| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Grilley MM and Takemoto JY | Assay of the Saccharomyces cerevisiae dihydrosphingosine C-4 hydroxylase. | 2000 | Meth. Enzymol. | pmid:10563305 |
| Chung N and Obeid LM | Use of yeast as a model system for studies of sphingolipid metabolism and signaling. | 2000 | Meth. Enzymol. | pmid:10563337 |
| Sharma C et al. | Inhibition of Ca2+ release channel (ryanodine receptor) activity by sphingolipid bases: mechanism of action. | 2000 | Chem. Phys. Lipids | pmid:10660207 |
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| Chung N et al. | Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. | 2000 | J. Biol. Chem. | pmid:10764732 |
| Azuma H et al. | Stereospecific total syntheses of sphingosine and its analogues from L-serine. | 2000 | J. Org. Chem. | pmid:10843643 |
| Zanolari B et al. | Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae. | 2000 | EMBO J. | pmid:10856228 |
| Mao C et al. | Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide. | 2000 | J. Biol. Chem. | pmid:10900202 |
| Jenkins GM and Hannun YA | Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae. | 2001 | J. Biol. Chem. | pmid:11056159 |
| Merrill AH et al. | Analysis of sphingoid bases and sphingoid base 1-phosphates by high-performance liquid chromatography. | 2000 | Meth. Enzymol. | pmid:11070857 |
| Wu WI and Carman GM | Kinetic analysis of sphingoid base inhibition of yeast phosphatidate phosphatase. | 2000 | Meth. Enzymol. | pmid:11070885 |
| He L et al. | A stereocontrolled, efficient synthetic route to bioactive sphingolipids: synthesis of phytosphingosine and phytoceramides from unsaturated ester precursors via cyclic sulfate intermediates. | 2000 | J. Org. Chem. | pmid:11076624 |
| Ardail D et al. | Occurrence of ceramides and neutral glycolipids with unusual long-chain base composition in purified rat liver mitochondria. | 2001 | FEBS Lett. | pmid:11163764 |
| Kang SS et al. | Cyclooxygenase-2 inhibitory cerebrosides from phytolaccae radix. | 2001 | Chem. Pharm. Bull. | pmid:11253924 |
| Toledo MS et al. | Characterization of cerebrosides from the thermally dimorphic mycopathogen Histoplasma capsulatum: expression of 2-hydroxy fatty N-acyl (E)-Delta(3)-unsaturation correlates with the yeast-mycelium phase transition. | 2001 | Glycobiology | pmid:11287398 |
| Sperling P et al. | Functional characterization of sphingolipid C4-hydroxylase genes from Arabidopsis thaliana. | 2001 | FEBS Lett. | pmid:11297741 |
| Yamada K et al. | Constituents of holothuroidea. 10. Isolation and structure of a biologically active ganglioside molecular species from the sea cucumber Holothuria leucospilota. | 2001 | Chem. Pharm. Bull. | pmid:11310672 |
| Bauman M et al. | Natural zeolite clinoptilolite increases the concentrations of sphingoid bases in the yeast Yarrowia lipolytica. | 2001 | J. Basic Microbiol. | pmid:11314249 |
| Abe M et al. | Yeast 1,3-beta-glucan synthase activity is inhibited by phytosphingosine localized to the endoplasmic reticulum. | 2001 | J. Biol. Chem. | pmid:11337502 |
| Guillas I et al. | C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p. | 2001 | EMBO J. | pmid:11387200 |
| Lee JS et al. | Phytosphingosine and C2-phytoceramide induce cell death and inhibit carbachol-stimulated phospholipase D activation in Chinese hamster ovary cells expressing the Caenorhabditis elegans muscarinic acetylcholine receptor. | 2001 | FEBS Lett. | pmid:11418117 |
| Chung N et al. | Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae. | 2001 | J. Biol. Chem. | pmid:11468289 |
| Loureiro y Penha CV et al. | Characterization of novel structures of mannosylinositolphosphorylceramides from the yeast forms of Sporothrix schenckii. | 2001 | Eur. J. Biochem. | pmid:11488918 |
| Friant S et al. | Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast. | 2001 | EMBO J. | pmid:11726514 |
| Levery SB et al. | Comparative analysis of glycosylinositol phosphorylceramides from fungi by electrospray tandem mass spectrometry with low-energy collision-induced dissociation of Li(+) adduct ions. | 2001 | Rapid Commun. Mass Spectrom. | pmid:11746891 |
| Inagaki M et al. | Constituents of ophiuroidea. 1. Isolation and structure of three ganglioside molecular species from the brittle star Ophiocoma scolopendrina. | 2001 | Chem. Pharm. Bull. | pmid:11767069 |
| Bäckhed F et al. | Identification of target tissue glycosphingolipid receptors for uropathogenic, F1C-fimbriated Escherichia coli and its role in mucosal inflammation. | 2002 | J. Biol. Chem. | pmid:11877427 |
| Bauman M et al. | Dependence of the sphingoid bases concentration on growth phase and temperature in the yeast Yarrowia lipolytica. | 2002 | J. Basic Microbiol. | pmid:11925759 |
| Min JK et al. | Simultaneous quantitative analysis of sphingoid base 1-phosphates in biological samples by o-phthalaldehyde precolumn derivatization after dephosphorylation with alkaline phosphatase. | 2002 | Anal. Biochem. | pmid:11950216 |
| Ferguson-Yankey SR et al. | Mutant analysis reveals complex regulation of sphingolipid long chain base phosphates and long chain bases during heat stress in yeast. | 2002 | Yeast | pmid:11967828 |
| Dickson RC and Lester RL | Sphingolipid functions in Saccharomyces cerevisiae. | 2002 | Biochim. Biophys. Acta | pmid:12069845 |
| Han G et al. | The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase. | 2002 | J. Biol. Chem. | pmid:12087109 |
| Grzanowski A et al. | Immunosuppressant-like effects of phenylbutyrate on growth inhibition of Saccharomyces cerevisiae. | 2002 | Curr. Genet. | pmid:12111095 |
| Swain E et al. | Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1. | 2002 | J. Biol. Chem. | pmid:12145310 |
| Macheleidt O et al. | Deficiency of epidermal protein-bound omega-hydroxyceramides in atopic dermatitis. | 2002 | J. Invest. Dermatol. | pmid:12164940 |
| Hamanaka S et al. | Human epidermal glucosylceramides are major precursors of stratum corneum ceramides. | 2002 | J. Invest. Dermatol. | pmid:12190865 |
| Maciel DM et al. | Glycosphingolipids from Magnaporthe grisea cells: expression of a ceramide dihexoside presenting phytosphingosine as the long-chain base. | 2002 | Arch. Biochem. Biophys. | pmid:12220534 |
| Candelore MR et al. | Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12270137 |
| Nenoff P and Haustein UF | In vitro activity of phytosphingosines against Malassezia furfur and Candida albicans. | 2002 | Acta Derm. Venereol. | pmid:12353705 |
| Kawatake S et al. | Isolation and structure of monomethylated GM3-type ganglioside molecular species from the starfish Luidia maculata. | 2002 | Chem. Pharm. Bull. | pmid:12372870 |
| Seefelder W et al. | Liquid chromatography/electrospray ionisation-mass spectrometry method for the quantification of sphingosine and sphinganine in cell cultures exposed to fumonisins. | 2002 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:12383489 |
| Takakuwa N et al. | Isolation and characterization of the genes encoding delta(8)-sphingolipid desaturase from Saccharomyces kluyveri and Kluyveromyces lactis. | 2002 | Curr. Microbiol. | pmid:12402089 |
| Lee MH et al. | Analysis of ceramides in cosmetics by reversed-phase liquid chromatography/electrospray ionization mass spectrometry with collision-induced dissociation. | 2003 | Rapid Commun. Mass Spectrom. | pmid:12478556 |
| De Paepe K et al. | Repair of acetone- and sodium lauryl sulphate-damaged human skin barrier function using topically applied emulsions containing barrier lipids. | 2002 | J Eur Acad Dermatol Venereol | pmid:12482041 |
| Cheng J et al. | Induction of apoptosis by sphingoid long-chain bases in Aspergillus nidulans. | 2003 | Mol. Cell. Biol. | pmid:12482970 |
| Maceyka M et al. | Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. | 2002 | Biochim. Biophys. Acta | pmid:12531554 |
| Park MT et al. | Phytosphingosine induces apoptotic cell death via caspase 8 activation and Bax translocation in human cancer cells. | 2003 | Clin. Cancer Res. | pmid:12576463 |
| Ardail D et al. | The mitochondria-associated endoplasmic-reticulum subcompartment (MAM fraction) of rat liver contains highly active sphingolipid-specific glycosyltransferases. | 2003 | Biochem. J. | pmid:12578562 |
| Fontaine T et al. | Structures of the glycosylphosphatidylinositol membrane anchors from Aspergillus fumigatus membrane proteins. | 2003 | Glycobiology | pmid:12626404 |
| Ponec M et al. | New acylceramide in native and reconstructed epidermis. | 2003 | J. Invest. Dermatol. | pmid:12648220 |
| Wright BS et al. | Synthesis of 4-hydroxysphinganine and characterization of sphinganine hydroxylase activity in corn. | 2003 | Arch. Biochem. Biophys. | pmid:12831841 |
| Chiu HY et al. | A facile synthesis of phytosphingosine from diisopropylidene-D-mannofuranose. | 2003 | J. Org. Chem. | pmid:12839486 |
| Kariotoglou DM and Mastronicolis SK | Sphingophosphonolipid molecular species from edible mollusks and a jellyfish. | 2003 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:12941637 |
| Fukuda Y et al. | Distribution of sphingosine kinase activity in mouse tissues: contribution of SPHK1. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12943676 |
| Turinsky J and Nagel GW | Effect of sphingoid bases on basal and insulin-stimulated 2-deoxyglucose transport in skeletal muscle. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1417855 |
| Patton JL et al. | Phenotypes of sphingolipid-dependent strains of Saccharomyces cerevisiae. | 1992 | J. Bacteriol. | pmid:1429441 |
| Takamatsu K | Phytosphingosine-containing neutral glycosphingolipids and sulfatides in the human female genital tract: their association in the cervical epithelium and the uterine endometrium and their dissociation in the mucosa of fallopian tube with the menstrual cycle. | 1992 | Keio J Med | pmid:1434311 |
| Park MT et al. | Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells. | 2003 | J. Biol. Chem. | pmid:14522966 |
| Seefelder W et al. | Induction of apoptosis in cultured human proximal tubule cells by fumonisins and fumonisin metabolites. | 2003 | Toxicol. Appl. Pharmacol. | pmid:14550748 |
| Teneberg S et al. | Carbohydrate recognition by enterohemorrhagic Escherichia coli: characterization of a novel glycosphingolipid from cat small intestine. | 2004 | Glycobiology | pmid:14576169 |
| Takagi S et al. | Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function. | 2003 | J. Clin. Invest. | pmid:14597763 |
| Kim HJ et al. | Differential regulation of cyclooxygenase-2 expression by phytosphingosine derivatives, NAPS and TAPS, and its role in the NAPS or TAPS-mediated apoptosis. | 2003 | J. Invest. Dermatol. | pmid:14708615 |
| Kim HJ et al. | Tetraacetyl phytosphingosine-induced caspase activation and apoptosis occur through G2 arrest in human keratinocyte HaCaT cells. | 2003 | J. Invest. Dermatol. | pmid:14708616 |
| Deguchi H et al. | Sphingolipids as bioactive regulators of thrombin generation. | 2004 | J. Biol. Chem. | pmid:14722105 |
| Kim HJ et al. | Induction of apoptosis and expression of cell cycle regulatory proteins in response to a phytosphingosine derivative in HaCaT human keratinocyte cells. | 2003 | Mol. Cells | pmid:14744023 |
| Barreto-Bergter E et al. | Structure and biological functions of fungal cerebrosides. | 2004 | An. Acad. Bras. Cienc. | pmid:15048196 |
| Bae JH et al. | Cloning and functional characterization of the SUR2/SYR2 gene encoding sphinganine hydroxylase in Pichia ciferrii. | 2004 | Yeast | pmid:15116344 |
| Aoki K et al. | Newly discovered neutral glycosphingolipids in aureobasidin A-resistant zygomycetes: Identification of a novel family of Gala-series glycolipids with core Gal alpha 1-6Gal beta 1-6Gal beta sequences. | 2004 | J. Biol. Chem. | pmid:15155728 |
| Welsch CA et al. | Genetic, biochemical, and transcriptional responses of Saccharomyces cerevisiae to the novel immunomodulator FTY720 largely mimic those of the natural sphingolipid phytosphingosine. | 2004 | J. Biol. Chem. | pmid:15190065 |
| Kim HJ et al. | Potentiation of UVB-induced apoptosis by novel phytosphingosine derivative, tetraacetyl phytosphingosine in HaCaT cell and mouse skin. | 2004 | Apoptosis | pmid:15192327 |
| Lu X et al. | Synthesis of l-lyxo-phytosphingosine and its 1-phosphonate analogue using a threitol acetal synthon. | 2004 | J. Org. Chem. | pmid:15287793 |
| Kawatake S et al. | Isolation and structure of a GD3-Type ganglioside molecular species possessing neuritogenic activity from the starfish Luidia maculata. | 2004 | Chem. Pharm. Bull. | pmid:15305002 |
| van den Berg RJ et al. | Effective, high-yielding, and stereospecific total synthesis of D-erythro-(2R,3S)-sphingosine from D-ribo-(2S,3S,4R)-phytosphingosine. | 2004 | J. Org. Chem. | pmid:15307742 |
| Gao JM et al. | Molecular species of ceramides from the ascomycete truffle Tuber indicum. | 2004 | Chem. Phys. Lipids | pmid:15351272 |
| de Jager M et al. | Acylceramide head group architecture affects lipid organization in synthetic ceramide mixtures. | 2004 | J. Invest. Dermatol. | pmid:15482479 |
| Park MT et al. | Phytosphingosine in combination with ionizing radiation enhances apoptotic cell death in radiation-resistant cancer cells through ROS-dependent and -independent AIF release. | 2005 | Blood | pmid:15486061 |
| Goff RD et al. | Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells. | 2004 | J. Am. Chem. Soc. | pmid:15493902 |
| Chen G et al. | Efficient synthesis of alpha-C-galactosyl ceramide immunostimulants: use of ethylene-promoted olefin cross-metathesis. | 2004 | Org. Lett. | pmid:15496103 |
| Pinto WJ et al. | Sphingolipid long-chain-base auxotrophs of Saccharomyces cerevisiae: genetics, physiology, and a method for their selection. | 1992 | J. Bacteriol. | pmid:1556075 |
| Cerbón J et al. | Inositol phosphoceramide synthase is a regulator of intracellular levels of diacylglycerol and ceramide during the G1 to S transition in Saccharomyces cerevisiae. | 2005 | Biochem. J. | pmid:15560753 |
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phytosphingosine
phytosphingosine is a lipid of Sphingolipids (SP) class. Phytosphingosine is associated with abnormalities such as Infection, Nodule, Dehydration, Neuropathy and nervous system disorder. The involved functions are known as Saturated, sphingomyelin synthase activity, Heat-Shock Response, Cell Growth and Apoptosis. Phytosphingosine often locates in Clone, Protoplasm, Mitochondria, soluble and Cytoplasmic matrix. The associated genes with phytosphingosine are SGMS1 gene, BCL2 gene, Chromatin, Homologous Gene and DLEU2 gene. The related lipids are Sphingolipids, inositolphosphorylceramide, Phosphatidylserines, dihydroceramide and Fatty Acids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of phytosphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phytosphingosine?
phytosphingosine is suspected in Infection, Nodule, Dehydration, Neuropathy, nervous system disorder, Atopic and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with phytosphingosine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phytosphingosine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with phytosphingosine?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with phytosphingosine?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with phytosphingosine?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with phytosphingosine?
Knock-out
Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001) and Knock-out are used in the study 'SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae.' (Brace JL et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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