phytosphingosine

phytosphingosine is a lipid of Sphingolipids (SP) class. Phytosphingosine is associated with abnormalities such as Infection, Nodule, Dehydration, Neuropathy and nervous system disorder. The involved functions are known as Saturated, sphingomyelin synthase activity, Heat-Shock Response, Cell Growth and Apoptosis. Phytosphingosine often locates in Clone, Protoplasm, Mitochondria, soluble and Cytoplasmic matrix. The associated genes with phytosphingosine are SGMS1 gene, BCL2 gene, Chromatin, Homologous Gene and DLEU2 gene. The related lipids are Sphingolipids, inositolphosphorylceramide, Phosphatidylserines, dihydroceramide and Fatty Acids. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of phytosphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phytosphingosine?

phytosphingosine is suspected in Infection, Nodule, Dehydration, Neuropathy, nervous system disorder, Atopic and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with phytosphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phytosphingosine?

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What functions are associated with phytosphingosine?


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What lipids are associated with phytosphingosine?

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What genes are associated with phytosphingosine?

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What common seen animal models are associated with phytosphingosine?

Knock-out

Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001) and Knock-out are used in the study 'SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae.' (Brace JL et al., 2007).

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NCBI Entrez Crosslinks

All references with phytosphingosine

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Authors Title Published Journal PubMed Link
Kołaczkowska A et al. The regulatory inputs controlling pleiotropic drug resistance and hypoxic response in yeast converge at the promoter of the aminocholesterol resistance gene RTA1. 2012 FEMS Yeast Res. pmid:22129104
Frank S et al. Structural characterization of Schistosoma mansoni adult worm glycosphingolipids reveals pronounced differences with those of cercariae. 2012 Glycobiology pmid:22241826
Zhao YY et al. Urinary metabonomics study on biochemical changes in an experimental model of chronic renal failure by adenine based on UPLC Q-TOF/MS. 2012 Clin. Chim. Acta pmid:22227165
Schorsch C et al. High-level production of tetraacetyl phytosphingosine (TAPS) by combined genetic engineering of sphingoid base biosynthesis and L-serine availability in the non-conventional yeast Pichia ciferrii. 2012 Metab. Eng. pmid:22178746
Li SF et al. Isolation and functional characterisation of the genes encoding Δ(8)-sphingolipid desaturase from Brassica rapa. 2012 J Genet Genomics pmid:22293117
Chang Y et al. Metabolic profiling based on LC/MS to evaluate unintended effects of transgenic rice with cry1Ac and sck genes. 2012 Plant Mol. Biol. pmid:22271304
Ramu Sridhar P et al. Stereoselective synthesis of C18-guggultetrol and C18-phytosphingosine analogues from D-fructose. 2012 Carbohydr. Res. pmid:22975277
Byun HJ et al. Lipid ingredients in moisturizers can modulate skin responses to UV in barrier-disrupted human skin in vivo. 2012 J. Dermatol. Sci. pmid:22209282
Chao DY et al. Sphingolipids in the root play an important role in regulating the leaf ionome in Arabidopsis thaliana. 2011 Plant Cell pmid:21421810
Guillas I et al. A matter of fat: interaction between nitric oxide and sphingolipid signaling in plant cold response. 2011 Plant Signal Behav pmid:21248493
Hinder A et al. Investigation of the molecular structure of the human stratum corneum ceramides [NP] and [EOS] by mass spectrometry. 2011 Skin Pharmacol Physiol pmid:21212722
Zitomer NC and Riley RT Extraction and analysis of fumonisins and compounds indicative of fumonisin exposure in plant and mammalian tissues and cultured cells. 2011 Methods Mol. Biol. pmid:21567327
Momin AA et al. A method for visualization of "omic" datasets for sphingolipid metabolism to predict potentially interesting differences. 2011 J. Lipid Res. pmid:21415121
BÅ‚achnio-Zabielska A et al. Aerobic training in rats increases skeletal muscle sphingomyelinase and serine palmitoyltransferase activity, while decreasing ceramidase activity. 2011 Lipids pmid:21181285
Wun KS et al. A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells. 2011 Immunity pmid:21376639
Bozna BL et al. Binding strength and dynamics of invariant natural killer cell T cell receptor/CD1d-glycosphingolipid interaction on living cells by single molecule force spectroscopy. 2011 J. Biol. Chem. pmid:21454514
Guo L et al. Phosphatidic acid binds and stimulates Arabidopsis sphingosine kinases. 2011 J. Biol. Chem. pmid:21330371
Bowe WP and Logan AC Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future? 2011 Gut Pathog pmid:21281494
Lee YJ et al. Defects in very long chain fatty acid synthesis enhance alpha-synuclein toxicity in a yeast model of Parkinson's disease. 2011 PLoS ONE pmid:21264320
Jervis PJ et al. Synthesis of a versatile building block for the preparation of 6-N-derivatized α-galactosyl ceramides: rapid access to biologically active glycolipids. 2011 J. Org. Chem. pmid:21155575