phytosphingosine

phytosphingosine is a lipid of Sphingolipids (SP) class. Phytosphingosine is associated with abnormalities such as Infection, Nodule, Dehydration, Neuropathy and nervous system disorder. The involved functions are known as Saturated, sphingomyelin synthase activity, Heat-Shock Response, Cell Growth and Apoptosis. Phytosphingosine often locates in Clone, Protoplasm, Mitochondria, soluble and Cytoplasmic matrix. The associated genes with phytosphingosine are SGMS1 gene, BCL2 gene, Chromatin, Homologous Gene and DLEU2 gene. The related lipids are Sphingolipids, inositolphosphorylceramide, Phosphatidylserines, dihydroceramide and Fatty Acids. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of phytosphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phytosphingosine?

phytosphingosine is suspected in Infection, Nodule, Dehydration, Neuropathy, nervous system disorder, Atopic and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with phytosphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phytosphingosine?

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What functions are associated with phytosphingosine?


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What lipids are associated with phytosphingosine?

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What genes are associated with phytosphingosine?

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What common seen animal models are associated with phytosphingosine?

Knock-out

Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001) and Knock-out are used in the study 'SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae.' (Brace JL et al., 2007).

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NCBI Entrez Crosslinks

All references with phytosphingosine

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Authors Title Published Journal PubMed Link
Skrzypek MS et al. Inhibition of amino acid transport by sphingoid long chain bases in Saccharomyces cerevisiae. 1998 J. Biol. Chem. pmid:9446592
Bodennec J et al. Phytosphingosine biosynthesis differs from sphingosine in fish leukocytes and involves a transfer of methyl groups from [3H-methyl]methionine precursor. 1998 Biochem. Biophys. Res. Commun. pmid:9735337
Jennemann R et al. Novel glycoinositolphosphosphingolipids, basidiolipids, from Agaricus. 1999 Eur. J. Biochem. pmid:9914511
Sharma C et al. Inhibition of Ca2+ release channel (ryanodine receptor) activity by sphingolipid bases: mechanism of action. 2000 Chem. Phys. Lipids pmid:10660207
Grilley MM and Takemoto JY Assay of the Saccharomyces cerevisiae dihydrosphingosine C-4 hydroxylase. 2000 Meth. Enzymol. pmid:10563305
Chung N and Obeid LM Use of yeast as a model system for studies of sphingolipid metabolism and signaling. 2000 Meth. Enzymol. pmid:10563337
Chung N et al. Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. 2000 J. Biol. Chem. pmid:10764732
Azuma H et al. Stereospecific total syntheses of sphingosine and its analogues from L-serine. 2000 J. Org. Chem. pmid:10843643
Zanolari B et al. Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae. 2000 EMBO J. pmid:10856228
Bodennec J et al. Purification of free sphingoid bases by solid-phase extraction on weak cation exchanger cartridges. 2000 Anal. Biochem. pmid:10706795