phytosphingosine

phytosphingosine is a lipid of Sphingolipids (SP) class. Phytosphingosine is associated with abnormalities such as Infection, Nodule, Dehydration, Neuropathy and nervous system disorder. The involved functions are known as Saturated, sphingomyelin synthase activity, Heat-Shock Response, Cell Growth and Apoptosis. Phytosphingosine often locates in Clone, Protoplasm, Mitochondria, soluble and Cytoplasmic matrix. The associated genes with phytosphingosine are SGMS1 gene, BCL2 gene, Chromatin, Homologous Gene and DLEU2 gene. The related lipids are Sphingolipids, inositolphosphorylceramide, Phosphatidylserines, dihydroceramide and Fatty Acids. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of phytosphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phytosphingosine?

phytosphingosine is suspected in Infection, Nodule, Dehydration, Neuropathy, nervous system disorder, Atopic and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with phytosphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phytosphingosine?

Related references are published most in these journals:

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What functions are associated with phytosphingosine?


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What lipids are associated with phytosphingosine?

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What genes are associated with phytosphingosine?

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What common seen animal models are associated with phytosphingosine?

Knock-out

Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001) and Knock-out are used in the study 'SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae.' (Brace JL et al., 2007).

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NCBI Entrez Crosslinks

All references with phytosphingosine

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Authors Title Published Journal PubMed Link
Barreto-Bergter E et al. Structural analysis of fungal cerebrosides. 2011 Front Microbiol pmid:22164155
Veerapen N et al. Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation. 2011 Bioorg. Med. Chem. pmid:21145749
Nimrichter L and Rodrigues ML Fungal glucosylceramides: from structural components to biologically active targets of new antimicrobials. 2011 Front Microbiol pmid:22025918
Martinková M et al. A facile synthesis of D-ribo-C(20)-phytosphingosine and its C2 epimer from D-ribose. 2011 Carbohydr. Res. pmid:21703597
Fu C et al. Metabonomics study of the protective effects of green tea polyphenols on aging rats induced by d-galactose. 2011 J Pharm Biomed Anal pmid:21444175
Van Zeebroeck G et al. A split-ubiquitin two-hybrid screen for proteins physically interacting with the yeast amino acid transceptor Gap1 and ammonium transceptor Mep2. 2011 PLoS ONE pmid:21912684
Uchida Y The role of fatty acid elongation in epidermal structure and function. 2011 Dermatoendocrinol pmid:21695014
Ideta R et al. Orally administered glucosylceramide improves the skin barrier function by upregulating genes associated with the tight junction and cornified envelope formation. 2011 Biosci. Biotechnol. Biochem. pmid:21821935
Lee WS Integral hair lipid in human hair follicle. 2011 J. Dermatol. Sci. pmid:21906914
Coddens A et al. Erythrocyte and porcine intestinal glycosphingolipids recognized by F4 fimbriae of enterotoxigenic Escherichia coli. 2011 PLoS ONE pmid:21949679
Merrill AH Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. 2011 Chem. Rev. pmid:21942574
Koeller CM and Heise N The Sphingolipid Biosynthetic Pathway Is a Potential Target for Chemotherapy against Chagas Disease. 2011 Enzyme Res pmid:21603271
Murakami I et al. Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors. 2011 Lipids Health Dis pmid:21861924
Rives A et al. Asymmetric synthesis and cytotoxic activity of isomeric phytosphingosine derivatives. 2011 Org. Biomol. Chem. pmid:21986639
Cheng JM et al. An improved synthesis of dansylated α-galactosylceramide and its use as a fluorescent probe for the monitoring of glycolipid uptake by cells. 2011 Carbohydr. Res. pmid:21463856
Hasegawa T et al. Dietary glucosylceramide enhances cornified envelope formation via transglutaminase expression and involucrin production. 2011 Lipids pmid:21416143
Becker S et al. Follicular fluid high-density lipoprotein-associated sphingosine 1-phosphate (S1P) promotes human granulosa lutein cell migration via S1P receptor type 3 and small G-protein RAC1. 2011 Biol. Reprod. pmid:20980685
Loewith R and Hall MN Target of rapamycin (TOR) in nutrient signaling and growth control. 2011 Genetics pmid:22174183
Jung JC et al. Phytoceramide shows neuroprotection and ameliorates scopolamine-induced memory impairment. 2011 Molecules pmid:22037667
Liu Z et al. Total synthesis of α-1C-galactosylceramide, an immunostimulatory C-glycosphingolipid, and confirmation of the stereochemistry in the first-generation synthesis. 2011 J. Org. Chem. pmid:21958232