolipid metabolism to predict potentially interesting differences. | 2011 | J. Lipid Res. | pmid:21415121 |
| Saucedo-GarcÃa M et al. | MPK6, sphinganine and the LCB2a gene from serine palmitoyltransferase are required in the signaling pathway that mediates cell death induced by long chain bases in Arabidopsis. | 2011 | New Phytol. | pmid:21534970 |
| Gupta S et al. | Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolism. | 2011 | BMC Syst Biol | pmid:21303545 |
| Dickson MA et al. | A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors. | 2011 | Clin. Cancer Res. | pmid:21257722 |
| Lachaud C et al. | Dihydrosphingosine-induced programmed cell death in tobacco BY-2 cells is independent of Hâ‚‚Oâ‚‚ production. | 2011 | Mol Plant | pmid:21199880 |
| Merrill AH | Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. | 2011 | Chem. Rev. | pmid:21942574 |
| Apraiz A et al. | Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells. | 2011 | BMC Cancer | pmid:22061047 |
| Murakami I et al. | Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors. | 2011 | Lipids Health Dis | pmid:21861924 |
| Michaelson LV | New insights into cell death induced by long chain bases in Arabidopsis. | 2011 | New Phytol. | pmid:21834911 |
| Saucedo-GarcÃa M et al. | Reactive oxygen species as transducers of sphinganine-mediated cell death pathway. | 2011 | Plant Signal Behav | pmid:21921699 |
| Watson ML et al. | Chronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cells. | 2011 | PLoS ONE | pmid:21998735 |