phytosphingosine

phytosphingosine is a lipid of Sphingolipids (SP) class. Phytosphingosine is associated with abnormalities such as Infection, Nodule, Dehydration, Neuropathy and nervous system disorder. The involved functions are known as Saturated, sphingomyelin synthase activity, Heat-Shock Response, Cell Growth and Apoptosis. Phytosphingosine often locates in Clone, Protoplasm, Mitochondria, soluble and Cytoplasmic matrix. The associated genes with phytosphingosine are SGMS1 gene, BCL2 gene, Chromatin, Homologous Gene and DLEU2 gene. The related lipids are Sphingolipids, inositolphosphorylceramide, Phosphatidylserines, dihydroceramide and Fatty Acids. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of phytosphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phytosphingosine?

phytosphingosine is suspected in Infection, Nodule, Dehydration, Neuropathy, nervous system disorder, Atopic and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with phytosphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phytosphingosine?

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What functions are associated with phytosphingosine?


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What lipids are associated with phytosphingosine?

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What genes are associated with phytosphingosine?

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What common seen animal models are associated with phytosphingosine?

Knock-out

Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001) and Knock-out are used in the study 'SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae.' (Brace JL et al., 2007).

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NCBI Entrez Crosslinks

All references with phytosphingosine

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Authors Title Published Journal PubMed Link
Zhang YL et al. Non-invasive assessment of culture media from goat cloned embryos associated with subjective morphology by gas chromatography - mass spectroscopy-based metabolomic analysis. 2018 Anim. Sci. J. pmid:28833899
Kitamura T et al. Phytosphingosine degradation pathway includes fatty acid α-oxidation reactions in the endoplasmic reticulum. 2017 Proc. Natl. Acad. Sci. U.S.A. pmid:28289220
Yanagawa D et al. Synthesis and degradation of long-chain base phosphates affect fumonisin B-induced cell death in Arabidopsis thaliana. 2017 J. Plant Res. pmid:28303405
Školová B et al. Phytosphingosine, sphingosine and dihydrosphingosine ceramides in model skin lipid membranes: permeability and biophysics. 2017 Biochim. Biophys. Acta pmid:28109750
Jang EJ et al. Anti-melanogenic activity of phytosphingosine via the modulation of the microphthalmia-associated transcription factor signaling pathway. 2017 J. Dermatol. Sci. pmid:28390782
Cubells-Baeza N et al. Identification of the ligand of Pru p 3, a peach LTP. 2017 Plant Mol. Biol. pmid:28299506
Jadhav S et al. Inositol Depletion Induced by Acute Treatment of the Bipolar Disorder Drug Valproate Increases Levels of Phytosphingosine. 2017 J. Biol. Chem. pmid:28100786
Gao H et al. Bacillus cereus strain S2 shows high nematicidal activity against Meloidogyne incognita by producing sphingosine. 2016 Sci Rep pmid:27338781
Luttgeharm KD et al. Substrate specificity, kinetic properties and inhibition by fumonisin B1 of ceramide synthase isoforms from Arabidopsis. 2016 Biochem. J. pmid:26635357
Yönel N et al. Anti-erosive effects of fluoride and phytosphingosine: an in vitro study. 2016 Eur. J. Oral Sci. pmid:27342101
Fischer C et al. Aptamer-based trapping of phytosphingosine in urine samples. 2016 J. Biotechnol. pmid:27637314
Sonnenberger S et al. Synthesis of ceramides NS and NP with perdeuterated and specifically ω deuterated N-acyl residues. 2016 J Labelled Comp Radiopharm pmid:27634543
Martínez-Montañés F et al. Accumulation of long-chain bases in yeast promotes their conversion to a long-chain base vinyl ether. 2016 J. Lipid Res. pmid:27561298
Hsu FF Complete structural characterization of ceramides as [M-H]- ions by multiple-stage linear ion trap mass spectrometry. 2016 Biochimie pmid:27523779
Stahlberg S et al. Probing the Role of Ceramide Headgroup Polarity in Short-Chain Model Skin Barrier Lipid Mixtures by ²H Solid-State NMR Spectroscopy. 2016 Langmuir pmid:26828109
Gómez-Torres MJ et al. Metabolites involved in cellular communication among human cumulus-oocyte-complex and sperm during in vitro fertilization. 2015 Reprod. Biol. Endocrinol. pmid:26553294
Cukkemane N et al. Anti-adherence and bactericidal activity of sphingolipids against Streptococcus mutans. 2015 Eur. J. Oral Sci. pmid:26094809
Valentijn-Benz M et al. Sphingoid bases inhibit acid-induced demineralization of hydroxyapatite. 2015 Caries Res. pmid:25300299
Marquês JT et al. Formation and Properties of Membrane-Ordered Domains by Phytoceramide: Role of Sphingoid Base Hydroxylation. 2015 Langmuir pmid:26262576
Tanaka K et al. Hypoxia remodels the composition of the constituent ceramide species of HexCer and Hex2Cer with phytosphingosine and hydroxy fatty acids in human colon cancer LS174T cells. 2015 Glycoconj. J. pmid:26194060
Veryser L et al. The influence of the acyl chain on the transdermal penetration-enhancing effect of synthetic phytoceramides. 2015 Skin Pharmacol Physiol pmid:25531080
Han SH et al. Phytosphingosine promotes megakaryocytic differentiation of myeloid leukemia cells. 2015 BMB Rep pmid:26077028
Swinnen E et al. The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae. 2014 Mol. Biol. Cell pmid:24196832
Kim BH et al. Phytosphingosine derivatives ameliorate skin inflammation by inhibiting NF-κB and JAK/STAT signaling in keratinocytes and mice. 2014 J. Invest. Dermatol. pmid:24177187
Nagahara Y et al. Loss of Bcl-2 expression correlates with increasing sensitivity to apoptosis in differentiating ES cells. 2014 Cell Biol. Int. pmid:24293136
Di Benedetto R et al. Protected sphingosine from phytosphingosine as an efficient acceptor in glycosylation reaction. 2014 Org. Lett. pmid:24428384
Crehuet R et al. Mechanistic studies on the intramolecular cyclization of O-tosyl phytosphingosines to jaspines. 2014 Nat Prod Commun pmid:25233579
Wu YF et al. First total synthesis of ganglioside DSG-A possessing neuritogenic activity. 2014 Org. Biomol. Chem. pmid:25338766
Grether-Beck S et al. Topical ceramides neither enhance UVB-induced apoptosis in normal human keratinocytes nor affect viability in UVB-irradiated reconstructed human epidermis. 2014 Exp. Dermatol. pmid:25078364
Kondo N et al. Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids. 2014 Nat Commun pmid:25345524
Pepe D et al. Protein transduction domain-containing microemulsions as cutaneous delivery systems for an anticancer agent. 2013 J Pharm Sci pmid:23436680
Lachaud C et al. 14-3-3-regulated Ca(2+)-dependent protein kinase CPK3 is required for sphingolipid-induced cell death in Arabidopsis. 2013 Cell Death Differ. pmid:22935611
Colabardini AC et al. Functional characterization of Aspergillus nidulans ypkA, a homologue of the mammalian kinase SGK. 2013 PLoS ONE pmid:23472095
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Murakami I et al. Improved high-fat diet-induced glucose intolerance by an oral administration of phytosphingosine. 2013 Biosci. Biotechnol. Biochem. pmid:23291756
Sigruener A et al. Effects of sphingoid bases on the sphingolipidome in early keratinocyte differentiation. 2013 Exp. Dermatol. pmid:24079743
Cichewicz A et al. Cutaneous delivery of α-tocopherol and lipoic acid using microemulsions: influence of composition and charge. 2013 J. Pharm. Pharmacol. pmid:23647675
Fischer CL et al. Sphingoid bases are taken up by Escherichia coli and Staphylococcus aureus and induce ultrastructural damage. 2013 Skin Pharmacol Physiol pmid:23128426
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Lu Y et al. Metabolomic profiles of myocardial ischemia under treatment with salvianolic acid B. 2012 Chin Med pmid:22409910
Demirkan A et al. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. 2012 PLoS Genet. pmid:22359512
Montefusco DJ et al. Sphingoid bases and the serine catabolic enzyme CHA1 define a novel feedforward/feedback mechanism in the response to serine availability. 2012 J. Biol. Chem. pmid:22277656
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Huang X et al. Down-regulating sphingolipid synthesis increases yeast lifespan. 2012 PLoS Genet. pmid:22319457
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Guo L et al. Connections between sphingosine kinase and phospholipase D in the abscisic acid signaling pathway in Arabidopsis. 2012 J. Biol. Chem. pmid:22275366
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