Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bu S et al. | Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway. | 2008 | J. Biol. Chem. | pmid:18482992 |
| van der Westhuizen L et al. | Sphingoid base levels in humans consuming fumonisin-contaminated maize in rural areas of the former Transkei, South Africa: a cross-sectional study. | 2008 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:19680846 |
| Davies KP and Melman A | Markers of erectile dysfunction. | 2008 | Indian J Urol | pmid:19468461 |
| Yazar S and Omurtag GZ | Fumonisins, trichothecenes and zearalenone in cereals. | 2008 | Int J Mol Sci | pmid:19330061 |
| Garcia J et al. | Mathematical modeling of pathogenicity of Cryptococcus neoformans. | 2008 | Mol. Syst. Biol. | pmid:18414484 |
| Gehrmann M et al. | Tumor-specific Hsp70 plasma membrane localization is enabled by the glycosphingolipid Gb3. | 2008 | PLoS ONE | pmid:18382692 |
| Masukawa Y et al. | Characterization of overall ceramide species in human stratum corneum. | 2008 | J. Lipid Res. | pmid:18359959 |
| Oda M et al. | The relationship between the metabolism of sphingomyelin species and the hemolysis of sheep erythrocytes induced by Clostridium perfringens alpha-toxin. | 2008 | J. Lipid Res. | pmid:18263851 |
| Dahm F et al. | Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice. | 2008 | Br. J. Cancer | pmid:18026195 |
| Abraham E et al. | Asymmetric synthesis of vicinal amino alcohols: xestoaminol C, sphinganine and sphingosine. | 2008 | Org. Biomol. Chem. | pmid:18421400 |
| Gude DR et al. | Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal. | 2008 | FASEB J. | pmid:18362204 |
| Pruett ST et al. | Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. | 2008 | J. Lipid Res. | pmid:18499644 |
| Matsuyama H et al. | Sphingobacterium kitahiroshimense sp. nov., isolated from soil. | 2008 | Int. J. Syst. Evol. Microbiol. | pmid:18599698 |
| Gangoiti P et al. | Implication of ceramide, ceramide 1-phosphate and sphingosine 1-phosphate in tumorigenesis. | 2008 | Transl Oncogenomics | pmid:21566746 |
| Mizugishi K et al. | Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice. | 2007 | J. Clin. Invest. | pmid:17885683 |
| Vessey DA et al. | Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart. | 2007 | J. Biochem. Mol. Toxicol. | pmid:17912702 |
| Giussani P et al. | Sphingosine-1-phosphate and calcium signaling in cerebellar astrocytes and differentiated granule cells. | 2007 | Neurochem. Res. | pmid:17151916 |
| Tuuf J and Mattjus P | Human glycolipid transfer protein--intracellular localization and effects on the sphingolipid synthesis. | 2007 | Biochim. Biophys. Acta | pmid:17980653 |
| Straczkowski M et al. | Increased skeletal muscle ceramide level in men at risk of developing type 2 diabetes. | 2007 | Diabetologia | pmid:17724577 |
| Son JH et al. | Activation of de novo synthetic pathway of ceramides is responsible for the initiation of hydrogen peroxide-induced apoptosis in HL-60 cells. | 2007 | J. Toxicol. Environ. Health Part A | pmid:17654249 |
| Burenjargal M et al. | Endogenous sphingolipid metabolites related to the growth in Sphingomonas chungbukensis. | 2007 | Arch. Pharm. Res. | pmid:17424937 |
| Delgado A et al. | Chemical tools to investigate sphingolipid metabolism and functions. | 2007 | ChemMedChem | pmid:17252619 |
| Li S et al. | basA regulates cell wall organization and asexual/sexual sporulation ratio in Aspergillus nidulans. | 2007 | Genetics | pmid:17409079 |
| Mansfield MA et al. | Relationship of sphinganine analog mycotoxin contamination in maize silage to seasonal weather conditions and to agronomic and ensiling practices. | 2007 | Phytopathology | pmid:18943291 |
| Walther TC et al. | Pkh-kinases control eisosome assembly and organization. | 2007 | EMBO J. | pmid:18034155 |
| Shephard GS et al. | Biomarkers of exposure to fumonisin mycotoxins: a review. | 2007 | Food Addit Contam | pmid:17886192 |
| Cai Q et al. | Validation of fumonisin biomarkers in F344 rats. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17904604 |
| Groener JE et al. | HPLC for simultaneous quantification of total ceramide, glucosylceramide, and ceramide trihexoside concentrations in plasma. | 2007 | Clin. Chem. | pmid:17332150 |
| Lahiri S et al. | Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. | 2007 | FEBS Lett. | pmid:17977534 |
| Cerantola V et al. | Yeast sphingolipids do not need to contain very long chain fatty acids. | 2007 | Biochem. J. | pmid:16987101 |
| Domijan AM et al. | Fumonisin B(1): oxidative status and DNA damage in rats. | 2007 | Toxicology | pmid:17291664 |
| Don AS et al. | Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues. | 2007 | J. Biol. Chem. | pmid:17400555 |
| Frgala T et al. | A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations. | 2007 | Mol. Cancer Ther. | pmid:17363483 |
| Tian YS et al. | Stereoselective synthesis of L-threo-sphingosine, L-threo-sphinganine, D-threo-sphingosine, and D-threo-sphinganine via oxazoline formation and olefin cross-metathesis; potent protein kinase C inhibitor analogues. | 2007 | Arch. Pharm. Res. | pmid:17366737 |
| Baranowski M et al. | PPARalpha agonist induces the accumulation of ceramide in the heart of rats fed high-fat diet. | 2007 | J. Physiol. Pharmacol. | pmid:17440226 |
| Separovic D et al. | Sphingomyelin synthase 1 suppresses ceramide production and apoptosis post-photodamage. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17467659 |
| Loiseau N et al. | Fumonisin B1 exposure and its selective effect on porcine jejunal segment: sphingolipids, glycolipids and trans-epithelial passage disturbance. | 2007 | Biochem. Pharmacol. | pmid:17499218 |
| Imamura T et al. | A rice dihydrosphingosine C4 hydroxylase (DSH1) gene, which is abundantly expressed in the stigmas, vascular cells and apical meristem, may be involved in fertility. | 2007 | Plant Cell Physiol. | pmid:17609219 |
| Hsiao SH et al. | Use of formalin-fixed tissues to determine fumonisin B1-induced sphingolipid alterations in swine. | 2007 | J. Vet. Diagn. Invest. | pmid:17609357 |
| Morales PR et al. | Safingol toxicology after oral administration to TRAMP mice: demonstration of safingol uptake and metabolism by N-acylation and N-methylation. | 2007 | Drug Chem Toxicol | pmid:17613006 |
| Cowart LA and Hannun YA | Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis. | 2007 | J. Biol. Chem. | pmid:17322298 |
| Baranowski M et al. | Pioglitazone induces de novo ceramide synthesis in the rat heart. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17259076 |
| Shi L et al. | Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis. | 2007 | Cell Res. | pmid:18059378 |
| Mun J et al. | Structural confirmation of the dihydrosphinganine and fatty acid constituents of the dental pathogen Porphyromonas gingivalis. | 2007 | Org. Biomol. Chem. | pmid:18004463 |
| Tardieu D et al. | Chronic toxicity of fumonisins in turkeys. | 2007 | Poult. Sci. | pmid:17704375 |
| Kim DH et al. | Elevation of sphingoid base 1-phosphate as a potential contributor to hepatotoxicity in fumonisin B1-exposed mice. | 2007 | Arch. Pharm. Res. | pmid:17879749 |
| Shin JH et al. | Sphingosine 1-phosphate triggers apoptotic signal for B16 melanoma cells via ERK and caspase activation. | 2007 | J. Korean Med. Sci. | pmid:17449940 |
| Suzuki H et al. | Inducible nitric oxide has protective effect on fumonisin B1 hepatotoxicity in mice via modulation of sphingosine kinase. | 2007 | Toxicology | pmid:17095132 |
| Alvarez-Vasquez F et al. | Coordination of the dynamics of yeast sphingolipid metabolism during the diauxic shift. | 2007 | Theor Biol Med Model | pmid:17974024 |
| He Q et al. | S-adenosylmethionine or 5'-methylthioadenosine are unable to prevent fumonisin B1 hepatotoxicity in mice despite increased oxidation in liver. | 2006 Nov-Dec | J Appl Toxicol | pmid:17080400 |