phytosphingosine

phytosphingosine is a lipid of Sphingolipids (SP) class. Phytosphingosine is associated with abnormalities such as Infection, Nodule, Dehydration, Neuropathy and nervous system disorder. The involved functions are known as Saturated, sphingomyelin synthase activity, Heat-Shock Response, Cell Growth and Apoptosis. Phytosphingosine often locates in Clone, Protoplasm, Mitochondria, soluble and Cytoplasmic matrix. The associated genes with phytosphingosine are SGMS1 gene, BCL2 gene, Chromatin, Homologous Gene and DLEU2 gene. The related lipids are Sphingolipids, inositolphosphorylceramide, Phosphatidylserines, dihydroceramide and Fatty Acids. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of phytosphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phytosphingosine?

phytosphingosine is suspected in Infection, Nodule, Dehydration, Neuropathy, nervous system disorder, Atopic and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with phytosphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phytosphingosine?

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What functions are associated with phytosphingosine?


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What lipids are associated with phytosphingosine?

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What genes are associated with phytosphingosine?

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What common seen animal models are associated with phytosphingosine?

Knock-out

Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001) and Knock-out are used in the study 'SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae.' (Brace JL et al., 2007).

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NCBI Entrez Crosslinks

All references with phytosphingosine

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Authors Title Published Journal PubMed Link
Van Zeebroeck G et al. A split-ubiquitin two-hybrid screen for proteins physically interacting with the yeast amino acid transceptor Gap1 and ammonium transceptor Mep2. 2011 PLoS ONE pmid:21912684
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Habrukowich C et al. Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells. 2010 J. Biol. Chem. pmid:20558741
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Choi GH et al. The effect of a phytosphingosine-like substance isolated from Asterina pectinifera on involucrin expression in mite antigen-stimulated HaCaT cells. 2010 Nat Prod Commun pmid:20734945
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Park SR et al. Cytotoxic effects of novel phytosphingosine derivatives, including N,N-dimethylphytosphingosine and N-monomethylphytosphingosine, in human leukemia cell line HL60. 2010 Leuk. Lymphoma pmid:20001229
Stroh A et al. Influence of a phytosphingosine-containing chlorhexidine shampoo on superficial bacterial counts and bacterial adherence to canine keratinocytes. 2010 Vet. Microbiol. pmid:19781867
Klang V et al. Enhancement of stability and skin permeation by sucrose stearate and cyclodextrins in progesterone nanoemulsions. 2010 Int J Pharm pmid:20434531
Snel M et al. The effect of dietary phytosphingosine on cholesterol levels and insulin sensitivity in subjects with the metabolic syndrome. 2010 Eur J Clin Nutr pmid:20179727
Peer M et al. Pseudomonas syringae infection triggers de novo synthesis of phytosphingosine from sphinganine in Arabidopsis thaliana. 2010 FEBS Lett. pmid:20732322
Ryu KR et al. Anti-scratching behavioral effects of N-stearoyl-phytosphingosine and 4-hydroxysphinganine in mice. 2010 Lipids pmid:20585891
Kim BM et al. N,N-Dimethyl phytosphingosine sensitizes HL-60/MX2, a multidrug-resistant variant of HL-60 cells, to doxorubicin-induced cytotoxicity through ROS-mediated release of cytochrome c and AIF. 2010 Apoptosis pmid:20512627
Thevissen K et al. Skn1 and Ipt1 negatively regulate autophagy in Saccharomyces cerevisiae. 2010 FEMS Microbiol. Lett. pmid:20030721
Bricard G et al. Α-galactosylceramide analogs with weak agonist activity for human iNKT cells define new candidate anti-inflammatory agents. 2010 PLoS ONE pmid:21179412
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Cowart LA et al. Revealing a signaling role of phytosphingosine-1-phosphate in yeast. 2010 Mol. Syst. Biol. pmid:20160710
Kumar P et al. A general and concise asymmetric synthesis of sphingosine, safingol and phytosphingosines via tethered aminohydroxylation. 2010 Org. Biomol. Chem. pmid:20844791
Popa I et al. Analysis of free and protein-bound ceramides by tape stripping of stratum corneum from dogs. 2010 Arch. Dermatol. Res. pmid:20361334
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Dieterle MG et al. Characterization of the temperature-sensitive mutations un-7 and png-1 in Neurospora crassa. 2010 PLoS ONE pmid:20502699
Park JJ et al. Syntheses and biological activities of KRN7000 analogues having aromatic residues in the acyl and backbone chains with varying stereochemistry. 2010 Bioorg. Med. Chem. Lett. pmid:20061147
Veerapen N et al. Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide. 2009 Bioorg. Med. Chem. Lett. pmid:19502056
Canals D et al. Synthesis and biological properties of Pachastrissamine (jaspine B) and diastereoisomeric jaspines. 2009 Bioorg. Med. Chem. pmid:19056278
Hoeller S et al. Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation. 2009 Int J Pharm pmid:19073240
Videira A et al. Transcriptional analysis of the response of Neurospora crassa to phytosphingosine reveals links to mitochondrial function. 2009 Microbiology (Reading, Engl.) pmid:19520721
Yin P et al. A metabonomic study of hepatitis B-induced liver cirrhosis and hepatocellular carcinoma by using RP-LC and HILIC coupled with mass spectrometry. 2009 Mol Biosyst pmid:19603122
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Jiang H et al. Achieving molecular complexity by organocatalytic one-pot strategies - a fast entry for synthesis of sphingoids, amino sugars, and polyhydroxylated alpha-amino acids. 2009 Angew. Chem. Int. Ed. Engl. pmid:19437516
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Mitsui K et al. Saccharomyces cerevisiae Na+/H+ antiporter Nha1p associates with lipid rafts and requires sphingolipid for stable localization to the plasma membrane. 2009 J. Biochem. pmid:19254924
Cerantola V et al. Aureobasidin A arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides. 2009 Mol. Microbiol. pmid:19210614
Hill JR and Wertz PW Structures of the ceramides from porcine palatal stratum corneum. 2009 Lipids pmid:19184160
Kim BM et al. N,N-dimethyl phytosphingosine induces caspase-8-dependent cytochrome c release and apoptosis through ROS generation in human leukemia cells. 2009 Toxicol. Appl. Pharmacol. pmid:19481559
Hicks AA et al. Genetic determinants of circulating sphingolipid concentrations in European populations. 2009 PLoS Genet. pmid:19798445
Dias BR et al. Identification of iGb3 and iGb4 in melanoma B16F10-Nex2 cells and the iNKT cell-mediated antitumor effect of dendritic cells primed with iGb3. 2009 Mol. Cancer pmid:19968878
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Jansson L et al. Sulfatide recognition by colonization factor antigen CS6 from enterotoxigenic Escherichia coli. 2009 PLoS ONE pmid:19242561
Inagaki M et al. Isolation and structure of hematoside-type ganglioside from the starfish Linckia laevigata. 2009 Chem. Pharm. Bull. pmid:19182413
Rodgers A et al. Sphingosine 1-phosphate regulation of extracellular signal-regulated kinase-1/2 in embryonic stem cells. 2009 Stem Cells Dev. pmid:19228106
Park JJ et al. Divergent syntheses of all stereoisomers of phytosphingosine and their use in the construction of a ceramide library. 2008 Bioorg. Chem. pmid:18279909
Pruett ST et al. Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. 2008 J. Lipid Res. pmid:18499644