| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
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| Min JK et al. | Simultaneous quantitative analysis of sphingoid base 1-phosphates in biological samples by o-phthalaldehyde precolumn derivatization after dephosphorylation with alkaline phosphatase. | 2002 | Anal. Biochem. | pmid:11950216 |
| Zhang J et al. | Metabonomics research of diabetic nephropathy and type 2 diabetes mellitus based on UPLC-oaTOF-MS system. | 2009 | Anal. Chim. Acta | pmid:19720167 |
| Jiang H et al. | Achieving molecular complexity by organocatalytic one-pot strategies - a fast entry for synthesis of sphingoids, amino sugars, and polyhydroxylated alpha-amino acids. | 2009 | Angew. Chem. Int. Ed. Engl. | pmid:19437516 |
| Zhang YL et al. | Non-invasive assessment of culture media from goat cloned embryos associated with subjective morphology by gas chromatography - mass spectroscopy-based metabolomic analysis. | 2018 | Anim. Sci. J. | pmid:28833899 |
| Fischer CL et al. | Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria. | 2012 | Antimicrob. Agents Chemother. | pmid:22155833 |
| Vandenbosch D et al. | Phytosphingosine-1-phosphate is a signaling molecule involved in miconazole resistance in sessile Candida albicans cells. | 2012 | Antimicrob. Agents Chemother. | pmid:22354293 |
| Kim HJ et al. | Potentiation of UVB-induced apoptosis by novel phytosphingosine derivative, tetraacetyl phytosphingosine in HaCaT cell and mouse skin. | 2004 | Apoptosis | pmid:15192327 |
| Kim BM et al. | N,N-Dimethyl phytosphingosine sensitizes HL-60/MX2, a multidrug-resistant variant of HL-60 cells, to doxorubicin-induced cytotoxicity through ROS-mediated release of cytochrome c and AIF. | 2010 | Apoptosis | pmid:20512627 |
| Wright BS et al. | Synthesis of 4-hydroxysphinganine and characterization of sphinganine hydroxylase activity in corn. | 2003 | Arch. Biochem. Biophys. | pmid:12831841 |
| Maciel DM et al. | Glycosphingolipids from Magnaporthe grisea cells: expression of a ceramide dihexoside presenting phytosphingosine as the long-chain base. | 2002 | Arch. Biochem. Biophys. | pmid:12220534 |
| Popa I et al. | Analysis of free and protein-bound ceramides by tape stripping of stratum corneum from dogs. | 2010 | Arch. Dermatol. Res. | pmid:20361334 |
| Chang YJ et al. | Structure-activity relationships of dimethylsphingosine (DMS) derivatives and their effects on intracellular pH and Ca2+ in the U937 monocyte cell line. | 2006 | Arch. Pharm. Res. | pmid:16964761 |
| Baek SW et al. | Anti-ulcer actions of phytosphingosine hydrochloride in different experimental rat ulcer models. | 2005 | Arzneimittelforschung | pmid:16149714 |
| Young SA et al. | Sphingolipid and ceramide homeostasis: potential therapeutic targets. | 2012 | Biochem Res Int | pmid:22400113 |
| Quintans J et al. | Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8048941 |
| Candelore MR et al. | Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12270137 |
| Bodennec J et al. | Phytosphingosine biosynthesis differs from sphingosine in fish leukocytes and involves a transfer of methyl groups from [3H-methyl]methionine precursor. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9735337 |
| Fukuda Y et al. | Distribution of sphingosine kinase activity in mouse tissues: contribution of SPHK1. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12943676 |
| Bouchon B et al. | Selective enrichment of phytosphingosine in glycosphingolipids of isolated human thyrocytes as compared to the whole thyroid. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3566758 |
| Lee YK et al. | Characterization of Ca2+ influx induced by dimethylphytosphingosine and lysophosphatidylcholine in U937 monocytes. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16904073 |
| Turinsky J and Nagel GW | Effect of sphingoid bases on basal and insulin-stimulated 2-deoxyglucose transport in skeletal muscle. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1417855 |
| Lanterman MM and Saba JD | Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants. | 1998 | Biochem. J. | pmid:9601083 |
| Luttgeharm KD et al. | Substrate specificity, kinetic properties and inhibition by fumonisin B1 of ceramide synthase isoforms from Arabidopsis. | 2016 | Biochem. J. | pmid:26635357 |
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| Hsu FF | Complete structural characterization of ceramides as [M-H]- ions by multiple-stage linear ion trap mass spectrometry. | 2016 | Biochimie | pmid:27523779 |
| Veerman EC et al. | Phytosphingosine kills Candida albicans by disrupting its cell membrane. | 2010 | Biol. Chem. | pmid:19919184 |
| Becker S et al. | Follicular fluid high-density lipoprotein-associated sphingosine 1-phosphate (S1P) promotes human granulosa lutein cell migration via S1P receptor type 3 and small G-protein RAC1. | 2011 | Biol. Reprod. | pmid:20980685 |
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| Canals D et al. | Synthesis and biological properties of Pachastrissamine (jaspine B) and diastereoisomeric jaspines. | 2009 | Bioorg. Med. Chem. | pmid:19056278 |
| Veerapen N et al. | Synthesis and biological activity of alpha-L-fucosyl ceramides, analogues of the potent agonist, alpha-D-galactosyl ceramide KRN7000. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20462758 |
| Moon BS et al. | Synthesis of novel phytosphingosine derivatives and their preliminary biological evaluation for enhancing radiation therapy. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17920885 |
| Park JJ et al. | Syntheses and biological activities of KRN7000 analogues having aromatic residues in the acyl and backbone chains with varying stereochemistry. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20061147 |
| Thevissen K et al. | Fungicidal activity of truncated analogues of dihydrosphingosine. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18524581 |
phytosphingosine
phytosphingosine is a lipid of Sphingolipids (SP) class. Phytosphingosine is associated with abnormalities such as Infection, Nodule, Dehydration, Neuropathy and nervous system disorder. The involved functions are known as Saturated, sphingomyelin synthase activity, Heat-Shock Response, Cell Growth and Apoptosis. Phytosphingosine often locates in Clone, Protoplasm, Mitochondria, soluble and Cytoplasmic matrix. The associated genes with phytosphingosine are SGMS1 gene, BCL2 gene, Chromatin, Homologous Gene and DLEU2 gene. The related lipids are Sphingolipids, inositolphosphorylceramide, Phosphatidylserines, dihydroceramide and Fatty Acids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of phytosphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phytosphingosine?
phytosphingosine is suspected in Infection, Nodule, Dehydration, Neuropathy, nervous system disorder, Atopic and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with phytosphingosine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phytosphingosine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with phytosphingosine?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with phytosphingosine?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with phytosphingosine?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with phytosphingosine?
Knock-out
Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001) and Knock-out are used in the study 'SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae.' (Brace JL et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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