Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chao DY et al. | Sphingolipids in the root play an important role in regulating the leaf ionome in Arabidopsis thaliana. | 2011 | Plant Cell | pmid:21421810 |
| Nimrichter L and Rodrigues ML | Fungal glucosylceramides: from structural components to biologically active targets of new antimicrobials. | 2011 | Front Microbiol | pmid:22025918 |
| Kim J et al. | Analysis of ceramide metabolites in differentiating epidermal keratinocytes treated with calcium or vitamin C. | 2011 | Nutr Res Pract | pmid:22125676 |
| Bensaci MF et al. | Fungicidal Activities and Mechanisms of Action of Pseudomonas syringae pv. syringae Lipodepsipeptide Syringopeptins 22A and 25A. | 2011 | Front Microbiol | pmid:22046175 |
| Lamour NF et al. | Ceramide kinase regulates the production of tumor necrosis factor α (TNFα) via inhibition of TNFα-converting enzyme. | 2011 | J. Biol. Chem. | pmid:22009748 |
| Ling Y et al. | Involvement of the PLCε/PKCα pathway in human BIU-87 bladder cancer cell proliferation. | 2011 | Cell Biol. Int. | pmid:21121899 |
| Cano-Sancho G et al. | Sphinganine and sphingosine levels and ratio in urine and blood samples from a Catalonian population, Spain. | 2011 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:21644119 |
| Ling LU et al. | The role of reactive oxygen species and autophagy in safingol-induced cell death. | 2011 | Cell Death Dis | pmid:21390063 |
| Separovic D et al. | C16-Ceramide Analog Combined with Pc 4 Photodynamic Therapy Evokes Enhanced Total Ceramide Accumulation, Promotion of DEVDase Activation in the Absence of Apoptosis, and Augmented Overall Cell Killing. | 2011 | J Lipids | pmid:21490809 |
| Sánchez BA et al. | Targeted analysis of sphingoid precursors in human biofluids by solid-phase extraction with in situ derivatization prior to μ-LC-LIF determination. | 2011 | Anal Bioanal Chem | pmid:21394454 |
| Wojewodka G et al. | Ceramide in cystic fibrosis: a potential new target for therapeutic intervention. | 2011 | J Lipids | pmid:21490807 |
| Huang WC et al. | Apoptotic sphingolipid ceramide in cancer therapy. | 2011 | J Lipids | pmid:21490804 |
| van Smeden J et al. | LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery. | 2011 | J. Lipid Res. | pmid:21444759 |
| Da Silva D et al. | Nitric oxide production is not required for dihydrosphingosine-induced cell death in tobacco BY-2 cells. | 2011 | Plant Signal Behav | pmid:21455022 |
| Momin AA et al. | A method for visualization of "omic" datasets for sphingolipid metabolism to predict potentially interesting differences. | 2011 | J. Lipid Res. | pmid:21415121 |
| Saucedo-GarcÃa M et al. | MPK6, sphinganine and the LCB2a gene from serine palmitoyltransferase are required in the signaling pathway that mediates cell death induced by long chain bases in Arabidopsis. | 2011 | New Phytol. | pmid:21534970 |
| Mortazavi PN et al. | Possible roles of phospholipase A(2) in the biological activities of Acanthamoeba castellanii (T4 Genotype). | 2011 | Protist | pmid:20650684 |
| Apraiz A et al. | Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells. | 2011 | BMC Cancer | pmid:22061047 |
| Murakami I et al. | Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors. | 2011 | Lipids Health Dis | pmid:21861924 |
| Watson ML et al. | Chronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cells. | 2011 | PLoS ONE | pmid:21998735 |