phytosphingosine

phytosphingosine is a lipid of Sphingolipids (SP) class. Phytosphingosine is associated with abnormalities such as Infection, Nodule, Dehydration, Neuropathy and nervous system disorder. The involved functions are known as Saturated, sphingomyelin synthase activity, Heat-Shock Response, Cell Growth and Apoptosis. Phytosphingosine often locates in Clone, Protoplasm, Mitochondria, soluble and Cytoplasmic matrix. The associated genes with phytosphingosine are SGMS1 gene, BCL2 gene, Chromatin, Homologous Gene and DLEU2 gene. The related lipids are Sphingolipids, inositolphosphorylceramide, Phosphatidylserines, dihydroceramide and Fatty Acids. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of phytosphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phytosphingosine?

phytosphingosine is suspected in Infection, Nodule, Dehydration, Neuropathy, nervous system disorder, Atopic and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with phytosphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phytosphingosine?

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What functions are associated with phytosphingosine?


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What lipids are associated with phytosphingosine?

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What genes are associated with phytosphingosine?

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What common seen animal models are associated with phytosphingosine?

Knock-out

Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001) and Knock-out are used in the study 'SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae.' (Brace JL et al., 2007).

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NCBI Entrez Crosslinks

All references with phytosphingosine

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Authors Title Published Journal PubMed Link
pmid:
Sauro S et al. Di-Calcium Phosphate and Phytosphingosine as an Innovative Acid-Resistant Treatment to Occlude Dentine Tubules. Caries Res. pmid:27179116
Pin D et al. An emulsion restores the skin barrier by decreasing the skin pH and inflammation in a canine experimental model. J. Comp. Pathol. pmid:24975893
Bouhours D and Bouhours JF Phytosphingosine in intestinal glycolipids of the rat fetus. 1984 Biochim. Biophys. Acta pmid:6733126
Li YT et al. Isolation and characterization of a novel phytosphingosine-containing GM2 ganglioside from mullet roe (Mugil cephalus). 1984 J. Biol. Chem. pmid:6746635
Crossman MW and Hirschberg CB Biosynthesis of 4D-hydroxysphinganine by the rat. En bloc incorporation of the sphinganine carbon backbone. 1984 Biochim. Biophys. Acta pmid:6477953
Radin NS Biosynthesis of the sphingoid bases: a provocation. 1984 J. Lipid Res. pmid:6442338
Bouhours D and Bouhours JF Developmental changes of the lipidic part of the neutral glycosphingolipids of the rat stomach. 1985 J. Biol. Chem. pmid:3972786
Nishimura K Phytosphingosine is a characteristic component of the glycolipids in the vertebrate intestine. 1987 Comp. Biochem. Physiol., B pmid:3829627
Bouchon B et al. Selective enrichment of phytosphingosine in glycosphingolipids of isolated human thyrocytes as compared to the whole thyroid. 1987 Biochem. Biophys. Res. Commun. pmid:3566758
Merrill AH et al. Quantitation of free sphingosine in liver by high-performance liquid chromatography. 1988 Anal. Biochem. pmid:3407935
Madison KC et al. Sphingolipid metabolism in organotypic mouse keratinocyte cultures. 1990 J. Invest. Dermatol. pmid:2123494
Röder B et al. The determination of phytosphingosine-containing globotriaosylceramide from human kidney in the presence of lactosylceramide. 1990 Chem. Phys. Lipids pmid:2162261
Pinto WJ et al. Sphingolipid long-chain-base auxotrophs of Saccharomyces cerevisiae: genetics, physiology, and a method for their selection. 1992 J. Bacteriol. pmid:1556075
Pinto WJ et al. Characterization of enzymatic synthesis of sphingolipid long-chain bases in Saccharomyces cerevisiae: mutant strains exhibiting long-chain-base auxotrophy are deficient in serine palmitoyltransferase activity. 1992 J. Bacteriol. pmid:1556076
Patton JL et al. Phenotypes of sphingolipid-dependent strains of Saccharomyces cerevisiae. 1992 J. Bacteriol. pmid:1429441
Takamatsu K Phytosphingosine-containing neutral glycosphingolipids and sulfatides in the human female genital tract: their association in the cervical epithelium and the uterine endometrium and their dissociation in the mucosa of fallopian tube with the menstrual cycle. 1992 Keio J Med pmid:1434311
Turinsky J and Nagel GW Effect of sphingoid bases on basal and insulin-stimulated 2-deoxyglucose transport in skeletal muscle. 1992 Biochem. Biophys. Res. Commun. pmid:1417855
Wu WI et al. Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by sphingoid bases. 1993 J. Biol. Chem. pmid:8314751
Gross SK et al. Expression of glycosphingolipids in serum-free primary cultures of mouse kidney cells: male-female differences and androgen sensitivity. 1994 Mol. Cell. Biochem. pmid:7845375